Search

Your search keyword '"Campieri M"' showing total 22 results
Start Over Author "Campieri M" Publisher springer science and business media llc
22 results on '"Campieri M"'

4. Use of anti-tumour necrosis factor agents in inflammatory bowel disease

Author

Schreiber, S., primary, Campieri, M., additional, Colombel, J.F., additional, van Deventer, S.J.H., additional, Feagan, B., additional, Fedorak, R., additional, Forbes, A., additional, Gassull, M., additional, Gendre, J.P., additional, van Hogezand, R.A., additional, Lofberg, R., additional, Modigliani, R., additional, Pallone, F., additional, Petritsch, W., additional, Prantera, C., additional, Rampton, D., additional, Seibold, F., additional, Vatn, M., additional, Zeitz, M., additional, and Rutgeerts, P., additional

Published
2001
Full Text
View/download PDF

5. Treatment of distal colitis

Author

Campieri, M., primary, Rizzello, F., additional, Venturi, A., additional, Romboli, E., additional, Palmonari, V., additional, and Gionchetti, P., additional

Published
2000
Full Text
View/download PDF

9. Abstract form for the Irish Journal of Medical Science v workshop on gastroduodenal pathology and Helicobacter pylori July 5th — 7th 1992 — Dublin, Ireland

Author

Logan, R. P. H., primary, Gummett, P. A., additional, Walker, M. M., additional, Karim, Q. N., additional, Baron, J. H., additional, Misiewicz, J. J., additional, Trieber, G., additional, Walker, S., additional, Klotz, U., additional, Lozniewski, A., additional, Weber, M., additional, de Korwin, J. D., additional, Floquet, J., additional, Conroy, M. C., additional, Burdin, J. C., additional, Mannes, G. A., additional, Bayerdörffer, E., additional, Höchter, W., additional, Weingart, J., additional, Heldwein, W., additional, Sommer, A., additional, Müller-Lissner, S., additional, Bomschein, W., additional, Miehlke, S., additional, Weinzierl, M., additional, Ruckdeschel, G., additional, von Wulffen, H., additional, Köpcke, W., additional, Stolte, M., additional, Rune, S. J., additional, Justesen, T., additional, Hansen, J. M., additional, Jensen, T. G., additional, Eriksen, J., additional, Thomsen, O. ø., additional, Scheibel, J., additional, Bonnevie, O., additional, Bremmelgaard, A., additional, Vilien, M., additional, Knuhtsen, S., additional, Elsborg, L., additional, Hansen, J., additional, Lauritsen, K., additional, Wulff, H. R., additional, Boixeda, D., additional, Ballestero, S., additional, Cantón, R., additional, De Rafael, L., additional, Martinm de Argila, C., additional, Pozuelo, M. J., additional, Sampedro, J., additional, Baquero, F., additional, Grigoriev, P. Ya., additional, Isakov, V. A., additional, Iakovenko, E. P., additional, Hirschl, A. M., additional, Brandstätter, G., additional, Dragosics, B., additional, Hentschel, E., additional, Kundi, M., additional, Rotter, M. L., additional, Schütze, K., additional, Taufer, M., additional, Neri, M, additional, Susi, D, additional, Bovani, I, additional, Pindo, R, additional, Cuccurullo, F., additional, Coelho, L. G. V., additional, Passos, M. C. F., additional, Chausson, Y., additional, Vieira, W. L. S., additional, Castro, F. J., additional, Franco, J. M. M., additional, Fernandes, M. L. M., additional, Castro, L. P., additional, Jonas, C., additional, De Koster, E., additional, Van Gossum, M., additional, Depierreux, M., additional, Cheval, M., additional, Deltenre, M., additional, Schütz, E., additional, Bethke, B., additional, Lee, A., additional, Hegedus, E., additional, O’Rourke, J., additional, Larsson, H., additional, Sjöstedt, S., additional, Veress, B., additional, Nord, C. E., additional, Sobala, G. M., additional, George, R., additional, Tompkins, D., additional, Finlay, J., additional, Manning, A., additional, Sant, S., additional, Xia, H. X., additional, Daw, M., additional, Gilvarry, J., additional, Keane, C. T., additional, O’Morain, C., additional, Rubio, M. A., additional, Hegarty, B., additional, Blum, A. L., additional, Sulser, E., additional, Stadelmann, O., additional, Munoz, N., additional, Buiatti, E., additional, Vivas, J., additional, Oliver, W., additional, Cano, E., additional, Peraza, S., additional, Castro, D., additional, Sanchez, V., additional, Andrade, O., additional, Benz, M., additional, Mendz, G. L., additional, Hazell, S. L., additional, Salmela, K. S., additional, Roire, R. P., additional, Hook-Nikanne, J., additional, Kosunen, T. U., additional, Salaspur, M., additional, Luke, C. J., additional, Reynolds, D. D. J., additional, Penn, C. W., additional, Bode, G., additional, Mauch, F., additional, Ditschuneit, H., additional, Malfertheiner, P., additional, Ferrero, Richard