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Start Over Author "Aquino, D" Publisher springer science and business media llc
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10. Effects of losartan on hypertension and left ventricular mass: a long-term study

Author

Diana Iarussi, Domenico Galzerano, Giuseppe Limongelli, Aldo Iacono, M A Tedesco, G. Di Salvo, D Aquino, Gennaro Ratti, S. Mennella, Tedesco, Ma, Ratti, G, Aquino, D, Caccavale, A, Limongelli, Giuseppe, and DI SALVO, Giovanni

Subjects
Adult, Male, medicine.medical_specialty, Left ventricular ma, Diastole, Angiotensin II receptor antagonist, Essential hypertension, Losartan, Left ventricular mass, Hydrochlorothiazide, Double-Blind Method, Internal medicine, Internal Medicine, Humans, Medicine, Antihypertensive Agents, Aged, business.industry, Female, Hypertension, Hypertrophy, Left Ventricular, Middle Aged, Hypertrophy, medicine.disease, Left Ventricular, Surgery, Blood pressure, Tolerability, Blood chemistry, Cardiology, business, medicine.drug
Abstract

This study evaluated the anti-hypertensive efficacy, tolerability and effects on left ventricular mass of losartan, a selective angiotensin II receptor antagonist, after 22 months in patients with essential hypertension. The study included 77 hypertensive patients who were randomised at baseline to 22 months double-blind once-daily treatment with losartan 50 mg (L group n = 44 patients, mean age 54+/-9 years) or hydrochlorothiazide 25 mg (HCTZ group, n = 33 patients, mean age 56+/-7 years). Routine haematology, blood chemistry, standard electrocardiography, echocardiography and ambulatory non-invasive 24-h blood pressure (BP) monitoring were performed at baseline and after 10 and 22 months. The results showed good tolerability and a significant mean systolic and diastolic BP reduction in all groups (L group: 22 mm Hg and 11 mm Hg; HCTZ group: 11 mm Hg and 7 mm Hg, respectively for systolic and diastolic mean BP). Moreover, a remarkable reduction in left ventricular mass index was reached after 10 and 22 months only in the L group (L group: delta = -11 g/m2, P

Published
1998
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