426 results on '"Blakemore"'
Search Results
2. Oligogenic inheritance in severe adult obesity
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Almansoori, Sumaya, primary, Alsters, Suzanne I., additional, Yiorkas, Andrianos M., additional, Nor Hashim, Nikman Adli, additional, Walters, Robin G., additional, Chahal, Harvinder S., additional, Purkayastha, Sanjay, additional, Lessan, Nader, additional, and Blakemore, Alexandra I. F., additional
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- 2024
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3. Evaluation of pre-implantation genetic testing for aneuploidy outcomes in patients without infertility undergoing in vitro fertilization compared to infertile controls
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Clarke, Emily A., primary, Dahiya, Asha K., additional, Cascante, Sarah D., additional, and Blakemore, Jennifer K., additional
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- 2023
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4. Functional impact and molecular binding modes of drugs that target the PI3K isoform p110δ
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Hassenrück, Floyd, primary, Farina-Morillas, Maria, additional, Neumann, Lars, additional, Landini, Francesco, additional, Blakemore, Stuart James, additional, Rabipour, Mina, additional, Alvarez-Idaboy, Juan Raul, additional, Pallasch, Christian P., additional, Hallek, Michael, additional, Rebollido-Rios, Rocio, additional, and Krause, Günter, additional
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- 2023
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5. How social media affects teen mental health: a missing link
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Amy Orben and Sarah-Jayne Blakemore
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Multidisciplinary - Published
- 2023
6. Crohn’s Disease Among the Poorest Billion: Burden of Crohn’s Disease in Low- and Lower-Middle-Income Countries
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Ruma Rajbhandari, Samantha Blakemore, Neil Gupta, Sara Mannan, Klejda Nikolli, Alison Yih, Laura Drown, and Gene Bukhman
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Physiology ,Gastroenterology - Published
- 2022
7. Re-evaluating consensus and uncertainty among treatment options for early onset scoliosis: a 10-year update
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Hiroko Matsumoto, Adam N. Fano, Theodore Quan, Behrooz A. Akbarnia, Laurel C. Blakemore, John M. Flynn, David L. Skaggs, John T. Smith, Brian D. Snyder, Paul D. Sponseller, Richard E. McCarthy, Peter F. Sturm, David P. Roye, John B. Emans, and Michael G. Vitale
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Orthopedics and Sports Medicine - Published
- 2022
8. Two is not always greater than one: patients with one ovary have similar assisted reproductive technology (ART) outcomes compared to patients with two ovaries
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Emily Auran, Sarah Cascante, and Jennifer Blakemore
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Pregnancy Rate ,Reproductive Techniques, Assisted ,Ovary ,Obstetrics and Gynecology ,Fertilization in Vitro ,General Medicine ,Ovulation Induction ,Reproductive Medicine ,Pregnancy ,Oocytes ,Genetics ,Humans ,Female ,Genetics (clinical) ,Retrospective Studies ,Developmental Biology - Abstract
To assess assisted reproductive technology (ART) outcomes in patients with one ovary compared to two ovaries.We performed a retrospective cohort study of all patients with one ovary who underwent ≥ 1 ART cycle between 2012 and 2020 at a large university-affiliated fertility center. Patients were 3-to-1 matched with two ovary controls during the same period. Primary outcome was metaphase II oocytes (MIIs) retrieved per cycle. Secondary outcomes included ovarian reserve markers, laboratory outcomes, and live birth rates (LBRs).A total of 104 one ovary patients (158 cycles; median age 35.5 years) were matched to 312 two ovary patients (474 cycles; median age 35.0 years). In one ovary patients, anti-Mullerian hormone was lower (median 1.1 vs. 2.2, p 0.01) and day 2 follicle-stimulating hormone was higher (median 7.4 vs. 6.2, p 0.01). One ovary patients yielded median 7.5 MIIs and 10 oocytes per cycle, fewer than two ovary patients (11.0 and 14.5, respectively; p 0.01). However, one ovary patients had ≥ 50% the MII and oocyte yield of two ovary patients (Z 5.8, p 0.01). Fertilization and blastocyst formation rates, euploidy rate, and rate of ≥ 1 embryo for transfer were equivalent between groups (p 0.40). Among the one and two ovary groups, LBRs per transfer (45.8% vs. 46.6%, p = 1.00) and per patient who underwent transfer (68.3% vs. 73.9%, p = 0.55) were equivalent.One ovary patients yielded fewer MIIs and oocytes than two ovary patients, but had ≥ 50% the yield of two ovary patients, suggesting a compensatory mechanism in oocyte yield in the solitary ovary. One and two ovary patients had equivalent LBRs.
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- 2022
9. An item response theory analysis of the matrix reasoning item bank (MaRs-IB)
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Zorowitz, Samuel, primary, Chierchia, Gabriele, additional, Blakemore, Sarah-Jayne, additional, and Daw, Nathaniel D., additional
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- 2023
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10. Thoracolumbar curve behavior after selective thoracic anterior vertebral body tethering in Lenke 1A vs Lenke 1C curve patterns
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Welborn, Michelle Cameron, primary, Blakemore, Laurel, additional, Handford, Cameron, additional, Miyanji, Firoz, additional, Parent, Stefan, additional, and El-Hawary, Ron, additional
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- 2023
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11. Associations between age, social reward processing and social anxiety symptoms
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Emma J. Kilford, Lucy Foulkes, and Sarah-Jayne Blakemore
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General Psychology - Abstract
Reward processing undergoes marked changes in adolescence, with social interactions representing a powerful source of reward. Reward processing is also an important factor in the development of social anxiety disorder, a condition that most commonly first appears in adolescence. This study investigated the relationship between age, social reward processing and social anxiety in a cross-sectional sample of female participants (N = 80) aged 13–34. Participants performed two versions of a probabilistic reward anticipation task, in which a speeded response could result in different probabilities of receiving either social or monetary rewarding feedback. Participants also completed self-report assessments of social reward value, trait anxiety and social anxiety symptoms. At high reward probabilities, performance on both reward tasks showed a quadratic effect of age, with the fastest responses at around 22–24 years. A similar quadratic effect was found for subjective liking ratings of both reward stimuli, although these were not associated with performance. Social anxiety was not associated with a subjective liking of the rewards but did predict performance on both tasks at all reward probabilities. Age-related variation in reward processing was not accounted for by age-related variation in social anxiety symptoms, suggesting that, while both social anxiety and age were associated with variation in reward processing, their effects were largely independent. Together, these findings provide evidence that social reward processing continues to develop across adolescence and that individual differences in social anxiety should be considered when considering reward sensitivity during this period.
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- 2023
12. An item response theory analysis of the matrix reasoning item bank (MaRs-IB)
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Samuel Zorowitz, Gabriele Chierchia, Sarah-Jayne Blakemore, and Nathaniel Daw
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Arts and Humanities (miscellaneous) ,Developmental and Educational Psychology ,Experimental and Cognitive Psychology ,Psychology (miscellaneous) ,General Psychology - Abstract
Matrix reasoning tasks are among the most widely used measures of cognitive ability in the behavioral sciences, but the lack of matrix reasoning tests in the public domain complicates their use. Here, we present an extensive investigation and psychometric validation of the matrix reasoning item bank (MaRs-IB), an open-access set of matrix reasoning items. In a first study, we calibrate the psychometric functioning of the items in the MaRs-IB in a large sample of adult participants (N = 1501). Using additive multilevel item structure models, we establish that the MaRs-IB has many desirable psychometric properties: its items span a wide range of difficulty, possess medium-to-large levels of discrimination, and exhibit robust associations between item complexity and difficulty. However, we also find that item clones are not always psychometrically equivalent and cannot be assumed to be exchangeable. In a second study, we demonstrate how experimenters can use the estimated item parameters to design new matrix reasoning tests using optimal item assembly. Specifically, we design and validate two new sets of test forms in an independent sample of adults (N = 600). We find these new tests possess good reliability and convergent validity with an established measure of matrix reasoning. We hope that the materials and results made available here will encourage experimenters to use the MaRs-IB in their research.
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- 2023
13. Thoracolumbar curve behavior after selective thoracic anterior vertebral body tethering in Lenke 1A vs Lenke 1C curve patterns
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Michelle Cameron Welborn, Laurel Blakemore, Cameron Handford, Firoz Miyanji, Stefan Parent, and Ron El-Hawary
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Orthopedics and Sports Medicine - Published
- 2023
14. How social media affects teen mental health: a missing link
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Orben, Amy, primary and Blakemore, Sarah-Jayne, additional
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- 2023
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15. Intersecting distributed networks support convergent linguistic functioning across different languages in bilinguals
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Geng, Shujie, primary, Guo, Wanwan, additional, Rolls, Edmund T., additional, Xu, Kunyu, additional, Jia, Tianye, additional, Zhou, Wei, additional, Blakemore, Colin, additional, Tan, Li-Hai, additional, Cao, Miao, additional, and Feng, Jianfeng, additional
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- 2023
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16. Intersecting distributed networks support convergent linguistic functioning across different languages in bilinguals
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Shujie Geng, Wanwan Guo, Edmund T. Rolls, Kunyu Xu, Tianye Jia, Wei Zhou, Colin Blakemore, Li-Hai Tan, Miao Cao, and Jianfeng Feng
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Medicine (miscellaneous) ,General Agricultural and Biological Sciences ,General Biochemistry, Genetics and Molecular Biology - Abstract
How bilingual brains accomplish the processing of more than one language has been widely investigated by neuroimaging studies. The assimilation-accommodation hypothesis holds that both the same brain neural networks supporting the native language and additional new neural networks are utilized to implement second language processing. However, whether and how this hypothesis applies at the finer-grained levels of both brain anatomical organization and linguistic functions remains unknown. To address this issue, we scanned Chinese-English bilinguals during an implicit reading task involving Chinese words, English words and Chinese pinyin. We observed broad brain cortical regions wherein interdigitated distributed neural populations supported the same cognitive components of different languages. Although spatially separate, regions including the opercular and triangular parts of the inferior frontal gyrus, temporal pole, superior and middle temporal gyrus, precentral gyrus and supplementary motor areas were found to perform the same linguistic functions across languages, indicating regional-level functional assimilation supported by voxel-wise anatomical accommodation. Taken together, the findings not only verify the functional independence of neural representations of different languages, but show co-representation organization of both languages in most language regions, revealing linguistic-feature specific accommodation and assimilation between first and second languages.
