11 results
Search Results
2. The association between objective vision impairment and mild cognitive impairment among older adults in low- and middle-income countries
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Hans Oh, Ai Koyanagi, Guillermo F. López-Sánchez, Jae Il Shin, Yvonne Barnett, Lee Smith, Pinar Soysal, Louis Jacob, Laurie T. Butler, Nicola Veronese, Shahina Pardhan, Université de Versailles Saint-Quentin-en-Yvelines - UFR Sciences de la santé Simone Veil (UVSQ Santé), Université de Versailles Saint-Quentin-en-Yvelines (UVSQ), National Institute on Aging, NIA: 08-CN-0020, OGHA 04034785, R01-AG034479, R21-AG034263, Y1-AG-1005, YA1323, This paper uses data from WHO?s Study on Global Ageing and Adult Health (SAGE). SAGE is supported by the U.S. National Institute on Aging through Interagency Agreements OGHA 04034785, YA1323?08-CN-0020, Y1-AG-1005?01 and through research grants R01-AG034479 and R21-AG034263., Smith, L., Shin, J.I., Jacob, L., López-Sánchez, G.F., Oh, H., Barnett, Y., Pardhan, S., Butler, L., Soysal, P., Veronese, N., Koyanagi, A., and SOYSAL, PINAR
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Male ,Gerontology ,China ,Aging ,medicine.medical_specialty ,Visual acuity ,genetic structures ,Epidemiology ,[SDV]Life Sciences [q-bio] ,Visual impairment ,Vision impairment ,Logistic regression ,Odds ,03 medical and health sciences ,0302 clinical medicine ,Prevalence ,Humans ,Medicine ,Dementia ,Cognitive Dysfunction ,030212 general & internal medicine ,Association (psychology) ,Developing Countries ,Aged ,Low- and middle-income countries ,business.industry ,Mild cognitive impairment ,medicine.disease ,eye diseases ,Smith L., Shin J. I. , Jacob L., López-Sánchez G. F. , Oh H., Barnett Y., Pardhan S., Butler L., Soysal P., Veronese N., et al., -The association between objective vision impairment and mild cognitive impairment among older adults in low- and middle-income countries.-, Aging clinical and experimental research, 2021 ,Vision impairment, Mild cognitive impairment, Older adults, Low- and middle-income countries, Epidemiology ,Cross-Sectional Studies ,Ageing ,Older adults ,Female ,Geriatrics and Gerontology ,medicine.symptom ,business ,030217 neurology & neurosurgery - Abstract
Aim: The association between visual impairment and mild cognitive impairment (MCI) has not been investigated to date. Thus, we assessed this association among older adults from six low- and middle-income countries (LMICs) (China, India, Ghana, Mexico, Russia, and South Africa) using nationally representative datasets. Methods: Cross-sectional, community-based data from the WHO Study on global AGEing and adult health (SAGE) were analyzed. Visual acuity was measured using the tumbling ElogMAR chart, and vision impairment (at distance and near) was defined as visual acuity worse than 6/18 (0.48 logMAR) in the better-seeing eye. The definition of MCI was based on the National Institute on Aging-Alzheimer’s Association criteria. Multivariable logistic regression was conducted. Results: Data on 32,715 individuals aged ≥ 50years [mean (SD) age 62.1 (15.6) years; 51.2% females] were analyzed. Compared to those without far or near vision impairment, those with near vision impairment but not far vision impairment (OR = 1.33; 95% CI = 1.16–1.52), and those with both far and near vision impairment (OR = 1.70; 95% CI = 1.27–2.29) had significantly higher odds for MCI. Only having far vision impairment was not significantly associated with MCI. Conclusions: Visual impairment is associated with increased odds for MCI among older adults in LMICs with the exception of far vision impairment only. Future longitudinal and intervention studies should examine causality and whether improvements in visual acuity, or early intervention, can reduce risk for MCI and ultimately, dementia. © 2021, The Author(s), under exclusive licence to Springer Nature Switzerland AG part of Springer Nature.
