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1. Very-low-calorie ketogenic diet vs hypocaloric balanced diet in the prevention of high-frequency episodic migraine: the EMIKETO randomized, controlled trial

Author

Caprio, Massimiliano, primary, Moriconi, Eleonora, additional, Camajani, Elisabetta, additional, Feraco, Alessandra, additional, Marzolla, Vincenzo, additional, Vitiello, Laura, additional, Proietti, Stefania, additional, Armani, Andrea, additional, Gorini, Stefania, additional, Mammi, Caterina, additional, Egeo, Gabriella, additional, Aurilia, Cinzia, additional, Fiorentini, Giulia, additional, Tomino, Carlo, additional, and Barbanti, Piero, additional

Published
2023
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4. Comparing the relative and absolute effect of erenumab: is a 50% response enough? Results from the ESTEEMen study

Author

Ornello, Raffaele, primary, Baraldi, Carlo, additional, Guerzoni, Simona, additional, Lambru, Giorgio, additional, Andreou, Anna P., additional, Raffaelli, Bianca, additional, Gendolla, Astrid, additional, Barbanti, Piero, additional, Aurilia, Cinzia, additional, Egeo, Gabriella, additional, Cevoli, Sabina, additional, Favoni, Valentina, additional, Vernieri, Fabrizio, additional, Altamura, Claudia, additional, Russo, Antonio, additional, Silvestro, Marcello, additional, Valle, Elisabetta Dalla, additional, Mancioli, Andrea, additional, Ranieri, Angelo, additional, Alfieri, Gennaro, additional, Latysheva, Nina, additional, Filatova, Elena, additional, Talbot, Jamie, additional, Cheng, Shuli, additional, Holle, Dagny, additional, Scheffler, Armin, additional, Nežádal, Tomáš, additional, Čtrnáctá, Dana, additional, Šípková, Jitka, additional, Matoušová, Zuzana, additional, Casalena, Alfonsina, additional, Maddestra, Maurizio, additional, Viola, Stefano, additional, Affaitati, Giannapia, additional, Giamberardino, Maria Adele, additional, Pistoia, Francesca, additional, Reuter, Uwe, additional, and Sacco, Simona, additional

Published
2022
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5. Dopamine-beta-hydroxylase 19-bp insertion/deletion polymorphism affects medication overuse in patients with chronic migraine

Author

David Della-Morte, Maria Laura De Marchis, Cristiano Ialongo, Cinzia Aurilia, Piero Barbanti, Patrizia Ferroni, Domenica Lovero, Gabriella Egeo, Luisa Fofi, Raffaele Palmirotta, and Fiorella Guadagni

Subjects
Adult, Male, medicine.medical_specialty, 19-bp insertion/deletion polymorphism, Genotype, Migraine Disorders, Population, Settore MED/09, Dopamine beta-Hydroxylase, Dermatology, 03 medical and health sciences, 0302 clinical medicine, Chronic Migraine, Genetic, INDEL Mutation, Internal medicine, medicine, Dopamine-beta-hydroxylase, Medication overuse, Migraine, Chronic Disease, Female, Genetic Predisposition to Disease, Humans, Middle Aged, Prescription Drug Overuse, 030212 general & internal medicine, Allele, education, Genotyping, Genetic association, education.field_of_study, business.industry, General Medicine, medicine.disease, Psychiatry and Mental health, Endophenotype, Neurology (clinical), business, 030217 neurology & neurosurgery
Abstract

Dopamine-beta-hydroxylase (DBH) enzyme activity is modulated at the genetic level by the presence of several polymorphisms. Among these, the 19-bp insertion/deletion (I/D) polymorphism (rs72393728/rs141116007) was investigated in several genetic association studies for its correlation with the susceptibility to develop episodic migraine, but conflicting results were achieved. In the present study we analyzed this genetic variant in a carefully characterized population of migraineurs encompassing both episodic and chronic migraine (with and without medication overuse) with the aim to perform a replication study and verify any possible correlation with migraine endophenotypes. Genotyping of the DBH 19-bp I/D polymorphism was performed on 400 migraine patients and 204 healthy individuals. The associations between genotypic frequencies and the clinical and sociodemographic features of migraineurs were then investigated. The DBH 19-bp I/D polymorphism did not correlate with migraine susceptibility or most clinical variables, with the exception of a statistically significant correlation within the subgroup of patients affected by chronic migraine were the individuals carrying the deleted (D) allele were significantly more prone to abuse in analgesics. As a result of this finding, the DBH 19-bp I/D polymorphism does not influence migraine susceptibility, but it might contribute to the development of medication overuse in patient with chronic migraine.