L., additional, Agnes, Labigne, additional, Eaton, K. A., additional, Krakowka, S., additional, Mobley, H. L. T., additional, Hu, Li-Tai, additional, Foxall, P. A., additional, Moran, A. P., additional, Helander, I. M., additional, Altman, C., additional, Sobhani, I., additional, Vissugaire, C., additional, Migrant, M., additional, Etienne, J. P., additional, Sommi, P., additional, Ricci, V., additional, Fiocca, R., additional, Cova, E., additional, Figura, N., additional, Romano, M., additional, Ivey, K. J., additional, Solcia, E., additional, Ventura, U., additional, Nilius, M., additional, Schieffer, S., additional, Hengels, K. J., additional, Jablonowski, H., additional, Strohmeyer, G., additional, Cabrai, M. D., additional, Barbosa, A. J. A., additional, Lima Hr., G. F., additional, Oliveira, C. A., additional, Polak, J. M., additional, Oderda, G., additional, Villani, L., additional, Altare, F., additional, Morra, I., additional, Miserendino, L., additional, Ansaldi, N., additional, Dixon, M. F., additional, Wyatt, J. I., additional, Axon, A. T. R., additional, Beattie, S., additional, Hamilton, H., additional, Shabib, S., additional, Cutz, E., additional, Drumm, B., additional, Sherman, P., additional, Noach, L. A., additional, Rolf, T., additional, Bosma, N. B., additional, Schwartz, M. P., additional, Oosting, J., additional, Rauws, E. A. J., additional, Tytgat, G. N. J., additional, Andrew, A., additional, Nardone, G., additional, d’Ormiento, F., additional, Pontillo, M., additional, Lobo, A. J., additional, Uff, J. S., additional, McNulty, C. N. M., additional, Wilkinson, S. P., additional, Suriani, R., additional, Pallante, C., additional, Ravizza, M., additional, Galliano, D., additional, Sallio, D., additional, Malandrino, M., additional, Oneglio, R., additional, Colozza, M., additional, Mazzucco, D., additional, Gaia, E., additional, Eidt, S., additional, Vincent, P., additional, Gottrand, F., additional, Turck, D., additional, Lecomte-Houcke, M., additional, Leclerc, H., additional, Bonvicini, F., additional, Pretolani, S., additional, Baraldini, M., additional, Cilla, D., additional, Baldinelli, S., additional, Bazocchi, E., additional, Acampora, P., additional, Careddu, N., additional, Brocchi, E., additional, Gasbarrini, G., additional, Joubert, M., additional, Bazin, N., additional, Thiaucourt, D., additional, Protte, E., additional, Gissler, C., additional, Duprez, A., additional, Merlin, P., additional, Forestier, S., additional, Labenz, J., additional, Gyenes, E., additional, Rühl, G. H., additional, Börsch, G., additional, Daskalopoulos, G., additional, Carrick, J., additional, Lian, R., additional, Wagner, S., additional, Bleck, J., additional, Gebel, M., additional, Bär, W., additional, Manns, M., additional, Lamouliatte, H., additional, Bernard, P. H., additional, Cayla, R., additional, Vialette, G., additional, Quinton, A., additional, Mégraud, F., additional, Lemaire, M., additional, Quinten, A., additional, De Mascarel, A., additional, Webb, P., additional, Forman, D., additional, Knight, T., additional, Wilson, A., additional, Graves, S., additional, Newell, D., additional, Elder, J., additional, Tonelli, E., additional, Gatte, M. R. A., additional, Ghironzi, G. C., additional, Giulianelli, G., additional, Bamford, K. B., additional, Collins, J. S. A., additional, Bickley, J., additional, Johnston, B. T., additional, Potts, S., additional, Boston, V., additional, Owen, R. J., additional, Sloan, J., additional, Basso, L., additional, Lawlor, S., additional, Clune, J., additional, Szelényi, H., additional, Stohmeyer, G., additional, Macedo, G., additional, Iglésias, I., additional, Chaves, A. P., additional, Loureiro, A., additional, Katelaris, P. H., additional, Seow, F., additional, Lin, B., additional, Napoli, J., additional, Hones, D. B., additional, Ngu, M. C., additional, Akopyantz, Natalia