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- 2021
3. Single-molecule localization microscopy
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Markus Sauer, Florian Schueder, Melike Lakadamyali, Gerti Beliu, Melina Theoni Gyparaki, Suliana Manley, Ralf Jungmann, Juliette Griffié, Mickaël Lelek, Christophe Zimmer, Imagerie et Modélisation - Imaging and Modeling, Institut Pasteur [Paris] (IP)-Centre National de la Recherche Scientifique (CNRS), University of Pennsylvania, University of Würzburg = Universität Würzburg, Ludwig Maximilian University [Munich] (LMU), Max-Planck-Institut für Biochemie = Max Planck Institute of Biochemistry (MPIB), Max-Planck-Gesellschaft, Ecole Polytechnique Fédérale de Lausanne (EPFL), Institut Pasteur [Paris] (IP)-Centre National de la Recherche Scientifique (CNRS)-Université Paris Cité (UPCité), C.Z. acknowledges funding by Institut Pasteur, Fondation pour la Recherche Médicale (grant DEQ 20150331762), Région Ile de France, Agence Nationale de la Recherche and Investissement d’Avenir grant ANR-16-CONV-0005. M.La. acknowledges funding from the National Institutes of Health/National Institutes of General Medical Sciences (NIH/NIGMS) under grant RO1 GM133842-01. G.B. and M.S. acknowledge funding by the German Research Foundation (DFG) (SA829/19-1) and the European Regional Development Fund (EFRE project ‘Center for Personalized Molecular Immunotherapy’). F.S. and R.J. acknowledge support by the DFG through SFB1032 (project A11) and the Max Planck Society. J.G. and S.M. acknowledge funding by the European Union’s H2020 programme under the Marie Skłodowska-Curie grant BALTIC (to J.G.) and ERC Piko (to S.M.)., The authors apologize to the authors of numerous papers that could not be cited owing to limited space. M.Le. and C.Z. thank B. Lelandais for excellent comments on the manuscript and M. Singh for acquiring the image shown in Fig. 3b., ANR-16-CONV-0005,INCEPTION,Institut Convergences pour l'étude de l'Emergence des Pathologies au Travers des Individus et des populatiONs(2016), Institut Pasteur [Paris]-Centre National de la Recherche Scientifique (CNRS), University of Pennsylvania [Philadelphia], Max Planck Institute of Biochemistry (MPIB), and Institut Pasteur [Paris]-Centre National de la Recherche Scientifique (CNRS)-Université Paris Cité (UPC)
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Single molecule localization ,light-microscopy ,Computer science ,business.industry ,General Medicine ,Article ,General Biochemistry, Genetics and Molecular Biology ,optical reconstruction microscopy ,diffraction-limit ,Fluorescent labelling ,3-dimensional superresolution ,live-cell ,correlative superresolution fluorescence ,Microscopy ,Time course ,Image acquisition ,colocalization analysis ,[SDV.SPEE]Life Sciences [q-bio]/Santé publique et épidémiologie ,Computer vision ,Artificial intelligence ,business ,living cells ,intramolecular spirocyclization ,Image resolution ,electron-microscopy - Abstract
Single-molecule localization microscopy (SMLM) describes a family of powerful imaging techniques that dramatically improve spatial resolution over standard, diffraction-limited microscopy techniques and can image biological structures at the molecular scale. In SMLM, individual fluorescent molecules are computationally localized from diffraction-limited image sequences and the localizations are used to generate a super-resolution image or a time course of super-resolution images, or to define molecular trajectories. In this Primer, we introduce the basic principles of SMLM techniques before describing the main experimental considerations when performing SMLM, including fluorescent labelling, sample preparation, hardware requirements and image acquisition in fixed and live cells. We then explain how low-resolution image sequences are computationally processed to reconstruct super-resolution images and/or extract quantitative information, and highlight a selection of biological discoveries enabled by SMLM and closely related methods. We discuss some of the main limitations and potential artefacts of SMLM, as well as ways to alleviate them. Finally, we present an outlook on advanced techniques and promising new developments in the fast-evolving field of SMLM. We hope that this Primer will be a useful reference for both newcomers and practitioners of SMLM. This Primer explains the central concepts of single-molecule localization microscopy (SMLM) before discussing experimental considerations regarding fluorophores, optics and data acquisition, processing and analysis. The Primer further describes recent high-impact discoveries made by SMLM techniques and concludes by discussing emerging methodologies.
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- 2021
4. Accounting for competition in multi-environment tree genetic evaluations: a case study with hybrid pines
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Nuno Borralho, Eduardo P. Cappa, Ector Belaber, Maria Elena Gauchat, Cristian Damián Schoffen, Facundo Muñoz, Leopoldo Sanchez, Instituto Nacional de Tecnología Agropecuaria (INTA), Consejo Nacional de Investigaciones Científicas y Técnicas [Buenos Aires] (CONICET), Animal, Santé, Territoires, Risques et Ecosystèmes (UMR ASTRE), Centre de Coopération Internationale en Recherche Agronomique pour le Développement (Cirad)-Institut National de Recherche pour l’Agriculture, l’Alimentation et l’Environnement (INRAE), Département Systèmes Biologiques (Cirad-BIOS), Centre de Coopération Internationale en Recherche Agronomique pour le Développement (Cirad), RAIZ – Forestry & Paper Research Institut, Instituto Superior Técnico, Universidade Técnica de Lisboa, Biologie intégrée pour la valorisation de la diversité des Arbres et de la Forêt (BioForA), Office National des Forêts (ONF)-Institut National de Recherche pour l’Agriculture, l’Alimentation et l’Environnement (INRAE), and This study was funded by the National Institute of Agricultural Technology (INTA) (grant numbers PNFOR-01104062, MSNES-1242204/5). E.P.C.’s research was partially supported by the National Agency for the Promotion of Science and Technology of Argentina (ANPCYT, PICT-2016 1048). F.M.’s research is partially supported by research grant MTM2016-77501-P from the State Research Agency of the Spanish Ministry of Science, Innovation and Universities jointly with the European Regional Development Fund, FEDER.
