1. Impact of dietary nano-zinc oxide on immune response and antioxidant defense of broiler chickens
- Author
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Azza Hafez, Elsayed Hegazi, Abdelnasser Bakr, Mabrouk Elsabagh, Mohamed Fahmy, and Eldsokey Nassef
- Subjects
Cellular immunity ,Antioxidant ,Health, Toxicology and Mutagenesis ,Lymphocyte ,medicine.medical_treatment ,010501 environmental sciences ,01 natural sciences ,Antioxidants ,Superoxide dismutase ,chemistry.chemical_compound ,Immune system ,Animal science ,medicine ,Animals ,Environmental Chemistry ,0105 earth and related environmental sciences ,biology ,Broiler ,General Medicine ,Malondialdehyde ,Animal Feed ,Pollution ,Diet ,medicine.anatomical_structure ,chemistry ,Dietary Supplements ,biology.protein ,Immunoglobulin Y ,Zinc Oxide ,Chickens - Abstract
This study aimed to elucidate the response of broiler chickens to the dietary nano-zinc supplementation in terms of immune response and antioxidant activity. Ninety-one-day-old chicks (Ross 308) were randomly assigned to one of three dietary treatments in three replicates, in a feeding trial that lasted for 5 weeks. Birds were fed a basal diet supplemented with inorganic zinc oxide at 40 mg/kg diet (control), zinc oxide nanoparticles (ZnONPs) at 40 mg/kg diet (ZN1), or ZnONPs at 80 mg/kg diet (ZN2). Birds were injected with DNP-KLH at the 7th and 21st days from the beginning of the experiment, and blood samples were collected on days 7, 14, 21, 28, and 35 to determine the levels of immunoglobulin Y (IgY) and malondialdehyde as well as the antioxidant enzyme activities. Cellular immunity was assayed by estimation of phagocytic percentage and index of peripheral monocytes of blood and estimation of the T lymphocyte activity using a lymphocyte transformation test. The results showed that feeding broiler chickens a diet supplemented with ZnONPs increased (p
- Published
- 2019