41 results on '"Amico G."'
Search Results
2. Expanding the clinical and neuroimaging features of post-varicella arteriopathy of childhood
- Author
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Bertamino, M., Signa, S., Veneruso, M., Prato, G., Caorsi, R., Losurdo, G., Teutonico, F., Esposito, S., Formica, F., Tovaglieri, N., Nagel, M. A., Amico, G., Zanetti, A., Tortora, D., Rossi, A., Moretti, P., Gattorno, M., Ravelli, A., Severino, M., Di Rocco, M., Cornaglia, S., Tacchino, C., Ceccherini, I., Banov, L., Nobili, L., Palmieri, A., Pavanello, M., Ramenghi, L., Ronchetti, A., Uccella, S., and Volpi, S.
- Subjects
Male ,Pediatrics ,medicine.medical_specialty ,Neurology ,Post varicella stroke ,Late recurrence ,Vasculopathy ,Neuroimaging ,Disease ,03 medical and health sciences ,symbols.namesake ,Chickenpox ,0302 clinical medicine ,Recurrence ,Risk Factors ,Vessel wall imaging ,medicine ,Humans ,Pediatric stroke ,030212 general & internal medicine ,Preschool ,Child ,Children ,Stroke ,Fisher's exact test ,Neuroradiology ,First episode ,Arterial ischemic stroke ,Child, Preschool ,Infant ,business.industry ,medicine.disease ,Rash ,symbols ,Neurology (clinical) ,medicine.symptom ,business ,030217 neurology & neurosurgery - Abstract
Post-varicella arterial ischemic stroke (AIS) is considered an uncommon cause of pediatric stroke that is considered a self-limiting, monophasic disease. However, in a subset of patients, disease recurs; the prevalence of vasculopathy or AIS recurrence, severity of clinical outcomes, and standardized therapies have not been well characterized. Herein, we determined the clinical-neuroradiological features, long-term evolution, and relationship between acute phase treatment and vasculopathy recurrence in a pediatric population with post-varicella AIS. Clinical, laboratory, and neuroradiological features of 22 children with post-varicella AIS between 2010 and 2019 (16 males, mean age at stroke 4 years, range 1.7–10) were reviewed. Statistical analyses were performed using χ2 and Fisher exact tests. Of the 22 cases, mean time from varicella to stroke was 4.5 months with 3 cases presenting more than 12 months after rash; 21 (95%) were not vaccinated for varicella; 3 (13.6%) had posterior circulation involvement; and 5 (22.7%) had AIS or vasculopathy recurrence, of which 4 recurred 6.1 months to 2.8 years after initial clinical onset. Recurrence was associated with lack of antiviral treatment during the first episode (p = 0.02). Post-varicella AIS can occur months after rash making diagnosis challenging. Because recurrent vasculopathy was seen predominantly in cases not treated with antiviral therapy during initial presentation, it is important to rapidly diagnose post-varicella AIS through clinical criteria and/or virological testing then treat with antivirals to prevent recurrence.
- Published
- 2021
3. QUBIC Experiment Toward the First Light
- Author
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D’Alessandro, G., primary, Battistelli, E. S., additional, de Bernardis, P., additional, De Petris, M., additional, Gamboa Lerena, M. M., additional, Grandsire, L., additional, Hamilton, J.-Ch., additional, Marnieros, S., additional, Masi, S., additional, Mennella, A., additional, Mousset, L., additional, O’Sullivan, C., additional, Piat, M., additional, Tartari, A., additional, Torchinsky, S. A., additional, Voisin, F., additional, Zannoni, M., additional, Ade, P., additional, Alberro, J. G., additional, Almela, A., additional, Amico, G., additional, Arnaldi, L. H., additional, Auguste, D., additional, Aumont, J., additional, Azzoni, S., additional, Banfi, S., additional, Baù, A., additional, Bélier, B., additional, Bennett, D., additional, Bergé, L., additional, Bernard, J.-Ph., additional, Bersanelli, M., additional, Bigot-Sazy, M.-A., additional, Bonaparte, J., additional, Bonis, J., additional, Bunn, E., additional, Burke, D., additional, Buzi, D., additional, Cavaliere, F., additional, Chanial, P., additional, Chapron, C., additional, Charlassier, R., additional, Cobos Cerutti, A. C., additional, Columbro, F., additional, Coppolecchia, A., additional, De Gasperis, G., additional, De Leo, M., additional, Dheilly, S., additional, Duca, C., additional, Dumoulin, L., additional, Etchegoyen, A., additional, Fasciszewski, A., additional, Ferreyro, L. P., additional, Fracchia, D., additional, Franceschet, C., additional, Ganga, K. M., additional, García, B., additional, García Redondo, M. E., additional, Gaspard, M., additional, Gayer, D., additional, Gervasi, M., additional, Giard, M., additional, Gilles, V., additional, Giraud-Heraud, Y., additional, Gómez Berisso, M., additional, González, M., additional, Gradziel, M., additional, Hampel, M. R., additional, Harari, D., additional, Henrot-Versillé, S., additional, Incardona, F., additional, Jules, E., additional, Kaplan, J., additional, Kristukat, C., additional, Lamagna, L., additional, Loucatos, S., additional, Louis, T., additional, Maffei, B., additional, Marty, W., additional, Mattei, A., additional, May, A., additional, McCulloch, M., additional, Mele, L., additional, Melo, D., additional, Montier, L., additional, Mundo, L. M., additional, Murphy, J. A., additional, Murphy, J. D., additional, Nati, F., additional, Olivieri, E., additional, Oriol, C., additional, Paiella, A., additional, Pajot, F., additional, Passerini, A., additional, Pastoriza, H., additional, Pelosi, A., additional, Perbost, C., additional, Perciballi, M., additional, Pezzotta, F., additional, Piacentini, F., additional, Piccirillo, L., additional, Pisano, G., additional, Platino, M., additional, Polenta, G., additional, Prêle, D., additional, Presta, G., additional, Puddu, R., additional, Rambaud, D., additional, Rasztocky, E., additional, Ringegni, P., additional, Romero, G. E., additional, Salum, J. M., additional, Schillaci, A., additional, Scóccola, C. G., additional, Scully, S., additional, Spinelli, S., additional, Stankowiak, G., additional, Stolpovskiy, M., additional, Supanitsky, A. D., additional, Thermeau, J.-P., additional, Timbie, P., additional, Tomasi, M., additional, Tucker, G., additional, Tucker, C., additional, Viganò, D., additional, Vittorio, N., additional, Wicek, F., additional, Wright, M., additional, and Zullo, A., additional
- Published
- 2022
- Full Text
