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1. Acute kidney injury requiring kidney replacement therapy in childhood lupus nephritis: a cohort study of the Pediatric Nephrology Research Consortium and Childhood Arthritis and Rheumatology Research Alliance

Author

Brian R. Stotter, Ellen Cody, Hongjie Gu, Ankana Daga, Larry A. Greenbaum, Minh Dien Duong, Alexandra Mazo, Beatrice Goilav, Alexis Boneparth, Mahmoud Kallash, Ahmed Zeid, Wacharee Seeherunvong, Rebecca R. Scobell, Issa Alhamoud, Caitlin E. Carter, Siddharth Shah, Caroline E. Straatmann, Bradley P. Dixon, Jennifer C. Cooper, Raoul D. Nelson, Deborah M. Levy, Hermine I. Brunner, Priya S. Verghese, and Scott E. Wenderfer

Subjects
Nephrology, Pediatrics, Perinatology and Child Health
Abstract

Acute kidney injury (AKI) is common in lupus nephritis (LN) and a risk factor for development of chronic kidney disease. In adults with LN, AKI severity correlates with the incidence of kidney failure and patient survival. Data on AKI outcomes in children with LN, particularly those requiring kidney replacement therapy (KRT), are limited.A multicenter, retrospective cohort study was performed in children diagnosed between 2010 and 2019 with LN and AKI stage 3 treated with dialysis (AKI stage 3D). Descriptive statistics were used to characterize demographics, clinical data, and kidney biopsy findings; treatment data for LN were not included. Logistic regression was used to examine the association of these variables with kidney failure.Fifty-nine patients (mean age 14.3 years, 84.7% female) were identified. The most common KRT indications were fluid overload (86.4%) and elevated blood urea nitrogen/creatinine (74.6%). Mean follow-up duration was 3.9 ± 2.9 years. AKI recovery without progression to kidney failure occurred in 37.3% of patients. AKI recovery with later progression to kidney failure occurred in 25.4% of patients, and there was no kidney recovery from AKI in 35.6% of patients. Older age, severe ( 50%) tubular atrophy and interstitial fibrosis, and National Institutes of Health (NIH) chronicity index score 4 on kidney biopsy were associated with kidney failure.Children with LN and AKI stage 3D have a high long-term risk of kidney failure. Severe tubular atrophy and interstitial fibrosis at the time of AKI, but not AKI duration, are predictive of kidney disease progression. A higher resolution version of the Graphical abstract is available as Supplementary information.

Published
2022
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2. Proceedings of the 2016 Childhood Arthritis and Rheumatology Research Alliance (CARRA) Scientific Meeting

