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2. Neuropsychological functioning of individuals at clinical evaluation of adult ADHD

Author

Christian Mette, Katerina Diers, Anselm B. M. Fuermaier, Oliver Tucha, Nana Guo, Lara Tucha, Bernhard Mueller, Aaron Mroß, Janneke Koerts, and Clinical Neuropsychology

Subjects
Adult, medicine.medical_specialty, Neurology, Medizin, Neuropsychological Tests, Assessment, Diagnosis, Differential, 03 medical and health sciences, Cognition, 0302 clinical medicine, Adult ADHD, Neuropsychology, Diagnosis, mental disorders, medicine, Humans, Attention deficit hyperactivity disorder, Biological Psychiatry, Retrospective Studies, medicine.diagnostic_test, business.industry, Psychiatry and Preclinical Psychiatric Studies - Original Article, Basic cognitive functions, Retrospective cohort study, Neuropsychological test, medicine.disease, 030227 psychiatry, Psychiatry and Mental health, Attention Deficit Disorder with Hyperactivity, Neurology (clinical), Differential diagnosis, business, 030217 neurology & neurosurgery, Clinical psychology
Abstract

Objectives Numerous studies showed that adults with attention deficit hyperactivity disorder (ADHD) suffer from impairments in a range of cognitive functions when compared to healthy controls. However, only little is known about the neuropsychological functions when compared to various clinical control groups and whether a distinct neuropsychological profile can be identified for adult ADHD. Method This retrospective study examined data of 199 outpatients referred for clinical evaluation of adult ADHD, allocated either to an ADHD group (n = 78) or to one of two clinical comparison groups, depending on whether they show indications (n = 71) or no indications (n = 50) for the presence of psychiatric disorders other than ADHD. All individuals performed a comprehensive neuropsychological test battery. Results Data analysis revealed impairments in a range of cognitive functions in a substantial number of patients of all three groups. However, profiles of neuropsychological impairments were similar between groups. Furthermore, significant small- to medium-sized correlations between basic and higher-order cognitive functions were revealed in the ADHD group and the clinical comparison group with indications for psychiatric disorders other than ADHD. Conclusion Neuropsychological impairments are prominent in psychiatric outpatients seeking a clinical evaluation of adult ADHD but are not specific for ADHD. It is concluded that neuropsychological test performance may have limited incremental value to support the psychiatric differential diagnosis. Furthermore, a clinical trajectory may need to take into account that deficits in a range of higher-order cognitive functions can be substantially explained by deficits in basic cognitive functions.

Published
2020
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4. 19th biennial IPEG Meeting