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4. Author Correction: Proton acceleration in thermonuclear nova explosions revealed by gamma rays
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Acciari, V. A., primary, Ansoldi, S., additional, Antonelli, L. A., additional, Engels, A. Arbet, additional, Artero, M., additional, Asano, K., additional, Baack, D., additional, Babić, A., additional, Baquero, A., additional, de Almeida, U. Barres, additional, Barrio, J. A., additional, Batković, I., additional, González, J. Becerra, additional, Bednarek, W., additional, Bellizzi, L., additional, Bernardini, E., additional, Bernardos, M., additional, Berti, A., additional, Besenrieder, J., additional, Bhattacharyya, W., additional, Bigongiari, C., additional, Biland, A., additional, Blanch, O., additional, Bökenkamp, H., additional, Bonnoli, G., additional, Bošnjak, Ž., additional, Busetto, G., additional, Carosi, R., additional, Ceribella, G., additional, Cerruti, M., additional, Chai, Y., additional, Chilingarian, A., additional, Cikota, S., additional, Colak, S. M., additional, Colombo, E., additional, Contreras, J. L., additional, Cortina, J., additional, Covino, S., additional, D’Amico, G., additional, D’Elia, V., additional, Da Vela, P., additional, Dazzi, F., additional, De Angelis, A., additional, De Lotto, B., additional, Del Popolo, A., additional, Delfino, M., additional, Delgado, J., additional, Mendez, C. Delgado, additional, Depaoli, D., additional, Di Pierro, F., additional, Di Venere, L., additional, Espiñeira, E. Do Souto, additional, Prester, D. Dominis, additional, Donini, A., additional, Dorner, D., additional, Doro, M., additional, Elsaesser, D., additional, Ramazani, V. Fallah, additional, Alonso, L. Fariña, additional, Fattorini, A., additional, Fonseca, M. V., additional, Font, L., additional, Fruck, C., additional, Fukami, S., additional, Fukazawa, Y., additional, López, R. J. García, additional, Garczarczyk, M., additional, Gasparyan, S., additional, Gaug, M., additional, Giglietto, N., additional, Giordano, F., additional, Gliwny, P., additional, Godinović, N., additional, Green, J. G., additional, Green, D., additional, Hadasch, D., additional, Hahn, A., additional, Hassan, T., additional, Heckmann, L., additional, Herrera, J., additional, Hoang, J., additional, Hrupec, D., additional, Hütten, M., additional, Inada, T., additional, Ishio, K., additional, Iwamura, Y., additional, Martínez, I. Jiménez, additional, Jormanainen, J., additional, Jouvin, L., additional, Kerszberg, D., additional, Kobayashi, Y., additional, Kubo, H., additional, Kushida, J., additional, Lamastra, A., additional, Lelas, D., additional, Leone, F., additional, Lindfors, E., additional, Linhoff, L., additional, Lombardi, S., additional, Longo, F., additional, López-Coto, R., additional, López-Moya, M., additional, López-Oramas, A., additional, Loporchio, S., additional, de Oliveira Fraga, B. Machado, additional, Maggio, C., additional, Majumdar, P., additional, Makariev, M., additional, Mallamaci, M., additional, Maneva, G., additional, Manganaro, M., additional, Mannheim, K., additional, Maraschi, L., additional, Mariotti, M., additional, Martínez, M., additional, Aguilar, A. Mas, additional, Mazin, D., additional, Menchiari, S., additional, Mender, S., additional, Mićanović, S., additional, Miceli, D., additional, Miener, T., additional, Miranda, J. M., additional, Mirzoyan, R., additional, Molina, E., additional, Moralejo, A., additional, Morcuende, D., additional, Moreno, V., additional, Moretti, E., additional, Nakamori, T., additional, Nava, L., additional, Neustroev, V., additional, Rosillo, M. Nievas, additional, Nigro, C., additional, Nilsson, K., additional, Nishijima, K., additional, Noda, K., additional, Nozaki, S., additional, Ohtani, Y., additional, Oka, T., additional, Otero-Santos, J., additional, Paiano, S., additional, Palatiello, M., additional, Paneque, D., additional, Paoletti, R., additional, Paredes, J. M., additional, Pavletić, L., additional, Peñil, P., additional, Persic, M., additional, Pihet, M., additional, Moroni, P. G. Prada, additional, Prandini, E., additional, Priyadarshi, C., additional, Puljak, I., additional, Rhode, W., additional, Ribó, M., additional, Rico, J., additional, Righi, C., additional, Rugliancich, A., additional, Sahakyan, N., additional, Saito, T., additional, Sakurai, S., additional, Satalecka, K., additional, Saturni, F. G., additional, Schleicher, B., additional, Schmidt, K., additional, Schweizer, T., additional, Sitarek, J., additional, Šnidarić, I., additional, Sobczynska, D., additional, Spolon, A., additional, Stamerra, A., additional, Strišković, J., additional, Strom, D., additional, Strzys, M., additional, Suda, Y., additional, Surić, T., additional, Takahashi, M., additional, Takeishi, R., additional, Tavecchio, F., additional, Temnikov, P., additional, Terzić, T., additional, Teshima, M., additional, Tosti, L., additional, Truzzi, S., additional, Tutone, A., additional, Ubach, S., additional, van Scherpenberg, J., additional, Vanzo, G., additional, Acosta, M. Vazquez, additional, Ventura, S., additional, Verguilov, V., additional, Vigorito, C. F., additional, Vitale, V., additional, Vovk, I., additional, Will, M., additional, Wunderlich, C., additional, Yamamoto, T., additional, Zarić, D., additional, Ambrosino, F., additional, Cecconi, M., additional, Catanzaro, G., additional, Ferrara, C., additional, Frasca, A., additional, Munari, M., additional, Giustolisi, L., additional, Alonso-Santiago, J., additional, Giarrusso, M., additional, Munari, U., additional, and Valisa, P., additional
- Published
- 2022
- Full Text
- View/download PDF
5. Proton acceleration in thermonuclear nova explosions revealed by gamma rays
- Author
