3 results on '"Amit K. Manjunath"'
Search Results
2. High rate of return-to-play following meniscal allograft transplantation
- Author
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Martin S Davey, Eric J. Strauss, M Shazil Jamal, Matthew T. Kingery, Eoghan T. Hurley, Michael J. Alaia, and Amit K. Manjunath
- Subjects
Adult ,Male ,medicine.medical_specialty ,medicine.medical_treatment ,MEDLINE ,Cochrane Library ,Menisci, Tibial ,Weight-Bearing ,Young Adult ,03 medical and health sciences ,0302 clinical medicine ,Informed consent ,medicine ,Humans ,Transplantation, Homologous ,Orthopedics and Sports Medicine ,Range of Motion, Articular ,030222 orthopedics ,Rehabilitation ,business.industry ,Recovery of Function ,030229 sport sciences ,Middle Aged ,Allografts ,Return to Sport ,Tibial Meniscus Injuries ,Systematic review ,Practice Guidelines as Topic ,Cohort ,Orthopedic surgery ,Physical therapy ,Female ,Surgery ,Range of motion ,business ,Sports - Abstract
In recent years, meniscal allograft transplantation (MAT) has been established as an effective option for young patients with symptomatic meniscus insufficiency with goals of functional improvement and joint preservation. Currently, there is little available information on return-to-play among patients in this cohort. The purpose of this study is to systematically review the literature and to evaluate the reported rehabilitation protocols, return-to-play guidelines, and subsequent rates of return-to-play following MAT. MEDLINE, EMBASE and the Cochrane Library were searched according to the Preferred Reporting Items for Systematic Reviews and Meta-Analyses guidelines to find studies on MAT. Studies were included if they reported return-to-play data or rehabilitation protocols. The rate and timing of return-to-play was assessed. The rehabilitation protocols were recorded, including time to start range of motion (ROM), full ROM, partial weight bearing (WB), and full WB. Overall, 67 studies met the inclusion criteria. Eleven studies, including 624 patients, reported 483 out of 624 patients (77.4%) returning to play, with 326 out of a reported 475 patients (68.6%) returning to the same/higher level, at a mean time to return of 9.0 months. There was significant variability in the reported rehabilitation protocols, but the most commonly reported time to begin ROM exercises was within the first week by 42 out of 60 studies (70.0%) and full ROM at 8 weeks by 18 out of 46 studies (39.1%). Partial weight bearing was most commonly begun in the fourth week by 20 out of 46 studies (43.5%), and for full WB the sixth week by 43 out of 65 studies (66.1%). Time elapsed following surgery was the most commonly reported criteria for return-to-play by 44 out of 48 studies (91.6%), with 6 months being the most common time point utilized by 17 out of 45 studies (37.8%). A small proportion of studies, 16 out of 48 (33.3%), advised against returning to competitive/collision sports altogether following MAT. In conclusion, there is a high rate of return-to-play following MAT, with the majority of patients returning to the same level of play. However, there is significant variability in reported rehabilitation protocols, and poor-quality reporting in return-to-play criteria in the literature indicates a need for further study and the development of an evidence-based consensus statement for this patient population. The results from this study can be used to better inform patients on their expected outcomes and provide a more informed consent process. IV.
- Published
- 2020
3. Bone Marrow Mesenchymal Stem Cell Therapy and Related Bone Marrow-Derived Orthobiologic Therapeutics
- Author
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Utkarsh Anil, Matthew T. Kingery, Eric J. Strauss, and Amit K. Manjunath
- Subjects
030222 orthopedics ,business.industry ,medicine.medical_treatment ,Mesenchymal stem cell ,Stem Cells in Orthopaedic Surgery (J Dragoo and K Jones, Section Editors) ,030229 sport sciences ,Osteoarthritis ,Stem-cell therapy ,medicine.disease ,Bioinformatics ,Regenerative medicine ,Clinical trial ,03 medical and health sciences ,0302 clinical medicine ,medicine.anatomical_structure ,Musculoskeletal injury ,medicine ,Orthopedics and Sports Medicine ,Bone marrow ,Stem cell ,business - Abstract
PURPOSE OF REVIEW: The purpose of the current article is to review the available literature related to bone marrow-derived mesenchymal stem cell therapy in the management of musculoskeletal pathologies and demonstrate the critical need for additional well-designed clinical studies. RECENT FINDINGS: In recent years, there has been a rapid increase in interest regarding the use of bone marrow-derived mesenchymal stem cells in the treatment of musculoskeletal injury and disease. The clinical use of BM-MSCs and other forms of stem cell therapy has far outpaced the basic and translational science evidence required to elucidate the potential efficacy of this orthobiologic treatment approach. Early studies have demonstrated potential clinical benefit of utilizing bone marrow-derived mesenchymal stem cell therapy in the management of knee osteoarthritis, focal chondral lesions, shoulder pathology including rotator cuff tears and glenohumeral arthritis, and degenerative disk disease in the spine. To date, most published studies are small case series often lacking a control group or a standardized method of treatment. SUMMARY: Bone marrow-derived mesenchymal stem cell therapy is becoming an increasingly common treatment for musculoskeletal injuries and disease. Although early clinical studies have shown promising outcomes, methodological flaws and lack of standardization among trials have limited the conclusions that can be drawn from the existing literature. A better understanding of the underlying mechanism of action and more carefully designed clinical trials will help reveal the efficacy and utility of BM-MSCs as a treatment modality for various orthopedic pathologies.
- Published
- 2019
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