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17 results on '"Brandi, R"'

4. Rare t(X;14)(q28;q32) translocation reveals link between MTCP1 and chronic lymphocytic leukemia

Author

Walker, Janek S., primary, Hing, Zachary A., additional, Sher, Steven, additional, Cronin, James, additional, Williams, Katie, additional, Harrington, Bonnie, additional, Skinner, Jordan N., additional, Cempre, Casey B., additional, Gregory, Charles T., additional, Pan, Alexander, additional, Yano, Max, additional, Beaver, Larry P., additional, Walker, Brandi R., additional, Labanowska, Jadwiga M., additional, Heerema, Nyla A., additional, Mrózek, Krzysztof, additional, Woyach, Jennifer A., additional, Ruppert, Amy S., additional, Lehman, Amy, additional, Ozer, Hatice Gulcin, additional, Coppola, Vincenzo, additional, Yan, Pearlly, additional, Byrd, John C., additional, Blachly, James S., additional, and Lapalombella, Rosa, additional

Published
2021
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5. Intracerebral Hemorrhage and Coronavirus Disease 2019 in a Cohort of 282,718 Hospitalized Patients

Author

Qureshi, Adnan I., primary, Baskett, William I., additional, Huang, Wei, additional, Myers, Danny, additional, Lobanova, Iryna, additional, Ishfaq, Muhammad F., additional, Naqvi, Syed Hasan, additional, French, Brandi R., additional, Chandrasekaran, Premkumar N., additional, Siddiq, Farhan, additional, Gomez, Camilo R., additional, and Shyu, Chi-Ren, additional

Published
2021
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7. Dose/Volume histogram patterns in Salivary Gland subvolumes influence xerostomia injury and recovery

Author

Y. Guo, Xuan Hui, Russell H. Taylor, M.R. Bowers, Ana P. Kiess, Sauleh Siddiqui, Ilya Shpitser, Zhi Cheng, P. Lakshminarayanan, Junghoon Lee, Brandi R. Page, Sang-Ho Lee, Khadija Sheikh, Harry Quon, Wei Jiang, Peijin Han, and Todd McNutt

Subjects
Male, Organs at Risk, 0301 basic medicine, Dose-volume histogram, medicine.medical_treatment, Submandibular Gland, lcsh:Medicine, Xerostomia, Salivary Glands, Article, 03 medical and health sciences, 0302 clinical medicine, stomatognathic system, medicine, Humans, Distribution (pharmacology), Prospective Studies, lcsh:Science, Prospective cohort study, Aged, Multidisciplinary, Radiotherapy, Salivary gland, Receiver operating characteristic, business.industry, lcsh:R, Head and neck cancer, Radiotherapy Dosage, Recovery of Function, medicine.disease, Peripheral, Radiation therapy, 030104 developmental biology, medicine.anatomical_structure, Head and Neck Neoplasms, lcsh:Q, Female, Nuclear medicine, business, Organ Sparing Treatments, 030217 neurology & neurosurgery
Abstract

Xerostomia is a common consequence of radiotherapy in head and neck cancer. The objective was to compare the regional radiation dose distribution in patients that developed xerostomia within 6 months of radiotherapy and those recovered from xerostomia within 18 months post-radiotherapy. We developed a feature generation pipeline to extract dose volume histogram features from geometrically defined ipsilateral/contralateral parotid glands, submandibular glands, and oral cavity surrogates for each patient. Permutation tests with multiple comparisons were performed to assess the dose difference between injury vs. non-injury and recovery vs. non-recovery. Ridge logistic regression models were applied to predict injury and recovery using clinical features along with dose features (D10-D90) of the subvolumes extracted from oral cavity and salivary gland contours + 3 mm peripheral shell. Model performances were assessed by the area under the receiver operating characteristic curve (AUC) using nested cross-validation. We found that different regional dose/volume metrics patterns exist for injury vs. recovery. Compared to injury, recovery has increased importance to the subvolumes receiving lower dose. Within the subvolumes, injury tends to have increased importance towards D10 from D90. This suggests that different threshold for xerostomia injury and recovery. Injury is induced by the subvolumes receiving higher dose, and the ability to recover can be preserved by further reducing the dose to subvolumes receiving lower dose.