S., additional, Bukanov, Nikolay O., additional, Westblom, T. Ulf, additional, Berg, Douglas E., additional, Nyst, J. F., additional, Denis, P., additional, Buset, M., additional, De Reuck, M., additional, Nielsen, H., additional, Andersen, L. P., additional, Birkholz, Sabine, additional, Knipp, Ulrich, additional, Nietzki, Claudia, additional, Opferkuch, Wolfgang, additional, Crabtree, J. E., additional, Peichl, P., additional, Lindly, I. J. D., additional, Deusch, K., additional, Seifirth, C., additional, Funk, A., additional, Dahie, I., additional, Reut, K., additional, Classen, M., additional, Gionchetti, P., additional, Vaira, D., additional, Campieri, M., additional, Bertinelli, E., additional, Menegatti, M., additional, Belluzzi, A., additional, Briognola, C., additional, Miglioli, M., additional, Barbara, L., additional, Tommaso, A. Di, additional, Magistris, M. T. De, additional, Bugnoli, M., additional, Petracca, R., additional, Covacci, A., additional, Censini, S., additional, Rappuoli, R., additional, Abrignani, S., additional, Territo, M. C., additional, Smela, K. L., additional, Reeve, J. R., additional, Lee, T. D., additional, Walsh, J. H., additional, Armellini, D., additional, Xiang, Z. Y., additional, Mitchell, H. M., additional, Hu, P. J., additional, Li, Y. Y., additional, Wang, Z. J., additional, Zhao, S. M., additional, Liu, Q., additional, Chen, M., additional, Du, G. G., additional, Filipe, M. I., additional, Reed, P. I., additional, Craanen, M. E., additional, Blok, P., additional, Dekker, W., additional, Colombo, E., additional, Redaelli, D., additional, Santangelo, M., additional, Spinelli, M., additional, Farinati, F., additional, Valiante, F., additional, Delia Libera, G., additional, Germanà, B., additional, Baffa, R., additional, Rugge, M., additional, Vianelo, F., additional, Di Mario, F., additional, Sipponen, Pentti, additional, Rokkas, T., additional, Popotheodorou, G., additional, Kaldgeropoulos, N., additional, Deprez, C., additional, Galand, P., additional, Fox, J. G., additional, Wishnok, P., additional, Murphy, J. C., additional, Tannenbaum, S., additional, Correa, P., additional, Parsonnet, Julie, additional, Macor, C., additional, Da Broi, G. L., additional, Avellinio, C., additional, Reifen, R., additional, Rasooly, I., additional, Millson, M. E., additional, Murphy, K., additional, Thomas, J. E., additional, Eastham, E. J., additional, Malorgio, E., additional, Dell’Olio, D., additional, Kemmer, T. P., additional, Dominguez-Munoz, J. E., additional, Klingel, H., additional, Gatto, M. R. A., additional, Olivieri, R., additional, Bayeli, R. F., additional, Abate, L., additional, De Gregorio, L., additional, Aziz, J., additional, Esposito, E., additional, Basagni, C., additional, Guilluy, R., additional, Rousseau-Tsangaris, M., additional, Brazier, J. L., additional, Wadstiöm, Torkel, additional, Tyszkiewicz, Tadeusz, additional, Bergenzaun, Per, additional, Olsson, Karin, additional, Birac, C., additional, Tall, F., additional, Albenque, M., additional, Labigne, A., additional, Megraud, F., additional, Feldman, R. A., additional, Deeks, J., additional, Glupczynski, Y., additional, Burette, A., additional, Goossens, H., additional, Van den Boore, C., additional, Butzler, J. P., additional, Veldhuyzen van Zanten, S., additional, Best, L., additional, Benzanson, G., additional, Haldane, D., additional, Hazell, S., additional, Mapstone, N. P., additional, Lynch, D. A. F., additional, Quirke, P., additional, Taylor, D. E., additional, Chang, N., additional, Eaton, M., additional, Stockdale, E., additional, Salama, S. M., additional, Thompson, L., additional, Cockayne, A., additional, Spiller, R. C., additional, Leen, E., additional, Sweeney, E., additional, Klann, H., additional, Hatz, R., additional, Bornschein, W., additional, Simon, T., additional, Eimiller, A., additional, Bolle, F., additional, Schweikert, C., additional, Köpeke, W., additional, Moss, S. F., additional, Bishop, A. E., additional, Calam, J., additional, Cahill, R. J., additional, Xia, H., additional, Solnick, J., additional, and Tompkins, L., additional