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Acciari, V. A., primary, Ansoldi, S., additional, Antonelli, L. A., additional, Arbet Engels, A., additional, Artero, M., additional, Asano, K., additional, Baack, D., additional, Babić, A., additional, Baquero, A., additional, Barres de Almeida, U., additional, Barrio, J. A., additional, Batković, I., additional, Becerra González, J., additional, Bednarek, W., additional, Bellizzi, L., additional, Bernardini, E., additional, Bernardos, M., additional, Berti, A., additional, Besenrieder, J., additional, Bhattacharyya, W., additional, Bigongiari, C., additional, Biland, A., additional, Blanch, O., additional, Bökenkamp, H., additional, Bonnoli, G., additional, Bošnjak, Ž., additional, Busetto, G., additional, Carosi, R., additional, Ceribella, G., additional, Cerruti, M., additional, Chai, Y., additional, Chilingarian, A., additional, Cikota, S., additional, Colak, S. M., additional, Colombo, E., additional, Contreras, J. L., additional, Cortina, J., additional, Covino, S., additional, D’Amico, G., additional, D’Elia, V., additional, Da Vela, P., additional, Dazzi, F., additional, De Angelis, A., additional, De Lotto, B., additional, Del Popolo, A., additional, Delfino, M., additional, Delgado, J., additional, Delgado Mendez, C., additional, Depaoli, D., additional, Di Pierro, F., additional, Di Venere, L., additional, Do Souto Espiñeira, E., additional, Prester, D. Dominis, additional, Donini, A., additional, Dorner, D., additional, Doro, M., additional, Elsaesser, D., additional, Fallah Ramazani, V., additional, Fariña Alonso, L., additional, Fattorini, A., additional, Fonseca, M. V., additional, Font, L., additional, Fruck, C., additional, Fukami, S., additional, Fukazawa, Y., additional, García López, R. J., additional, Garczarczyk, M., additional, Gasparyan, S., additional, Gaug, M., additional, Giglietto, N., additional, Giordano, F., additional, Gliwny, P., additional, Godinović, N., additional, Green, J. G., additional, Green, D., additional, Hadasch, D., additional, Hahn, A., additional, Hassan, T., additional, Heckmann, L., additional, Herrera, J., additional, Hoang, J., additional, Hrupec, D., additional, Hütten, M., additional, Inada, T., additional, Ishio, K., additional, Iwamura, Y., additional, Jiménez Martínez, I., additional, Jormanainen, J., additional, Jouvin, L., additional, Kerszberg, D., additional, Kobayashi, Y., additional, Kubo, H., additional, Kushida, J., additional, Lamastra, A., additional, Lelas, D., additional, Leone, F., additional, Lindfors, E., additional, Linhoff, L., additional, Lombardi, S., additional, Longo, F., additional, López-Coto, R., additional, López-Moya, M., additional, López-Oramas, A., additional, Loporchio, S., additional, Machado de Oliveira Fraga, B., additional, Maggio, C., additional, Majumdar, P., additional, Makariev, M., additional, Mallamaci, M., additional, Maneva, G., additional, Manganaro, M., additional, Mannheim, K., additional, Maraschi, L., additional, Mariotti, M., additional, Martínez, M., additional, Mas Aguilar, A., additional, Mazin, D., additional, Menchiari, S., additional, Mender, S., additional, Mićanović, S., additional, Miceli, D., additional, Miener, T., additional, Miranda, J. M., additional, Mirzoyan, R., additional, Molina, E., additional, Moralejo, A., additional, Morcuende, D., additional, Moreno, V., additional, Moretti, E., additional, Nakamori, T., additional, Nava, L., additional, Neustroev, V., additional, Nievas Rosillo, M., additional, Nigro, C., additional, Nilsson, K., additional, Nishijima, K., additional, Noda, K., additional, Nozaki, S., additional, Ohtani, Y., additional, Oka, T., additional, Otero-Santos, J., additional, Paiano, S., additional, Palatiello, M., additional, Paneque, D., additional, Paoletti, R., additional, Paredes, J. M., additional, Pavletić, L., additional, Peñil, P., additional, Persic, M., additional, Pihet, M., additional, Prada Moroni, P. G., additional, Prandini, E., additional, Priyadarshi, C., additional, Puljak, I., additional, Rhode, W., additional, Ribó, M., additional, Rico, J., additional, Righi, C., additional, Rugliancich, A., additional, Sahakyan, N., additional, Saito, T., additional, Sakurai, S., additional, Satalecka, K., additional, Saturni, F. G., additional, Schleicher, B., additional, Schmidt, K., additional, Schweizer, T., additional, Sitarek, J., additional, Šnidarić, I., additional, Sobczynska, D., additional, Spolon, A., additional, Stamerra, A., additional, Strišković, J., additional, Strom, D., additional, Strzys, M., additional, Suda, Y., additional, Surić, T., additional, Takahashi, M., additional, Takeishi, R., additional, Tavecchio, F., additional, Temnikov, P., additional, Terzić, T., additional, Teshima, M., additional, Tosti, L., additional, Truzzi, S., additional, Tutone, A., additional, Ubach, S., additional, van Scherpenberg, J., additional, Vanzo, G., additional, Vazquez Acosta, M., additional, Ventura, S., additional, Verguilov, V., additional, Vigorito, C. F., additional, Vitale, V., additional, Vovk, I., additional, Will, M., additional, Wunderlich, C., additional, Yamamoto, T., additional, Zarić, D., additional, Ambrosino, F., additional, Cecconi, M., additional, Catanzaro, G., additional, Ferrara, C., additional, Frasca, A., additional, Munari, M., additional, Giustolisi, L., additional, Alonso-Santiago, J., additional, Giarrusso, M., additional, Munari, U., additional, and Valisa, P., additional
- Published
- 2022
- Full Text
- View/download PDF
6. QUBIC: Using NbSi TESs with a Bolometric Interferometer to Characterize the Polarization of the CMB
- Author
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Piat, M., primary, Bélier, B., additional, Bergé, L., additional, Bleurvacq, N., additional, Chapron, C., additional, Dheilly, S., additional, Dumoulin, L., additional, González, M., additional, Grandsire, L., additional, Hamilton, J.-Ch., additional, Henrot-Versillé, S., additional, Hoang, D. T., additional, Marnieros, S., additional, Marty, W., additional, Montier, L., additional, Olivieri, E., additional, Oriol, C., additional, Perbost, C., additional, Prêle, D., additional, Rambaud, D., additional, Salatino, M., additional, Stankowiak, G., additional, Thermeau, J.-P., additional, Torchinsky, S., additional, Voisin, F., additional, Ade, P., additional, Alberro, J. G., additional, Almela, A., additional, Amico, G., additional, Arnaldi, L. H., additional, Auguste, D., additional, Aumont, J., additional, Azzoni, S., additional, Banfi, S., additional, Battaglia, P., additional, Battistelli, E. S., additional, Baù, A., additional, Bennett, D., additional, Bernard, J.-Ph., additional, Bersanelli, M., additional, Bigot-Sazy, M.