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Your search keyword '"3'-fluorothymidine"' showing total 2 results
Start Over Descriptor "3'-fluorothymidine" Publisher springer science and business media llc
2 results on '"3'-fluorothymidine"'

1. Evaluation of the radiochemical impurities arising during the competitive fluorination of nosyl group during the synthesis of 3′-deoxy-3′-fluorothymidine, [18F]FLT

Author

M. G. R. Rajan, N. V. Krishnamurthy, and S. K. Nandy

Subjects
Hplc analysis, Chemistry, Health, Toxicology and Mutagenesis, Radiochemistry, Public Health, Environmental and Occupational Health, Pollution, High-performance liquid chromatography, Chloride, Analytical Chemistry, 3'-fluorothymidine, Nuclear Energy and Engineering, Impurity, medicine, Organic chemistry, Radiology, Nuclear Medicine and imaging, Mass spectrum analysis, Spectroscopy, medicine.drug
Abstract

The study is aimed at the analysis and identification of radiochemical and chemical impurities present in [18F]FLT synthesized by a simplified combination-column purification procedure, instead of the currently used HPLC purification. HPLC analysis of the final product showed an anionic radioactive byproduct, which was established as [18F]4-FBSA. The identity of the product was also confirmed by the radiofluorination of nosyl chloride. Mass spectrum analysis of both a decayed sample of [18F]FLT and fluorinated nosyl chloride showed a major peak at 242. We have also investigated the possible interference of this byproduct during PET-imaging in rabbits.

Published
2009
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2. Letter to the Editor re: Positron Emission Tomography with [18F]-3′-Deoxy-3′fluorothymidine (FLT) as a Predictor of Outcome in Patients with Locally Advanced Resectable Rectal Cancer: a Pilot Study

Author

G. Mikhaeel, Anastasia Chalkidou, Michael O'Doherty, and Paul Marsden

Subjects
Male, Cancer Research, medicine.medical_specialty, Letter to the editor, medicine.diagnostic_test, Rectal Neoplasms, Colorectal cancer, business.industry, Locally advanced, medicine.disease, Dideoxynucleosides, Surgery, 3'-fluorothymidine, Oncology, Positron emission tomography, Positron-Emission Tomography, medicine, Humans, Female, Radiology, Nuclear Medicine and imaging, In patient, Radiology, business
Published
2013
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