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Additive and competition genotype–environment interaction ,0106 biological sciences ,Mixed model ,[SDV]Life Sciences [q-bio] ,media_common.quotation_subject ,Accounting ,Tree breeding ,010603 evolutionary biology ,01 natural sciences ,Genetic correlation ,Competition (biology) ,Competition model ,Genetic variation ,Gene–environment interaction ,media_common ,Mathematics ,[SDV.EE]Life Sciences [q-bio]/Ecology, environment ,Ecology ,business.industry ,Diameter at breast height ,Forestry ,15. Life on land ,Total heritable variance ,[SDE.BE]Environmental Sciences/Biodiversity and Ecology ,business ,010606 plant biology & botany - Abstract
International audience; Key message: A novel multi-environment competition individual-tree mixed model resulted in better fit, and greater individual narrow- and broad-sense heritabilities than the model without competition, notably for traits showing competition. In multi-environment tests, the proposed model would allow tree breeders to select genotypes with the best performance in both additive direct and competition breeding values, increasing forest productivity. Context: Genetic merit of trees is known to be affected and interact with local competition effects as well as changes across environmental conditions. Recent studies showed that competition genetic effects can affect the genetic variance and bias the tree breeding values, and its covariance with direct breeding values has been variable across traits. Aims: The present paper extends a mixed-model methodology to the problem of accounting for competition in a multi-environment set of forest genetic trials and exploring its impact on genetic variances as well as the multi-environment genetic correlation. Methods: The proposed model is illustrated using data from two full-sib trials of Pinus elliottii var. elliottii × Pinus caribaea var. hondurensis F1. Dispersion parameters and (co)variance of total breeding values were estimated for diameter at breast height, total tree height, and stem straightness at age 10. Results: For traits showing competition effects (diameter at breast height and total tree height), the proposed multi-environment competition model gave better fit than the simpler model. Accounting for competition increased the direct additive variance, reduced the residual variances, and did not change significantly the across-site additive genetic correlation. However, for diameter at breast height, top 5% best genetic rankings showed differences. Conclusion: When traits are strongly affected by inter-tree competition, the use of the proposed model in multi-environment analyses can efficiently identify the phenomenon with general benefits in the fitting of genetic components and open the door to select on the basis of competitiveness.
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- 2021
5. Combining probability with qualitative degree-of-certainty metrics in assessment
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Richard Bradley, Brian Hill, Casey Helgeson, Groupement de Recherche et d'Etudes en Gestion à HEC (GREGH), Ecole des Hautes Etudes Commerciales (HEC Paris)-Centre National de la Recherche Scientifique (CNRS), Centre National de la Recherche Scientifique (CNRS), HEC Paris - Recherche - Hors Laboratoire, Ecole des Hautes Etudes Commerciales (HEC Paris), Department of Archaeology, University of Reading (UOR), HEC Research Paper Series, and Hill, Brian
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Atmospheric Science ,010504 meteorology & atmospheric sciences ,Operations research ,Computer science ,[SDE.MCG]Environmental Sciences/Global Changes ,media_common.quotation_subject ,Climate change ,B Philosophy (General) ,050905 science studies ,01 natural sciences ,[SHS.PHIL] Humanities and Social Sciences/Philosophy ,Consistency (database systems) ,Degree of certainty ,[SHS.ECO] Humanities and Social Sciences/Economics and Finance ,0105 earth and related environmental sciences ,media_common ,Global and Planetary Change ,business.industry ,05 social sciences ,[SHS.PHIL]Humanities and Social Sciences/Philosophy ,Usability ,Ambiguity ,Certainty ,[SHS.ECO]Humanities and Social Sciences/Economics and Finance ,[SDE.MCG] Environmental Sciences/Global Changes ,climate change ,uncertainty reporting ,[SHS.GESTION]Humanities and Social Sciences/Business administration ,confidence ,0509 other social sciences ,business ,GE Environmental Sciences ,Decision analysis - Abstract
International audience; Reports of the Intergovernmental Panel on Climate Change (IPCC) employ an evolving framework of calibrated language for assessing and communicating degrees of certainty in findings. A persistent challenge for this framework has been ambiguity in the relationship between multiple degree-of-certainty metrics. We aim to clarify the relationship between the likelihood and confidence metrics used in the Fifth Assessment Report (2013), with benefits for mathematical consistency among multiple findings and for usability in downstream modeling and decision analysis. We discuss how our proposal meshes with current and proposed practice in IPCC uncertainty assessment.