Author

Sonja Simpraga, Rosanna Tortelli, Jill C. Richardson, Bernhard Mueller, Berrie J.L. Gerrits, Marieke Jepma, Silvia Armenise, Martin F.J. Perescis, Inga Griskova-Bulanova, C. Wintmolders, Haitham S. Mohammed, J. Leon Kenemans, Matteo Demuru, Paolo Ranzi, Jakub Korcak, J. A. Kemp, Georg Gruber, T. A. Iseger, N. Marzano, Giuseppe Bertini, Caitlyn Kruiper, Anke Sambeth, Ronald J. Swatzyna, Iris Schutte, Robert A. Comley, Frans C. T. van der Helm, Juergen Dukart, Robin L. Carhart-Harris, Flavio Nobili, Martin Brunovsky, Maria Vasileva, José Carlos Millán-Calenti, Kelly Holt, Jan A. Freund, S. Deepeshwar, Alexandra Kirsten, Yasser A. Khadrawy, Daniel Brandeis, Martin Bareš, Roshan Cools, Eduardo Ekman Schenberg, Sigita Melynyte, Antonio Ivano Triggiani, Ashley Baddeley, Karlijn I. van Aerde, Gerhard Trube, Leonardo Jose Trejo, Stephane Nave, D. A. Jackson, Tomáš Páleníček, Raffaella Franciotti, A. E. Maqueda, Laura Bonanni, E. Saifutdinova, Rahul Chaudhary, Natasja de Bruin, Christoph Mulert, Gilles van Luijtelaar, Hans-Christian Pape, Jeannette Hofmeijer, Martin Brunovský, Marijtje L.A. Jongsma, L. Raeymaekers, Boris Ferger, Donna Palmer, Robert Aidelbaum, Nash N. Boutros, Hanneke E. M. den Ouden, Genevieve N. Izzo, Jessica I. Määttä, Lucilla Parnetti, Gerald P. Kozlowski, Arjan Hillebrand, C. Bouyssières, Philip L.C. van den Broek, David J. Nutt, Jay D. Tarnow, Vlastimil Koudelka, Paolo Maria Rossini, Anna-Lena Dohrmann, Peter Veselcic, Asbjørn Mohr Drewes, Antonio Giannini, Ole Jensen, Christiane M. Thiel, Grazia Buenza, Tomas Novak, Chris G. Kruse, Alexander Sumich, Gaetano Scianatico, Jan-Mathijs Schoffelen, V. Duveau, K. Tahon, Lana Donse, Vladimir Krajca, Pierre Payoux, Vaclava Sedlamyerova, Else A. Tolner, M. Arns, Jennifer Mollon, Michael Derks, Nazimah Hamid, Andrea Szabo, Loreto Gesualdo, Shelly M. Menolascino, M. A. Mañanas, Thorsten Mikoteit, D. Balschun, Mitchell Belgin, Giacomo Tattoli, Cestmir Vejmola, Bob Oranje, Barbora Kohutova, Giovanni B. Frisoni, Iris E. C. Sommer, Dylan Smith, Rosa van Mourik, Michel D. Ferrari, Christian Zöllner, Maria-Clemancia Hernandez, Nick Seneca, James Miller, Martijn Arns, Timothy K. Murphy, Giancarlo Logroscino, Annika Lüttjohann, Noreen Rahmani, Christopher Timmermann, Martien J H Kas, Grace Y. Wang, Klaus Linkenkaer-Hansen, F. Nobili, Tieme W. P. Janssen, R. Biermans, Fernando H. Lopes da Silva, Bernd Saletu, Brian A. Coffman, Ileana L. Hanganu-Opatz, Sian Lennon-Chrimes, Madelon A. Vollebregt, D. Moechars, Brittany Duncan, Joerg F. Hipp, Y. Roche, Valentina Cardinali, Neveen A. Noor, Christoph Wandel, S. Romero, Anna Bravermanová, J. Koprivova, Gerda M. Saletu-Zyhlarz, Nicola Walter Falasca, Marco Onofrj, Jaap Oosterlaan, J. L. Kenemans, J. Prasko, Jürgen Gallinat, C. Roucard, Vaclava Piorecka, Karsten Wicke, Jennifer C. Swart, Peterjan Ris, Heba S. Aboul Ezz, M Valle, Jesper F. Bastlund, Ivo Heitland, Paul B. Fitzgerald, Katleen Geladé, W. H. Drinkenburg, Lillian E. Fisher, Lars Eichler, J. Riba, Hélène Brisebois, Régis Bordet, Robert Leech, Roberta Lizio, Cornelis J. Stam, M. Avinash, N. K. Manjunath, Parissa Azadi, Raffaele Ferri, Cyril Höschl, Susanna Cordone, Sander Nieuwenhuis, Gregor Leicht, Alexandra J. Roark, Esben Bolvig Mark, Jakub Polak, Alexander T. Sack, Iris Eichler, Heidi Haavik, Athanasios Maras, Dirk J. Heslenfeld, Hans-Peter Landolt, A. Bottelbergs, Galina Surova, Ross Apparies, Lin Tiffany, Angelisa Frasca, Ida A. Nissen, Dario Arnaldi, Alessandro Bertolino, Wilhelmus Drinkenburg, Philip Scheltens, Cristina Bagnoli, Matthijs J.L. Perenboom, Dane M. Chetkovich, Thomas Budde, Annette Beatrix Brühl, Wilfried Dimpfel, Yuan Yang, Jonathan Kelley, Hervé Caci, Christoph Herrmann, Olivier Blin, Robert P. Turner, Georg Dorffner, Michaela Viktorinova, Igor Timofeev, Stephanie Thiebes, Dina Lelic, K. Van Kolen, P. F. Fabene, Frédéric Knoflach, S. Jacob, John Wallerius, Claudio Del Percio, Marina Bentivoglio, Mendel Kaelen, Peter Anderer, Imran Khan Niazi, Iman M. Mourad, S. Barker, Muhammad Samran Navid, Giuseppe Noce, Dean F. Salisbury, Huibert D. Mansvelder, Premysl Vlcek, Marek Adamczyk, Emmanouil Spanakis, Vitoantonio Bevilacqua, Orietta Barulli, Roy P. C. Kessels, Axel Steiger, Darren Bentley, Antonio Brunetti, Clementina M. van Rijn, Nikita van der Vinne, Evian Gordon, Nash Boutros, Lukáš Kadeřábek, Brendan Parsons, A. Ahnaou, Tilman Hensch, Christian Sander, Torsten Meyer, Barbora Cimrová, Marleen C. Tjepkema-Cloostermans, Molly Hyde, Robert Oostenveld, Liesbeth Heijink, Eléonore Czarik, Paolo F. Fabene, Jean-Paul Laurent, Stig Hollup, Leon Kenemans, Ana Buján, Vadim Ilivitsky, Danielle Impey, Alfred C. Schouten, Claudio Babiloni, M. Pawlowski, Ricardo Alvarez-Jimenez, Joop M. A. van Gerven, Filip Tylš, Jan van Egmond, Saskia Steinmann, Caroline Dupont, B. Mandé-Nidergang, Sebastian Olbrich, Geert Jan Groeneveld, H. Huysmans, Kastytis Dapsys, P. Sos, M. Raszka, C. Walsh, Justin Piché, Giovanni Frisoni, Silvia Parapatics, Annika Lütjohann, Simon-Shlomo Poil, Erin K. MacInerney, T. Nekovarova, Jana Nöldeke, Michel J.A.M. van Putten, Ilse E. C. W. van Straaten, Suresh D. Muthukumaraswamy, Mehrnoush Zobeiri, Magda Tsolaki, Ulrich Hegerl, Jaap C. Reijneveld, Patrizia Voehringer, N. V. Manyakov, Sandra K. Loo, Patrick Meuth, Bettina Clausen, Roman Rosipal, David Bartrés Faz, Nenad Polomac, Renata Androvicova, Pantaleo Spagnolo, Pilar Garcés, Andrea Soricelli, Amanda Feilding, R. Maury, Aleksandras Voicikas, Stjepan Curic, Verner Knott, Tabitha A. Iseger, Jiri Horacek, Susanna Lopez, Joelle Choueiry, Gianluigi Forloni, Andrew WThomas, Lyudmila V. Vinogradova, Alida A. Gouw, Sarah M. Haigh, and B. Pouyatos

