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The archaeology and heritage of South Sinai is rich and varied. Most research to date has focused on the High Mountains, specifically the area around the famous St Catherine’s Monastery, placed on the UNESCO World Heritage List in 2002 (Saint Catherine Area, World Heritage Site 954). Recently, the Sinai Peninsula Research and the Endangered Archaeology in the Middle East and North Africa projects have focused on the landscape surrounding the St Catherine’s Monastery. These projects highlighted the wealth of archaeological and heritage sites spanning the prehistoric to modern periods, including sites that are still in use by local communities today, as well as the environmental and anthropogenic factors that threaten their survival, such as climate change, tourism, and the impact of infrastructure developments. By contrast, the archaeology and heritage of the coastal areas was never surveyed systematically until the research presented in this paper. Remote sensing work by the Maritime Endangered Archaeology project revealed a coastal landscape that is likewise rich in archaeological and heritage sites. As in the High Mountains, many of the coastal sites are under significant threat, but they do not enjoy the same level of recognition and protection. This paper compares the coastal sites to those in the High Mountains, including their disturbances and threats, and demonstrates the need for a locally specific heritage management and protection strategy for different parts of South Sinai.

Livestock production by smallholder farmers in southern Africa is often constrained by insufficient fodder during the dry season. The aim of this study was to determine if inclusion of pigeon pea (Cajanus cajan (L.) Millsp.) hedgerows in Megathyrsus maximus ‘Gatton’ pastures could improve fodder production and nutritional yields, and to investigate effects of hedgerow cutting height on fodder production (including both browse and herbage). Treatments included three simulated silvopastoral systems with M. maximus planted between hedgerows, and one treatment that was M. maximus pasture alone. Hedgerows were cut at 60 or 90 cm above ground, or were uncut. Over the first two growing seasons, browse and grass fodder was harvested, dried and weighed four times. A portion of the fodder (comprising browse and herbage) was conserved in the second year and samples analysed for crude protein (CP), neutral detergent fibre (NDF) and acid detergent fibre (ADF) contents (%) and CP, phosphorus (P) and zinc (Zn) yields (kg ha−1). Hedgerows decreased cumulative grass biomass by 18.5%, but increased 1.22-fold the cumulative total fodder biomass when hedgerows were cut to 90 cm, compared to no hedgerows. Hedgerows had no effect on conserved grass herbage biomass (2.7 Mg ha−1 on average), but doubled biomass of conserved total fodder (5.0 Mg ha−1 on average) if hedgerows were cut. Cutting hedgerows increased CP, P and Zn yields, and increased CP and ADF contents, compared to not cutting them or not including them, while NDF was unaffected. Cutting hedgerows to 90 cm increased total browse production, compared to cutting to 60 cm. Pigeon pea seed biomass was unaffected by hedgerow cutting height (870 kg ha−1 on average). In conclusion, pigeon pea hedgerows included into grass pastures increase the quantity and quality of total fodder for livestock feed supplementation during the dry season.

This study is a meta-analytical study that examines the effectiveness of gamification in learning performance in educational settings (n = 29; year-span = 2011–2019). Specifically, it aimed to investigate (a) whether gamification could improve learning performance, and (b) whether peer interaction (i.e., peer competition and peer collaboration) moderated the effectiveness of gamification in learning performance. Results from random-effects models showed significant effects of gamification in learning performance (g = .595, 95% CI [.432, .758], N = 3515). This effect remained robust after excluding outliers and was stable in a sub-split analysis that excludes studies with low methodological rigor (i.e., studies with pre-post test design). Subgroup analyses revealed a moderating effect of peer competition in gamification in learning, suggesting that competitive games were better than non-competitive games for promoting learning performance in educational settings. However, this effect was not robust and no evidence of subgroup differences were found in the sub-split analysis. Peer collaboration did not moderate the effectiveness of gamification in learning as no subgroup differences were found between collaborative games and non-collaborative games. The effectiveness of games that were both competitive and collaborative did not differ from those that were only competitive. Other moderators such as education level and research design were also investigated. No subgroup differences were found for these two moderators. Educational implications and limitations were further discussed.