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- 2018
6. Energy-efficient joint video encoding and transmission framework for WVSN
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Youssef Fakhri, Patrick Corlay, Driss Aboutajdine, François-Xavier Coudoux, Othmane Alaoui-Fdili, Institut d’Électronique, de Microélectronique et de Nanotechnologie - UMR 8520 (IEMN), Centrale Lille-Institut supérieur de l'électronique et du numérique (ISEN)-Université de Valenciennes et du Hainaut-Cambrésis (UVHC)-Université de Lille-Centre National de la Recherche Scientifique (CNRS)-Université Polytechnique Hauts-de-France (UPHF), Laboratoire de Recherche en Informatique et Télécommunications [Rabat] (GSCM-LRIT), University of Mohammed V, COMmunications NUMériques - IEMN (COMNUM - IEMN), Institut d’Électronique, de Microélectronique et de Nanotechnologie - Département Opto-Acousto-Électronique - UMR 8520 (IEMN-DOAE), Centrale Lille-Institut supérieur de l'électronique et du numérique (ISEN)-Université de Valenciennes et du Hainaut-Cambrésis (UVHC)-Université de Lille-Centre National de la Recherche Scientifique (CNRS)-Université Polytechnique Hauts-de-France (UPHF)-Centrale Lille-Institut supérieur de l'électronique et du numérique (ISEN)-Université de Valenciennes et du Hainaut-Cambrésis (UVHC)-Université de Lille-Centre National de la Recherche Scientifique (CNRS)-Université Polytechnique Hauts-de-France (UPHF)-INSA Institut National des Sciences Appliquées Hauts-de-France (INSA Hauts-De-France)-Institut d’Électronique, de Microélectronique et de Nanotechnologie - UMR 8520 (IEMN), Centrale Lille-Institut supérieur de l'électronique et du numérique (ISEN)-Université de Valenciennes et du Hainaut-Cambrésis (UVHC)-Université de Lille-Centre National de la Recherche Scientifique (CNRS)-Université Polytechnique Hauts-de-France (UPHF)-Centrale Lille-Institut supérieur de l'électronique et du numérique (ISEN)-Université de Valenciennes et du Hainaut-Cambrésis (UVHC)-Université de Lille-Centre National de la Recherche Scientifique (CNRS)-Université Polytechnique Hauts-de-France (UPHF)-INSA Institut National des Sciences Appliquées Hauts-de-France (INSA Hauts-De-France), Faculté des Sciences [Kenitra], Université Ibn Tofaïl (UIT), Université Mohammed V de Rabat [Agdal] (UM5), Centrale Lille-Institut supérieur de l'électronique et du numérique (ISEN)-Université de Valenciennes et du Hainaut-Cambrésis (UVHC)-Université de Lille-Centre National de la Recherche Scientifique (CNRS)-Université Polytechnique Hauts-de-France (UPHF)-Centrale Lille-Institut supérieur de l'électronique et du numérique (ISEN)-Université de Valenciennes et du Hainaut-Cambrésis (UVHC)-Université de Lille-Centre National de la Recherche Scientifique (CNRS)-Université Polytechnique Hauts-de-France (UPHF), Centrale Lille-Institut supérieur de l'électronique et du numérique (ISEN)-Université de Valenciennes et du Hainaut-Cambrésis (UVHC)-Université de Lille-Centre National de la Recherche Scientifique (CNRS)-Université Polytechnique Hauts-de-France (UPHF)-Centrale Lille-Institut supérieur de l'électronique et du numérique (ISEN)-Université de Valenciennes et du Hainaut-Cambrésis (UVHC)-Université de Lille-Centre National de la Recherche Scientifique (CNRS)-Université Polytechnique Hauts-de-France (UPHF)-Institut d’Électronique, de Microélectronique et de Nanotechnologie - UMR 8520 (IEMN), and Acknowledgements This research was supported by the excellence fellowships program of the National Center for Scientific and Technical Research (CNRST) of Morocco (G01/003) and the Franco-Moroccan cooperation program in STICs for the research project 'RECIF'. The authors would also like to thank the editorial office Christian Malan, the editor-in-chief, the guest editors as well as the anonymous reviewers for their efforts and valuable comments and suggestions that have led to improvements in this paper.