Published
1992
Full Text
View/download PDF

10. Microbiology

Author

Figura, N., primary, Owen, R. J., additional, Desai, M., additional, Bayeli, P. F., additional, HGregorio, L. Di, additional, Russi, M., additional, Musmanno, R. A., additional, Hawtin, P. R., additional, Sharpstone, D., additional, Hayes, L., additional, Nøorgaard, A., additional, Nielsen, H., additional, Andersen, L. P., additional, Geis, G., additional, Leying, H., additional, Suerbaum, S., additional, Opferkuch, W., additional, Tonokatsu, Y., additional, Hayashi, T., additional, Fukuda, Y., additional, Yamamoto, I., additional, Takami, S., additional, Tamura, T., additional, Shimoyama, T., additional, Lopez-Brea, M., additional, Martin, E., additional, C.Sanz, J., additional, Alonso, M., additional, Alarcon, T., additional, Michetti, P., additional, Porta, N., additional, Racine, L., additional, P.Kraehenbuhl, J., additional, L.Blum, A., additional, Cardeñoso, L., additional, Moran, A. P., additional, Muotiala, A., additional, Pyhälä, L., additional, Kosunen, T. U., additional, Helander, I. M., additional, Roine, R. P., additional, Salmela, K. S., additional, Höök-Nikanne, J., additional, Salaspuro, M., additional, Daw, M. A., additional, Xia, H. X., additional, O’Morain, C., additional, Lelwala-Guruge, J., additional, Ascencio, F., additional, Ljungh, Å., additional, Wadström, T., additional, Ringnér, Martina, additional, Valkonen, Kaija, additional, Paulsson, Marianne, additional, Ljungh, Åsa, additional, Wadström, Torkel, additional, Guldvog, I., additional, Tannaes, T., additional, Bukholm, G., additional, Grav, H., additional, Corinaldesi, R., additional, Tucci, A., additional, Stanghellini, V., additional, Gasperoni, S., additional, Varoli, O., additional, Paparo, G. F., additional, Gaetani, M., additional, Cioffi, G., additional, Barbara, L., additional, Husson, M. O., additional, Legrand, D., additional, Mazurier, J., additional, Caron, C., additional, Leclerc, H., additional, Spik, G., additional, English, L., additional, Keane, C. T., additional, O’Morain, C. A., additional, Fox, J. G., additional, Correa, P., additional, Taylor, N. S., additional, Fatela, N., additional, Melo Cristino, J., additional, Monteiro, L., additional, Ramalho, F., additional, Saragoça, A., additional, Salgado, M.J, additional, Mauch, F., additional, Bode, G., additional, Ditschuneit, H., additional, Malfertheiner, P., additional, Nilius, M., additional, Pugliese, M., additional, Moshkowitz, M., additional, Gorea, A., additional, Santo, M., additional, Berger, S., additional, Gilat, T., additional, Belluzzi, A., additional, Vaira, D., additional, Campieri, M., additional, Boschi, S., additional, Gionchetti, P., additional, Mulè, P., additional, Brignola, C., additional, Rizzello, F., additional, Miglioli, M., additional, Lamouliatte, H., additional, Brugmann, D., additional, Cayla, R., additional, H. Bernard, P., additional, Mégraud, F., additional, Quinton, A., additional, Bär, W., additional, Wagner, S., additional, Glen-Calvo, E., additional, Koopmann, H., additional, Szentmihalyi, A., additional, Radnai, Z., additional, Molnar, Gy., additional, Bálint, A., additional, and Ihász, M., additional