Inadequate nutrition limits small-scale livestock production by smallholder farmers in South Africa but can be addressed by the introduction of woody fodder species. Cutting woody plants to harvest fodder affects their productivity and thus it is necessary to determine the optimum cutting height. Cutting affects the productivity and survival of woody plants because it alters concentrations of non-structural carbohydrates, which are used to support their recovery. Since pigeon pea (Cajanus cajan (L.) Millsp.) is not widely grown in South Africa and is not managed as a pruned hedgerow, there was a need to investigate the effect of cutting height under local conditions, especially in areas that experience frost. The trial was established in November 2016, ran over two growing seasons (2016/2017 and 2017/2018) and concluded in August 2018. The treatments comprised three silvopastoral systems with Panicum maximum planted between pigeon pea hedgerows that were cut at 60 cm and 90 cm above the ground, or left uncut and sole P. maximum. Over the two year period, the pigeon pea plants cut at 90 cm above ground produced significantly more leaf, twig and total biomass than the plants cut at 60 cm. Cutting height also had a significant effect on the percentage twig, with pigeon pea plants cut at 90 cm having significantly higher percentage twig than those cut at 60 cm (P 0.05). In July 2018 there were a number of days with temperatures below 0 °C. Prior to this no mortalities had been observed, but the frost events resulted in die-off. The mortality rates were determined in August 2018 when it was clear which of the shrubs had clearly died. The shrub mortality rates were higher for pruned relative to unpruned shrubs, but the effect was not significant (P > 0.05). It was concluded that the choice of cutting height is important for maximising browse production. Future research should consider the effect of pruning on non-structural carbohydrate concentration and total pool in the roots to better understand the reasons for reduced production and shrub mortalities.

Background There is a compelling need to prepare our societies and healthcare systems to deal with the oncoming wave of population ageing. The majority of older persons maintain a desire to be valued and useful members of society and of their social networks. Aims We sought to investigate the perception of usefulness among persons aged 65 years and over in four European countries. Methods We performed a cross-sectional survey with a representative sample of individuals aged 65 years or older from the population of retired persons (including recently retired persons and oldest-old individuals) from 4 European countries selected using quota sampling. In February 2016, an internet questionnaire was sent to all selected individuals. The characteristics used for the quota sampling method were sex, age, socio-professional category, region, city size, number of persons in household, autonomy, marital status, place of residence, income and educational status. The questionnaire contained 57 questions. Sociodemographic characteristics were recorded. Responses were analysed with principal components analysis (PCA). Results A total of 4025 persons participated; 51% were males, and 70% were aged 65–75 years. PCA identified six classes of individuals, of which two classes (Classes 2 and 3) were characterized by more socially isolated individuals with little or no sense of usefulness, low self-esteem and a poor sense of well-being. These two classes accounted for almost 20% of the population. Younger and more autonomous classes reported a more salient sense of usefulness. Conclusions The loss of the sense of usefulness is associated with dissatisfaction with life and a loss of pleasure, and persons with profiles corresponding to Classes 2 and 3 should, therefore, be targeted for interventions aimed at restoring social links.

Some birds replace feathers after the formative plumage of the first cycle and after basic plumages in subsequent cycles as a consequence of prealternate molts. The presence of prealternate molts has been suggested to be due to prolonged exposure to sunlight, especially for birds inhabiting exposed and scrubby areas. Although prealternate molts appear to be common in many Nearctic-Neotropic passerines, these can be also present in resident Neotropical species. For example, prealternate molt has been reported in 14 species among nine genera in thraupids. Here, using wild individuals and museum specimens, we describe the presence of a Complex Alternate Strategy in the molt cycle of the Peru’s Blue-and-yellow Tanager (Pipraeidea bonariensis darwinii). We categorized seven molt cycle–based age groups in 75 wild-captured birds and thirteen molt cycle–based age categories across 167 museum specimens. Our results confirm the existence of limited to partial prealternate molts in Blue-and-yellow Tanager and demonstrate the importance of investigating the presence of these types of molts in wild bird populations.