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Computer Networks and Communications ,Computer science ,Real-time computing ,02 engineering and technology ,Video quality ,[INFO.INFO-AI]Computer Science [cs]/Artificial Intelligence [cs.AI] ,[INFO.INFO-NI]Computer Science [cs]/Networking and Internet Architecture [cs.NI] ,[SPI]Engineering Sciences [physics] ,Packet loss ,Video encoding ,Region of interest ,0202 electrical engineering, electronic engineering, information engineering ,Media Technology ,[INFO]Computer Science [cs] ,Block-matching algorithm ,"Energy-efficiency in WVSN" ,business.industry ,020206 networking & telecommunications ,Scalable Video Coding ,[SPI.TRON]Engineering Sciences [physics]/Electronics ,"Video distortion prediction" ,Rate–distortion optimization ,Transmission (telecommunications) ,Hardware and Architecture ,"Cross-layer design" ,020201 artificial intelligence & image processing ,"Energy consumption prediction" ,business ,[SPI.SIGNAL]Engineering Sciences [physics]/Signal and Image processing ,Wireless sensor network ,Encoder ,"Energy-efficient reliable routing" ,Software ,Computer network - Abstract
JIF=2.101; International audience; In this paper, we propose an energy-efficient joint video encoding and transmission framework for network lifetime extension, under an end-to-end video quality constraint in the Wireless Video Sensor Networks (WVSN). This framework integrates an energy-efficient and adaptive intra-only video encoding scheme based on the H.264/AVC standard, that outputs two service differentiated macroblocks categories, namely the Region Of Interest and the Background. Empirical models describing the physical behavior of the measured energies and distortions, during the video encoding and transmission phases, are derived. These models enable the video source node to dynamically adapt its video encoder's configuration in order to meet the desired quality, while extending the network lifetime. An energy-efficient and reliable multipath multi-priority routing protocol is proposed to route the encoded streams to the sink, while considering the remaining energy, the congestion level as well as the packet loss rates of the intermediate nodes. Moreover, this protocol interacts with the application layer in order to bypass congestion situations and continuously feed it with current statistics. Through extensive numerical simulations, we demonstrate that the proposed framework does not only extend the video sensor lifetime by 54%, but it also performs significant end-to-end video quality enhancement of 35% in terms of Mean Squared Error (MSE) measurement.
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- 2017
7. Randomised, double-blind, placebo-controlled clinical trial for evaluating the efficacy of intracoronary injection of autologous bone marrow mononuclear cells in the improvement of the ventricular function in patients with idiopathic dilated myocardiopathy: a study protocol
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Miguel Romero, José Suárez-de-Lezo, Concha Herrera, Manuel Pan, José López-Aguilera, Flor Baeza-Garzón, Francisco Javier Hidalgo-Lesmes, Olga Fernández-López, Juliana Martínez-Atienza, Eva Cebrián, Vanesa Martín-Palanco, Rosario Jiménez-Moreno, Rosario Gutiérrez-Fernández, Sonia Nogueras, Maria Dolores Carmona, Soledad Ojeda, Natividad Cuende, Rosario Mata, [Romero,M, Suárez-de-Lezo, Pan,M, López-Aguilera,J, Suárez-de-Lezo Jr,J, Baeza-Garzón,F, Hidalgo-Lesmes,FJ, Cebrián,E, Ojeda,S] Cardiology Unit, Reina Sofía University Hospital, Córdoba, Spain. [Herrera,C, Martín-Palanco,V, Jiménez-Moreno,R, Gutiérrez-Fernández,R, Nogueras,S, Carmona,MD] Cell Production Unit, Reina Sofía University Hospital, Córdoba, Spain. [Fernández-López,O, Martínez-Atienza,J, Cuende,N, Mata,R] Andalusian Initiative for Advanced Therapies, Andalusian Public Foundation Progress and Health, Seville, Spain., and This paper presents an investigator-driven Clinical trial partially funded by research grant provided by the Regional Ministry of Health of Andalusia (Grant Reference Number salud-201600073587-tra).
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Male ,lcsh:Diseases of the circulatory (Cardiovascular) system ,Time Factors ,Ensayo clínico controlado aleatorio ,030204 cardiovascular system & hematology ,Cell therapy ,Ventricular Function, Left ,law.invention ,Organisms::Eukaryota::Animals::Chordata::Vertebrates::Mammals::Primates::Haplorhini::Catarrhini::Hominidae::Humans [Medical Subject Headings] ,Study Protocol ,Cardiomiopatía dilatada ,0302 clinical medicine ,Randomized controlled trial ,law ,Dilated myocardiopathy ,Multicenter Studies as Topic ,030212 general & internal medicine ,Myocardial infarction ,Diseases::Cardiovascular Diseases::Heart Diseases::Cardiomyopathies::Cardiomyopathy, Dilated [Medical Subject Headings] ,Bone Marrow Transplantation ,Randomized Controlled Trials as Topic ,Analytical, Diagnostic and Therapeutic Techniques and Equipment::Investigative Techniques::Evaluation Studies as Topic::Clinical Trials as Topic::Controlled Clinical Trials as Topic::Randomized Controlled Trials as Topic [Medical Subject Headings] ,Diseases::Cardiovascular Diseases::Vascular Diseases::Myocardial Ischemia::Myocardial Infarction [Medical