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- 2023
17. Serum Gonadotropin Levels Predict Post-Trigger Luteinizing Hormone Response in Antagonist Controlled Ovarian Hyperstimulation Cycles
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Wiltshire, Ashley, primary, Tozour, Jessica, additional, Hamer, Dina, additional, Akerman, Meredith, additional, McCulloh, David H., additional, Grifo, James A., additional, and Blakemore, Jennifer, additional
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- 2022
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18. Correction: Re-evaluating consensus and uncertainty among treatment options for early onset scoliosis: a 10-year update
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Matsumoto, Hiroko, primary, Fano, Adam N., additional, Quan, Theodore, additional, Akbarnia, Behrooz A., additional, Blakemore, Laurel C., additional, Flynn, John M., additional, Skaggs, David L., additional, Smith, John T., additional, Snyder, Brian D., additional, Sponseller, Paul D., additional, McCarthy, Richard E., additional, Sturm, Peter F., additional, Roye, David P., additional, Emans, John B., additional, and Vitale, Michael G., additional
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- 2022
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19. Inter- and intra-rater reliability and accuracy of Sanders Skeletal Maturity Staging System when used by surgeons performing vertebral body tethering
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Peter O. Newton, Ahmet Alanay, Laurel C. Blakemore, Joshua M. Pahys, James O Sanders, A. Noelle Larson, Kevin M Neal, Todd A. Milbrandt, Patrick J. Cahill, and Lauren M Swany
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medicine.medical_specialty ,business.industry ,Gold standard ,Intra-rater reliability ,Scoliosis ,medicine.disease ,Inter-rater reliability ,Cohen's kappa ,Orthopedic surgery ,Physical therapy ,Medicine ,Orthopedics and Sports Medicine ,Stage (cooking) ,business ,Reliability (statistics) - Abstract
Pediatric orthopedic surgeons must accurately assess the skeletal stage of adolescent idiopathic scoliosis (AIS) patients for selection and timing of optimal treatment. Successful treatment using vertebral growth modulation is highly dependent on skeletal growth remaining. We sought to evaluate the current-state use of the Sanders Skeletal Maturity System (SSMS) in regard to precision and accuracy. We hypothesized that pediatric orthopedic surgeons currently use SSMS with moderate precision and accuracy. Eight practicing pediatric orthopedic surgeons who perform vertebral body tethering surgery without specific training in SSMS were asked to assign the SSMS stage for 34 de-identified hand radiographs from AIS patients. Precision was evaluated as inter-rater reliability, using both Krippendorff’s α and Weighted Cohen’s kappa statistics, and as intra-rater reliability, using only Weighted Cohen’s kappa statistics. Surgeon accuracy was evaluated using Weighted Cohen’s kappa statistics with comparison of surveyed surgeons’ responses to the gold standard rating. Inter-rater reliability across the surveyed surgeons indicated moderate to substantial agreement using both statistical methods (α = 0.766, κ = 0.627) with the majority of discord occurring when assigning SSMS stages 2 through 4. The surveyed surgeons displayed substantial accuracy when compared to the gold standard (κ = 0.627) with the majority of inaccuracy involving the identification of stage 3B. When re-surveyed, the surgeons showed substantial intra-rater reliability (κ = 0.71) with increased inconsistencies when deciding between SSMS stage 3A and stage 3B. The current-state use of SSMS across pediatric orthopedic surgeons for evaluation of AIS patients displays adequate but imperfect precision and accuracy with difficulties delineating SSMS stages 2 through 4, which correlate with adolescent growth periods germane to scoliosis growth modulation surgery. Centralized assessment of hand-bone age may help ensure standardized reporting for non-fusion scoliosis research.
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- 2021
20. Universal Mindfulness Training in Schools for Adolescents: a Scoping Review and Conceptual Model of Moderators, Mediators, and Implementation Factors
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Tudor, Kate, Maloney, Shannon, Raja, Anam, Baer, Ruth, Blakemore, Sarah-Jayne, Byford, Sarah, Crane, Catherine, Dalgleish, Tim, De Wilde, Katherine, Ford, Tamsin, Greenberg, Mark, Hinze, Verena, Lord, Liz, Radley, Lucy, Opaleye, Emerita Satiro, Taylor, Laura, Ukoumunne, Obioha C, Viner, Russell, MYRIAD Team, Kuyken, Willem, Montero-Marin, Jesus, Kuyken, Willem [0000-0002-8596-5252], and Apollo - University of Cambridge Repository
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Schools ,Prevention programmes ,Adolescent ,Implementation ,School-based programmes ,Moderators ,Humans ,Universal interventions ,Mindfulness ,Adolescence ,Mediators - Abstract
There is evidence that universal school-based mindfulness training (SBMT) can have positive effects for young people. However, it is unknown who benefits most from such training, how training exerts effects, and how implementation impacts effects. This study aimed to provide an overview of the evidence on the mediators, moderators, and implementation factors of SBMT, and propose a conceptual model that can be used both to summarize the evidence and provide a framework for future research. A scoping review was performed, and six databases and grey literature were searched. Inclusion and exclusion criteria were applied to select relevant material. Quantitative and qualitative information was extracted from eligible articles and reported in accordance with PRISMA-ScR guidelines. The search produced 5479 articles, of which 31 were eligible and included in the review. Eleven studies assessed moderators of SBMT on pupil outcomes, with mixed findings for all variables tested. Five studies examined the mediating effect of specific variables on pupil outcomes, with evidence that increases in mindfulness skills and decreases in cognitive reactivity and self-criticism post-intervention are related to better pupil outcomes at follow-up. Twenty-five studies assessed implementation factors. We discuss key methodological shortcomings of included studies and integrate our findings with existing implementation frameworks to propose a conceptual model. Widespread interest in universal SBMT has led to increased research over recent years, exploring who SBMT works for and how it might work, but the current evidence is limited. We make recommendations for future research and provide a conceptual model to guide theory-led developments.
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- 2022
21. Genetic mechanisms of critical illness in COVID-19
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Pairo-Castineira, Erola, Clohisey, Sara, Klaric, Lucija, Bretherick, Andrew D, Rawlik, Konrad, Pasko, Dorota, Walker, Susan, Parkinson, Nick, Fourman, Max Head, Russell, Clark D, Furniss, James, Richmond, Anne, Gountouna, Elvina, Wrobel, Nicola, Harrison, David, Wang, Bo, Yang, Wu, Meynert, Alison, Griffiths, Fiona, Oosthuyzen, Wilna, Kousathanas, Athanasios, Moutsianas, Loukas, Yang, Zhijian, Zhai, Ranran, Zheng, Chenqing, Grimes, Graeme, Beale, Rupert, Millar, Jonathan, Shih, Barbara, Keating, Sean, Zechner, Marie, Haley, Chris, Porteous, David J, Hayward, Caroline, Yang, Jian, Knight, Julian, Summers, Charlotte, Shankar-Hari, Manu, Klenerman, Paul, Turtle, Lance, Antonia, Ho, Moore, Shona C, Hinds, Charles, Horby, Peter, Nichol, Alistair, Maslove, David, Ling, Lowell, Mcauley, Danny, Montgomery, Hugh, Walsh, Timothy, Pereira, Alexandre C, Renieri, Johnny, Millar, Alistair, Nichol, Tim, Walsh, Manu, Shankar-Hari, Chris, Ponting, Jen, Meikle, Paul, Finernan, Ellie, Mcmaster, Andy, Law, J Kenneth Baillie, Trevor, Paterson, Tony, Wackett, Ruth, Armstrong, Richard, Clark, Audrey, Coutts, Lorna, Donnelly, Tammy, Gilchrist, Katarzyna, Hafezi, Louise, Macgillivray, Alan, Maclean, Sarah, Mccafferty, Kirstie, Morrice, Jane, Weaver, Ceilia, Boz, Ailsa, Golightly, Mari, Ward, Hanning, Mal, Helen, Szoor-McElhinney, Adam, Brown, Ross, Hendry, Andrew, Stenhouse, Louise, Cullum, Dawn, Law, Sarah, Law, Rachel, Law, Maaike, Swets, Nicky, Day, Filip, Taneski, Esther, Duncan, Nicholas, Parkinson, Collier, D, Wood, S, Zak, A, Borra, C, Matharu, M, May, P, Alldis, Z, Mitchelmore, O, Bowles, R, Easthope, A, Bibi, F, Lancoma-Malcolm, I, Gurasashvili, J, Pheby, J, Shiel, J, Bolton, M, Patel, M, Taylor, M, Zongo, O, Ebano, P, Harding, P, Astin-Chamberlain, R, Choudhury, Y, Cox, A, Kallon, D, Burton, M, Hall, R, Blowes, S, Prime, Z, Biddle, J, Prysyazhna, O, Newman, T, Tierney, C, Kassam, J, Shankar-Hari, M, Ostermann, M, Campos, S, Bociek, A, Lim, R, Grau, N, O