Author

Peggy Lee, Victor Hasselblad, Anja Schnabel, Timo Siepmann, Liza Bermudez, Ting Wang, Gloria C. Higgins, Ann M. Reed, Reinhard Berner, Katharine Moore, Sriharsha Grevich, Amy J. Starr, Jerome C. Lane, Mark F. Hoeltzel, Emily von Scheven, Yvonne Chiu, Brian M. Feldman, Edward J Oberle, Susan Kim, Laurence Greenbaum, Adam M. Huber, Judyann C. Olson, Suzanne Li, Lorie Luyrink, Elizabeth Roth Wojcicki, Dana Toib, Doruk Erkan, Michelle Bayer, Rie Karasawa, Lynn Spiegel, Charles Victor, Polly J. Ferguson, T. Brent Graham, Mark Connelly, James N. Jarvis, Laura B Lewandowski, Jacinthe Bisaillon, Elizabeth D. Mellins, Stephanie Luca, Gloria Higgins, Suhas Ganguli, Mary Hintermeyer, Jennifer E. Weiss, Jessica Foster, Phillip I. Tarr, Timothy S. H. Kwok, Kristyn L. Maletta, Christine Smith, Mileka Gilbert, Shirley M. L. Tse, L. Nandini Moorthy, Ciaran Duffy, Beatrice Goilav, Kevin Baszis, Rayfel Schneider, Marc D. Natter, Martha Rodriguez, Chitra Lalloo, Yukiko Kimura, Rob C. Fuhbrigge, Eleanor Pullenayegum, Megan L. Curran, Hernan Correa, Colleen K. Correll, Cassyanne L. Aguiar, Suzanne C. Li, Khaled Alsaeid, Laura Brungs, Tim Beukelman, Sampath Prahalad, Susan D. Thompson, Xiaohu Li, Brian Best, Tao Liu, Stacey M. Martinetti, Kevin W. Baszis, Alexis Boneparth, Monica Tsoras, Darshan H. Mehta, Anne M. Stevens, Annabelle N. Chua, Sangeeta Sule, Gretchen R. Heckel, Argerie Tsimicalis, Lucie Brosseau, Helen Bristow, Sarah Ringold, Thomas G. Mason, Mara L. Becker, Laura E. Schanberg, Ezra M. Cohen, Kaiyu Jiang, Yonit Sterba Ruas, Katie Stewart, Anne Dennos, Alexei A. Grom, Kalpana Manthiram, Yanmin Chen, Joshua Newsom, Peter R. Blier, Jennifer M. P. Woo, Lori B. Tucker, Michelle L. Dossett, Deirdre De Ranieri, Ginger Janow, Nicole Johnson, Hatice Ezgi Baris, Andrew H. Eichenfield, Laiping Wong, Pamela F. Weiss, Marisa S. Klein-Gitelman, Esi M. Morgan, Jennifer Stinson, Christian M. Hedrich, Ashlea Cook, Marsha M. Malloy, Megan Yuasa, M.S.C.E. Mara Becker M.D., Patrick J. McGrath, Max Shenberger, Beth Gottlieb, Daryl M. Okamura, Timothy Beukelman, Esra Meidan, Natasha M. Ruth, Lisha Zhu, Kazuo Yudoh, Kelly L. Mieszkalski, James A. Jegers, Mayumi Tamaki, Peter A. Nigrovic, Karen Onel, Christiaan Scott, Linda Wagner-Weiner, Kader Cetin Gedik, Ursula Range, Vikas R. Dharnidharka, Melissa S Tesher, Daniel J. Lovell, Jason Dare, Natalie J. Shiff, Karine Toupin April, Soko Setoguchi, Michael J. Buck, Yvonne C. Lee, Nadia Luca, Sarah Campillo, Suhas M. Radhakrishna, Lauren J. Lahey, Anna Carmela P. Sagcal-Gironella, Brandi Stevens, William H. Robinson, Hazim Alsaeed, Rachel Kaufmann, Anca D. Askanase, Stacy P. Ardoin, Egla Rabinovich, Paul Dancey, Kathryn S. Torok, Norm Ilowite, Elizabeth L. Roth-Wojcicki, Mario Medvedovic, Brian G. Leroux, Thomas A. Griffin, Megumi Tanaka, Richard K. Vehe, Lampros Fotis, Ronald M. Laxer, Salma Siddique, Joyce Hui-Yuen, Marilynn Punaro, Roberta A. Berard, Gabriele Hahn, Halima Moncrieffe, Kathryn M. Edwards, Dominic O. Co, Lauren Harris, Hannah Leahey, George Tomlinson, Maria Ibarra, Ciarán M. Duffy, Sarah Thomson, Jeremy Sokolove, Stacy Ardoin, Sandy D. Hong, Fatma Dedeoglu, Dustin J. Hahn, Nur Shaikh, Y. Ingrid Goh, Amir B. Orandi, Margalit Rosenkranz, Naweed Tajuddin, Elena Pope, Grendel Burrell, Shannon Carr, C. Egla Rabinovich, Jasim Alfailakawi, Roger Davis, Anabelle Chua, Toshiko Sato, Kathleen M. O'Neil, Anthony R. French, Lisa Imundo, Paula Morris, Joseph A Cafazzo, Maria F. Ibarra, Scott E. Wenderfer, Tamar Rubinstein, Danielle R. Bullock, Huan Xu, Joyce J. Hsu, Ritesh Korumilli, Hamid Alenezi, Julia Barsalou, John Matelski, Nicole Hershey, Heather Van Mater, Marsha Malloy, Lei Zhang, and Mark F. Bennett