Published
2019
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6. Effects of early respiratory physiotherapy on spontaneous respiratory activity of preterm infants: study protocol for a randomized controlled trial

Author

Di Polito, Alessia, primary, Del Vecchio, Arianna, additional, Tana, Milena, additional, Papacci, Patrizia, additional, Vento, Anna Laura, additional, Campagnola, Benedetta, additional, Celona, Sefora, additional, Cricenti, Laura, additional, Bastoni, Ilaria, additional, Tirone, Chiara, additional, Lio, Alessandra, additional, Aurilia, Claudia, additional, Bottoni, Anthea, additional, Paladini, Angela, additional, Cota, Francesco, additional, Ferrara, Paola Emilia, additional, Ronconi, Gianpaolo, additional, and Vento, Giovanni, additional

Published
2021
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8. Locking down the CGRP pathway during the COVID-19 pandemic lockdown: the PandeMig study

Author

Altamura, Claudia, primary, Cevoli, Sabina, additional, Aurilia, Cinzia, additional, Egeo, Gabriella, additional, Fofi, Luisa, additional, Torelli, Paola, additional, Brunelli, Nicoletta, additional, Pierangeli, Giulia, additional, Favoni, Valentina, additional, Fallacara, Adriana, additional, Pensato, Umberto, additional, Barbanti, Piero, additional, and Vernieri, Fabrizio, additional

Published
2020
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9. Migraineurs’ psychological traits do not influence response to erenumab

Author

Altamura, Claudia, primary, Costa, Carmelinda, additional, Fofi, Luisa, additional, Viticchi, Giovanna, additional, Fallacara, Adriana, additional, Brunelli, Nicoletta, additional, Egeo, Gabriella, additional, Aurilia, Cinzia, additional, Migliore, Simone, additional, Barbanti, Piero, additional, Silvestrini, Mauro, additional, and Vernieri, Fabrizio, additional

Published
2020
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10. Effectiveness, safety, and tolerability of galcanezumab in a real-life setting in patients with migraine in Italy (the GARLIT study)

Author

Vernieri, Fabrizio, primary, Altamura, Claudia, additional, Aurilia, Cinzia, additional, Brunelli, Nicoletta, additional, Egeo, Gabriella, additional, Fofi, Luisa, additional, Costa, Carmelina Maria, additional, Fallacara, Adriana, additional, Favoni, Valentina, additional, Pierangeli, Giulia, additional, Aguggia, Marco, additional, Bertuzzo, Davide, additional, Albanese, Maria, additional, Di Fiore, Paola, additional, Frediani, Fabio, additional, Cevoli, Sabina, additional, and Barbanti, Piero, additional

Published
2020
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11. Erenumab during pregnancy: a case report in a patient with chronic migraine

Author

Piero Barbanti, Gabriella Egeo, Cinzia Aurilia, and Luisa Fofi

Subjects
medicine.medical_specialty, Pregnancy, Pediatrics, Neurology, business.industry, MEDLINE, Dermatology, General Medicine, medicine.disease, Psychiatry and Mental health, Chronic Migraine, medicine, Neurology (clinical), Neurosurgery, business, Neuroradiology
Abstract