Jones, T, Whitton, C, Marotti, M, Arbane, G, Bonner, S, Hugill, K, Reid, J, Welters, I, Waugh, V, Williams, K, Shaw, D, J Fernandez Roman, M Lopez Martinez, Johnson, E, Waite, A, Johnston, B, Hamilton, D, Mulla, S, Mcphail, M, Smith, J, K Baillie, J, Barclay, L, Hope, D, Mcculloch, C, Mcquillan, L, Clark, S, Singleton, J, Priestley, K, Rea, N, Callaghan, M, Campbell, R, Andrew, G, Marshall, L, Mckechnie, S, Hutton, P, Bashyal, A, Davidson, N, Summers, C, Polgarova, P, Stroud, K, Pathan, N, Elston, K, Agrawal, S, Battle, C, Newey, L, Rees, T, Harford, R, Brinkworth, E, Williams, M, Murphy, C, White, I, Croft, M, Bandla, N, Gellamucho, M, Tomlinson, J, Turner, H, Davies, M, Quinn, A, Hussain, I, Thompson, C, Parker, H, Bradley, R, Griffiths, R, Scriven, J, Nilsson, A, Bates, M, Dasgin, J, Gill, J, Puxty, A, Cathcart, S, Salutous, D, Turner, L, Duffy, K, Puxty, K, Joseph, A, Herdman-Grant, R, Simms, R, Swain, A, Naranjo, A, Crowe, R, Sollesta, K, Loveridge, A, Baptista, D, Morino, E, Davey, M, Golden, D, Jones, J, J Moreno Cuesta, Haldeos, A, Bakthavatsalam, D, Vincent, R, Elhassan, M, Xavier, K, Ganesan, A, Purohit, D, Abdelrazik, M, Morgan, J, Akeroyd, L, Bano, S, Lawton, T, Warren, D, Bromley, M, Sellick, K, Gurr, L, Wilkinson, B, Nagarajan, V, Szedlak, P, Cupitt, J, Stoddard, E, Benham, L, Preston, S, Laha, S, Slawson, N, Bradshaw, Z, Brown, J, Caswell, M, Melling, S, Bamford, P, Faulkner, M, Cawley, K, Jeffrey, H, London, E, Sainsbury, H, Nagra, I, Nasir, F, Dunmore, C, Jones, R, Abraheem, A, Al-Moasseb, M, Girach, R, Padden, G, Egan, J, Brantwood, C, Alexander, P, Bradley-Potts, J, Allen, S, Felton, T, Manna, S, Farnell-Ward, S, Leaver, S, Queiroz, J, Maccacari, E, Dawson, D, C Castro Delgado, R Pepermans Saluzzio, Ezeobu, O, Ding, L, Sicat, C, Kanu, R, Durrant, G, Texeira, J, Harrison, A, Samakomva, T, Willis, H, Hopkins, B, Thrasyvoulou, L, Jackson, M, Zaki, A, Tibke, C, Bennett, S, Woodyatt, W, Kent, A, Goodwin, E, Brandwood, C, Clark, R, Smith, L, Rooney, K, Thomson, N, Rodden, N, Hughes, E, Mcglynn, D, Clark, C, Clark, P, Abel, L, Sundaram, R, Gemmell, L, Brett, M, Hornsby, J, Macgoey, P, Price, R, Digby, B, O'Neil, P, Mcconnell, P, Henderson, P, Henderson, S, Sim, M, Kennedy-Hay, S, Mcparland, C, Rooney, L, Baxter, N, Pogson, D, Rose, S, Daly, Z, Brimfield, L, K Phull, M, Hussain, M, Pogreban, T, Rosaroso, L, Salciute, E, Grauslyte, L, Brealey, D, Raith, E, Maccallum, N, Bercades, G, Hass, I, Smyth, D, Reyes, A, Martir, G, D Clement, I, Webster, K, Hays, C, Gulati, A, Hodgson, L, Margarson, M, Gomez, R, Baird, Y, Thirlwall, Y, Folkes, L, Butler, A, Meadows, E, Moore, S, Raynard, D, Fox, H, Riddles, L, King, K, Kimber, S, Hobden, G, Mccarthy, A, Cannons, V, Balagosa, I, Chadbourn, I, Gardner, A, Horner, D, Mclaughlanv, D, Charles, B, Proudfoot, N, Marsden, T, Mcmorrow, L, Blackledge, B, Pendlebury, J, Harvey, A, Apetri, E, Basikolo, C, Catlow, L, Doonan, R, Knowles, K, Lee, S, Lomas, D, Lyons, C, Perez, J, Poulaka, M, Slaughter, M, Slevin, K, Thomas, V, Walker, D, Harris, J, Drummond, A, Tully, R, Dearden, J, Philbin, J, Munt, S, Rishton, C, O'Connor, G, Mulcahy, M, Dobson, E, Cuttler, J, Edward, M, Norris, J, Hanson, K, Poole, A, Rose, A, Sloan, B, Buckley, S, Brooke, H, Smithson, E, Charlesworth, R, Sandhu, R, Thirumaran, M, Wagstaff, V, J Cebrian Suarez, Kaliappan, A, Vertue, M, Nicholson, A, Riches, J, Solesbury, A, Kittridge, L, Forsey, M, Maloney, G, Cole, J, Davies, R, Hill, H, Thomas, E, Williams, A, Duffin, D, Player, B, Radhakrishnan, J, Gibson, S, Lyle, A, Mcneela, F, Patel, B, Gummadi, M, Sloane, G, Dormand, N, Salmi, S, Farzad, Z, Cristiano, D, Liyanage, K, Thwaites, V, Varghese, M, Meredith, M, Mills, G, Willson, J, Harrington, K, Lenagh, B, Cawthron, K, Masuko, S, Raithatha, A, Bauchmuller, K, Wiles, M, Ahmad, N, Barker, J, Jackson, Y, Kibutu, F, Bird, S, Watson, G, Martin, J, Bevan, E, C Wrey Brown, Trodd, D, English, K, Bell, G, Wilcox, L, Katary, A, Gopal, S, Lake, V, Harris, N, Metherell, S, Radford, E, Moore, F, Bancroft, H, Daglish, J, Sangombe, M, Carmody, M, Rhodes, J, Bellamy, M, Garg, A, Kuravi, A, Virgilio, E, Ranga, P, Butler, J, Botfield, L, Dexter, C, Fletcher, J, Shanmugasundaram, P, Hambrook, G, Burn, I, Manso, K, Thornton, D, Tebbutt, J, Penn, R, Hulme, J, Hussain, S, Maqsood, Z, Joseph, S, Colley, J, Hayes, A, Ahmed, C, Haq, R, Clamp, S, Kumar, R, Purewal, M, Baines, B, Frise, M, Jacques, N, Coles, H, Caterson, J, S Gurung Rai, Brunton, M, Tilney, E, Keating, L, Walden, A, Antcliffe, D, Brett, S, Gordon, A, Templeton, M, Rojo, R, Banach, D, S Sousa Arias, Fernandez, Z, Coghlan, P, Williams, D, Jardine, C, Bewley, J, Sweet, K, Grimmer, L, Johnson, R, Garland, Z, Gumbrill, B, Phillips, C, L Ortiz-Ruiz de Gordoa, Peasgood, E, Tridente, A, Shuker, K, Greer, S, Lynch, C, Pothecary, C, Roche, L, Deacon, B, Turner, K, Singh, J, G Sera Howe, Paul, P, Gill, M, Wynter, I, Ratnam, V, Shelton, S, Naisbitt, J, Melville, J, Baruah, R, Morrison, S, Mcgregor, A, Parris, V, Mpelembue, M, Srikaran, S, Dennis, C, Sukha, A, Verlander, M, Holding, K, Riches, K, Downes, C, Swan, C, Rostron, A, Roy, A, Woods, L, Cornell, S, Wakinshaw, F, Creagh-Brown, B, Blackman, H, Salberg, A, Smith, E, Donlon, S, Mtuwa, S, Michalak-Glinska, N, Stone, S, Beazley, C, Pristopan, V, Nikitas, N, Lankester, L, Wells, C, S Raj, A, Fletcher, K, Khade, R, Tsinaslanidis, G, Macmahon, M, Fowler, S, Coventry, T, Stewart, R, Wren, L, Mwaura, E, Mew, L, Scaletta, D, Williams, F, Inweregbu, K, Lancaster, N, Cunningham, M, Daniels, A, Harrison, L, Hope, S, Jones, S, Crew, A, Wray, G, Matthews, J, Crawley, R, Carter, J, Birkinshaw, I, Ingham, J, Scott, Z, Pearson, H, Howard, K, Joy, R, Roche, S, Clark, M, Purvis, S, Morrison, A, Strachan, D, Clements, S, Black, K, Parmar, C, Altabaibeh, A, Simpson, K, Mostoles, L, Gilbert, K, L, Ma, Alvaro, A, Thomas, M, Faulkner, B, Worner, R, Hayes, K, Gendall, E, Blakemore, H, Borislavova, B, Goff, E, Vuylsteke, A, Mwaura, L, Zamikula, J, Garner, L, Mitchell, A, Mepham, S, Cagova, L, Fofano, A, Holcombe, H, Praman, K, Szakmany, T, E Heron, A, Cherian, S, Cutler, S, Roynon-Reed, A, Randell, G, Convery, K, Stammers, K, Fottrell-Gould, D, Hudig, L, Keshet-Price, J, Peters, M, O'Neill, L, Ray, S, Belfield, H, Mchugh, T, Jones, G, Akinkugbe, O, Tomas, A, Abaleke, E, Beech, E, Meghari, H, Yussuf, S, Bamford, A, Hairsine, B, Dooks, E, Farquhar, F, Packham, S, Bates, H, Armstrong, L, Kaye, C, Allan, A, Medhora, J, Liew, J, Botello, A, Anderson, F, Cusack, R, Golding, H, Prager, K, Williams, T, Leggett, S, Golder, K, Male, M, Jones, O, Criste, K, Marani, M, Anumakonda, V, Amin, V, Karthik, K, Kausar, R, Anastasescu, E, Reid, K, Smith, M, Hormis, A, Walker, R, Duncan, T, Uriel, A, Ustianowski, A, T-Michael, H, Bruce, M, Connolly, K, Smith, K, Partridge, R, Griffin, D, Mupudzi, M, Muchenje, N, Martin, D, Filipe, H, Eastgate, C, Jackson, C, Gratrix, A, Foster, L, Martinson, V, Stones, E, Caroline, Abernathy, Parkinson, P, Reed, A, Prendergast, C, Rogers, P, 