Published
2019
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8. Dose/Volume histogram patterns in Salivary Gland subvolumes influence xerostomia injury and recovery

Author

Han, Peijin, primary, Lakshminarayanan, Pranav, additional, Jiang, Wei, additional, Shpitser, Ilya, additional, Hui, Xuan, additional, Lee, Sang Ho, additional, Cheng, Zhi, additional, Guo, Yue, additional, Taylor, Russell H., additional, Siddiqui, Sauleh A., additional, Bowers, Michael, additional, Sheikh, Khadija, additional, Kiess, Ana, additional, Page, Brandi R., additional, Lee, Junghoon, additional, Quon, Harry, additional, and McNutt, Todd R., additional

Published
2019
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9. Risk factors for leptomeningeal carcinomatosis in patients with brain metastases who have previously undergone stereotactic radiosurgery

Author

Glenn J. Lesser, Karen E. Huang, Brandi R. Page, Stephen B. Tatter, D.N. Ayala-Peacock, John T. Lucas, Adrian W. Laxton, Michael D. Chan, and Andrew J. Huang

Subjects
Male, Cancer Research, medicine.medical_specialty, medicine.medical_treatment, Radiosurgery, Postoperative Complications, Risk Factors, Interquartile range, Neoplasms, Meningeal Neoplasms, medicine, Humans, Cumulative incidence, Prospective cohort study, Neoplastic meningitis, Retrospective Studies, Brain Neoplasms, business.industry, Hazard ratio, Retrospective cohort study, Middle Aged, Prognosis, medicine.disease, Surgery, Meningeal carcinomatosis, Neurology, Oncology, Female, Neurology (clinical), Radiology, Neoplasm Grading, business, Meningeal Carcinomatosis, Follow-Up Studies
Abstract

Our objective was to explore the hypothesis that the risk of leptomeningeal dissemination (LMD) in patients who underwent stereotactic radiosurgery (SRS) for brain metastases is influenced by the site of the primary cancer, the addition of whole brain radiation therapy (WBRT), surgical resection, and control over their sys- temic disease. We conducted a retrospective cohort ana- lysis of 805 patients who were treated with SRS for brain metastases between 1999 and 2012 at the Wake Forest Baptist Medical Center, and excluded all patients with evidence of LMD before SRS. The primary outcome was LMD. Forty-nine of 795 patients developed LMD with a cumulative incidence of 6.2 % (95 % Confidence Interval (CI), 4.7-8.0). Median time from SRS to LMD was 7.4 months (Interquartile Range (IQR), 3.3-15.4). A colorectal primary site (Hazard Ratio (HR), 4.5; 95 % CI 2.5-8.0; p \ 0.0001), distant brain failure (HR, 2.0; 95 % CI 1.2-3.2; p = 0.007), breast primary site (HR, 1.6; 95 % CI 1.0-2.7; p = 0.05), the number of intracranial metas- tases at time of initial SRS (HR, 1.1; 95 % CI 1.0-1.2; p = 0.02), and age (by 5-year interval) (HR, 0.9; 95 % CI 0.8, 0.9; p = 0.0006) were independent factors associated with LMD. There was no evidence that surgical resection before SRS altered the risk of LMD (HR, 1.1; 95 % CI 0.6-2.0, p = 0.78). In patients who underwent SRS for brain metastases, a colorectal or breast primary site, distant brain failure, younger age, and an increased number of intracranial metastases were independently associated with LMD. Given its relative rarity as an outcome, multi-insti- tutional prospective studies will likely be necessary to validate and quantify these relationships.

Published
2014
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10. Safety of pioglitazone during and after radiation therapy in patients with brain tumors: a phase I clinical trial

Author

Cramer, Christina K., primary, Alphonse-Sullivan, Natalie, additional, Isom, Scott, additional, Metheny-Barlow, Linda J., additional, Cummings, Tiffany L., additional, Page, Brandi R., additional, Brown, Doris R., additional, Blackstock, Arthur W., additional, Peiffer, Ann M., additional, Strowd, Roy E., additional, Rapp, Stephen, additional, Lesser, Glenn J., additional, Shaw, Edward G., additional, and Chan, Michael D., additional

Published
2018
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11. Prediction of new brain metastases after radiosurgery: validation and analysis of performance of a multi-institutional nomogram

Author

Ayala-Peacock, Diandra N., primary, Attia, Albert, additional, Braunstein, Steve E., additional, Ahluwalia, Manmeet S., additional, Hepel, Jaroslaw, additional, Chung, Caroline, additional, Contessa, Joseph, additional, McTyre, Emory, additional, Peiffer, Ann M., additional, Lucas, John T., additional, Isom, Scott, additional, Pajewski, Nicholas M., additional, Kotecha, Rupesh, additional, Stavas, Mark J., additional, Page, Brandi R., additional, Kleinberg, Lawrence, additional, Shen, Colette, additional, Taylor, Robert B., additional, Onyeuku, Nasarachi E., additional, Hyde, Andrew T., additional, Gorovets, Daniel, additional, Chao, Samuel T., additional, Corso, Christopher, additional, Ruiz, Jimmy, additional, Watabe, Kounosuke, additional, Tatter, Stephen B., additional, Zadeh, Gelareh, additional, Chiang, Veronica L. S., additional, Fiveash, John B., additional, and Chan, Michael D., additional

Published
2017
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12. Genomic predictors of patterns of progression in glioblastoma and possible influences on radiation field design