Background: Migraine is very common in women of childbearing age. Erenumab is a first-in-class anti-CGRP monoclonal antibody with a a favorable efficacy/tolerability profile. However, there are very limited data on its effects during pregnancy.Case presentation: We report a case of a 37-years-old woman affected by chronic migraine who became pregnant during erenumab treatment. At the time of her first visit at our Unit she was on prophylaxis with sodium valproate 600 mg/day reporting low efficacy (18 headache days/month) and tolerability (weight gain). She had already failed 5 prior preventative treatments. On the same day started erenumab 70 mg, tapering down valproate. Erenumab was rapidly effective, reducing migraine frequency (7 days/month) since the first administration. On the follow-up visit scheduled for the fifth erenumab administration, the patient informed us of her pregnancy, documented by appropriate serological test the day before. Erenumab was immediately stopped. The last erenumab administration was made on 04/07/2019, probably corresponding to the first two weeks of pregnancy. Serological fetal DNA test was normal. During the I pregnancy trimester the frequency of migraine increased up to 10 days/month, markedly improving and progressively disappearing during the II-III trimesters. Migraine attacks started again from the 34th week of pregnancy throughout delivery and breast feeding. No other adverse event or complication occurred during pregnancy. The baby, born by vaginal birth in healthy conditions, developed breastfeeding jaundice which progressively normalized over time.Conclusions: We document no complications, abnormalities, or adverse events in both the mother and the child, and a physiological normal course of pregnancy, delivery and breastfeeding in the first report of erenumab exposure during pregnancy in a migraine patient. More data from clinical studies and post-marketing surveillance are necessary to confirm our findings.

Published
2020
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12. Dopamine-beta-hydroxylase 19-bp insertion/deletion polymorphism affects medication overuse in patients with chronic migraine

Author

Barbanti, Piero, primary, Guadagni, Fiorella, additional, De Marchis, Maria Laura, additional, Ialongo, Cristiano, additional, Egeo, Gabriella, additional, Fofi, Luisa, additional, Aurilia, Cinzia, additional, Lovero, Domenica, additional, Della-Morte, David, additional, Ferroni, Patrizia, additional, and Palmirotta, Raffaele, additional

Published
2019
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15. Rationale for use of onabotulinum toxin A (BOTOX) in chronic migraine

Author

Gabriella Egeo, Cinzia Aurilia, Luisa Fofi, S. Piroso, and Piero Barbanti

Subjects
Drug, medicine.medical_specialty, Neurology, Migraine Disorders, media_common.quotation_subject, Acetylcholine Release Inhibitors, Dermatology, Pharmacology, chemistry.chemical_compound, Chronic Migraine, Humans, Medicine, Botulinum Toxins, Type A, Neurotransmitter, Receptor, media_common, Opioidergic, business.industry, General Medicine, medicine.disease, Psychiatry and Mental health, Nociception, chemistry, Migraine, Chronic Disease, Neurology (clinical), business
Abstract

Chronic migraine is a severely disabling headache evolving from episodic migraine as a result of different transforming factors and characterized by atypical pain modulation and peripheral and central sensitization. Discovered by serendipity, onabotulinum toxin A (BoNT-A) represents the only drug specifically approved for CM prophylaxis. According to the dominant opinion, BoNT-A acts peripherally, impairing the exocytosis of neuropeptide and neurotransmitter and the delivery of receptors and ion channels on the cell surface of peripheral trigeminal endings, thereby indirectly reducing central sensitization. However, it is not excluded that BoNT-A has also a central antinociceptive action, probably associated with an enhanced opioidergic and GABA-ergic transmission. This review discusses the rationale for use of BoNT-A in CM including its mechanisms of action and molecular targets and provides suggestions for a more tailored BoNT-A prophylaxis in patients with CM.

Published
2015
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16. Treatment of tension-type headache: from old myths to modern concepts

Author

Gabriella Egeo, Cinzia Aurilia, Piero Barbanti, and Luisa Fofi

Subjects
medicine.medical_specialty, Neurology, business.industry, Tension-Type Headache, Dermatology, General Medicine, Placebo, Psychiatry and Mental health, Human disease, Tolerability, Physical therapy, Humans, Pain Management, Medicine, Neurology (clinical), Neurosurgery, business, Intensive care medicine
Abstract

Tension-type headache (TTH) is the second most common human disease, accounting for intense disability, high costs and numerous workdays lost. Tension-type headache is less simple and easy-to-treat than commonly thought. Antidepressants, despite their poor tolerability, are still the first-choice drugs for preventing TTH. The most widely studied non-pharmacological approach to TTH, cognitive-behavioral techniques, effectively relieve pain only in selected patients. The most frequently used and recommended treatments for acute TTH, NSAIDs and paracetamol have scarce efficacy as documented by their low therapeutic gain over placebo in the 2-h pain-free response. Their effectiveness may be increased by a more proper use and by the adjunction of caffeine, antiemetics, myorelaxants or tranquillizers but the risk of medication-overuse headache must be considered. Hence, the need for more effective and tailored treatments in TTH remains.