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C., Saluzzio, R. P., Ezeobu, O., Ding, L., Sicat, C., Kanu, R., Durrant, G., Texeira, J., Harrison, A., Samakomva, T., Willis, H., Hopkins, B., Thrasyvoulou, L., Jackson, M., Zaki, A., Tibke, C., Bennett, S., Woodyatt, W., Kent, A., Goodwin, E., Brandwood, C., Smith, L., Rooney, K., Thomson, N., Rodden, N., Hughes, E., Mcglynn, D., Clark, C., Clark, P., Abel, L., Sundaram, R., Gemmell, L., Brett, M., Hornsby, J., Macgoey, P., Price, R., Digby, B., O'Neil, P., Mcconnell, P., Henderson, P., Henderson, S., Sim, M., Kennedy-Hay, S., Mcparland, C., Rooney, L., Baxter, N., Pogson, D., Rose, S., Daly, Z., Brimfield, L., Phull, M. K., Hussain, M., Pogreban, T., Rosaroso, L., Salciute, E., Grauslyte, L., Brealey, D., Raith, E., Maccallum, N., Bercades, G., Hass, I., Smyth, D., Reyes, A., Martir, G., Clement, I. D., Webster, K., Hays, C., Gulati, A., Hodgson, L., Margarson, M., Gomez, R., Baird, Y., Thirlwall, Y., Folkes, L., Butler, A., Meadows, E., Moore, S., Raynard, D., Fox, H., Riddles, L., King, K., Kimber, S., Hobden, G., Mccarthy, A., Cannons, V., Balagosa, I., Chadbourn, I., Gardner, A., Horner, D., Mclaughlanv, D., Charles, B., Proudfoot, N., Marsden, T., Mcmorrow, L., Blackledge, B., Pendlebury, J., Harvey, A., Apetri, E., Basikolo, C., Catlow, L., Doonan, R., Knowles, K., Lee, S., Lomas, D., Lyons, C., Perez, J., Poulaka, M., Slaughter, M., Slevin, K., Thomas, V., Walker, D., Harris, J., Drummond, A., Tully, R., Dearden, J., Philbin, J., Munt, S., Rishton, C., O'Connor, G., Mulcahy, M., Dobson, E., Cuttler, J., Edward, M., Norris, J., Hanson, K., Poole, A., Rose, A., Sloan, B., Buckley, S., Brooke, H., Smithson, E., Charlesworth, R., Sandhu, R., Thirumaran, M., Wagstaff, V., Suarez, J. C., Kaliappan, A., Vertue, M., Nicholson, A., Riches, J., Solesbury, A., Kittridge, L., Forsey, M., Maloney, G., Cole, J., Davies, R., Hill, H., Thomas, E., Williams, A., Duffin, D., Player, B., Radhakrishnan, J., Gibson, S., Lyle, A., Mcneela, F., Patel, B., Gummadi, M., Sloane, G., Dormand, N., Salmi, S., Farzad, Z., Cristiano, D., Liyanage, K., Thwaites, V., Varghese, M., Meredith, M., Mills, G., Willson, J., Harrington, K., Lenagh, B., Cawthron, K., Masuko, S., Raithatha, A., Bauchmuller, K., Wiles, M., Ahmad, N., Barker, J., Jackson, Y., Kibutu, F., Bird, S., Watson, G., Martin, J., Bevan, E., Brown, C. W., Trodd, D., English, K., Bell, G., Wilcox, L., Katary, A., Gopal, S., Lake, V., Harris, N., Metherell, S., Radford, E., Moore, F., Bancroft, H., Daglish, J., Sangombe, M., Carmody, M., Rhodes, J., Bellamy, M., Garg, A., Kuravi, A., Virgilio, E., Ranga, P., Butler, J., Botfield, L., Dexter, C., Fletcher, J., Shanmugasundaram, P., Hambrook, G., Burn, I., Manso, K., Thornton, D., Tebbutt, J., Penn, R., Hulme, J., Hussain, S., Maqsood, Z., Joseph, S., Colley, J., Hayes, A., Ahmed, C., Haq, R., Clamp, S., Kumar, R., Purewal, M., Baines, B., Frise, M., Jacques, N., Coles, H., Caterson, J., Rai, S. G., Brunton, M., Tilney, E., Keating, L., Walden, A., Antcliffe, D., Brett, S., Gordon, A., Templeton, M., Rojo, R., Banach, D., Arias, S. S., Fernandez, Z., Coghlan, P., Williams, D., Jardine, C., Bewley, J., Sweet, K., Grimmer, L., Johnson, R., Garland, Z., Gumbrill, B., Phillips, C., Ortiz-Ruiz de Gordoa, L., Peasgood, E., Tridente, A., Shuker, K., Greer, S., Lynch, C., Pothecary, C., Roche, L., Deacon, B., Turner, K., Singh, J., Howe, G. S., Paul, P., Gill, M., Wynter, I., Ratnam, V., Shelton, S., Naisbitt, J., Melville, J., Baruah, R., Morrison, S., Mcgregor, A., Parris, V., Mpelembue, M., Srikaran, S., Dennis, C., Sukha, A., Verlander, M., Holding, K., Riches, K., Downes, C., Swan, C., Rostron, A., Roy, A., Woods, L., Cornell, S., Wakinshaw, F., Creagh-Brown, B., Blackman, H., Salberg, A., Smith, E., Donlon, S., Mtuwa, S., Michalak-Glinska, N., Stone, S., Beazley, C., Pristopan, V., Nikitas, N., Lankester, L., Wells, C., Raj, A. S., Fletcher, K., Khade, R., Tsinaslanidis, G., Macmahon, M., Fowler, S., Coventry, T., Stewart, R., Wren, L., Mwaura, E., Mew, L., Scaletta, D., Williams, F., Inweregbu, K., Lancaster, N., Cunningham, M., Daniels, A., Harrison, L., Hope, S., Jones, S., Crew, A., Wray, G., Matthews, J., Crawley, R., Carter, J., Birkinshaw, I., Ingham, J., Scott, Z., Pearson, H., Howard, K., Joy, R., Roche, S., Clark, M., Purvis, S., Morrison, A., Strachan, D., Clements, S., Black, K., Parmar, C., Altabaibeh, A., Simpson, K., Mostoles, L., Gilbert, K., Ma, L., Alvaro, A., Thomas, M., Faulkner, B., Worner, R., Hayes, K., Gendall, E., Blakemore, H., Borislavova, B., Goff, E., Vuylsteke, A., Mwaura, L., Zamikula, J., Garner, L., Mitchell, A., Mepham, S., Cagova, L., Fofano, A., Holcombe, H., Praman, K., Szakmany, T., Heron, A. E., Cherian, S., Cutler, S., Roynon-Reed, A., Randell, G., Convery, K., Stammers, K., Fottrell-Gould, D., Hudig, L., Keshet-Price, J., Peters, M., O'Neill, L., Ray, S., Belfield, H., Mchugh, T., Jones, G., Akinkugbe, O., Tomas, A., Abaleke, E., Beech, E., Meghari, H., Yussuf, S., Bamford, A., Hairsine, B., Dooks, E., Farquhar, F., Packham, S., Bates, H., Armstrong, L., Kaye, C., Allan, A., Medhora, J., Liew, J., Botello, A., Anderson, F., Cusack, R., Golding, H., Prager, K., Williams, T., Leggett, S., Golder, K., Male, M., Jones, O., Criste, K., Marani, M., Anumakonda, V., Amin, V., Karthik, K., Kausar, R., Anastasescu, E., Reid, K., Smith, M., Hormis, A., Walker, R., Duncan, T., Uriel, A., Ustianowski, A., T-Michael, H., Bruce, M., Connolly, K., Smith, K., Partridge, R., Griffin, D., Mupudzi, M., Muchenje, N., Martin, D., Filipe, H., Eastgate, C., Jackson, C., Gratrix, A., Foster, L., Martinson, V., Stones, E., Abernathy, C., Parkinson, P., Reed, A., Prendergast, C., Rogers, P., Woodruff, M., Shokkar, R., Kaul, S., Barron, A., Collins, C., Beavis, S., Whileman, A., Dale, K., Hawes, J., Pritchard, K., Gascoyne, R., Stevenson, L., Jha, R., Lim, L., Krishnamurthy, V., Parker, R., Turner-Bone, I., Wilding, L., Reddy, A., Whiteley, S., Wilby, E., Howcroft, C., Aspinwall, A., Charlton, S., Ogg, B., Menzies, D., Pugh, R., Allan, E., Lean, R., Davies, F., Easton, J., Qiu, X., Kumar, S., Darlington, K., Houston, G., O'Brien, P., Geary, T., Allan, J., Meikle, A., Hughes, G., Balasubramaniam, M., Latham, S., Mckenna, E., Flanagan, R., Sathe, S., Davies, E., Chablani, M., Kirkby, A., Netherton, K., Archer, S., Yates, B., Ashbrook-Raby, C., Cole, S., Casey, M., Cabrelli, L., Chapman, S., Hutcheon, A., Whyte, C., Almaden-Boyle, C., Pattison, N., Cruz, C., Vochin, A., Kent, H., Thomas, A., Murdoch, S., David, B., Penacerrada, M., Lubimbi, G., Bastion, V., Wulandari, R., Lorusso, R., Valentine, J., Clarke, D., Serrano-Ruiz, A., Hierons, S., Eckbad, C., Ramos, L., Demetriou, C., Mitchard, S., White, K., White, N., Pitts, S., Branney, D., Frankham, J., Watters, M., Langton, H., Prout, R., Page, V., Varghes, T., Cowton, A., Kay, A., Potts, K., Birt, M., Kent, M., Wilkinson, A., Jude, E. B., Turner, V., Savill, H., Mccormick, J., Coulding, M., Siddiqui, S., Mercer, O., Rehman, H., Potla, D., Capps, N., Donaldson, D., Button, H., Martin, T., Hard, K., Agasou, A., Tonks, L., Arden, T., Boyle, P., Carnahan, M., Strickley, J., Adams, C., Childs, D., Rikunenko, R., Leigh, M., Breekes, M., Wilcox, R., Bowes, A., Tiveran, H., Hurford, F., Summers, J., Carter, A., Hussain, Y., Ting, L., Javaid, A., Motherwell, N., Moore, H., Millward, H., Jose, S., Schunki, N., Noakes, A., Clulow, C., Sadera, G., Jacob, R., Jones, C., Blunt, M., Coton, Z., Curgenven, H., Ally, S. M., Beaumont, K., Elsaadany, M., Fernandes, K., Ali Mohamed Ali, I., Rangarajan, H., Sarathy, V., Selvanayagam, S., Vedage, D., White, M., Truman, N., Chukkambotla, S., Keith, S., Cockerill-Taylor, J., Ryan-Smith, J., Bolton, R., Springle, P., Dykes, J., Thomas, J., Khan, M., Hijazi, M. T., Massey, E., Croston, G., Reschreiter, H., Camsooksai, J., Patch, S., Jenkins, S., Humphrey, C., Wadams, B., Msiska, M., Adanini, O., Attwood, B., Parsons, P., Tatham, K., Jhanji, S., Black, E., Dela Rosa, A., Howle, R., Thomas, B., Bemand, T., Raobaikady, R., Saha, R., Staines, N., Daniel, A., Finn, J., Hutter, J., Doble, P., Shovelton, C., Pawley, C., Kannan, T., Hill, M., Combes, E., Monnery, S., Joefield, T., Popescu, M., Thankachen, M., Oblak, M., Little, J., Mcivor, S., Brady, A., Whittle, H., Prady, H., Chan, R., Ahmed, A., Morris, A., Gibson, C., Gordon, E., Keenan, S., Quinn, H., Benyon, S., Marriott, S., Zitter, L., Park, L., Baines, K., Lyons, M., Holland, M., Keenan, N., Young, M., Garrioch, S., Dawson, J., Tolson, M., Scholefield, B., Bi, R., Richardson, N., Schumacher, N., Cosier, T., Millen, G., Higham, A., Turki, S., Allen, L., Crisp, N., Hazleton, T., Knight, A., Deery, J., Price, C., Turney, S., Tilbey, S., Beranova, E., Wright, D., George, L., Twiss, S., Wadd, S., Postlethwaite, K., Gondo, P., Masunda, B., Kayani, A., Hadebe, B., Whiteside, J., Clarke, N., Donnison, P., Trim, F., Leadbitter, I., Butcher, D., O'Sullivan, S., Purewal, B., Bell, S., Rivers, V., O'Leary, R., Birch, J., Collins, E., Anderson, S., Hammerton, K., Andrews, E., Burns, K., Edmond, I., Todd, A., Donnachie, J., Turner, P., Prentice, L., Symon, L., Runciman, N., Auld, F., Halkes, M., Mercer, P., Thornton, L., Debreceni, G., Wilkins, J., Crickmore, V., Subramanian, G., Marshall, R., Jennings, C., Latif, M., Bunni, L., Spivey, M., Bean, S., Burt, K., Linnett, V., Ritzema, J., Sanderson, A., Mccormick, W., Bokhari, M., Kapoor, R., Loader, D., Ayers, A., Harrison, W., North, J., Belagodu, Z., Paramsothy, R., Olufuwa, O., Gherman, A., Fuller, B., Stuart, C., Kelsall, O., Davis, C., Wild, L., Wood, H., Thrush, J., Durie, A., Austin, K., Archer, K., Anderson, P., Vigurs, C., Thorpe, C., Knights, E., Boyle, N., Price, A., Kubisz-Pudelko, A., Wood, D., Lewis, A., Board, S., Pippard, L., Perry, J., Beesley, K., Rattray, A., Lee, E., Lennon, L., Douglas, K., Bell, D., Boyle, R., Glass, L., Nauman