-A., additional, Bonaparte, J., additional, Bonis, J., additional, Bottani, A., additional, Bunn, E., additional, Burke, D., additional, Buzi, D., additional, Buzzelli, A., additional, Cavaliere, F., additional, Chanial, P., additional, Charlassier, R., additional, Columbro, F., additional, Coppi, G., additional, Coppolecchia, A., additional, D’Alessandro, G., additional, de Bernardis, P., additional, De Gasperis, G., additional, De Leo, M., additional, De Petris, M., additional, Di Donato, A., additional, Etchegoyen, A., additional, Fasciszewski, A., additional, Ferreyro, L. P., additional, Fracchia, D., additional, Franceschet, C., additional, Gamboa Lerena, M. M., additional, Ganga, K., additional, García, B., additional, García Redondo, M. E., additional, Gaspard, M., additional, Gault, A., additional, Gayer, D., additional, Gervasi, M., additional, Giard, M., additional, Gilles, V., additional, Giraud-Heraud, Y., additional, Gómez Berisso, M., additional, Gradziel, M., additional, Harari, D., additional, Haynes, V., additional, Incardona, F., additional, Jules, E., additional, Kaplan, J., additional, Korotkov, A., additional, Kristukat, C., additional, Lamagna, L., additional, Loucatos, S., additional, Louis, T., additional, Luterstein, R., additional, Maffei, B., additional, Masi, S., additional, Mattei, A., additional, May, A., additional, McCulloch, M., additional, Medina, M. C., additional, Mele, L., additional, Melhuish, S., additional, Mennella, A., additional, Mousset, L., additional, Mundo, L. M., additional, Murphy, J. A., additional, Murphy, J. D., additional, Nati, F., additional, O’Sullivan, C., additional, Paiella, A., additional, Pajot, F., additional, Passerini, A., additional, Pastoriza, H., additional, Pelosi, A., additional, Perciballi, M., additional, Pezzotta, F., additional, Piacentini, F., additional, Piccirillo, L., additional, Pisano, G., additional, Platino, M., additional, Polenta, G., additional, Puddu, R., additional, Ringegni, P., additional, Romero, G. E., additional, Salum, J. M., additional, Schillaci, A., additional, Scóccola, C., additional, Scully, S., additional, Spinelli, S., additional, Stolpovskiy, M., additional, Suarez, F., additional, Tartari, A., additional, Timbie, P., additional, Tomasi, M., additional, Tucker, C., additional, Tucker, G., additional, Vanneste, S., additional, Viganò, D., additional, Vittorio, N., additional, Watson, B., additional, Wicek, F., additional, Zannoni, M., additional, and Zullo, A., additional
- Published
- 2020
- Full Text
- View/download PDF
7. QUBIC: The Q & U Bolometric Interferometer for Cosmology
- Author
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Battistelli, E. S., primary, Ade, P., additional, Alberro, J. G., additional, Almela, A., additional, Amico, G., additional, Arnaldi, L. H., additional, Auguste, D., additional, Aumont, J., additional, Azzoni, S., additional, Banfi, S., additional, Battaglia, P., additional, Baù, A., additional, Bélier, B., additional, Bennett, D., additional, Bergé, L., additional, Bernard, J.-Ph., additional, Bersanelli, M., additional, Bigot-Sazy, M.-A., additional, Bleurvacq, N., additional, Bonaparte, J., additional, Bonis, J., additional, Bottani, A., additional, Bunn, E., additional, Burke, D., additional, Buzi, D., additional, Buzzelli, A., additional, Cavaliere, F., additional, Chanial, P., additional, Chapron, C., additional, Charlassier, R., additional, Columbro, F., additional, Coppi, G., additional, Coppolecchia, A., additional, D’Alessandro, G., additional, de Bernardis, P., additional, De Gasperis, G., additional, De Leo, M., additional, De Petris, M., additional, Dheilly, S., additional, Di Donato, A., additional, Dumoulin, L., additional, Etchegoyen, A., additional, Fasciszewski, A., additional, Ferreyro, L. P., additional, Fracchia, D., additional, Franceschet, C., additional, Lerena, M. M. Gamboa, additional, Ganga, K., additional, García, B., additional, Redondo, M. E. García, additional, Gaspard, M., additional, Gault, A., additional, Gayer, D., additional, Gervasi, M., additional, Giard, M., additional, Gilles, V., additional, Giraud-Heraud, Y., additional, Berisso, M. Gómez, additional, González, M., additional, Gradziel, M., additional, Grandsire, L., additional, Hamilton, J.-Ch., additional, Harari, D., additional, Haynes, V., additional, Henrot-Versillé, S., additional, Hoang, D. T., additional, Incardona, F., additional, Jules, E., additional, Kaplan, J., additional, Korotkov, A., additional, Kristukat, C., additional, Lamagna, L., additional, Loucatos, S., additional, Louis, T., additional, Luterstein, R., additional, Maffei, B., additional, Marnieros, S., additional, Marty, W., additional, Masi, S., additional, Mattei, A., additional, May, A., additional, McCulloch, M., additional, Medina, M. C., additional, Mele, L., additional, Melhuish, S., additional, Mennella, A., additional, Montier, L., additional, Mousset, L., additional, Mundo, L. M., additional, Murphy, J. A., additional, Murphy, J. D., additional, Nati, F., additional, Olivieri, E., additional, Oriol, C., additional, O’Sullivan, C., additional, Paiella, A., additional, Pajot, F., additional, Passerini, A., additional, Pastoriza, H., additional, Pelosi, A., additional, Perbost, C., additional, Perciballi, M., additional, Pezzotta, F., additional, Piacentini, F., additional, Piat, M., additional, Piccirillo, L., additional, Pisano, G., additional, Platino, M., additional, Polenta, G., additional, Prêle, D., additional, Puddu, R., additional, Rambaud, D., additional, Ringegni, P., additional, Romero, G. E., additional, Salatino, M., additional, Salum, J. M., additional, Schillaci, A., additional, Scóccola, C., additional, Scully, S., additional, Spinelli, S., additional, Stankowiak, G., additional, Stolpovskiy, M., additional, Suarez, F., additional, Tartari, A., additional, Thermeau, J.-P., additional, Timbie, P., additional, Tomasi, M., additional, Torchinsky, S., additional, Tristram, M., additional, Tucker, C., additional, Tucker, G., additional, Vanneste, S., additional, Viganò, D., additional, Vittorio, N., additional, Voisin, F., additional, Watson, B., additional, Wicek, F., additional, Zannoni, M., additional, and Zullo, A., additional
- Published
- 2020
- Full Text
- View/download PDF
8. TES Bolometer Arrays for the QUBIC B-Mode CMB Experiment
- Author
