1. Genome-wide association scan identifies a colorectal cancer susceptibility locus on chromosome 8q24
- Author
-
Elio Riboli, Michelle Cotterchio, Emmanuel Tubacher, Mary Porteous, Sylviane Olschwang, Brent W. Zanke, Hélène Blanché, Stephen J. Chanock, Frederick Robidoux, Stéphane Bézieau, John D. Potter, Polly A. Newcomb, Vincent Ferretti, Albert Tenesa, Steven Gallinger, James G. D. Prendergast, George Zogopoulos, Philippe Laflamme, Sébastien Küry, Bruno Buecher, Harry Campbell, Ban Younghusband, Stéphanie Roumy, John R. McLaughlin, Peter T. Campbell, Mourad Sahbatou, Alexandre Montpetit, Anne Marie O'Shea, Malcolm G. Dunlop, Jagadish Rangrej, Jean François Olivier, Rafal Kustra, Celia M. T. Greenwood, Saravanan Sundararajan, Theodore Chiang, Thomas J. Hudson, Robert Sladek, Susan M. Farrington, Roger C. Green, Catherine Bonaïti-Pellié, Gilles Thomas, Edgar Crowdy, and Jane Green
- Subjects
Genetics ,Linkage disequilibrium ,Chromosome Mapping ,Locus (genetics) ,Single-nucleotide polymorphism ,Odds ratio ,Middle Aged ,Biology ,Polymorphism, Single Nucleotide ,Linkage Disequilibrium ,Gene mapping ,Polymorphism (computer science) ,Case-Control Studies ,Chromosomal region ,Humans ,Genetic Predisposition to Disease ,Colorectal Neoplasms ,Chromosomes, Human, Pair 8 ,Genetic association - Abstract
Using a multistage genetic association approach comprising 7,480 affected individuals and 7,779 controls, we identified markers in chromosomal region 8q24 associated with colorectal cancer. In stage 1, we genotyped 99,632 SNPs in 1,257 affected individuals and 1,336 controls from Ontario. In stages 2-4, we performed serial replication studies using 4,024 affected individuals and 4,042 controls from Seattle, Newfoundland and Scotland. We identified one locus on chromosome 8q24 and another on 9p24 having combined odds ratios (OR) for stages 1-4 of 1.18 (trend; P = 1.41 x 10(-8)) and 1.14 (trend; P = 1.32 x 10(-5)), respectively. Additional analyses in 2,199 affected individuals and 2,401 controls from France and Europe supported the association at the 8q24 locus (OR = 1.16, trend; 95% confidence interval (c.i.): 1.07-1.26; P = 5.05 x 10(-4)). A summary across all seven studies at the 8q24 locus was highly significant (OR = 1.17, c.i.: 1.12-1.23; P = 3.16 x 10(-11)). This locus has also been implicated in prostate cancer.
- Published
- 2007