Akhtar, M., Dent, K., Potoczna, D., Pearson, S., Horsley, E., Spencer, S., Mullan, D., Skinner, D., Gaylard, J., Barber, R., Hewitt, C., Hilldrith, A., Shepardson, S., Wills, M., Jackson-Lawrence, K., Gupta, A., Timlick, E., Gorman, C., Otahal, I., Gales, A., Coetzee, S., Sell, C., Raj, M., Peiu, M., Quaid, S., Watson, E., Elliott, K., Mallinson, J., Chandler, B., Turnbull, A., Finch, C., Holl, C., Cooper, J., Evans, A., Khaliq, W., Collins, A., Gude, E. T., Love, N., van Koutrik, L., Hunt, J., Kaye, D., Fisher, E., Brayne, A., Tuckey, V., Jackson, P., Parkin, J., Tariq, A., Houlden, H., Tucci, A., Hardy, J., Moncur, E., Highgate, J., Cowley, A., Mitra, A., Stead, R., Behan, T., Burnett, C., Newton, M., Heeney, E., Pollard, R., Hatton, J., Patel, A., Kasipandian, V., Allibone, S., Genetu, R. M., O'Brien, L., Omar, Z., Perkins, E., Davies, K., Tetla, D., Shelley, B., Irvine, V., Williams, S., Williams, P., Goodsell, J., Tutton, R., Bough, L., Winter-Goodwin, B., Kitson, R., Pinnell, J., Wilson, A., Nortcliffe, T., Wood, T., Home, M., Holdroyd, K., Robinson, M., Shaw, R., Greig, J., Brady, M., Haigh, A., Matupe, L., Usher, M., Mellor, S., Dale, S., Gledhill, L., Shaw, L., Turner, G., Kelly, D., Anwar, B., Riley, H., Sturgeon, H., Ali, A., Thomis, L., Melia, D., Dance, A., Humphreys, S., Frost, I., Gopal, V., Godden, J., Holden, A., Swann, S., Smith, T., Clapham, M., Poultney, U., Harper, R., Rice, P., Reece-Anthony, R., Gurung, B., Moultrie, S., Odam, M., Mayer, A., Bellini, A., Pickard, A., Bryant, J., Roe, N., Sowter, J., Lang, K., Taylor, J., Barry, P., Hobrok, M., Tench, H., Wolf-Roberts, R., Mcguinness, H., Loosley, R., Hawcutt, D., Rad, L., O'Malley, L., Saunderson, P., Seddon, G., Anderson, T., Rogers, N., Ruddy, J., Harkins, M., Beith, C., Mcalpine, A., Ferguson, L., Grant, P., Macfadyen, S., Mclaughlin, M., Baird, T., Rundell, S., Welsh, B., Hamill, R., Fisher, F., Gregory, J., Campbell, A., Smuts, S., Kenneth Baillie, J., Carson, G., Alex, B., Bach, B., Barclay, W. S., Bogaert, D., Chand, M., Cooke, G. S., Docherty, A. B., Dunning, J., da Silva Filipe, A., Fletcher, T., Green, C. A., Harrison, E. M., Hiscox, J. A., Ho, A. Y. W., Horby, P. W., Ijaz, S., Khoo, S., Lim, W. S., Mentzer, A. J., Merson, L., Meynert, A. M., Noursadeghi, M., Palmarini, M., Paxton, W. A., Pollakis, G., Price, N., Rambaut, A., Robertson, D. L., Sancho-Shimizu, V., Scott, J. T., de Silva, T., Sigfrid, L., Solomon, T., Sriskandan, S., Stuart, D., Tedder, R. S., Thomson, E. C., Thompson, A. A. R., Thwaites, R. S., Turtle, L. C. W., Zambon, M., Hardwick, H., Donohue, C., Lyons, R., Norman, L., Pius, R., Drake, T. M., Fairfield, C. J., Knight, S. R., Mclean, K. A., Murphy, D., Shaw, C. A., Dalton, J., Girvan, M., Saviciute, E., Roberts, S., Harrison, J., Marsh, L., Connor, M., Halpin, S., Gamble, C., Leeming, G., Wham, M., Greenhalf, W., Shaw, V., Mcdonald, S., Ganna, A., Sulem, P., van Heel, D. A., Cordioli, M., Sveinbjornsson, G., Niemi, M. E. K., Shelton, J. F., Shastri, A. J., Ye, C., Weldon, C. H., Filshtein-Sonmez, T., Coker, D., Symons, A., Esparza-Gordillo, J., Aslibekyan, S., Auton, A., Krieger, J. E., Marques, E., Jannes, C. E., Mari, F., Daga, S., Baldassarri, M., Benetti, E., Furini, S., Fallerini, C., Fava, F., Valentino, F., Doddato, G., Giliberti, A., Tita, R., Amitrano, S., Bruttini, M., Croci, S., Meloni, I., Pinto, A. M., Frullanti, E., Mencarelli, M. A., Rizzo, C. L., Montagnani, F., Di Sarno, L., Tommasi, A., Palmieri, M., Emiliozzi, A., Fabbiani, M., Rossetti, B., Zanelli, G., Bargagli, E., Bergantini, L., D'Alessandro, M., Cameli, P., Bennet, D., Anedda, F., Marcantonio, S., Scolletta, S., Franchi, F., Mazzei, M. A., Guerrini, S., Conticini, E., Cantarini, L., Frediani, B., Tacconi, D., Spertilli, C., Feri, M., Donati, A., Scala, R., Guidelli, L., Spargi, G., Corridi, M., Nencioni, C., Croci, L., Caldarelli, G. P., Spagnesi, M., Piacentini, P., Bandini, M., Desanctis, E., Cappelli, S., Canaccini, A., Verzuri, A., Anemoli, V., Ognibene, A., Vaghi, M., D'Arminio Monforte, A., Merlini, E., Mondelli, M. U., Mantovani, S., Ludovisi, S., Girardis, M., Venturelli, S., Sita, M., Cossarizza, A., Antinori, A., Vergori, A., Rusconi, S., Siano, M., Gabrieli, A., Riva, A., Francisci, D., Schiaroli, E., Scotton, P. G., Andretta, F., Panese, S., Scaggiante, R., Gatti, F., Parisi, S. G., Castelli, F., Quiros-Roldan, M. E., Magro, P., Zanella, I., Della Monica, M., Piscopo, C., Capasso, M., Russo, R., Andolfo, I., Iolascon, A., Fiorentino, G., Carella, M., Castori, M., Merla, G., Aucella, F., Raggi, P., Marciano, C., Perna, R., Bassetti, M., Di Biagio, A., Sanguinetti, M., Masucci, L., Valente, S., Mandala, M., Giorli, A., Salerni, L., Zucchi, P., Parravicini, P., Menatti, E., Baratti, S., Trotta, T., Giannattasio, F., Coiro, G., Lena, F., Coviello, D. A., Mussini, C., Bosio, G., Martinelli, E., Mancarella, S., Tavecchia, L., Crotti, L., Picchiotti, N., Gori, M., Gabbi, C., Sanarico, M., Ceri, S., Pinoli, P., Raimondi, F., Biscarini, F., Stella, A., Shen, X., Ponting, C. P., Fawkes, A., Tenesa, A., Caulfield, M., Scott, R., Rowan, K., Murphy, L., Openshaw, P. J. M., Semple, M. G., Vitart, V., and Wilson, J. F.
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0301 basic medicine ,Male ,CCR2 ,Chromosomes, Human, Pair 21 ,Genome-wide association study ,Receptor, Interferon alpha-beta ,Disease ,Bioinformatics ,Genome-wide association studies ,23andMe Investigators ,Interferon alpha-beta ,0302 clinical medicine ,Receptors ,2',5'-Oligoadenylate Synthetase ,Pair 12 ,genetics ,Lung ,BRACOVID Investigators ,Multidisciplinary ,GenOMICC Investigators ,Tyrosine kinase 2 ,030220 oncology & carcinogenesis ,Multigene Family ,Medical genetics ,Female ,Dipeptidyl-Peptidases and Tripeptidyl-Peptidase ,5'-Oligoadenylate Synthetase ,Human ,Receptor ,medicine.medical_specialty ,Critical Care ,Receptors, CCR2 ,General Science & Technology ,Critical Illness ,Chromosomes ,03 medical and health sciences ,Intensive care ,Mendelian randomization ,Immunogenetics ,medicine ,Humans ,Dipeptidyl-Peptidases and Tripeptidyl-Peptidases ,Gen-COVID Investigators ,Inflammation ,TYK2 Kinase ,Chromosomes, Human, Pair 12 ,Pair 19 ,SARS-CoV-2 ,business.industry ,Drug Repositioning ,COVID-19 ,United Kingdom ,COVID-19 Human Genetics Initiative ,030104 developmental biology ,Viral infection ,Chromosomes, Human, Pair 19 ,Genome-Wide Association Study ,Pharmacogenomics ,ISARICC Investigators ,Pair 21 ,2' ,business - Abstract
Host-mediated lung inflammation is present1, and drives mortality2, in the critical illness caused by coronavirus disease 2019 (COVID-19). Host genetic variants associated with critical illness may identify mechanistic targets for therapeutic development3. Here we report the results of the GenOMICC (Genetics Of Mortality In Critical Care) genome-wide association study in 2,244 critically ill patients with COVID-19 from 208 UK intensive care units. We have identified and replicated the following new genome-wide significant associations: on chromosome 12q24.13 (rs10735079,P=1.65×10−8) in a gene cluster that encodes antiviral restriction enzyme activators (OAS1,OAS2andOAS3); on chromosome 19p13.2 (rs74956615,P=2.3×10−8) near the gene that encodes tyrosine kinase 2 (TYK2); on chromosome 19p13.3 (rs2109069,P=3.98× 10−12) within the gene that encodes dipeptidyl peptidase 9 (DPP9); and on chromosome 21q22.1 (rs2236757,P=4.99×10−8) in the interferon receptor geneIFNAR2. We identified potential targets for repurposing of licensed medications: using Mendelian randomization, we found evidence that low expression ofIFNAR2, or high expression ofTYK2, are associated with life-threatening disease; and transcriptome-wide association in lung tissue revealed that high expression of the monocyte–macrophage chemotactic receptorCCR2is associated with severe COVID-19. Our results identify robust genetic signals relating to key host antiviral defence mechanisms and mediators of inflammatory organ damage in COVID-19. Both mechanisms may be amenable to targeted treatment with existing drugs. However, large-scale randomized clinical trials will be essential before any change to clinical practice.