Subject Headings] ,Ejection fraction ,Middle Aged ,Treatment Outcome ,Disciplines and Occupations::Natural Science Disciplines::Science::Research::Biomedical Research [Medical Subject Headings] ,Female ,Cardiology and Cardiovascular Medicine ,Adult ,Cardiomyopathy, Dilated ,medicine.medical_specialty ,Information Science::Information Science::Communications Media::Publications [Medical Subject Headings] ,Adolescent ,Cell- and tissue-based therapy ,Células de la médula ósea ,Bone Marrow Cells ,Placebo ,Transplantation, Autologous ,Young Adult ,03 medical and health sciences ,Clinical Trials, Phase II as Topic ,Double-Blind Method ,Tratamiento basado en trasplante de células y tejidos ,Internal medicine ,medicine ,Humans ,Analytical, Diagnostic and Therapeutic Techniques and Equipment::Therapeutics::Biological Therapy::Cell- and Tissue-Based Therapy [Medical Subject Headings] ,Aged ,Angiology ,Anatomy::Cells::Bone Marrow Cells [Medical Subject Headings] ,business.industry ,Consolidated Standards of Reporting Trials ,Recovery of Function ,medicine.disease ,Interim analysis ,Clinical trial ,lcsh:RC666-701 ,Spain ,Bone marrow mononuclear cells ,business - Abstract
Cellular therapies have been increasingly applied to diverse human diseases. Intracoronary infusion of bone marrow-derived mononuclear cells (BMMNC) has demonstrated to improve ventricular function after acute myocardial infarction. However, less information is available about the role of BMMNC therapy for the treatment of dilated myocardiopathies (DCs) of non-ischemic origin. This article presents the methodological description of a study aimed at investigating the efficacy of intracoronary injection of autologous BMMNCs in the improvement of the ventricular function of patients with DC. This randomised, placebo-controlled, double-blinded phase IIb clinical trial compares the improvement on ventricular function (measured by the changes on the ejection fraction) of patients receiving the conventional treatment for DC in combination with a single dose of an intracoronary infusion of BMMNCs, with the functional recovery of patients receiving placebo plus conventional treatment. Patients assigned to both treatment groups are monitored for 24 months. This clinical trial is powered enough to detect a change in Left Ventricular Ejection Fraction (LVEF) equal to or greater than 9%, although an interim analysis is planned to re-calculate sample size. The study protocol was approved by the Andalusian Coordinating Ethics Committee for Biomedical Research (Comite Coordinador de Etica en Investigacion Biomedica de Andalucia), the Spanish Medicines and Medical Devices Agency (Agencia Espanola de Medicamentos y Productos Sanitarios), and is registered at the EU Clinical Trials Register (EudraCT: 2013–002015-98). The publication of the trial results in scientific journals will be performed in accordance with the applicable regulations and guidelines to clinical trials. ClinicalTrials.gov Identifier NCT02033278 (First Posted January 10, 2014): https://clinicaltrials.gov/ct2/show/NCT02033278 ; EudraCT number: 2013–002015-98, EU CT Register: https://www.clinicaltrialsregister.eu/ctr-search/search?query=2013-002015-98 . Trial results will also be published according to the CONSORT statement at conferences and reported peer-reviewed journals.
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- 2019
8. Films based on crosslinked TEMPO-oxidized cellulose and predictive analysis via machine learning
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Jouni Paltakari, Merve Özkan, Alp Karakoç, Orlando J. Rojas, Maryam Borghei, Paper Converting and Packaging, Department of Bioproducts and Biosystems, Aalto-yliopisto, and Aalto University
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Materials science ,Oxidized cellulose ,lcsh:Medicine ,02 engineering and technology ,010402 general chemistry ,Machine learning ,computer.software_genre ,01 natural sciences ,Polyvinyl alcohol ,Article ,chemistry.chemical_compound ,Transmittance ,Surface roughness ,Cellulose ,lcsh:Science ,Multidisciplinary ,business.industry ,lcsh:R ,021001 nanoscience & nanotechnology ,Flexible electronics ,0104 chemical sciences ,chemistry ,Nanofiber ,lcsh:Q ,Wetting ,Artificial intelligence ,0210 nano-technology ,business ,computer - Abstract
We systematically investigated the effect of film-forming polyvinyl alcohol and crosslinkers, glyoxal and ammonium zirconium carbonate, on the optical and surface properties of films produced from TEMPO-oxidized cellulose nanofibers (TOCNFs). In this regard, UV-light transmittance, surface roughness and wetting behavior of the films were assessed. Optimization was carried out as a function of film composition following the “random forest” machine learning algorithm for regression analysis. As a result, the design of tailor-made TOCNF-based films can be achieved with reduced experimental expenditure. We envision this approach to be useful in facilitating adoption of TOCNF for the design of emerging flexible electronics, and related platforms.
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- 2018
9. Forests and global change: what can genetics contribute to the major forest management and policy challenges of the twenty-first century?