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Marnieros, S., primary, Ade, P., additional, Alberro, J. G., additional, Almela, A., additional, Amico, G., additional, Arnaldi, L. H., additional, Auguste, D., additional, Aumont, J., additional, Azzoni, S., additional, Banfi, S., additional, Battaglia, P., additional, Battistelli, E. S., additional, Baù, A., additional, Bélier, B., additional, Bennett, D., additional, Bergé, L., additional, Bernard, J.-Ph., additional, Bersanelli, M., additional, Bigot-Sazy, M.-A., additional, Bleurvacq, N., additional, Bonaparte, J., additional, Bonis, J., additional, Bottani, A., additional, Bunn, E., additional, Burke, D., additional, Buzi, D., additional, Cavaliere, F., additional, Chanial, P., additional, Chapron, C., additional, Charlassier, R., additional, Columbro, F., additional, Coppolecchia, A., additional, D’Alessandro, G., additional, de Bernardis, P., additional, De Gasperis, G., additional, De Leo, M., additional, De Petris, M., additional, Dheilly, S., additional, Dumoulin, L., additional, Etchegoyen, A., additional, Fasciszewski, A., additional, Ferreyro, L. P., additional, Fracchia, D., additional, Franceschet, C., additional, Gamboa Lerena, M. M., additional, Ganga, K., additional, García, B., additional, García Redondo, M. E., additional, Gaspard, M., additional, Gayer, D., additional, Gervasi, M., additional, Giard, M., additional, Gilles, V., additional, Giraud-Heraud, Y., additional, Gómez Berisso, M., additional, González, M., additional, Gradziel, M., additional, Grandsire, L., additional, Hamilton, J.-Ch., additional, Harari, D., additional, Henrot-Versillé, S., additional, Hoang, D. T., additional, Incardona, F., additional, Jules, E., additional, Kaplan, J., additional, Kristukat, C., additional, Lamagna, L., additional, Loucatos, S., additional, Louis, T., additional, Maffei, B., additional, Marty, W., additional, Masi, S., additional, Mattei, A., additional, May, A., additional, McCulloch, M., additional, Mele, L., additional, Melhuish, S., additional, Mennella, A., additional, Montier, L., additional, Mousset, L., additional, Mundo, L. M., additional, Murphy, J. A., additional, Murphy, J. D., additional, Nati, F., additional, Olivieri, E., additional, Oriol, C., additional, O’Sullivan, C., additional, Paiella, A., additional, Pajot, F., additional, Passerini, A., additional, Pastoriza, H., additional, Pelosi, A., additional, Perbost, C., additional, Perciballi, M., additional, Pezzotta, F., additional, Piacentini, F., additional, Piat, M., additional, Piccirillo, L., additional, Pisano, G., additional, Platino, M., additional, Polenta, G., additional, Prêle, D., additional, Puddu, R., additional, Rambaud, D., additional, Ringegni, P., additional, Romero, G. E., additional, Salatino, M., additional, Salum, J. M., additional, Schillaci, A., additional, Scóccola, C., additional, Scully, S., additional, Spinelli, S., additional, Stankowiak, G., additional, Stolpovskiy, M., additional, Tartari, A., additional, Thermeau, J.-P., additional, Timbie, P., additional, Tomasi, M., additional, Torchinsky, S., additional, Tucker, G., additional, Tucker, C., additional, Viganò, D., additional, Vittorio, N., additional, Voisin, F., additional, Wicek, F., additional, Zannoni, M., additional, and Zullo, A., additional
- Published
- 2020
- Full Text
- View/download PDF
9. Associations between the presence of specific antibodies to the West Nile Virus infection and candidate genes in Romanian horses from the Danube delta
- Author
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Stejskalova, K., primary, Janova, E., additional, Horecky, C., additional, Horecka, E., additional, Vaclavek, P., additional, Hubalek, Z., additional, Relling, K., additional, Cvanova, M., additional, D’Amico, G., additional, Mihalca, A. D., additional, Modry, D., additional, Knoll, A., additional, and Horin, P., additional
- Published
- 2019
- Full Text
- View/download PDF
10. Quantum test of the equivalence principle for atoms in coherent superposition of internal energy states
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Rosi, G., primary, D’Amico, G., additional, Cacciapuoti, L., additional, Sorrentino, F., additional, Prevedelli, M., additional, Zych, M., additional, Brukner, Č., additional, and Tino, G. M., additional
- Published
- 2017
- Full Text
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11. Spatio-temporal monitoring by ground-based and air- and space-borne lidars of a moderate Saharan dust event affecting southern Europe in June 2013 in the framework of the ADRIMED/ChArMEx campaign
- Author
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Barragan, R., primary, Sicard, M., additional, Totems, J., additional, Léon, J. F., additional, Dulac, F., additional, Mallet, M., additional, Pelon, J., additional, Alados-Arboledas, L., additional, Amodeo, A., additional, Augustin, P., additional, Boselli, A., additional, Bravo-Aranda, J. A., additional, Burlizzi, P., additional, Chazette, P., additional, Comerón, A., additional, D’Amico, G., additional, Dubuisson, P., additional, Granados-Muñoz, M. J., additional, Leto, G., additional, Guerrero-Rascado, J. L., additional, Madonna, F., additional, Mona, L., additional, Muñoz-Porcar, C., additional, Pappalardo, G., additional, Perrone, M. R., additional, Pont, V., additional, Rocadenbosch, F., additional, Rodriguez-Gomez, A., additional, Scollo, S., additional, Spinelli, N., additional, Titos, G., additional, Wang, X., additional, and Sanchez, R. Zanmar, additional
- Published
- 2017
- Full Text
- View/download PDF
12. Identification of a novel agrin-dependent pathway in cell signaling and adhesion within the erythroid niche
- Author
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Anselmo, A, primary, Lauranzano, E, additional, Soldani, C, additional, Ploia, C, additional, Angioni, R, additional, D'amico, G, additional, Sarukhan, A, additional, Mazzon, C, additional, and Viola, A, additional
- Published
- 2016
- Full Text
- View/download PDF
13. Mouse mesenchymal stem cells inhibit high endothelial cell activation and lymphocyte homing to lymph nodes by releasing TIMP-1
- Author
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Zanotti, L, primary, Angioni, R, additional, Calì, B, additional, Soldani, C, additional, Ploia, C, additional, Moalli, F, additional, Gargesha, M, additional, D'Amico, G, additional, Elliman, S, additional, Tedeschi, G, additional, Maffioli, E, additional, Negri, A, additional, Zacchigna, S, additional, Sarukhan, A, additional, Stein, J V, additional, and Viola, A, additional
- Published
- 2016
- Full Text
- View/download PDF
14. Ixodid ticks in red foxes (Vulpes vulpes) from Romania
- Author