Published
1992
Full Text
View/download PDF

19. Sporadic small bowel tumors detected by capsule endoscopy in patients with occult gastrointestinal bleeding

Author

Fernando Rizzello, Nico Pagano, Paolo Gionchetti, Massimo Campieri, Carlo Calabrese, A. Calafiore, Calabrese, C, Gionchetti, P, Calafiore, A, Pagano, N, Campieri, M, and Rizzello, F

Subjects
Adult, Male, Enteroscopy, medicine.medical_specialty, Gastrointestinal bleeding, Capsule endoscopy, Small bowel tumors, Occult gastrointestinal bleeding, Context (language use), Capsule Endoscopy, Gastroenterology, law.invention, Capsule endoscopy, law, Internal medicine, Intestinal Neoplasms, Internal Medicine, medicine, Humans, Prospective Studies, Aged, Retrospective Studies, Aged, 80 and over, GiST, business.industry, Middle Aged, medicine.disease, Occult, digestive system diseases, Hyperplastic Polyp, Emergency Medicine, Adenocarcinoma, Gastrointestinal Hemorrhage, business
Abstract

Intestinal tumors represent less than 6 % of digestive tumors, and, because of the limitations of intestinal investigations, these tumors are difficult to diagnose. In this context, capsule endoscopy has proven effective, especially in patients with obscure digestive bleeding. In a large series of patients undergoing capsule endoscopy, small bowel tumors are found in 2.4–8.9 % of cases. The aim of this retrospective, single-center study, based on prospective database, is to evaluate the frequency of small bowel tumors detected by capsule endoscopy in patients with occult gastrointestinal bleeding. During 2004–2014, 849 consecutive patients underwent CE at our Department for occult gastrointestinal bleeding. Following capsule endoscopy, the medical records of the study population were reviewed. Results of double-balloon enteroscopy or surgery performed after capsule endoscopy were retrieved. Capsule endoscopy identified 55 small bowel tumors (6.5 %), of which 28 malignancies (51 %) and 27 benign neoplasms (49 %) underwent surgery or endoscopic treatment. Malignancies included adenocarcinoma (18.7 %), gastrointestinal stromal tumors (GIST) (12 %) and lymphoma (6.7 %). Benign neoplasms included dysplastic adenomatous polyps (36 %) and hyperplastic polyps (25.3 %). Non-neoplastic masses included one inflammatory polyp. Capsule retention occurred in four patients (5.3 %) and the retained capsule was retrieved during surgery. In our experience neoplasms of small bowel are found in 6.5 % of patients with occult gastrointestinal bleeding. Of these malignancies, small bowel neoplasms are found in 3.3 % of cases. Capsule endoscopy is an effective and sensitive diagnostic tool, and plays an important role in the algorithm for the diagnostic workup of suspected small bowel tumors.