Published
2014
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17. A modified physiologic test for bronchopulmonary dysplasia: a clinical tool for weaning from CPAP and/or oxygen-therapy the premature babies?

Author

Vento, Giovanni, primary, Vendettuoli, Valentina, additional, Aurilia, Claudia, additional, Tana, Milena, additional, Tirone, Chiara, additional, Lio, Alessandra, additional, Matassa, Piero Giuseppe, additional, Priolo, Francesca, additional, Catenazzi, Piero, additional, Corsello, Mirta, additional, Zecca, Enrico, additional, and Mosca, Fabio, additional

Published
2019
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18. Validation of a self-reported instrument to assess work-related difficulties in patients with migraine: the HEADWORK questionnaire

Author

Raggi, Alberto, primary, Covelli, Venusia, additional, Guastafierro, Erika, additional, Leonardi, Matilde, additional, Scaratti, Chiara, additional, Grazzi, Licia, additional, Bartolini, Marco, additional, Viticchi, Giovanna, additional, Cevoli, Sabina, additional, Pierangeli, Giulia, additional, Tedeschi, Gioacchino, additional, Russo, Antonio, additional, Barbanti, Piero, additional, Aurilia, Cinzia, additional, Lovati, Carlo, additional, Giani, Luca, additional, Frediani, Fabio, additional, Di Fiore, Paola, additional, Bono, Francesco, additional, Rapisarda, Laura, additional, and D’Amico, Domenico, additional

Published
2018
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19. The evaluation of difficulties with work-related activities caused by migraine: towards a specific questionnaire

Author

Covelli, Venusia, primary, Guastafierro, Erika, additional, Raggi, Alberto, additional, Grazzi, Licia, additional, Leonardi, Matilde, additional, Scaratti, Chiara, additional, Bartolini, Marco, additional, Viticchi, Giovanna, additional, Cevoli, Sabina, additional, Pierangeli, Giulia, additional, Tedeschi, Gioacchino, additional, Russo, Antonio, additional, Barbanti, Piero, additional, Aurilia, Cinzia, additional, Lovati, Carlo, additional, Giani, Luca, additional, Fredian, Fabio, additional, Di Fiore, Paola, additional, Bono, Francesco, additional, Rapisarda, Laura, additional, and D’Amico, Domenico, additional

Published
2018
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20. Dopaminergic symptoms in migraine

Author

Gabriella Egeo, Cinzia Aurilia, Luisa Fofi, and Piero Barbanti

Subjects
medicine.medical_specialty, Dopamine, Migraine Disorders, Dopaminergic, Dermatology, General Medicine, medicine.disease, Euphoriant, Psychiatry and Mental health, Endocrinology, Polyuria, Migraine, Dopamine receptor, Internal medicine, medicine, Vomiting, Animals, Humans, Neurology (clinical), medicine.symptom, Psychology, Somnolence, medicine.drug
Abstract

Migraine pain is often preceded, accompanied and followed by dopaminergic symptoms (premonitory yawning and somnolence, accompanying nausea and vomiting, postdromal somnolence, euphoria and polyuria). After reviewing evidence from pharmacological, biochemical, genetic and animal experimental studies on the relationship between dopamine and migraine, and matching these data with patients' clinical features, we postulate that migraine attacks could be characterized by an ictal dopamine release in a subject with dopamine receptor hypersensitivity due to a chronic dopaminergic deficit synergistic to serotoninergic impairment. Our review suggests that when the attack begins, a low dopamine plasma concentration stimulates hypersensitive central presynaptic dopamine receptors thus causing prodromal symptoms such as yawning and somnolence. Increasing dopamine levels, though still insufficient to stop trigeminovascular activation, stimulate postsynaptic dopamine receptors thus inducing nausea, vomiting and hypotension. Finally, dopamine levels slowly return to baseline, giving rise to somnolence and fatigue, but, in some cases, continue to rise triggering postdromal symptoms such as euphoria and polyuria.