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Dumitrache, MO, primary, D'Amico, G, additional, Matei, IA, additional, Ionică, A, additional, Gherman, CM, additional, Sikó Barabási, S, additional, Ionescu, DT, additional, Oltean, M, additional, Balea, A, additional, Ilea, IC, additional, Sándor, AD, additional, and Mihalca, AD, additional
- Published
- 2014
- Full Text
- View/download PDF
15. Borrelia turcica in Hyalomma aegyptium ticks in Romania
- Author
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Kalmár, Z, primary, D'Amico, G, additional, Matei, IA, additional, Paștiu, AI, additional, Mărcuţan, DI, additional, Dumitrache, MO, additional, and Mihalca, AD, additional
- Published
- 2014
- Full Text
- View/download PDF
16. Prevalence of Anaplasma phagocytophilum in ticks collected from migratory birds in Danube Delta, Romania
- Author
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Mărcuţan, ID, primary, Sándor, AD, additional, Mihalca, AD, additional, Gherman, CM, additional, Kalmár, Z, additional, D'Amico, G, additional, Dumitrache, MO, additional, and Cozma, V, additional
- Published
- 2014
- Full Text
- View/download PDF
17. Next generation sequencing as a novel tool for diagnostics of apicomplexan pathogen in ticks and mammalian hosts
- Author
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Qablan, MA, primary, Boyer, F, additional, Miquel, C, additional, D'Amico, G, additional, Mihalca, AD, additional, Pompanon, F, additional, and Modrý, D, additional
- Published
- 2014
- Full Text
- View/download PDF
18. Mesenchymal stem cells from Shwachman–Diamond syndrome patients display normal functions and do not contribute to hematological defects
- Author
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André, V, primary, Longoni, D, additional, Bresolin, S, additional, Cappuzzello, C, additional, Dander, E, additional, Galbiati, M, additional, Bugarin, C, additional, Di Meglio, A, additional, Nicolis, E, additional, Maserati, E, additional, Serafini, M, additional, Warren, A J, additional, te Kronnie, G, additional, Cazzaniga, G, additional, Sainati, L, additional, Cipolli, M, additional, Biondi, A, additional, and D'Amico, G, additional
- Published
- 2012
- Full Text
- View/download PDF
19. Encapsulated mesenchymal stem cells for in vivo immunomodulation
- Author
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Zanotti, L, primary, Sarukhan, A, additional, Dander, E, additional, Castor, M, additional, Cibella, J, additional, Soldani, C, additional, Trovato, A E, additional, Ploia, C, additional, Luca, G, additional, Calvitti, M, additional, Mancuso, F, additional, Arato, I, additional, Golemac, M, additional, Jonjic, N, additional, Biondi, A, additional, Calafiore, R, additional, Locati, M, additional, D'Amico, G, additional, and Viola, A, additional
- Published
- 2012
- Full Text
- View/download PDF
20. Ixodes ricinus is the dominant questing tick in forest habitats in Romania: the results from a countrywide dragging campaign
- Author
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Mihalca, A. D., primary, Gherman, C. M., additional, Magdaş, C., additional, Dumitrache, M. O., additional, Györke, A., additional, Sándor, A. D., additional, Domşa, C., additional, Oltean, M., additional, Mircean, V., additional, Mărcuţan, D. I., additional, D’Amico, G., additional, Păduraru, A. O., additional, and Cozma, V., additional
- Published
- 2012
- Full Text
- View/download PDF
21. Mesenchymal stromal cells for the treatment of graft-versus-host disease: understanding the in vivo biological effect through patient immune monitoring
- Author
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Dander, E, primary, Lucchini, G, additional, Vinci, P, additional, Introna, M, additional, Masciocchi, F, additional, Perseghin, P, additional, Balduzzi, A, additional, Bonanomi, S, additional, Longoni, D, additional, Gaipa, G, additional, Belotti, D, additional, Parma, M, additional, Algarotti, A, additional, Capelli, C, additional, Golay, J, additional, Rovelli, A, additional, Rambaldi, A, additional, Biondi, A, additional, Biagi, E, additional, and D'Amico, G, additional
- Published
- 2012
- Full Text
- View/download PDF
22. Which Is the Last Stage before Packing in Elective Liver Surgery?
- Author
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Di Benedetto, F., primary, Tarantino, G., additional, D’Amico, G., additional, Ballarin, R., additional, and Gerunda, G. E., additional
- Published
- 2011
- Full Text
- View/download PDF
23. Reply to Chhablani
- Author
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Forte, R, primary, Cennamo, G L, additional, Finelli, M, additional, Farese, E, additional, D'Amico, G, additional, Nicoletti, G, additional, de Crecchio, G, additional, and Cennamo, G, additional
- Published
- 2010
- Full Text
- View/download PDF
24. Intravitreal bevacizumab vs intravitreal triamcinolone combined with macular laser grid for diffuse diabetic macular oedema
- Author
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Forte, R, primary, Cennamo, G L, additional, Finelli, M, additional, Farese, E, additional, D'Amico, G, additional, Nicoletti, G, additional, de Crecchio, G, additional, and Cennamo, G, additional
- Published
- 2010
- Full Text
- View/download PDF
25. T cells stimulated by CD40L positive leukemic blasts-pulsed dendritic cells meet optimal functional requirements for adoptive T-cell therapy
- Author
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D'Amico, G, primary, Bonamino, M, additional, Dander, E, additional, Marin, V, additional, Basso, G, additional, Balduzzi, A, additional, Biagi, E, additional, and Biondi, A, additional
- Published
- 2006
- Full Text
- View/download PDF
26. Functional transfer of CD40L gene in human B-cell precursor ALL blasts by second-generation SIN lentivectors
- Author
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Bonamino, M, primary, Serafini, M, additional, D'Amico, G, additional, Gaipa, G, additional, Todisco, E, additional, Bernasconi, S, additional, Golay, J, additional, Biondi, A, additional, and Introna, M, additional
- Published
- 2003
- Full Text
- View/download PDF
27. Diode laser slit-jet spectra and analysis of the fundamental of 1-chloro-1,1-difluoroethane (HCFC-142b)
- Author
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Snels, M., primary and D'Amico, G., additional
- Published
- 2002
- Full Text
- View/download PDF