Monitoring of airborne pollen concentrations provides an important source of information for the globally increasing number of hay fever patients. Airborne pollen is traditionally counted under the microscope, but with the latest developments in image recognition methods, automating this process has become feasible. A challenge that persists, however, is that many pollen grains cannot be distinguished beyond the genus or family level using a microscope. Here, we assess the use of Convolutional Neural Networks (CNNs) to increase taxonomic accuracy for airborne pollen. As a case study we use the nettle family (Urticaceae), which contains two main genera (Urtica and Parietaria) common in European landscapes which pollen cannot be separated by trained specialists. While pollen from Urtica species has very low allergenic relevance, pollen from several species of Parietaria is severely allergenic. We collect pollen from both fresh as well as from herbarium specimens and use these without the often used acetolysis step to train the CNN model. The models show that unacetolyzed Urticaceae pollen grains can be distinguished with > 98% accuracy. We then apply our model on before unseen Urticaceae pollen collected from aerobiological samples and show that the genera can be confidently distinguished, despite the more challenging input images that are often overlain by debris. Our method can also be applied to other pollen families in the future and will thus help to make allergenic pollen monitoring more specific.

Background Premenstrual dysphoric disorder (PMDD) is an understudied, debilitating disorder of women. Given evidence for prefrontal cortical and limbic dysfunction in PMDD, we compared intrinsic connectivity of the executive control network (ECN), default mode network (DMN), and amygdala in women with PMDD vs. controls. Methods Thirty-six women (18 PMDD, 18 control) participated in fMRI during the follicular and luteal phases of the menstrual cycle. At each time, resting-state functional connectivity was evaluated both before and after participants performed an emotion regulation task. The ECN was identified using independent components analysis, and connectivity of left and right amygdala seeds was also evaluated. Results Nonparametric permutation testing identified a cluster in the left middle temporal gyrus (MTG) with significantly stronger connectivity to the left ECN in women with PMDD vs. controls in all four fMRI sessions. Women with PMDD exhibited no difference in functional connectivity between menstrual cycle phases. Amygdala connectivity did not differ between the groups but differed significantly with menstrual phase, with left amygdala connectivity to cingulate cortex being significantly stronger during the follicular vs. luteal phase. Right amygdala connectivity to the middle frontal gyrus was also stronger during the follicular vs. luteal phase, with no group differences. These findings suggest that women with PMDD have different intrinsic network dynamics in the left executive control network compared to healthy controls.

De aanleiding voor ons bezoek was het landelijke project terugdringen van dwang en drang, waar Emergis aan deelneemt. Een belangrijk onderdeel daarvan wordt bij ons gevormd door deelprojecten, die door GGZ-verpleegkundig specialisten worden begeleid. De deelprojecten hebben als thema’s: signaleringsplannen, familie betrekken, ervaringsverhalen, spiegelgesprekken en non-specifieke factoren. Op zeven pilotafdelingen (waar de meeste dwangen drangsituaties voorkomen) worden die thema’s afgestemd op de specifieke situatie.

The present study determines lead content in onion root tip cells (Allium cepa L.), correlating it with its toxicity. The treatment was carried at 25 +/- 0.5 degrees C using aqueous solutions of lead chloride at 0.1, 0.25, 0.50, 0.75, and 1 ppm for 12, 24, 48, and 72 h. For each treatment, a control where the lead solution was substituted by distilled water was included. After treatment, the meristems were fixed with a mixture of alcohol-acetic acid (3:1) and colored according to the technique of Feulgen. Lead content was quantified by graphite furnace absorption atomic spectrometry. The lead content in the roots ranged from 3.25 to 244.72 microg/g dry weight, with a direct relation with the concentration and time of exposure. A significant negative correlation was presented (r = -0.3629; p < 0.01) among lead content and root growth increment, and a positive correlation (r = 0.7750; p < 0.01) with the induction of chromosomic aberrations. In conclusion, lead is able to induce a toxic effect in the exposed roots, correlated with its content.

Quantification of airborne pollen is an important tool in scientific research and patient care in allergy. The currently available method relies on microscopic examination of pollen slides, performed by qualified researchers. Although highly reliable, the method is labor intensive and requires extensive training of the researchers involved. In an approach to develop alternative detection methods, we performed a feasibility study on the automated recognition of the allergenic relevant pollen, grass, birch, and mugwort, by utilizing digital image analysis and pattern recognition tools. Of a total of 254 pollen samples (including 79 of grass, 79 of birch and 96 of mugwort), 97.2% were recognized correctly. This encouraging result provides a promising prospect for future developments.