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- 2020
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22. Crohn’s Disease Among the Poorest Billion: Burden of Crohn’s Disease in Low- and Lower-Middle-Income Countries
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Rajbhandari, Ruma, primary, Blakemore, Samantha, additional, Gupta, Neil, additional, Mannan, Sara, additional, Nikolli, Klejda, additional, Yih, Alison, additional, Drown, Laura, additional, and Bukhman, Gene, additional
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- 2022
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23. Re-evaluating consensus and uncertainty among treatment options for early onset scoliosis: a 10-year update
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Matsumoto, Hiroko, primary, Fano, Adam N., additional, Quan, Theodore, additional, Akbarnia, Behrooz A., additional, Blakemore, Laurel C., additional, Flynn, John M., additional, Skaggs, David L., additional, Smith, John T., additional, Snyder, Brian D., additional, Sponseller, Paul D., additional, McCarthy, Richard E., additional, Sturm, Peter F., additional, Roye, David P., additional, Emans, John B., additional, and Vitale, Michael G., additional
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- 2022
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24. Two is not always greater than one: patients with one ovary have similar assisted reproductive technology (ART) outcomes compared to patients with two ovaries
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Auran, Emily, primary, Cascante, Sarah, additional, and Blakemore, Jennifer, additional
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- 2022
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25. The association between deaths from infection and mutations of the BRAF, FBXW7, NRAS and XPO1 genes: a report from the LRF CLL4 trial
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Monica Else, Stuart Blakemore, Daniel Catovsky, and Jonathan C. Strefford
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Male ,Proto-Oncogene Proteins B-raf ,Neuroblastoma RAS viral oncogene homolog ,Chronic lymphocytic leukaemia ,Cancer Research ,medicine.medical_specialty ,F-Box-WD Repeat-Containing Protein 7 ,Receptors, Cytoplasmic and Nuclear ,Karyopherins ,Gene mutation ,Infections ,medicine.disease_cause ,Article ,GTP Phosphohydrolases ,Neoplasms ,Internal medicine ,Antineoplastic Combined Chemotherapy Protocols ,medicine ,Humans ,In patient ,Cancer genetics ,Gene ,Aged ,Cause of death ,Mutation ,Lymphocytic leukaemia ,business.industry ,Membrane Proteins ,Hematology ,Odds ratio ,Prognosis ,Survival Rate ,Oncology ,Infectious diseases ,Female ,business ,Follow-Up Studies - Abstract
Causes of death, in particular deaths due to infection, have not been widely studied in randomised trials in chronic lymphocytic leukaemia. With long-term follow-up (median 13 years) we examined the cause of death in 600/777 patients in the LRF CLL4 trial. Blood samples, taken at randomisation from 499 patients, were available for identifying gene mutations. Infection was a cause of death in 258 patients (43%). Patients dying of infection were more likely than those who died of other causes to have received ≥2 lines of treatment (194/258 [75%] versus 231/342 [68%], P = 0.04) and to have died in the winter months (149/258 [58%] versus 166/342 [49%], P = 0.03), respectively. In patients with mutation data, the factors significantly associated with death from infection versus all other deaths were 11q deletion (47/162 [29%] versus 40/209 [19%], P = 0.03) and mutations of the BRAF, FBXW7, NRAS and XPO1 genes. Death was caused by an infection in 46/67 assessable patients (69%) who had a mutation of one or more of these four genes versus only 129/333 patients (39%) without any of these mutations (odds ratio: 3.46 [95% CI 1.98–6.07] P
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- 2021
26. Prospective analysis of progesterone exposure in programmed single thawed euploid embryo transfer cycles and outcomes
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Elizabeth Fino, Carly I. Hirschberg, Jamie Grifo, and Jennifer K. Blakemore
- Subjects
Adult ,0301 basic medicine ,medicine.medical_specialty ,Pregnancy Rate ,Reproductive medicine ,Fertilization in Vitro ,Abortion ,Endometrium ,03 medical and health sciences ,0302 clinical medicine ,Pregnancy ,Single Embryo Transfer ,Genetics ,medicine ,Humans ,Embryo Implantation ,Precision Medicine ,Assisted Reproduction Technologies ,Prospective cohort study ,Progesterone ,Genetics (clinical) ,Cryopreservation ,030219 obstetrics & reproductive medicine ,Obstetrics ,business.industry ,Area under the curve ,Obstetrics and Gynecology ,General Medicine ,medicine.disease ,Embryo transfer ,Abortion, Spontaneous ,030104 developmental biology ,medicine.anatomical_structure ,Reproductive Medicine ,Female ,Analysis of variance ,business ,Live Birth ,Developmental Biology - Abstract
PURPOSE: In the era of personalized medicine and the increased use of frozen embryo transfer (FET), assay of the endometrium’s receptivity prior to transfer has gained popularity, especially among patients. However, the optimal timing for single thawed euploid embryo transfers (STEET) in a programmed FET has yet to be determined Mackens et al. (Hum Reprod. 32(11):2234–42, 2017). We sought to examine the outcomes of euploid FETs by length of progesterone (P4) exposure. METHODS: Prospective cohort study of programmed FETs of single euploid embryos between June 1, 2018, and December, 18, 2018, at our center. Subjects reported the exact start time for initiating progesterone. The transfer time was noted to calculate the primary independent variable, duration of progesterone exposure. Statistical analysis included ANOVA and Spearman’s rho correlation, with p
- Published
- 2021
27. Universal Mindfulness Training in Schools for Adolescents: a Scoping Review and Conceptual Model of Moderators, Mediators, and Implementation Factors.
- Author
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Tudor, K, Maloney, S, Raja, A, Baer, R, Blakemore, S-J, Byford, S, Crane, C, Dalgleish, T, De Wilde, K, Ford, T, Greenberg, M, Hinze, V, Lord, L, Radley, L, Opaleye, ES, Taylor, L, Ukoumunne, OC, Viner, R, MYRIAD Team, Kuyken, W, Montero-Marin, J, Tudor, K, Maloney, S, Raja, A, Baer, R, Blakemore, S-J, Byford, S, Crane, C, Dalgleish, T, De Wilde, K, Ford, T, Greenberg, M, Hinze, V, Lord, L, Radley, L, Opaleye, ES, Taylor, L, Ukoumunne, OC, Viner, R, MYRIAD Team, Kuyken, W, and Montero-Marin, J
- Abstract
There is evidence that universal school-based mindfulness training (SBMT) can have positive effects for young people. However, it is unknown who benefits most from such training, how training exerts effects, and how implementation impacts effects. This study aimed to provide an overview of the evidence on the mediators, moderators, and implementation factors of SBMT, and propose a conceptual model that can be used both to summarize the evidence and provide a framework for future research. A scoping review was performed, and six databases and grey literature were searched. Inclusion and exclusion criteria were applied to select relevant material. Quantitative and qualitative information was extracted from eligible articles and reported in accordance with PRISMA-ScR guidelines. The search produced 5479 articles, of which 31 were eligible and included in the review. Eleven studies assessed moderators of SBMT on pupil outcomes, with mixed findings for all variables tested. Five studies examined the mediating effect of specific variables on pupil outcomes, with evidence that increases in mindfulness skills and decreases in cognitive reactivity and self-criticism post-intervention are related to better pupil outcomes at follow-up. Twenty-five studies assessed implementation factors. We discuss key methodological shortcomings of included studies and integrate our findings with existing implementation frameworks to propose a conceptual model. Widespread interest in universal SBMT has led to increased research over recent years, exploring who SBMT works for and how it might work, but the current evidence is limited. We make recommendations for future research and provide a conceptual model to guide theory-led developments.
- Published
- 2022
28. Planned Oocyte Cryopreservation and the Black Obstetrician Gynecologist: Utilization and Perspectives
- Author
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Wiltshire, Ashley, primary, Ghidei, Luwam, additional, Lantigua-Martinez, Meralis, additional, Licciardi, Frederick, additional, and Blakemore, Jennifer, additional
- Published
- 2022
- Full Text
- View/download PDF
29. Windows of developmental sensitivity to social media
- Author
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Orben, Amy, primary, Przybylski, Andrew K., additional, Blakemore, Sarah-Jayne, additional, and Kievit, Rogier A., additional
- Published
- 2022
- Full Text
- View/download PDF
30. The use of oocyte cryopreservation for fertility preservation in patients with sex chromosome disorders: a case series describing outcomes
- Author
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Martel, Rachel A., primary, Blakemore, Jennifer K., additional, and Fino, M. Elizabeth, additional
- Published
- 2022
- Full Text
- View/download PDF
31. Sociodemographic differences in utilization of fertility services among reproductive age women diagnosed with cancer in the USA
- Author
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Voigt, Paxton, primary, Persily, Jesse, additional, Blakemore, Jennifer K., additional, Licciardi, Frederick, additional, Thakker, Sameer, additional, and Najari, Bobby, additional
- Published
- 2022
- Full Text
- View/download PDF
32. Access to infertility care in a low-resource setting: bridging the gap through resident and fellow education in a New York City public hospital
- Author
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S.M. Maxwell, Brooke Hodes-Wertz, Kara N. Goldman, and Jennifer K. Blakemore
- Subjects
Adult ,Male ,0301 basic medicine ,medicine.medical_specialty ,Reproductive Techniques, Assisted ,Reproductive endocrinology and infertility ,media_common.quotation_subject ,Population ,Reproductive medicine ,Graduate medical education ,Genetic Counseling ,Fertility ,Fertilization in Vitro ,Health Services Accessibility ,03 medical and health sciences ,0302 clinical medicine ,Pregnancy ,Genetics ,Humans ,Medicine ,education ,Genetics (clinical) ,media_common ,education.field_of_study ,030219 obstetrics & reproductive medicine ,Hospitals, Public ,business.industry ,Public health ,Obstetrics and Gynecology ,General Medicine ,Middle Aged ,Fertility clinic ,030104 developmental biology ,Reproductive Medicine ,Education, Medical, Graduate ,Infertility ,Family medicine ,Public hospital ,Commentary ,Female ,New York City ,business ,Developmental Biology - Abstract
PURPOSE: Improving access to care is an issue at the forefront of reproductive medicine. We sought to describe how one academic center, set in the background of a large and diverse metropolitan city, cares for patients with extremely limited access to reproductive specialists. METHODS: The NYU Reproductive Endocrinology and Infertility (REI) Fellowship program provides a “fellow-run clinic” within Manhattan’s Bellevue Hospital Center, which is led by the REI fellows and supervised by the REI attendings of the NYU Langone Health system. A description of the history of the hospital as well as the logistics of the fertility clinic is provided as a logistical template for implementation. RESULTS: The fellow-run fertility clinic at Bellevue hospital is held on two half days per month seeing approximately 150 new patients per year. The fertility workup, counseling, surgery, as well as ovulation induction, and early pregnancy management are offered within the construct of the fellowship and residency at NYU. Barriers to care and ways to circumvent those barriers are discussed in detail. CONCLUSION: By utilizing the ambition and construct of the OB/GYN programs, we greatly improve care for an otherwise underserved patient population by offering an efficient and optimal infertility workup and treatment in a population that would otherwise be without care. We utilize the framework of graduate medical education to provide autonomy, experience, and mentorship to both residents and fellows in our programs in an effort to provide a solution to combating inequity in infertility care.