28. Uncoupling of inflammatory chemokine receptors by IL-10: generation of functional decoys
- Author
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D'Amico, G., primary, Frascaroli, G., additional, Bianchi, G., additional, Transidico, P., additional, Doni, A., additional, Vecchi, A., additional, Sozzani, S., additional, Allavena, P., additional, and Mantovani, A., additional
- Published
- 2000
- Full Text
- View/download PDF
29. Pravastatin vs Gemfibrozil in the Treatment of Primary Hypercholesterolaemia
- Author
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Malacco, E., primary, Magni, Alberto, additional, Scandiani, L., additional, Casini, A., additional, Albano, S., additional, Ansuini, R., additional, Biasion, T., additional, Biffi, E., additional, Bilardo, G., additional, Boccuzzi, G., additional, Breda, E., additional, Buttafarro, A., additional, Chella, P. S., additional, Chieffo, C., additional, Coletta, D., additional, Coli, L., additional, Colombo, L., additional, Compagnoni, A., additional, D’Amico, G., additional, D’Ascia, C., additional, Gregori, M., additional, Joannon, U., additional, Distante, R., additional, Donadon, V., additional, Donnini, P., additional, Fallucca, F., additional, Ferrari, L., additional, Fesce, E., additional, Formoso, L., additional, Furlani, M., additional, Galetta, F., additional, Gianni, R., additional, Giustina, G., additional, Irace, L., additional, Lipizer, A., additional, Maggio, F., additional, Magri, F., additional, Mangiameli, S., additional, Marasco, S., additional, Marchetti, M., additional, Marrazza, B., additional, Melandri, F., additional, Mondillo, G., additional, Montagnani, M., additional, Napoli, C., additional, Neri, G. F., additional, Orlandi, M., additional, Pantaleoni, M., additional, Papa, A., additional, Perrella, G., additional, Pileggi, V., additional, Pilleri, G. P., additional, Pittalis, M., additional, Piva, M., additional, Resta, F., additional, Rodari, T., additional, Savastano, A., additional, Savona, M., additional, Sensi, S., additional, Sorrentino, F., additional, Squadrito, S., additional, Stocchiero, C., additional, Stranieri, A., additional, Susco, G., additional, Tani, F., additional, Tassone, F., additional, Taverniti, R., additional, Terrosu, P. F., additional, Tirella, G., additional, and Vicario, A., additional
- Published
- 1994
- Full Text
- View/download PDF
30. Sonography after renal biopsy: Assessment of its role in 230 consecutive cases
- Author
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Castoldi, M. C., primary, Del Moro, R. M., additional, D'Urbano, M. L., additional, Ferrario, F., additional, Porri, M. T., additional, Maldifassi, P., additional, D'Amico, G., additional, and Casolo, F., additional
- Published
- 1994
- Full Text
- View/download PDF
31. Lipid changes in the nephrotic syndrome: New insights into pathomechanisms and treatment
- Author
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D'Amico, G., primary
- Published
- 1991
- Full Text
- View/download PDF
32. From meetings
- Author
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Arias, I. M., primary, Jezequel, A. M., additional, Berg, P. A., additional, Gatta, A., additional, Angeli, P., additional, Galanti, B., additional, Gaeta, G. B., additional, Gallo, C., additional, Giusti, G., additional, Pourcel, C., additional, Zignego, A. L., additional, Bréchot, C., additional, Cantley, L., additional, Rizzetto, M., additional, Mazzanti, R., additional, Moscarella, S., additional, Gentilini, P., additional, Buzzelli, G., additional, Smorlesi, C., additional, Dattolo, P., additional, Focardi, G. P., additional, Laffi, G., additional, Meacci, E., additional, Marra, F., additional, Reynolds, T. B., additional, Arroyo, V., additional, Haupert, G. T., additional, Gerbes, A. L., additional, Varticovski, L., additional, Villari, N., additional, Bartoletti, S., additional, Strazzabosco, M., additional, Muraca, M., additional, Venuti, M., additional, Varotto, A., additional, Iemmolo, R. M., additional, Fragasso, A., additional, Passera, D., additional, Okolicsanyi, L., additional, Capocaccia, L., additional, Ariosto, F., additional, Merli, M., additional, Riggio, O., additional, Romiti, A., additional, Pagliaro, L., additional, D’Amico, G., additional, Traina, M., additional, Montalbano, L., additional, Gatto, G., additional, Pisa, R., additional, Maisano, S., additional, Politi, F., additional, Colletti, P., additional, Tiné, F., additional, Barbara, L., additional, Corinaldesi, R., additional, Giorgio, R., additional, Stanghellini, V., additional, Scuro, L. A., additional, Vantini, I., additional, Dobrilla, G., additional, Amplatz, S., additional, Naccarato, R., additional, Mario, F., additional, Blasi, A., additional, Mangiameli, A., additional, Bianchi Porro, G., additional, Petrillo, M., additional, Forgac, M. D., additional, Donowitz, M., additional, Rood, R. P., additional, Wesolek, J. H., additional, Emmer, E., additional, Cohen, M., additional, McCullen, J., additional, Braithwaite, R. S., additional, Sharp, G. W. G., additional, Murer, H., additional, Ward, H. D., additional, and Pereira, M. E. A., additional
- Published
- 1988
- Full Text
- View/download PDF
33. Cation transport in normal human red cells treated with sulfhydryl compounds
- Author
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D'Amico, G., primary, Sirchia, G., additional, Ferrone, S., additional, and Romagnoni, M., additional
- Published
- 1966
- Full Text
- View/download PDF
34. La risoluzione dei sistemi lineari sparsi di grandi dimensioni
- Author
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D'Amico, G., primary
- Published
- 1972
- Full Text
- View/download PDF
35. Studies on cation transport in cold-stored human erythrocytes. I. Effect of aldosterone on sodium and potassium transfer
- Author
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D'Amico, G., primary and Cesana, A., additional
- Published
- 1961
- Full Text
- View/download PDF
36. Thaimycins, new anthelmintic and antiprotozoal antibiotics produced by Streptomyces michiganensis var. amylolyticus var. nova
- Author
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Cassinelli, G., primary, Cotta, E., additional, D'Amico, G., additional, Bruna, C. Della, additional, Grein, A., additional, Mazzoleni, R., additional, Ricciardi, M. L., additional, and Tintinelli, R., additional