Published
2015
Full Text
View/download PDF

20. Effects of new fish oil derivative on fatty acid phospholipid-membrane pattern in a group of Crohn's disease patients

Author

G. De Simone, Corrado Brignola, E. P. Camporesi, Paolo Gionchetti, C. Belloli, Fernando Rizzello, Andrea Belluzzi, Stefano Boschi, Massimo Campieri, Luigi Barbara, M. Miglioli, Belluzzi A., Brignola C., Campieri M., Camporesi E.P., Gionchetti P., Rizzello F., Belloli C., De Simone G., Boschi S., Miglioli M., and Barbara L.

Subjects
Adult, Male, Docosahexaenoic Acids, Physiology, Phospholipid, Pharmacology, Inflammatory bowel disease, Dosage form, Membrane Lipids, chemistry.chemical_compound, Fish Oils, Crohn Disease, Dietary Fats, Unsaturated, Drug Combination, Delayed-Action Preparation, Fatty Acids, Omega-3, medicine, Humans, Phospholipids, Docosahexaenoic Acid, chemistry.chemical_classification, Triglyceride, business.industry, Erythrocyte Membrane, Gastroenterology, Fatty acid, Fish Oil, Fish oil, medicine.disease, Eicosapentaenoic acid, Crohn's disease, Drug Combinations, Eicosapentaenoic Acid, chemistry, Biochemistry, Docosahexaenoic acid, Delayed-Action Preparations, Membrane Lipid, Patient Compliance, Female, lipids (amino acids, peptides, and proteins), business, Human
Abstract

Fish oil has been recently proposed as a possible effective treatment in inflammatory bowel disease (IBD); however, a lot of annoying side effects (ie, belching, halitosis, diarrhea, etc) affect patient compliance. We carried out a study of patient tolerance in a group of Crohn's disease (CD) patients with a new fish oil derivative consisting of 500-mg capsules of eicosapentaenoic-docosahexaenoic (EPA 40%-DHA 20%), a free fatty acid mixture (Purepa), and we also evaluated its incorporation into phospholipids, both in plasma and in red cell membranes. Five groups of 10 CD patients in remission received nine Purepa capsules daily in four different preparations (A: uncoated, B: coated, pH 5.5; C: coated, pH 5.5, 60 min time release; D: coated, pH 6.9) and 12 × 1-g capsules daily of a triglyceride preparation (Max-EPA, EPA 18%-DHA 10%), respectively. We coated three of the four Purepa preparations in order to delay the release of contents in an attempt to minimize the side effects. After six weeks of treatment, the group taking Purepa capsules, coated, pH 5.5, 60 min time release (group C) showed the best incorporation of EPA and DHA in red blood cell phospholipid membranes (EPA from 0.2 to 4.4%, DHA from 3.7 to 6.3%), and no side effects were registered, whereas in all other groups side effects were experienced in 50% or more of subjects. This new preparation will make it possible to treat patients for long periods. © 1994 Plenum Publishing Corporation.

Published
1994
Full Text
View/download PDF

21. Mucosal concentrations of interleukin-1β, interleukin-6, interleukin-8, and tumor necrosis factor-α in pelvic ileal pouches

Author

Massimo Campieri, Luigi Barbara, E. Bertinelli, Corrado Brignola, Andrea Belluzzi, Gilberto Poggioli, Paolo Gionchetti, M Ferretti, M. Miglioli, Gionchetti P., Campieri M., Belluzzi A., Bertinelli E., Ferretti M., Brignola C., Poggioli G., Miglioli M., and Barbara L.