Published
2013
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21. Establishment of a biorepository for migraine research: the experience of Interinstitutional Multidisciplinary BioBank (BioBIM)

Author

Maria Laura De Marchis, David Della-Morte, Patrizia Ferroni, Cinzia Aurilia, Gabriella Egeo, Raffaele Palmirotta, Antonella Spila, Luisa Fofi, Fiorella Guadagni, Giorgia Ludovici, and Piero Barbanti

Subjects
Adult, Male, medicine.medical_specialty, Pathology, Adolescent, Migraine Disorders, Operating procedures, Translational research, Dermatology, Specimen Handling, Young Adult, Multidisciplinary approach, medicine, Humans, Medical physics, Aged, Biological Specimen Banks, business.industry, General Medicine, Middle Aged, Biobank, Psychiatry and Mental health, Biorepository, Female, Neurology (clinical), business
Abstract

The development of Biobanks and recent advances in molecular biology have enhanced the possibility to accelerate translational research studies. The Interinstitutional Multidisciplinary BioBank (BioBIM) is organized in a large healthy donors collection and pathology-based biobanks with the aim to provide a service for development of interdisciplinary studies. A new pathology-based biobank has been organized to specifically collect biospecimen from patients affected by migraine, with the final goal to centralize data, collect blood, plasma, serum, DNA and RNA of patients with this disease. The BioBIM is fully equipped for the automation of sampling/processing, storage and tracking of biospecimens. Standard Operating Procedures have been developed for processing and storage phases as well as archive of clinical data. The availability of biospecimens and clinical data will constitute a resource for various research projects.

Published
2013
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22. Future trends in drugs for migraine prophylaxis

Author

Piero Barbanti, Luisa Fofi, Gabriella Egeo, and Cinzia Aurilia

Subjects
medicine.medical_specialty, Neurology, Aura, Migraine Disorders, Dermatology, Pharmacology, Tonabersat, Migraine prophylaxis, Humans, Medicine, Botulinum Toxins, Type A, Analgesics, Clinical Trials as Topic, business.industry, General Medicine, medicine.disease, Migraine with aura, Psychiatry and Mental health, Migraine, Cortical spreading depression, Neuronal Hyperexcitability, Anticonvulsants, Plant Preparations, Neurology (clinical), medicine.symptom, business, Forecasting
Abstract

Migraine prevention hinges on a variety of non-specific drugs that mainly reduce neuronal hyperexcitability, the putative pathophysiological hallmark for migraine. The improved knowledge about migraine circuitry and neurobiology has prompted research to develop new specific migraine preventive medications targeted to innovative sites and mechanisms. Drugs designed to inhibit cortical spreading depression, for example tonabersat, might offer a useful option for the management of migraine with aura but not for migraine without aura. Inducible nitric-oxide synthase (iNOS) inhibition seems ineffective as a prophylactic strategy. Results are awaited from recent and ongoing phase II trials with glutamate receptor antagonists, third-generation antiepileptics, melatonin agonists, vitamin D3 and statins.

Published
2012
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23. Rizatriptan in migraineurs with unilateral cranial autonomic symptoms: a double-blind trial

Author

Piero Barbanti, Cinzia Aurilia, Stefano Bonassi, Nicola Vanacore, Luisa Fofi, Gabriella Egeo, and Valentina Dall'Armi

Subjects
Adult, Male, medicine.medical_specialty, Time Factors, Neurology, Migraine Disorders, Clinical Neurology, Physical examination, Triptans, Cranial autonomic symptoms, Placebo, Functional Laterality, law.invention, Double-Blind Method, Randomized controlled trial, law, medicine, Humans, Clinical Trials, Physical Examination, Trigemino-autonomic reflex, Migraine, Pain Measurement, Chi-Square Distribution, medicine.diagnostic_test, business.industry, Rizatriptan, General Medicine, Middle Aged, Triazoles, medicine.disease, Tryptamines, Serotonin Receptor Agonists, Treatment, Treatment Outcome, Anesthesiology and Pain Medicine, Autonomic Nervous System Diseases, Anesthesia, Female, Neurology (clinical), business, Chi-squared distribution, medicine.drug
Abstract