- Published
- 1970
- Full Text
- View/download PDF
37. Mannosidohydroxystreptomycin fromStreptomyces sp.
- Author
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Arcamone, F., primary, Cassinelli, G., additional, d'Amico, G., additional, and Orezzi, P., additional
- Published
- 1968
- Full Text
- View/download PDF
38. II. Effect of a steroidal antagonist of aldosterone (SC 9420) on sodium and potassium transfer
- Author
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D'Amico, G., primary and Cesana, A., additional
- Published
- 1961
- Full Text
- View/download PDF
39. New concepts on the clinical course and stratification of compensated and decompensated cirrhosis
- Author
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Giuseppe Malizia, Alberto Morabito, Linda Pasta, Maria Grazia Valsecchi, Paola Rebora, Mario D'Amico, Gennaro D'Amico, D'Amico, G, Morabito, A, D'Amico, M, Pasta, L, Malizia, G, Rebora, P, and Valsecchi, M
- Subjects
Liver Cirrhosis ,medicine.medical_specialty ,Multistate model ,Cirrhosis ,Prognosi ,Portal venous pressure ,Jaundice ,Esophageal and Gastric Varices ,Risk Assessment ,Severity of Illness Index ,03 medical and health sciences ,0302 clinical medicine ,Predictive Value of Tests ,Recurrence ,Sepsis ,Hypertension, Portal ,Ascites ,medicine ,Humans ,Clinical state ,Decompensation ,Renal Insufficiency ,Portal hypertension ,Intensive care medicine ,Risk stratification ,Cirrhosi ,Hepatology ,Proportional hazards model ,business.industry ,Recurrent encephalopathy ,Models, Theoretical ,Competing risk ,Prognosis ,medicine.disease ,Portal Pressure ,Hepatic Encephalopathy ,030220 oncology & carcinogenesis ,Disease Progression ,030211 gastroenterology & hepatology ,medicine.symptom ,Gastrointestinal Hemorrhage ,Varices ,business - Abstract
The clinical course of cirrhosis has been typically described by a compensated and a decompensated state based on the absence or, respectively, the presence of any of bleeding, ascites, encephalopathy or jaundice. More recently, it has been recognized that increasing portal hypertension and several major clinical events are followed by a marked worsening in prognosis, and disease states have been proposed accordingly in a multistate model. The development of multistate models implies the assessment of the probabilities of more than one possible outcome from each disease state. This requires the use of competing risks analysis which investigates the risk of several competing outcomes. In such a situation, the Kaplanâ Meier risk estimates and the Cox regression may be not appropriate. Clinical states of cirrhosis presently considered as suitable for a comprehensive multistate model include: in compensated cirrhosis, early (mild) portal hypertension with hepatic venous pressure gradient (HVPG) >5 and
- Published
- 2017
40. T cells stimulated by CD40L positive leukemic blasts-pulsed dendritic cells meet optimal functional requirements for adoptive T-cell therapy
- Author
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Virna Marin, Martín Hernán Bonamino, Giuseppe Basso, Adriana Balduzzi, Erica Dander, Andrea Biondi, Giovanna D'Amico, Ettore Biagi, D'Amico, G, Bonamino, M, Dander, E, Marin, V, Basso, G, Balduzzi, A, Biagi, E, and Biondi, A
- Subjects
Cancer Research ,T cell ,CD40 Ligand ,Antigen-Presenting Cells ,Bone Marrow Cells ,Cell Communication ,Immunophenotyping ,Interleukin 21 ,Cell Movement ,Humans ,Medicine ,Cytotoxic T cell ,Cell Lineage ,IL-2 receptor ,Child ,Antigen-presenting cell ,Cells, Cultured ,CD40L, leukemia, adoptive immunotherapy ,Interleukin 3 ,B-Lymphocytes ,business.industry ,Dendritic Cells ,Hematology ,Precursor Cell Lymphoblastic Leukemia-Lymphoma ,Th1 Cells ,Natural killer T cell ,Adoptive Transfer ,Coculture Techniques ,medicine.anatomical_structure ,Oncology ,Immunology ,Cancer research ,Interleukin 12 ,business ,Immunologic Memory - Abstract
Adoptive T-cell immunotherapy may provide complementary therapy for childhood B-cell precursor acute lymphoblastic leukemia (BCP-ALL). In this study, we have analyzed the functional characteristics of anti-BCP-ALL effector T cells generated by co-culturing T lymphocytes and dendritic cells (DC) from allogeneic human stem cell transplantation (HSCT) donors. After 21-day co-culture with DC pulsed with CD40L+ apoptotic BCP-ALL blasts, T cells presented with both effector and central memory phenotype, and showed high and specific cytotoxic activity against leukemic cells (average lysis = 77%), mostly mediated by CD8+ T cells. Noticeably, growth of CD4 T cells was maintained (45% of total cells), which actively produced Th1 cytokines (IFN-gamma, TNF-alpha, IL-2), but not IL-4, IL-5 and IL-10. Anti-BCP-ALL T cells expressed CD49d and CXCR4 (implicated in the recruitment to bone marrow), and CD62L and CCR7 (involved in the migration to lymphoid organs). In accordance with this profile, T cells significantly migrated in response to the chemokines CXCL12 and CCL19. In conclusion, stimulation of T cells with CD40L+BCP-ALL cells-loaded DC not only elicited the generation of potent and specific anti-leukemic cytotoxic effectors, but also the differentiation of specific and functional Th-1 CD4 lymphocytes. These effectors are fully equipped to reach leukemia-infiltrated tissues and have characteristics to support and orchestrate the anti-tumor immune-response.
- Published
- 2006
41. Functional transfer of CD40L gene in human B-cell precursor ALL blasts by second-generation SIN lentivectors
- Author
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Martino Introna, E Todisco, M Serafini, M Bonamino, J. Golay, Andrea Biondi, Sergio Bernasconi, Giovanna D'Amico, Giuseppe Gaipa, Bonamino, M, Serafini, M, D'Amico, G, Gaipa, G, Todisco, E, Bernasconi, S, Golay, J, Biondi, A, and Introna, M
- Subjects
Stromal cell ,Transcription, Genetic ,Genetic enhancement ,CD40 Ligand ,Genetic Vectors ,Green Fluorescent Proteins ,Cytomegalovirus ,Gene Expression ,acute lymphoblastic leukemia ,Biology ,lentiviru ,Transduction (genetics) ,Transduction, Genetic ,Cell Line, Tumor ,Precursor B-Cell Lymphoblastic Leukemia-Lymphoma ,Precursor cell ,Genetics ,CD40L ,Humans ,dendritic cells ,Promoter Regions, Genetic ,Molecular Biology ,CD40 ,Lentivirus ,Genetic transfer ,Genetic Therapy ,Dendritic cell ,Virology ,Molecular biology ,Luminescent Proteins ,Cell culture ,biology.protein ,Molecular Medicine - Abstract
Three different second-generation lentiviral self-inactivating vectors containing CMV, EF1alpha and PGK promoter, respectively, and all carrying the exogenous GFP gene, were compared for expression in human B-cell precursor ALL blasts. At a comparable percentage of transduction and vector DNA copy number, CMV clearly showed better efficiency of transcription. Human bone marrow stromal cells were favored compared to the MRC-5 cell line, as support for cell viability during infection. Cells were infected and analyzed after variable culture times ranging from 4 to 12 days, to reduce the possibility of pseudotransduction. In 10/ 14 samples, we detected more than 20% GFP-positive cells after exposure to high-titer viral supernatants. We then tested a similar vector carrying the human CD40L cDNA and, in similar infection conditions, obtained more than 20% transduction in 6/6 samples. The levels of transduction obtained were sufficient to induce the upregulation of CD83 molecule in cocultured immature dendritic cells.
- Published
- 2003
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