Subjects
medicine.medical_specialty, 05 social sciences, Clinical Neurology, Neuropsychology, 050105 experimental psychology, 03 medical and health sciences, Psychiatry and Mental health, 0302 clinical medicine, Physiology (medical), Family medicine, medicine, 0501 psychology and cognitive sciences, Psychology, 030217 neurology & neurosurgery
Published
2016
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5. LC–MS analysis of low molecular weight organic acids derived from root exudation

Author

Stephan Hann, Eva Oburger, Daniela Huber, Bernhard Mueller, Markus Puschenreiter, Leonhard Jaitz, and Gunda Koellensperger

Subjects
Spectrometry, Mass, Electrospray Ionization, Fumaric acid, Chromatography, Molecular Structure, Oxalic Acid, Brassica napus, Oxalic acid, Malates, Hydrochloric acid, Malonic acid, Plant Roots, Biochemistry, Citric Acid, Analytical Chemistry, Molecular Weight, chemistry.chemical_compound, chemistry, Tandem Mass Spectrometry, Succinic acid, Aconitic acid, Malic acid, Citric acid, Chromatography, High Pressure Liquid
Abstract

A sensitive method for quantification of citric, fumaric, malic, malonic, oxalic, trans aconitic, and succinic acid in soil- and root-related samples is presented. The method is based on a novel, fast, and simple esterification procedure and subsequent analysis via liquid chromatography-mass spectrometry. Derivatization comprises in situ generation of HCl, which catalyzes the Fischer esterification with benzyl alcohol. As a key advance, the esterification with the aromate allows reversed-phase separation and improves electrospray ionization efficiency. The method provided procedural detection limits of 1 nM for citric, 47 nM for fumaric, 10 nM for malic, 10 nM for malonic, 16 nM for oxalic, 15 nM for succinic, and 2 nM for aconitic acid utilizing 500 μL of liquid sample. The working range was 3 nM to 10 μM for citric acid, 158 nM to 10 μM for fumaric acid, 34 nM to 10 μM for malic acid, 33 nM to 10 μM for malonic acid, 53 nM to 10 μM for oxalic acid, 48 nM to 10 μM for succinic acid, and 6 nM to 10 μM for aconitic acid. Quantification of the analytes in soil-related samples was performed via external calibration of the entire procedure utilizing (13)C-labeled oxalic and citric acid as internal standards. The robustness of the method was tested with soil extracts and samples from hydroponic experiments. The latter concerned the regulation of phosphorus solubilization via plant root exudation of citric, malic, and oxalic acid.

Published
2010
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6. Synthesis of Carbo- and Heterocyclic Aldehydes Bearing an Adjacent Donor Group ? Ozonolysis versus OsO4/KIO4-Oxidation

Author

Marko D. Mihovilovic, Peter Stanetty, Markus Spina, and Bernhard Mueller

Subjects
chemistry.chemical_classification, Olefin fiber, Bearing (mechanical), Ozonolysis, Alcohol, General Medicine, General Chemistry, Methylation, Medicinal chemistry, Aldehyde, law.invention, Potassium periodate, chemistry.chemical_compound, Donor group, Osmium tetroxide, chemistry, law, Organic chemistry
Abstract

The synthesis of carbo- and heterocyclic aldehydes bearing an ipso-methoxy group is investigated. The synthetic sequence is based on an initial Grignard addition of an olefin to a cyclic ketone followed by methylation of the resulting tertiary alcohol. The terminal olefin serves as precursor for the aldehyde functionality. Oxidation by ozonolysis turned out to depend significantly on the distance of the donor methoxy group. The observed side reactions could be circumvented by applying a one-pot OsO4 mediated diol formation followed by Malaprade oxidation using KIO4. A series of carbo- and heterocyclic precursors were successfully converted to the title products.

Published
2004
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