- Published
- 2020
33. MRI utilization and rates of abnormal pretreatment MRI findings in early-onset scoliosis: review of a global cohort
- Author
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Stefan Parent, Peter Sturm, John B. Emans, Behrooz A. Akbarnia, Brendan A. Williams, Anna McClung, Laurel C. Blakemore, Jeff B Pawelek, Suken A. Shah, Burt Yaszay, and Paul D. Sponseller
- Subjects
medicine.medical_specialty ,Radiography ,Comorbidity ,Scoliosis ,Cohort Studies ,03 medical and health sciences ,0302 clinical medicine ,Prevalence ,medicine ,Humans ,Orthopedics and Sports Medicine ,Syrinx (medicine) ,Registries ,Age of Onset ,Retrospective Studies ,Chiari malformation ,030222 orthopedics ,medicine.diagnostic_test ,business.industry ,Racial Groups ,Age Factors ,Magnetic resonance imaging ,Patient Acceptance of Health Care ,medicine.disease ,Magnetic Resonance Imaging ,Arnold-Chiari Malformation ,Spinal Cord ,Preoperative Period ,Orthopedic surgery ,Cohort ,Radiology ,Abnormality ,business ,030217 neurology & neurosurgery - Abstract
Retrospective review OBJECTIVES: To report the frequency of pretreatment magnetic resonance imaging (MRI) utilization and rates and types of intra-spinal abnormalities identified on MRI in patients with early-onset scoliosis (EOS). MRI can help identify spinal cord abnormalities in patients with EOS.We reviewed data from patients enrolled from 1993-2018 in an international EOS registry. Patients with incomplete/unverifiable data and those with spinal deformities secondary to infection or tumor were excluded, leaving 1343 patients for analysis. Demographic characteristics, pretreatment major curve magnitude, treatment type, and MRI findings were analyzed. Patients were categorized by EOS type (congenital, idiopathic, neuromuscular, syndromic), pretreatment MRI utilization, and presence of intra-spinal abnormality on MRI. Univariate testing and multivariate logistic regression were performed to identify demographic, radiographic, and clinical predictors of MRI utilization and abnormal MRI findings.MRI was used in 836 patients (62%). Pretreatment MRI utilization rates ranged from 42% in neuromuscular EOS to 74% in congenital EOS. Prevalence of abnormal MRI findings was 24% overall, ranging from 13% in patients with idiopathic EOS to 39% in neuromuscular EOS. Compared with white/Caucasian patients, Asian/Asian-American patients had higher odds of MRI utilization and abnormal MRI findings. Treatment type, pretreatment major curve magnitude, age at MRI, and age at treatment were not associated with abnormal MRI findings. Overall, 249 abnormalities were identified in 197 patients. The most common findings were syrinx and tethered cord. Syrinx with Chiari malformation was the most frequent combination of abnormal findings.In the two-thirds of patients who underwent MRI before EOS treatment, findings were abnormal in 24%. EOS type and race/ethnicity were associated with both MRI utilization and abnormal findings. The most frequent abnormalities were syrinx and tethered cord, and the type of abnormalities appeared to differ by EOS type.Prognostic, Level III.
- Published
- 2020
34. Mendelian randomisation analyses of UK Biobank and published data suggest that increased adiposity lowers risk of breast and prostate cancer
- Author
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Amin, HA, Kaewsri, P, Yiorkas, AM, Cooke, H, Blakemore, AI, and Drenos, F
- Subjects
Multidisciplinary ,cancer prevention ,Science ,Breast Neoplasms ,Article ,Cancer prevention ,breast cancer ,Breast cancer ,Cancer epidemiology ,Risk factors ,genetic association study ,risk factors ,Medicine ,cancer epidemiology ,Genetic association study - Abstract
Copyright © The Authors 2022. Breast (BCa) and prostate (PrCa) cancer are the first and second most common types of cancer in women and men, respectively. We aimed to explore the causal effect of adiposity on BCa and PrCa risk in the UK Biobank and published data. We used Mendelian randomisation (MR) to assess the causal effect of body mass index (BMI), body fat percentage (BFP), waist circumference (WC), hip circumference (HC), and waist-to-hip ratio (WHR) on BCa and PrCa risk. We found that increased BMI, WC and HC decreased the risk of breast cancer (OR 0.70 per 5.14 kg/m2 [0.59–0.85, p = 2.1 × 10–4], 0.76 per 12.49 cm [60–0.97, p = 0.028] and 0.73 per 10.31 cm [0.59–0.90, p = 3.7 × 10–3], respectively) and increased WC and BMI decreased the risk of prostate cancer (0.68 per 11.32 cm [0.50–0.91, p = 0.01] and 0.76 per 10.23 kg/m2 [0.61–0.95, p = 0.015], respectively) in UK Biobank participants. We confirmed our results with a two-sample-MR of published data. In conclusion, our results suggest a protective effect of adiposity on the risk of BCa and PrCa highlighting the need to re-evaluate the role of adiposity as cancer risk factor. Brunel Research Initiative and Enterprise Fund; HAA is the recipient of a PhD studentship from the College of Health and Life Sciences, Brunel University London.
- Published
- 2022
35. New treatment for amblyopia based on rules of synaptic plasticity: a randomized clinical trial
- Author
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Huang, Xin, primary, Xia, Huika, additional, Zhang, Qi, additional, Blakemore, Colin, additional, Nan, Yan, additional, Wang, Wenyao, additional, Gao, Jie, additional, Ng, Spencer S., additional, Wen, Jing, additional, Huang, Tiejun, additional, Li, Xiaoqing, additional, and Pu, Mingliang, additional
- Published
- 2022
- Full Text
- View/download PDF
36. Long-Term Weight Outcome After Bariatric Surgery in Patients with Melanocortin-4 Receptor Gene Variants: a Case–Control Study of 105 Patients
- Author
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Cooiman, Mellody I., primary, Alsters, Suzanne I. M., additional, Duquesnoy, Maeva, additional, Hazebroek, Eric J., additional, Meijers-Heijboer, Hanne J., additional, Chahal, Harvinder, additional, Le Beyec-Le Bihan, Johanne, additional, Clément, Karine, additional, Soula, Hedi, additional, Blakemore, Alex I., additional, Poitou, Christine, additional, and van Haelst, Mieke M., additional
- Published
- 2022
- Full Text
- View/download PDF
37. Correction: Re-evaluating consensus and uncertainty among treatment options for early onset scoliosis: a 10-year update
- Author
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Hiroko Matsumoto, Adam N. Fano, Theodore Quan, Behrooz A. Akbarnia, Laurel C. Blakemore, John M. Flynn, David L. Skaggs, John T. Smith, Brian D. Snyder, Paul D. Sponseller, Richard E. McCarthy, Peter F. Sturm, David P. Roye, John B. Emans, and Michael G. Vitale
- Subjects
Orthopedics and Sports Medicine - Published
- 2022
38. Transfer of embryos with positive results following preimplantation genetic testing for monogenic disorders (PGT-M): experience of two high-volume fertility clinics
- Author
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Andria G. Besser, Emily L. Mounts, James A. Grifo, and Jennifer K. Blakemore
- Subjects
Male ,0301 basic medicine ,Heterozygote ,medicine.medical_specialty ,animal structures ,Genetic counseling ,media_common.quotation_subject ,medicine.medical_treatment ,Reproductive medicine ,Fertility ,03 medical and health sciences ,0302 clinical medicine ,Pregnancy ,Neoplasms ,Genetics ,medicine ,Humans ,Genetic Predisposition to Disease ,Age of Onset ,Preimplantation Diagnosis ,Genetics (clinical) ,Genes, Dominant ,Retrospective Studies ,Genetic testing ,media_common ,Fertility Clinics ,030219 obstetrics & reproductive medicine ,In vitro fertilisation ,Adrenal Hyperplasia, Congenital ,medicine.diagnostic_test ,Obstetrics ,business.industry ,Obstetrics and Gynecology ,Embryo ,General Medicine ,Embryo Transfer ,Penetrance ,Embryo transfer ,030104 developmental biology ,Reproductive Medicine ,embryonic structures ,Female ,business ,Developmental Biology - Abstract
PURPOSE: To assess the experiences of two large fertility clinics in which embryos with positive results following preimplantation genetic testing for monogenic disorders (PGT-M) were transferred upon patient request, in order to explore the nature of the conditions for which these requests have been made and review ethical considerations. METHODS: Retrospective review of previous embryo transfers at the NYU Langone Fertility Center and ORM Fertility was performed. Embryo transfers prior to May 2019 in which embryo biopsy and PGT-M occurred were reviewed, and transferred embryos that were positive for a monogenic disorder (excluding autosomal recessive carriers) were identified. RESULTS: Seventeen patients were identified who elected to transfer 23 embryos that tested positive for nine different monogenic disorders. Most of the embryos transferred were positive for disorders that are autosomal dominant (15/23), are adult-onset (14/23), are associated with reduced penetrance (16/23), and have available management to lessen symptom severity (22/23). Transfer of positive embryos most commonly occurred for hereditary cancer susceptibility syndromes (9/23 embryos), particularly hereditary breast and ovarian cancer syndrome. CONCLUSIONS: When unaffected embryos are not produced following in vitro fertilization with PGT-M, some patients request to transfer embryos with positive test results. The majority of transfers were for embryos positive for adult-onset, reduced penetrance diseases. As these requests will likely increase over time, it is essential to consider the practical and ethical implications.
- Published
- 2019
39. Peer connectedness during the transition to secondary school: a collaborative opportunity for education and social work
- Author
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Milena Heinsch, Hannah Cootes, Kylie Agllias, Amanda Howard, Tamara Blakemore, and Dara Sampson
- Subjects
Medical education ,Social work ,Social connectedness ,media_common.quotation_subject ,05 social sciences ,050301 education ,Educational psychology ,Focus group ,Mental health ,Education ,Friendship ,General partnership ,Happiness ,0501 psychology and cognitive sciences ,Psychology ,0503 education ,050104 developmental & child psychology ,media_common - Abstract
The Creating Meaningful Connections project is a longitudinal study that resulted from a partnership between social work academics at the University of Newcastle and educators at a regional secondary school in NSW, Australia. It seeks to better understand the relationship between school connectedness and youth mental health. In stage 1, focus groups were conducted with 99 students 9 months after their transition to secondary school. The shift to secondary school created a range of social and academic challenges for young people. It often resulted in limited—or no—contact with friends from primary school, requiring the negotiation of new friendships. While this process was relatively trouble-free for many students, others described it as risky and challenging. Positive peer relationships appeared to increase happiness, feelings of safety, offer support during difficult periods and facilitate secondary school adjustment. This paper offers a unique perspective by capturing student voice and commentary about the nature and importance of peer relationships during transition. It also highlights the potential for social work and education to work collaboratively to enhance peer relationships, mental health and school connectedness during transition.
- Published
- 2019
40. Experiences and psychological outcomes of the oocyte donor: a survey of donors post-donation from one center
- Author
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Jennifer K. Blakemore, M. Elizabeth Fino, Shelley Lee, Andria G. Besser, Mindy R Schiffman, and Paxton E. Voigt
- Subjects
Adult ,Counseling ,0301 basic medicine ,medicine.medical_specialty ,Tissue and Organ Procurement ,media_common.quotation_subject ,Reproductive medicine ,Fertility ,03 medical and health sciences ,0302 clinical medicine ,Informed consent ,Surveys and Questionnaires ,Genetics ,medicine ,Humans ,Assisted Reproduction Technologies ,Genetics (clinical) ,media_common ,030219 obstetrics & reproductive medicine ,Oocyte Donation ,Obstetrics and Gynecology ,Electronic information ,General Medicine ,Tissue Donors ,Oocyte donor ,030104 developmental biology ,Reproductive Medicine ,Feeling ,Donation ,Family medicine ,Respondent ,Oocytes ,Female ,Psychology ,Developmental Biology - Abstract
PURPOSE: To assess the experiences and psychological outcomes of oocyte donors from one fertility center. METHODS: An anonymous survey was distributed via a secure email to 161 donors who underwent oocyte donation—anonymous, directed/known, and recruited agency—between January 2008 and January 2019 at the NYU Langone Fertility Center. RESULTS: Thirty-six donors completed the survey with the majority between 2 and 10 years since donation. Respondents reported a high prevalence of psychiatric symptoms or diagnoses post-donation. The majority of donors reported positive thoughts and feelings toward their donation process as well as to the knowledge of children born from their donation. Negative comments about donation were in the minority but focused on unexpected aspects about the process or outcome. Based on qualitative analysis, thoughts about family or “family-oriented thoughts” were the most frequent theme in respondent comments. 62.5% of respondents reporting that they would be open to identity-disclosure or open donation after experiencing the process. CONCLUSIONS: Despite a high reported prevalence of psychiatric symptoms, the majority of respondents felt positively about the donation experience as well as the prospect of open donation or identity-disclosure post-donation. Further research on long-term psychological outcomes, related to all aspects of donation, is important as the counseling and informed consent of oocyte donors continues to evolve. These data will be particularly important with regard to the aspect of disclosure, both planned and unplanned, in the modern era of electronic information sharing.
