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9 results on '"Ashare, Alix"'

2. Lung function and microbiota diversity in cystic fibrosis

Author

Cuthbertson, Leah, primary, Walker, Alan W., additional, Oliver, Anna E., additional, Rogers, Geraint B., additional, Rivett, Damian W., additional, Hampton, Thomas H., additional, Ashare, Alix, additional, Elborn, J. Stuart, additional, De Soyza, Anthony, additional, Carroll, Mary P., additional, Hoffman, Lucas R., additional, Lanyon, Clare, additional, Moskowitz, Samuel M., additional, O’Toole, George A., additional, Parkhill, Julian, additional, Planet, Paul J., additional, Teneback, Charlotte C., additional, Tunney, Michael M., additional, Zuckerman, Jonathan B., additional, Bruce, Kenneth D., additional, and van der Gast, Christopher J., additional

Published
2020
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4. Genome-wide DNA methylation profiling shows a distinct epigenetic signature associated with lung macrophages in cystic fibrosis

Author

Chen, Youdinghuan, primary, Armstrong, David A., additional, Salas, Lucas A., additional, Hazlett, Haley F., additional, Nymon, Amanda B., additional, Dessaint, John A., additional, Aridgides, Daniel S., additional, Mellinger, Diane L., additional, Liu, Xiaoying, additional, Christensen, Brock C., additional, and Ashare, Alix, additional

Published
2018
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5. VISTA deficiency attenuates antibody-induced arthritis and alters macrophage gene expression in response to simulated immune complexes

Author

Ceeraz, Sabrina, primary, Eszterhas, Susan K., additional, Sergent, Petra A., additional, Armstrong, David A., additional, Ashare, Alix, additional, Broughton, Thomas, additional, Wang, Li, additional, Pechenick, Dov, additional, Burns, Christopher M., additional, Noelle, Randolph J., additional, Vincenti, Matthew P., additional, and Fava, Roy A., additional

Published
2017
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7. Characterization and quantification of the fungal microbiome in serial samples from individuals with cystic fibrosis

Author

Willger, Sven D, primary, Grim, Sharon L, additional, Dolben, Emily L, additional, Shipunova, Anna, additional, Hampton, Thomas H, additional, Morrison, Hilary G, additional, Filkins, Laura M, additional, O‘Toole, George A, additional, Moulton, Lisa A, additional, Ashare, Alix, additional, Sogin, Mitchell L, additional, and Hogan, Deborah A, additional

Published
2014
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9. Lung function and microbiota diversity in cystic fibrosis

Author

Cuthbertson, Leah, Walker, Alan W, Oliver, Anna E, Rogers, Geraint B, Rivett, Damian W, Hampton, Thomas H, Ashare, Alix, Elborn, J Stuart, De Soyza, Anthony, Carroll, Mary P, Hoffman, Lucas R, Lanyon, Clare, Moskowitz, Samuel M, O'Toole, George A, Parkhill, Julian, Planet, Paul J, Teneback, Charlotte C, Tunney, Michael M, Zuckerman, Jonathan B, Bruce, Kenneth D, and Van Der Gast, Christopher J

Subjects
Adult, Male, Cystic Fibrosis, Lung microbiome, Ecological patterns, Young Adult, Antibiotics, Microbial surveillance, Humans, Disease severity, Lung, Inflammation, Bacteria, Microbiota, Sputum, Sequence Analysis, DNA, respiratory system, Lung function, United States, respiratory tract diseases, 3. Good health, Anti-Bacterial Agents, Respiratory Function Tests, Europe, Biogeography, Disease Progression, Lung microbiota, Female
Abstract

BACKGROUND: Chronic infection and concomitant airway inflammation is the leading cause of morbidity and mortality for people living with cystic fibrosis (CF). Although chronic infection in CF is undeniably polymicrobial, involving a lung microbiota, infection surveillance and control approaches remain underpinned by classical aerobic culture-based microbiology. How to use microbiomics to direct clinical management of CF airway infections remains a crucial challenge. A pivotal step towards leveraging microbiome approaches in CF clinical care is to understand the ecology of the CF lung microbiome and identify ecological patterns of CF microbiota across a wide spectrum of lung disease. Assessing sputum samples from 299 patients attending 13 CF centres in Europe and the USA, we determined whether the emerging relationship of decreasing microbiota diversity with worsening lung function could be considered a generalised pattern of CF lung microbiota and explored its potential as an informative indicator of lung disease state in CF. RESULTS: We tested and found decreasing microbiota diversity with a reduction in lung function to be a significant ecological pattern. Moreover, the loss of diversity was accompanied by an increase in microbiota dominance. Subsequently, we stratified patients into lung disease categories of increasing disease severity to further investigate relationships between microbiota characteristics and lung function, and the factors contributing to microbiota variance. Core taxa group composition became highly conserved within the severe disease category, while the rarer satellite taxa underpinned the high variability observed in the microbiota diversity. Further, the lung microbiota of individual patient were increasingly dominated by recognised CF pathogens as lung function decreased. Conversely, other bacteria, especially obligate anaerobes, increasingly dominated in those with better lung function. Ordination analyses revealed lung function and antibiotics to be main explanators of compositional variance in the microbiota and the core and satellite taxa. Biogeography was found to influence acquisition of the rarer satellite taxa. CONCLUSIONS: Our findings demonstrate that microbiota diversity and dominance, as well as the identity of the dominant bacterial species, in combination with measures of lung function, can be used as informative indicators of disease state in CF. Video Abstract.

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