Subjects
Adult, Male, medicine.medical_specialty, Pathology, Cellular immunity, Physiology, medicine.medical_treatment, Enzyme-Linked Immunosorbent Assay, Ileum, Gastroenterology, ulcerative coliti, Internal medicine, Biopsy, cytokine, medicine, Humans, Ileitis, Interleukin 8, Intestinal Mucosa, pouchiti, Inflammation, medicine.diagnostic_test, Interleukin-6, Tumor Necrosis Factor-alpha, Proctocolectomy, business.industry, Interleukins, pelvic ileal pouch, Interleukin-8, Proctocolectomy, Restorative, Pouchitis, Interleukin, medicine.disease, Ulcerative colitis, medicine.anatomical_structure, Colitis, Ulcerative, Female, business, Human, Interleukin-1
Abstract

Concentrations of interleukin-1β (IL-1β), interleukin-6 (IL-6), interleukin-8 (IL-8), and tumor necrosis factor-α (TNF-α) were determined by solid-phase ELISA in tissue homogenates of mucosal biopsy specimens obtained from pelvic ileal pouches in 13 patients with pouchitis (reservoir ileitis) and 17 with pouches without pouchitis. Normal ileal mucosa was used as a control. IL-1β was detected in all tissue homogenates from patients with pouchitis compared with only 29% from pouches without pouchitis and none from controls. IL-6 and IL-8 were present in all pouchitis specimens, in 70% of the specimens from nonpouchitis and only 30% of specimens from controls. TNF-α was undetectable in all specimens examined. The concentrations of IL-1β, IL-6, and IL-8 were significantly greater (P

Published
1994
Full Text
View/download PDF

22. Scavenger effect of sulfasalazine, 5-aminosalicylic acid, and olsalazine on superoxide radical generation

Author

Corrado Brignola, Paolo Gionchetti, Mario Miglioli, Andrea Belluzzi, P. Iannone, Carlo Guarnieri, Luigi Barbara, Massimo Campieri, Gionchetti P., Guarnieri C., Campieri M., Belluzzi A., Brignola C., Iannone P., Miglioli M., and Barbara L.

Subjects
Xanthine Oxidase, Aminosalicylic acid, Neutrophils, Physiology, In Vitro Techniques, superoxide radical, Pharmacology, Xanthine, chemistry.chemical_compound, Superoxides, medicine, Humans, Mesalamine, Xanthine oxidase, Antibacterial agent, Olsalazine, Oxidase test, Dose-Response Relationship, Drug, In Vitro Technique, Superoxide, Neutrophil, Gastroenterology, 5-aminosalicylic acid, Free Radical Scavengers, Aminosalicylic Acid, chemiluminescence, Sulfasalazine, Aminosalicylic Acids, chemistry, Biochemistry, Mechanism of action, Spectrophotometry, Xanthines, Luminescent Measurement, Luminescent Measurements, Tetradecanoylphorbol Acetate, medicine.symptom, olsalazine, Human, medicine.drug
Abstract

The in vitro antioxidant capacity of sulfasalazine (SASP), its metabolites (SP, 5-SSA), and olsalazine (OAZ), was studied by evaluating their effects on superoxide (O2-•) production. Assay systems were the xanthine-xanthine oxidase (X/XOD) reaction and phorbol myristate acetate (PMA)-activated polymorphonuclear leukocytes (PMNs), using the cytochrome c (cyt-c) reduction assay and a luminol-dependent chemiluminescence method. 5-ASA, SASP, and OAZ showed a dose-dependent scavenger effect in both O2-• generating systems, 5-ASA being the most powerful (>50% of inhibition in the PMNs system and >70% in the X/XOD system at 10 μM concentration). SP had an inhibitory effect only in the PMNs system but did not modify the activity of xanthine oxidase, thus excluding a scavenger action. These data suggest that the scavenger effect of 5-ASA, SASP, and OAZ may be an important mechanism of action. © 1991 Plenum Publishing Corporation.

Published
1991
Full Text
View/download PDF

Catalog

Books, media, physical & digital resources
See catalog results