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Arantxa Prada, Joan Cottrell, Santiago C. González-Martínez, Bart Muys, Lennart Ackzell, Ricardo Alía, Bruno Fady, Ecologie des Forêts Méditerranéennes (URFM), Institut National de Recherche pour l’Agriculture, l’Alimentation et l’Environnement (INRAE), Forest Research, Northern Research Station, The Roslin Institute, Biotechnology and Biological Sciences Research Council (BBSRC)-Biotechnology and Biological Sciences Research Council (BBSRC), Federation of Swedish Family Forest Owners, Partenaires INRAE, Centro de Investigacion Forestal (INIA-CIFOR), Instituto Nacional de Investigación y Tecnología Agraria y Alimentaria = National Institute for Agricultural and Food Research and Technology (INIA), European Forest Institute (EFI), Catholic University of Leuven - Katholieke Universiteit Leuven (KU Leuven), General Directorate for Environment, Centro de Tecnologías Físicas [Universitat Politècnica de València], Universitat Politècnica de València (UPV), This paper stems from the work of the stakeholder panel of the EU supported EraNet BiodivERsA project 'Linking genetic variability with ecological responses to environmental changes: forest trees as model systems (LinkTree)' whose financial help is acknowledged. BF wishes to thank the French 'Commission des ressources genetiques forestieres (http://agriculture.gouv.fr/conservation-des-ressources)' (CRGF) and EUFORGEN (http://www.euforgen.org/) for insightful discussions. SCG-M acknowledges receipt of a Senior Marie Curie Intra European Fellowship within the 7th European Community Framework Programme (PIEF-GA-2012-328146) at the Department of Ecology and Evolution, University of Lausanne, Switzerland, European Project: 328146,EC:FP7:PEOPLE,FP7-PEOPLE-2012-IEF,SEX-NGS(2013), Institut National de la Recherche Agronomique (INRA), Forest Research, Northern Research Station, European Forest Institute = Institut Européen de la Forêt = Euroopan metsäinstituutti (EFI), and Université Catholique de Louvain = Catholic University of Louvain (UCL)
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0106 biological sciences ,Environmental change ,[SDE.MCG]Environmental Sciences/Global Changes ,media_common.quotation_subject ,Forest management ,Climate change ,Context (language use) ,adaptation ,010603 evolutionary biology ,01 natural sciences ,Adaptability ,Ecosystem services ,assisted migration ,Resilience (network) ,media_common ,2. Zero hunger ,Genetics ,Global and Planetary Change ,business.industry ,Environmental resource management ,genetic diversity ,15. Life on land ,[SDE.ES]Environmental Sciences/Environmental and Society ,sustainable forestry ,climate change ,gene conservation ,13. Climate action ,Sustainability ,Business ,010606 plant biology & botany - Abstract
International audience; The conservation and sustainable use of forests in the twenty-first century pose huge challenges for forest management and policy. Society demands that forests provide a wide range of ecosystem services, from timber products, raw materials and renewable energy to sociocultural amenities and habitats for nature conservation. Innovative management and policy approaches need to be developed to meet these often-conflicting demands in a context of environmental change of uncertain magnitude and scale. Genetic diversity is a key component of resilience and adaptability. Overall, forest tree populations are genetically very diverse, conferring them an enormous potential for genetic adaptation via the processes of gene flow and natural selection. Here, we review the main challenges facing our forests in the coming century and focus on how recent progress in genetics can contribute to the development of appropriate practical actions that forest managers and policy makers can adopt to promote forest resilience to climate change. Emerging knowledge will inform and clarify current controversies relating to the choice of appropriate genetic resources for planting, the effect of silvicultural systems and stand tending on adaptive potential and the best ways to harness genetic diversity in breeding and conservation programs. Gaps in our knowledge remain, and we identify where additional information is needed (e.g., the adaptive value of peripheral populations or the genetic determinism of key adaptive traits) and the types of studies that are required to provide this key understanding.
- Published
- 2015
10. Natural Scales in Geographical Patterns
- Author
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Telmo Menezes, Camille Roth, Centre Marc Bloch (CMB), Ministère de l'Europe et des Affaires étrangères (MEAE)-Bundesministerium für Bildung und Forschung-Ministère de l'Education nationale, de l’Enseignement supérieur et de la Recherche (M.E.N.E.S.R.)-Centre National de la Recherche Scientifique (CNRS), Médialab (Sciences Po) (Médialab), Sciences Po (Sciences Po), Centre National de la Recherche Scientifique (CNRS), This paper has been partially supported by grants 'Phantomgrenzen' and 'Algodiv' (ANR-15-CE38-0001), funded respectively by the BMBF (German Federal Ministry for Education and Research) and by the ANR (French National Agency of Research)., and ANR-15-CE38-0001,ALGODIV,Algodiv: Recommandation algorithmique et diversité des informations du web(2015)
- Subjects
FOS: Computer and information sciences ,0301 basic medicine ,Physics - Physics and Society ,FOS: Physical sciences ,Distribution (economics) ,computer science ,Network science ,Physics and Society (physics.soc-ph) ,Space (commercial competition) ,human movement ,Article ,[INFO.INFO-SI]Computer Science [cs]/Social and Information Networks [cs.SI] ,Natural (archaeology) ,geographical networks ,03 medical and health sciences ,network science ,community detection ,applied mathematics ,91D20 ,91D30 ,Social and Information Networks (cs.SI) ,[SHS.STAT]Humanities and Social Sciences/Methods and statistics ,Multidisciplinary ,business.industry ,Orders of magnitude (acceleration) ,Computer Science - Social and Information Networks ,[SHS.GEO]Humanities and Social Sciences/Geography ,Partition (database) ,Discontinuity (linguistics) ,030104 developmental biology ,Geography ,business ,Scale (map) ,Cartography - Abstract
Human mobility is known to be distributed across several orders of magnitude of physical distances, which makes it generally difficult to endogenously find or define typical and meaningful scales. Relevant analyses, from movements to geographical partitions, seem to be relative to some ad-hoc scale, or no scale at all. Relying on geotagged data collected from photo-sharing social media, we apply community detection to movement networks constrained by increasing percentiles of the distance distribution. Using a simple parameter-free discontinuity detection algorithm, we discover clear phase transitions in the community partition space. The detection of these phases constitutes the first objective method of characterising endogenous, natural scales of human movement. Our study covers nine regions, ranging from cities to countries of various sizes and a transnational area. For all regions, the number of natural scales is remarkably low (2 or 3). Further, our results hint at scale-related behaviours rather than scale-related users. The partitions of the natural scales allow us to draw discrete multi-scale geographical boundaries, potentially capable of providing key insights in fields such as epidemiology or cultural contagion where the introduction of spatial boundaries is pivotal.