- Published
- 2019
41. The Interplay Between Adolescent Friendship Quality and Resilient Functioning Following Childhood and Adolescent Adversity
- Author
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Van Harmelen, A-L, Blakemore, SJ, Goodyer, IM, Kievit, RA, van Harmelen, A-L [0000-0003-1108-2921], and Apollo - University of Cambridge Repository
- Subjects
Pediatric ,Pediatric Research Initiative ,Mental Health ,52 Psychology ,32 Biomedical and Clinical Sciences ,3 Good Health and Well Being ,sense organs ,5205 Social and Personality Psychology ,humanities ,Brain Disorders - Abstract
Child and adolescent adversity (‘CA’) is a major predictor of mental health problems in adolescence and early adulthood. However, not all young people who have experienced CA develop psychopathology; their mental health functioning can be described as resilient. We previously found that resilient functioning in adolescence following CA is facilitated by adolescent friendships. However, during adolescence, friendships undergo significant change. It is unknown whether resilient functioning after CA fluctuates with these normative changes in friendship quality. We used Latent Change Score Modelling in a large sample of adolescents (i.e. the ROOTS cohort; N = 1238) to examine whether and how emergent friendship quality and resilient functioning at ages 14 and 17 inter-relate and change together. We found that friendships quality and resilient functioning had strong associations at age 14, although friendships at 14 did not predict higher resilient functioning at 17. Higher resilient functioning in 14-year-olds with a history of CA was associated with a positive change in friendships from age 14 to 17. Finally, improvements in friendship quality and resilient functioning went hand-in-hand, even when taking into account baseline levels of both, the change within friendship quality or resilient functioning over time, and the association between resilient functioning and change in friendship quality over time. We show that friendship quality and resilient functioning after CA inter-relate and change together between ages 14 and 17. Our results suggest that improving friendship quality or resilient functioning within this timeframe may benefit this vulnerable adolescent group, and this should be tested in future research.
- Published
- 2021
42. Inter- and intra-rater reliability and accuracy of Sanders Skeletal Maturity Staging System when used by surgeons performing vertebral body tethering
- Author
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Swany, Lauren M., primary, Larson, A. Noelle, additional, Milbrandt, Todd A., additional, Sanders, James O., additional, Neal, Kevin M., additional, Blakemore, Laurel C., additional, Newton, Peter O., additional, Pahys, Joshua M., additional, Cahill, Patrick J., additional, and Alanay, Ahmet, additional
- Published
- 2021
- Full Text
- View/download PDF
43. Evaluating the unevaluated: a secondary analysis of the National Survey for Family Growth (NSFG) examining infertile women who did not access care
- Author
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Thakker, Sameer, primary, Persily, Jesse, additional, Voigt, Paxton, additional, Blakemore, Jennifer, additional, Licciardi, Frederick, additional, and Najari, Bobby B., additional
- Published
- 2021
- Full Text
- View/download PDF
44. Radiographic Outcome Differences in Distraction-Based Growing Rod Constructs Using Tandem Versus Wedding Band Connectors
- Author
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Allison Matthews, Behrooz A. Akbarnia, Francisco Sanchez Perez-Grueso, Paul D. Sponseller, Matthew E. Oetgen, Jeff Pawelek, Yunfei Wang, Laurel Blakemore, and Anna McClung
- Subjects
Male ,medicine.medical_specialty ,Radiography ,Kyphosis ,Scoliosis ,Cohort Studies ,03 medical and health sciences ,0302 clinical medicine ,medicine ,Deformity ,Humans ,Orthopedic Procedures ,Orthopedics and Sports Medicine ,Child ,Orthodontics ,030222 orthopedics ,Cobb angle ,business.industry ,medicine.disease ,Spine ,Sagittal plane ,medicine.anatomical_structure ,Coronal plane ,Orthopedic surgery ,Female ,medicine.symptom ,business ,030217 neurology & neurosurgery - Abstract
Study Design Comparative cohort study. Objective To compare coronal deformity control, lengthening efficacy, and sagittal alignment between distraction-based growing rod constructs utilizing tandem versus wedding band connectors. Summary of Background Data Different construct designs exist for growing rod treatment of early-onset scoliosis. All use a version of a rod connector, with the two main types being tandem and wedding band. Little data exist to quantify the impact of connector choice on radiographic outcomes of treatment. Methods A multicenter database of prospectively and retrospectively collected data on early-onset scoliosis patients was reviewed. Patients of any thoracic or thoracolumbar coronal plane deformity whose initial growing rod treatment was initiated before age 10 years and underwent at least 3 years of dual growing rod treatment with either tandem or wedding band connectors were included. Preoperative, immediate postoperative, and prefinal radiographs were reviewed and compared in regard to major curve magnitude, T1–T12 and T1–S1 spinal length, length of instrumentation, and sagittal plane measures. Results A total of 209 patients were included. The overall percent change from preoperative to prefinal in all radiographic parameters was not different between the two groups indicating similar efficacy in treatment. After controlling for institutional variation, the improvement of the major coronal Cobb angle from preoperative to prefinal was statistically improved for the tandem group (34° vs. 29°, p = .002) and the difference in T5–T12 kyphosis from preoperative to prefinal was significantly different between the groups (−6° vs. +1.3°, p = .008). Conclusion We identified little difference in the effects of connector type on radiographic outcomes of patients treated with traditional growing rod, which indicates that both wedding band and tandem connectors function similarly. The small differences detected suggest that tandem connectors may improve major Cobb correction, and wedding band connectors may maintain thoracic kyphosis over time. Level of Evidence Level III
- Published
- 2018
45. Studying individual differences in human adolescent brain development
- Author
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Sarah-Jayne Blakemore and Lucy Foulkes
- Subjects
Male ,Adolescent ,Culture ,Individuality ,Behavioural sciences ,050105 experimental psychology ,Developmental psychology ,Young Adult ,03 medical and health sciences ,0302 clinical medicine ,Neuroimaging ,Social cognition ,Humans ,0501 psychology and cognitive sciences ,Child ,Socioeconomic status ,General Neuroscience ,05 social sciences ,Perspective (graphical) ,Brain ,Adolescent Development ,Variation (linguistics) ,Social Class ,Female ,Psychology ,Psychosocial ,Neurocognitive ,Neuroscience ,030217 neurology & neurosurgery - Abstract
Adolescence is a period of social, psychological and biological development. During adolescence, relationships with others become more complex, peer relationships are paramount and social cognition develops substantially. These psychosocial changes are paralleled by structural and functional changes in the brain. Existing research in adolescent neurocognitive development has focused largely on averages, but this obscures meaningful individual variation in development. In this Perspective, we propose that the field should now move toward studying individual differences. We start by discussing individual variation in structural and functional brain development. To illustrate the importance of considering individual differences in development, we consider three sources of variation that contribute to neurocognitive processing: socioeconomic status, culture and peer environment. To assess individual differences in neurodevelopmental trajectories, large-scale longitudinal datasets are required. Future developmental neuroimaging studies should attempt to characterize individual differences to move toward a more nuanced understanding of neurocognitive changes during adolescence.
- Published
- 2018
46. Effect of health literacy on the quality of life of older patients with long-term conditions: a large cohort study in UK general practice
- Author
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Kelly Howells, Peter Bower, David Reeves, Amy Blakemore, Mark Hann, Maria Panagioti, and Suzanne M. Skevington
- Subjects
Male ,Quality of life ,Gerontology ,medicine.medical_specialty ,General Practice ,Psychological intervention ,Health literacy ,Article ,Cohort Studies ,03 medical and health sciences ,Social support ,0302 clinical medicine ,Humans ,Medicine ,Longitudinal Studies ,030212 general & internal medicine ,Disease management (health) ,Prospective cohort study ,Depression (differential diagnoses) ,Aged ,Aged, 80 and over ,business.industry ,030503 health policy & services ,Public health ,Public Health, Environmental and Occupational Health ,United Kingdom ,humanities ,Long-term conditions ,Older adults ,Female ,0305 other medical science ,business - Abstract
Purpose The levels of health literacy in patients with long-term conditions (LTCs) are critical for better disease management and quality of life (QoL). However, the impact of health literacy on QoL in older adults with LTCs is unclear. This study examined the association between health literacy and domains of QoL in older people with LTCs, investigating key socio-demographic and clinical variables, as confounders. Methods A prospective cohort study was conducted on older adults (n = 4278; aged 65 years and over) with at least one LTC, registered in general practices in Salford, UK. Participants completed measures of health literacy, QoL, multi-morbidity, depression, social support, and socio-demographic characteristics. Multivariate linear regressions were performed to examine the effects of health literacy on four QoL domains at baseline, and then changes in QoL over 12 months. Results At baseline, poor health literacy was associated with lower scores in all four QoL domains (physical, psychological, social relationships and environment), after adjusting for the effects of multi-morbidity, depression, social support and socio-demographic factors. At 12-month follow-up, low health literacy significantly predicted declines in the physical, psychological and environment domains of QoL, but not in social relationships QoL. Conclusions This is the largest, most complete assessment of the effects of health literacy on QoL in older adults with LTCs. Low health literacy is an independent indicator of poor QoL older patients with LTCs. Interventions to improve health literacy in older people with LTCs are encouraged by these findings.
- Published
- 2018
47. The association between deaths from infection and mutations of the BRAF, FBXW7, NRAS and XPO1 genes: a report from the LRF CLL4 trial
- Author
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Else, Monica, primary, Blakemore, Stuart J., additional, Strefford, Jonathan C., additional, and Catovsky, Daniel, additional
- Published
- 2021
- Full Text
- View/download PDF
48. Secondary analyses of global datasets: do obesity and physical activity explain variation in diabetes risk across populations?
- Author
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Alkaf, Budour, primary, Blakemore, Alexandra I., additional, Järvelin, Marjo-Riitta, additional, and Lessan, Nader, additional
- Published
- 2021
- Full Text
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49. Prospective analysis of progesterone exposure in programmed single thawed euploid embryo transfer cycles and outcomes
- Author
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Hirschberg, Carly I., primary, Blakemore, Jennifer K., additional, Fino, Elizabeth, additional, and Grifo, Jamie A., additional
- Published
- 2021
- Full Text
- View/download PDF
50. The Interplay Between Adolescent Friendship Quality and Resilient Functioning Following Childhood and Adolescent Adversity
- Author
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van Harmelen, A.-L., primary, Blakemore, S. J., additional, Goodyer, I. M., additional, and Kievit, R. A., additional
- Published
- 2020
- Full Text
- View/download PDF
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