The objective and background is to confirm in a double-blind, placebo-controlled study the high triptan response rates we had previously reported in an open study in migraine patients with unilateral cranial autonomic symptoms. In this randomized, double-blind, placebo-controlled study 80 migraineurs with unilateral cranial autonomic symptoms were assigned to receive rizatriptan 10 mg wafer or placebo (ratio 1:1) and treated for a single moderate or severe migraine attack. The primary endpoints were pain freedom at 2 h and total migraine freedom at 2 h. Secondary endpoints included pain relief, no associated symptoms and sustained pain freedom or relief. Significantly more patients reported pain freedom at 2 h after taking rizatriptan (54 %) than after placebo (8 %) (therapeutic gain 46 % [28 %; 64 %]; P

Published
2012
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28. Thermostable Proteins as Probe for the Design of Advanced Fluorescence Biosensors

Author

Sabato D'Auria, Maria Staiano, Antonietta Parracino, Mosè Rossi, Olesia V. Stepanenko, Marcella de Champdoré, and Vincenzo Aurilia

Subjects
chemistry.chemical_classification, Analyte, Environmental Engineering, Thermophile, Binding protein, Biology, Ligand (biochemistry), Pollution, Applied Microbiology and Biotechnology, Fluorescence, Quantitative determination, Enzyme, Biochemistry, chemistry, Waste Management and Disposal, Biosensor
Abstract

In this review we explore the advantages deriving from the use of either enzymes or sugar binding proteins isolated from thermophilic organisms to develop stable fluorescence biosensors. We report on a novel approach to address the consumption of the analyte by enzyme-based biosensors, namely the utilization of apo-enzymes as non-active forms of proteins which are still able to bind the ligand but cannot transform it into product. We also report recent studies in which the fluorescence labeling of a naturally thermostable binding protein allows a quantitative determination of glucose.

Published
2006
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29. Socio–economic costs of migraine

Author

Piero Barbanti, Valeria Rondelli, Rosanna Cerbo, Marina Pesare, and Cinzia Aurilia

Subjects
medicine.medical_specialty, education.field_of_study, Neurology, business.industry, Pain medicine, Population, Migraine and Disability, General Medicine, Disease, medicine.disease, Pharmacoeconomics, Indirect costs, Anesthesiology and Pain Medicine, Quality of life (healthcare), Migraine, medicine, Neurology (clinical), Psychiatry, business, education
Abstract

Migraine is one of the most common neurological diseases afflicting 12% of general population but is poorly recognized and largely untreated. Migraine is a disabling disease with very high social costs as it affects young individuals during their productive age. Quality of life in migraineurs is impaired. Furthermore, the economic burden of migraine, usually evaluated in terms of direct and indirect costs, is relevant and could be reduced by an early diagnosis and an appropriate treatment.

Published
2001
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30. Hypertension as a risk factor for migraine chronification

Author

Cinzia Aurilia, Gabriella Egeo, Piero Barbanti, and Luisa Fofi

Subjects
medicine.medical_specialty, Neurology, Migraine Disorders, Dermatology, Pharmacology, Cerebral circulation, Chronic Migraine, Risk Factors, Internal medicine, Humans, Medicine, Risk factor, Endothelial dysfunction, business.industry, Calcium channel, General Medicine, medicine.disease, Psychiatry and Mental health, Blood pressure, Migraine, Chronic Disease, Hypertension, Disease Progression, Cardiology, Neurology (clinical), business
Abstract

Progression of episodic migraine to chronic migraine may be related to comorbid medical conditions. In this study, we focused on the role played by arterial hypertension in migraine transformation. Several studies reveal that hypertension is associated with chronic migraine and may induce migraine chronification. Hypertension probably amplifies the effects of migraine on the vascular wall further enhancing the endothelial dysfunction in cerebral vasculature. Consequently, monitoring of blood pressure is recommended in migraineurs showing an otherwise unexplained increase in attack frequency. Studies are needed to verify if prophylactic treatment with drugs improving endothelial function (e.g. calcium channel blockers, beta blockers, calcium inhibitors, ACE inhibitors and sartans) may selectively ameliorate the course of migraine in these patients.

