1. Role of Neurotrophins in the Development and Function of Neural Circuits That Regulate Energy Homeostasis
- Author
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Amy L. Frick, Cheng Jiang, Wei-Jye Lin, Masato Sadahiro, Stephen R.J. Salton, Samira Fargali, Valeria Cogliani, Jelle Welagen, and Tricia Indall
- Subjects
Sympathetic Nervous System ,Corticotropin-Releasing Hormone ,Central nervous system ,Hypothalamus ,Artemin ,Receptors, Nerve Growth Factor ,Ciliary neurotrophic factor ,Article ,Energy homeostasis ,Eating ,Cellular and Molecular Neuroscience ,Neurotrophic factors ,Neural Pathways ,medicine ,Animals ,Homeostasis ,Humans ,Nerve Growth Factors ,Glucocorticoids ,biology ,Neuropeptides ,Neurogenesis ,General Medicine ,medicine.anatomical_structure ,Nerve growth factor ,nervous system ,Adipose Tissue ,Gene Expression Regulation ,Spinal Cord ,biology.protein ,Autonomic Fibers, Postganglionic ,Basal Metabolism ,Energy Metabolism ,Neuroscience ,Brain Stem ,Signal Transduction ,Neurotrophin - Abstract
Members of the neurotrophin family, including nerve growth factor (NGF), brain-derived neurotrophic factor (BDNF), neurotrophin-3 (NT-3), and neurotrophin-4/5 (NT-4/5), and other neurotrophic growth factors such as ciliary neurotrophic factor (CNTF) and artemin, regulate peripheral and central nervous system development and function. A subset of the neurotrophin-dependent pathways in the hypothalamus, brainstem, and spinal cord, and those that project via the sympathetic nervous system to peripheral metabolic tissues including brown and white adipose tissue (BAT and WAT), muscle and liver, regulate feeding, energy storage, and energy expenditure. We briefly review the role that neurotrophic growth factors play in energy balance, as regulators of neuronal survival and differentiation, neurogenesis, and circuit formation and function, and as inducers of critical gene products that control energy homeostasis.
- Published
- 2012