NVVA-guidelines ensure and improve the quality of medical science in nursing homes. This article describes the process that is used to develop these guidelines. Medical issues are suitable for NVVA-guidelines when they occur frequently in the nursing home practice and when sufficient scientific literature is available. This scientific information is gathered and selected by a group of nursing home physicians and other professionals. The actual composition of the group depends on the subject of the guideline. The obtained information is translated into several advises for daily practice. If the guidelines meet specific quality criteria and when a second opinion by other community members has been exerted, implementation of the guidelines will follow. The whole process takes about 2 years. Subsequently the guidelines need to be evaluated and adjusted to new insights on a regular basis. It is necessary to use the NVVA-guidelines in daily practice, since they stimulate evidence-based medicine in nursing homes. NVVA-richtlijnen zijn professionele standaarden die de kwaliteit van de verpleeghuisgeneeskunde in de praktijk moeten waarborgen en verbeteren. In dit tweede artikel over richtlijnontwikkeling zal worden ingegaan op de totstandkoming van een NVVA-richtlijn.NVVA-richtlijnen handelen over verpleeghuisgeneeskundige onderwerpen die vaak voorkomen en waarvan voldoende wetenschappelijk onderzoek beschikbaar is. Bij het samenstellen van een richtlijn wordt wetenschappelijke informatie in kaart gebracht en vertaald naar aanbevelingen voor de praktijk. De richtlijnwerkgroepen die deze taak verrichten bestaan uit vertegenwoordigers uit de betrokken disciplines met affiniteit voor het onderwerp. Een richtlijn wordt pas geimplementeerd wanneer het aan specifieke kwaliteitseisen voldoet en is beoordeeld door werkveld en specialisten. In totaal duurt het ontwikkelen van een richtlijn ongeveer 2 jaar, waarna ze regelmatig geevalueerd en aangepast dienen te worden. Omdat richtlijnen het evidence-based handelen van de verpleeghuisarts stimuleren, verdienen ze uw aandacht.

Guidelines are important in the policy of quality in health care. Since some decades scientific societies of family physicians, nursing home physicians and medical specialists are engaged in developing guidelines. At first development of guidelines was consensus-based and has been more and more evidence-based after the foundation of the Cochrane Collaboration. Patients and their representatives participate increasingly in development of guidelines. For appropriate use of guidelines in daily practice it is important to take into account expectable problems with implementation. Guidelines aren't strict dictates but they have juridical significance.

Wild rabbit (Oryctolagus cuniculus) restocking is a common practice in management in France. However rabbits generally experience heavy mortality after release, which jeopardizes restocking efficiency. Release success is full only when introduced individuals produce offspring.

The bioluminescently marked Pseudomonas fluorescens strain 5RL, has been used previously to follow colonisation of soy bean roots (De Weger et al. [1991] Appl. Environ. Microbiol. 57:36-41). In the present paper the method has been further developed and optimized for wheat roots and it is used to get a quick overview of the colonisation patterns of many different root systems at the same time. Colonisation was followed on wheat plants grown in our gnotobiotic sand system (Simons et al., 1996. Mol Plant Microbe Interact 9: 600–607) and the following results were obtained. (i) A spatio-temporal analysis of the colonisation of wheat roots showed that 4 days after planting the highest bacterial activity was observed at the upper part of the root. After 6 days the high bacterial activity at the upper part was further increased, whereas spot-like activities were observed on the lower root parts, possibly due to micro-colonies. (ii) Bacterial mutations causing lack of motility or auxotrophy for amino acids resulted in impaired colonisation of the lower root parts, indicating that motility and prototrophy for the involved amino acid(s) are important factors for wheat root colonisation by strain 5RL. (iii) Coinoculation of strain 5RL with other wild type Pseudomonas strains on the root influenced the colonisation pattern observed for strain 5RL. Colonisation was not visually affected when the competing strain was a poor root coloniser, but was severely reduced when the competing strain was a good root coloniser. The results show that the spatio-temporal colonisation of wheat root by P. fluorescens strain 5RL and derivatives is similar to that of strain WCS365 on tomato. The advantage of the use of lux-marked strains is that the results are obtained much quicker than when conventional methods are used and that the result is supplied as an image of the colonisation pattern of many different roots.