Published
2010
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31. Efficacy of a new technique – INtubate-RECruit-SURfactant-Extubate – “IN-REC-SUR-E” – in preterm neonates with respiratory distress syndrome: study protocol for a randomized controlled trial

Author

Vento, Giovanni, primary, Pastorino, Roberta, additional, Boni, Luca, additional, Cota, Francesco, additional, Carnielli, Virgilio, additional, Cools, Filip, additional, Dani, Carlo, additional, Mosca, Fabio, additional, Pillow, Jane, additional, Polglase, Graeme, additional, Tagliabue, Paolo, additional, van Kaam, Anton H., additional, Ventura, Maria Luisa, additional, Tana, Milena, additional, Tirone, Chiara, additional, Aurilia, Claudia, additional, Lio, Alessandra, additional, Ricci, Cinzia, additional, Gambacorta, Alessandro, additional, Consigli, Chiara, additional, D’Onofrio, Danila, additional, Gizzi, Camilla, additional, Massenzi, Luca, additional, Cardilli, Viviana, additional, Casati, Alessandra, additional, Bottino, Roberto, additional, Pontiggia, Federica, additional, Ciarmoli, Elena, additional, Martinelli, Stefano, additional, Ilardi, Laura, additional, Colnaghi, Mariarosa, additional, Matassa, Piero Giuseppe, additional, Vendettuoli, Valentina, additional, Villani, Paolo, additional, Fusco, Francesca, additional, Gazzolo, Diego, additional, Ricotti, Alberto, additional, Ferrero, Federica, additional, Stasi, Ilaria, additional, Magaldi, Rosario, additional, Maffei, Gianfranco, additional, Presta, Giuseppe, additional, Perniola, Roberto, additional, Messina, Francesco, additional, Montesano, Giovanna, additional, Poggi, Chiara, additional, Giordano, Lucio, additional, Roma, Enza, additional, Grassia, Carolina, additional, Ausanio, Gaetano, additional, Sandri, Fabrizio, additional, Mescoli, Giovanna, additional, Giura, Francesco, additional, Garani, Giampaolo, additional, Solinas, Agostina, additional, Lucente, Maria, additional, Nigro, Gabriella, additional, Del Vecchio, Antonello, additional, Petrillo, Flavia, additional, Orfeo, Luigi, additional, Grappone, Lidia, additional, Quartulli, Lorenzo, additional, Scorrano, Antonio, additional, Messner, Hubert, additional, Staffler, Alex, additional, Gargano, Giancarlo, additional, Balestri, Eleonora, additional, Nobile, Stefano, additional, Cacace, Caterina, additional, Meli, Valerio, additional, Dallaglio, Sara, additional, Pasqua, Betta, additional, Mattia, Loretta, additional, Gitto, Eloisa, additional, Vitaliti, Marcello, additional, Re, Maria Paola, additional, Vedovato, Stefania, additional, Grison, Alessandra, additional, Berardi, Alberto, additional, Torcetta, Francesco, additional, Guidotti, Isotta, additional, di Fabio, Sandra, additional, Maranella, Eugenia, additional, Mondello, Isabella, additional, Visentin, Stefano, additional, and Tormena, Francesca, additional

Published
2016
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32. Donepezil in the treatment of hallucinations and delusions in Parkinson’s disease

Author

Giovanni Fabbrini, Cinzia Aurilia, Caterina Pauletti, Piero Barbanti, Giuseppe Meco, and Gian Luigi Lenzi

Subjects
Male, Sleep Wake Disorders, medicine.medical_specialty, Neurology, Parkinson's disease, Hallucinations, Movement, Dermatology, Bedtime, Delusions, Piperidines, Internal medicine, medicine, Humans, Donepezil, Sexual Dysfunctions, Psychological, Psychiatry, Aged, Cholinesterase, Aged, 80 and over, biology, Parkinson Disease, General Medicine, medicine.disease, Clinical trial, Psychiatry and Mental health, Treatment Outcome, Cholinergic Fibers, Tolerability, Basal Nucleus of Meynert, Indans, biology.protein, Female, Cholinesterase Inhibitors, Neurology (clinical), Neurosurgery, Psychology, medicine.drug
Abstract

As cholinergic mechanisms may be at least partially responsible for hallucinations and delusions in Parkinson's disease (PD), we conducted an open study in 8 PD patients to assess the efficacy and tolerability of the cholinesterase inhibitor donepezil, 5 mg at bedtime for two months, in the treatment of these complications. Hallucinations and delusions improved significantly in all patients. Donezepil was overall well tolerated, but a deterioration in motor disability was noted in 2 out of 8 patients.