- Published
- 2017
11. Consistency of the French white certificates evaluation system with the framework proposed for the European energy services
- Author
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Luc Bodineau, Jérôme Adnot, Bernard Bourges, Jean-Sébastien Broc, Dominique Osso, Paul Baudry, Laboratoire de génie des procédés - environnement - agroalimentaire (GEPEA), Mines Nantes (Mines Nantes)-Université de Nantes - UFR des Sciences et des Techniques (UN UFR ST), Université de Nantes (UN)-Université de Nantes (UN)-Ecole Nationale Vétérinaire, Agroalimentaire et de l'alimentation Nantes-Atlantique (ONIRIS)-Centre National de la Recherche Scientifique (CNRS), Mines Nantes (Mines Nantes), EDF R&D (EDF R&D), EDF (EDF), CEP/Paris, Centre Énergétique et Procédés (CEP), MINES ParisTech - École nationale supérieure des mines de Paris, Université Paris sciences et lettres (PSL)-Université Paris sciences et lettres (PSL)-MINES ParisTech - École nationale supérieure des mines de Paris, Université Paris sciences et lettres (PSL)-Université Paris sciences et lettres (PSL), Agence de l'Environnement et de la Maîtrise de l'Energie (ADEME), This paper was built on the work carried out under the EMEEES project. Financial support from Intelligent Energy Europe (EIE) program of the European Community is gratefully acknowledged., European Project, Université de Nantes (UN)-Université de Nantes (UN)-École nationale vétérinaire, agroalimentaire et de l'alimentation Nantes-Atlantique (ONIRIS)-Centre National de la Recherche Scientifique (CNRS), Mines Paris - PSL (École nationale supérieure des mines de Paris), and Université Paris sciences et lettres (PSL)-Université Paris sciences et lettres (PSL)-Mines Paris - PSL (École nationale supérieure des mines de Paris)
- Subjects
Engineering ,Building retrofitting ,020209 energy ,media_common.quotation_subject ,02 engineering and technology ,010501 environmental sciences ,7. Clean energy ,01 natural sciences ,Unit (housing) ,Consistency (database systems) ,Energy services directive ,[SPI.ENERG]Engineering Sciences [physics]/domain_spi.energ ,0202 electrical engineering, electronic engineering, information engineering ,Operations management ,Quality (business) ,National energy efficiency action plans ,0105 earth and related environmental sciences ,media_common ,Sustainable development ,Energy savings (or White) certificates ,business.industry ,Bottom-up evaluation ,Environmental economics ,Directive ,Energy conservation ,General Energy ,13. Climate action ,business ,White certificates ,Efficient energy use - Abstract
International audience; According to the directive on energy end-use efficiency and energy services (ESD), the European Member States shall adopt a national indicative energy savings target of 9% (or beyond) in 2016. The issue of the energy savings evaluation is crucial for its implementation. The French White Certificates (FWC) scheme is one of the important measures for France to fulfill its ESD target. However, the accountings of energy savings in the FWC scheme and in the ESD are different. Therefore, an analysis of the consistency of the two systems is needed. A concrete example of actions on residential buildings is used to illustrate the challenges for policy marker and stakeholders to set harmonized evaluation rules. The FWC and ESD calculations appear to be consistent from a physics point of view, as long as calculations are well-documented. But due to differences in the policy objectives, calculation routines may be necessary to convert national energy savings unit (e.g., kWh cumac) into supranational energy savings unit (e.g., ESD kWh). Finally, the work done to establish a transparent evaluation system brings additional benefits (e.g., increased visibility and quality of the actions), which will improve the results of the energy efficiency policies on long term.
- Published
- 2010
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