Author

Holmes, Jordan A., primary, Paulsson, Anna K., additional, Page, Brandi R., additional, Miller, Lance D., additional, Liu, Wennuan, additional, Xu, Jianfeng, additional, Hinson, William H., additional, Lesser, Glenn J., additional, Laxton, Adrian W., additional, Tatter, Stephen B., additional, Debinski, Waldemar, additional, and Chan, Michael D., additional

Published
2015
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16. ProNGF\NGF imbalance triggers learning and memory deficits, neurodegeneration and spontaneous epileptic-like discharges in transgenic mice

Author

Tiveron, C, primary, Fasulo, L, additional, Capsoni, S, additional, Malerba, F, additional, Marinelli, S, additional, Paoletti, F, additional, Piccinin, S, additional, Scardigli, R, additional, Amato, G, additional, Brandi, R, additional, Capelli, P, additional, D'Aguanno, S, additional, Florenzano, F, additional, La Regina, F, additional, Lecci, A, additional, Manca, A, additional, Meli, G, additional, Pistillo, L, additional, Berretta, N, additional, Nisticò, R, additional, Pavone, F, additional, and Cattaneo, A, additional

Published
2013
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17. ProNGF\NGF imbalance triggers learning and memory deficits, neurodegeneration and spontaneous epileptic-like discharges in transgenic mice

Author

Rossella Brandi, Sonia Piccinin, Luisa Fasulo, Raffaella Scardigli, Simona Capsoni, Antonino Cattaneo, Francesca Malerba, Gianluca Amato, Annalisa Manca, Fulvio Florenzano, Giovanni Meli, Francesca Paoletti, P Capelli, Robert Nisticò, Sara Marinelli, F La Regina, Cecilia Tiveron, Agnese Lecci, Nicola Berretta, Flaminia Pavone, L. Pistillo, Simona D'Aguanno, Tiveron, C, Fasulo, L, Capsoni, Simona, Malerba, Francesca, Marinelli, S, Paoletti, Francesca, Piccinin, S, Scardigli, R, Amato, G, Brandi, R, Capelli, Paolo, D'Aguanno, S, Florenzano, F, La Regina, F, Lecci, A, Manca, A, Meli, GIOVANNI ANTONIO, Pistillo, L, Berretta, N, Nistico, R, Pavone, F, and Cattaneo, Antonino

Subjects
Male, Genetically modified mouse, Aging, medicine.medical_specialty, Transgene, Socio-culturale, Hippocampus, Mice, Transgenic, physiology, Animals, Behavior, Animal, physiology, Disease Models, Animal, Epilepsy, physiopathology, Hippocampus, physiopathology, Homeostasis, physiology, Learning Disorders, physiopathology, Male, Memory Disorders, physiopathology, Mice, Mice, Inbred C57BL, Mice, Transgenic, Nerve Growth Factor, deficiency/genetics/physiology, Neurodegenerative Diseases, physiopathology, Phenotype, Protein Precursors, deficiency/genetics/physiology, Inbred C57BL, Transgenic, Animals, Behavior, Animal, Disease Models, Animal, Epilepsy, Homeostasis, Learning Disorders, Memory Disorders, Mice, Mice, Inbred C57BL, Nerve Growth Factor, Neurodegenerative Diseases, Phenotype, Protein Precursors, Internal medicine, medicine, Amyloid precursor protein, Molecular Biology, Original Paper, Behavior, biology, Learning Disabilities, Neurodegeneration, Settore BIO/14, Cell Biology, medicine.disease, Endocrinology, Nerve growth factor, physiology, Disease Models, biology.protein, Cholinergic, physiopathology, Neuroscience, Neurotrophin
Abstract

ProNGF, the precursor of mature nerve growth factor (NGF), is the most abundant form of NGF in the brain. ProNGF and mature NGF differ significantly in their receptor interaction properties and in their bioactivity. ProNGF increases markedly in the cortex of Alzheimer's disease (AD) brains and proNGF\NGF imbalance has been postulated to play a role in neurodegeneration. However, a direct proof for a causal link between increased proNGF and AD neurodegeneration is lacking. In order to evaluate the consequences of increased levels of proNGF in the postnatal brain, transgenic mice expressing a furin cleavage-resistant form of proNGF, under the control of the neuron-specific mouse Thy1.2 promoter, were derived and characterized. Different transgenic lines displayed a phenotypic gradient of neurodegenerative severity features. We focused the analysis on the two lines TgproNGF#3 and TgproNGF#72, which shared learning and memory impairments in behavioral tests, cholinergic deficit and increased Aβ-peptide immunoreactivity. In addition, TgproNGF#3 mice developed Aβ oligomer immunoreactivity, as well as late diffuse astrocytosis. Both TgproNGF lines also display electrophysiological alterations related to spontaneous epileptic-like events. The results provide direct evidence that alterations in the proNGF/NGF balance in the adult brain can be an upstream driver of neurodegeneration, contributing to a circular loop linking alterations of proNGF/NGF equilibrium to excitatory/inhibitory synaptic imbalance and amyloid precursor protein (APP) dysmetabolism.

Published
2013
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