Published
2002
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33. A proposal for a national registry on chronic migraines

Author

Vanacore, Nicola, primary, Cevoli, Sabina, additional, Torelli, Paola, additional, Aurilia, Cinzia, additional, Egeo, Gabriella, additional, Fofi, Luisa, additional, Grazzi, Licia, additional, Bussone, Gennaro, additional, Manzoni, Gian Camillo, additional, Cortelli, Pietro, additional, and Barbanti, Piero, additional

Published
2015
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34. O039. Case-control genetic association studies in migraine: a 7-year experience at the Interinstitutional Multidisciplinary Biobank (BioBIM) of IRCCS San Raffaele Pisana

Author

Barbanti, Piero, primary, Palmirotta, Raffaele, additional, De Marchis, Maria Laura, additional, Ialongo, Cristiano, additional, Egeo, Gabriella, additional, Aurilia, Cinzia, additional, Fofi, Luisa, additional, Piroso, Serena, additional, Fratangeli, Federica, additional, Valente, Maria Giovanna, additional, and Guadagni, Fiorella, additional

Published
2015
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38. Look beyond Catechol-O-Methyltransferase genotype for cathecolamines derangement in migraine: the BioBIM rs4818 and rs4680 polymorphisms study

Author

De Marchis, Maria Laura, primary, Barbanti, Piero, additional, Palmirotta, Raffaele, additional, Egeo, Gabriella, additional, Aurilia, Cinzia, additional, Fofi, Luisa, additional, Piroso, Serena, additional, Ialongo, Cristiano, additional, Della-Morte, David, additional, D’Andrea, Giovanni, additional, Ferroni, Patrizia, additional, and Guadagni, Fiorella, additional

Published
2015
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42. Association of high levels of α-defensins and S100A proteins with Candida mannan detection in bronchoalveolar lavage fluid of preterm neonates

Author

Vento, Giovanni, primary, Lio, Alessandra, additional, Tirone, Chiara, additional, Aurilia, Claudia, additional, Tana, Milena, additional, Piras, Andrea, additional, Ricci, Cinzia, additional, Perelli, Sarah, additional, Romagnoli, Costantino, additional, Posteraro, Brunella, additional, Iavarone, Federica, additional, Cabras, Tiziana, additional, Fanali, Chiara, additional, Messana, Irene, additional, and Castagnola, Massimo, additional

Published
2013
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43. Establishment of a biorepository for migraine research: the experience of Interinstitutional Multidisciplinary BioBank (BioBIM)

Author

Palmirotta, Raffaele, primary, Barbanti, Piero, additional, Ludovici, Giorgia, additional, Egeo, Gabriella, additional, Aurilia, Cinzia, additional, Fofi, Luisa, additional, De Marchis, Maria Laura, additional, Spila, Antonella, additional, Ferroni, Patrizia, additional, Della-Morte, David, additional, and Guadagni, Fiorella, additional

Published
2013
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47. Correlation of Levels of α–Defensins Determined by HPLC-ESI-MS in Bronchoalveolar Lavage Fluid With the Diagnosis of Pneumonia in Premature Neonates

Author

Tirone, Chiara, primary, Boccacci, Simona, additional, Inzitari, Rosanna, additional, Tana, Milena, additional, Aurilia, Claudia, additional, Fanali, Chiara, additional, Cabras, Tiziana, additional, Messana, Irene, additional, Castagnola, Massimo, additional, Romagnoli, Costantino, additional, and Vento, Giovanni, additional

Published
2010
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49. Enzymes and proteins from extremophiles as hyperstable probes in nanotechnology: the use of D-trehalose/D-maltose-binding protein from the hyperthermophilic archaeon Thermococcus litoralis for sugars monitoring

Author

De Stefano, Luca, primary, Vitale, Annalisa, additional, Rea, Ilaria, additional, Staiano, Maria, additional, Rotiroti, Lucia, additional, Labella, Tullio, additional, Rendina, Ivo, additional, Aurilia, Vincenzo, additional, Rossi, Mose’, additional, and D’Auria, Sabato, additional

Published
2007
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