Subjects
030203 arthritis & rheumatology, Pediatrics, medicine.medical_specialty, business.industry, Norm (group), 3. Good health, 03 medical and health sciences, 0302 clinical medicine, Alliance, Rheumatology, Griffin, Pediatrics, Perinatology and Child Health, Immunology and Allergy, Medicine, 030212 general & internal medicine, business, Humanities
Abstract

Author(s): Fotis, Lampros; Shaikh, Nur; Baszis, Kevin; French, Anthony; Tarr, Phillip; Grevich, Sriharsha; Lee, Peggy; Ringold, Sarah; Leroux, Brian; Leahey, Hannah; Yuasa, Megan; Foster, Jessica; Sokolove, Jeremy; Lahey, Lauren; Robinson, William; Newsom, Joshua; Stevens, Anne; Karasawa, Rie; Tamaki, Mayumi; Tanaka, Megumi; Sato, Toshiko; Yudoh, Kazuo; Jarvis, James N; Moncrieffe, Halima; Bennett, Mark F; Tsoras, Monica; Luyrink, Lorie; Xu, Huan; Prahalad, Sampath; Morris, Paula; Dare, Jason; Nigrovic, Peter A; Rosenkranz, Margalit; Becker, Mara; O’Neil, Kathleen M; Griffin, Thomas; Lovell, Daniel J; Grom, Alexei A; Medvedovic, Mario; Thompson, Susan D; Zhu, Lisha; Jiang, Kaiyu; Wong, Laiping; Buck, Michael J; Chen, Yanmin; Moncrieffe, Halima; Brungs, Laura; Liu, Tao; Wang, Ting; Jarvis, James N; Alsaeid, Khaled; Alfailakawi, Jasim; Alenezi, Hamid; Alsaeed, Hazim; Beukelman, Tim; Natter, Marc; Ilowite, Norm; Mieszkalski, Kelly; Burrell, Grendel; Best, Brian; Bristow, Helen; Carr, Shannon; Dennos, Anne; Kaufmann, Rachel; Kimura, Yukiko; Schanberg, Laura; Blier, Peter R; Boneparth, Alexis; Wenderfer, Scott E; Moorthy, L Nandini; Radhakrishna, Suhas M; Sagcal-Gironella, Anna Carmela P; von Scheven, Emily; Gedik, Kader Cetin; Siddique, Salma; Aguiar, Cassyanne L; Erkan, Doruk; Cohen, Ezra; Lee, Yvonne; Dossett, Michelle; Mehta, Darshan; Davis, Roger; Gilbert, Mileka; Goilav, Beatrice; Meidan, Esra

Published
2016
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3. B-cell activating factor targeted therapy and lupus

Author

Anne Davidson and Alexis Boneparth

Subjects
medicine.medical_specialty, medicine.medical_treatment, Immunology, Review, Antibodies, Monoclonal, Humanized, Targeted therapy, Mice, stomatognathic system, Rheumatology, immune system diseases, Internal medicine, B-Cell Activating Factor, Antibody targeting, medicine, Animals, Humans, Lupus Erythematosus, Systemic, Immunology and Allergy, skin and connective tissue diseases, B-cell activating factor, Systemic lupus erythematosus, business.industry, medicine.disease, Belimumab, stomatognathic diseases, business, medicine.drug
Abstract

B-cell activating factor (BAFF), a member of the family of TNF-like cytokines, supports the survival and differentiation of B cells. The successful development of belimumab, a human antibody targeting soluble BAFF, has marked an important milestone in the development of biologic therapy for treatment of systemic lupus erythematosus (SLE), although much remains unknown regarding the clinical utility of BAFF inhibition in SLE and other autoimmune diseases. In the present review, we provide an overview of the knowledge concerning BAFF's role in murine and human B-cell development and maturation, as well as the clinical and mechanistic effects of BAFF inhibition in human SLE.

Published
2012
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