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The development of endometrial cancer is related to the status of the intracellular proteasome system. Total proteasome activity and pools 26S and 20S activities are higher in tumor tissue than in intact endometrium, and their composition is different. The expression of α1α2α3α5α6α7 is lower in endometrial cancer tissue in comparison with intact endometrium and the content of immune subunits LMP7, LMP2, and PA28β is increased. Total proteasome activity depends on the disease stage.

The effect of the methods for hardening-finish treatment on the structure, phase composition, surface layer parameters, and fatigue resistance of blades for stage III of a low-pressure compressor is considered.

Problems of alloying of high-temperature nickel alloys resistant to high-temperature corrosion in combustion products of low-grade fuel are considered. The relationship between the structure and properties of alloys and the alloying set that provides high service characteristics is studied. The obtained dependences are used to create new alloys resistant to high-temperature corrosion. Their structure and properties are described.

The authors examine the results of experimental investigation of local and average heat transfer over a flat plate, with the entire plate heated, and with the initial section heated, in the Reynolds number range 2 · 102 to 5 · 105.

Relations are given for calculating the local heat transfer in the dynamic initial section of a longitudinally washed generator of a one-sided wedge for the case of constant wall temperature and turbulent boundary layer.

The three-dimensional heat-conduction problem is solved for a multilayer domain with a local source in one of the layers. The numerical results of the solution are analyzed in application to the layered structure of a semiconductor integrated circuit.

Experimental data [i] on heat transfer on a heat plate with longitudinal flow of air show evidence of the existence of an unstable regime in the region RexI < I00,000, in which the distribution of local heattransfer coefficients along the surface has quite a complex, and at first sight a random, nature. Since the experiment in [I] was performed on a relatively short plate, the variation in the heat-transfer law for Rex1 < i00,000 could be a consequence of two quite different phenonema. There is no doubt that the nature of the heat transfer in the entrance section is dictated to some extent by the shape of the entrance, even if the boundary layer is assumed to be turbulent everywhere. However, under conditions of developed turbulent motion of an air stream, near the leading edge of the plate a laminar boundary layer can exist, which is unstable at the stagnation point, and later undergoes transition to a turbulent boundary layer [2]. Unfortunately, the results given in [i] do not afford a sufficiently clear answer to the question as to which of the above factors plays the dominant part in generating the transition.