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Objective To investigate the effect of T lymphocytes PD-1/B7-H1 path expression in patients with severe hepatitis depression from promoting liver cell growth hormone combinations from Gongying Yinchen soup. Methods With reference to the American psychiatric association’s diagnostic statistical manual of mental disorders, fourth edition (dsm-iv) criteria, 88 cases of fulminant hepatitis in patients with depression were collected as treatment group, which consist of acute severe hepatitis (n = 31), chronic severe hepatitis (n = 28) and subacute severe hepatitis (n = 29),120 mg promoting liver cell growth hormone to join within 250 ml of 10 % glucose injection, intravenous drip, 1 times a day, 15 d for a period of treatment, At the same time to add with the Gongying Yinchen soup (dandelion, radix et rhizoma rhei, radix bupleuri, herba artemisiae capillaris, glabrous greenbrier rhizome, radix isatidis, grifola, bitter arguments). Three period of treatment. Thirty healthy persons of control group come from blood donor of central blood stations. The expressions of PD-1/B7-H1 of T lymphocytes and T lymphocyte subsets of two groups were determined by flow cytometry. Results The positive expression of PD1 and B7—H1of T lymphocytes in patients of the treatment group was significant higher than that in healthy control group (P < 0.05); The positive expression of PD1and B7—H1of T lymphocytes significantly decreased after treatment in the treatment group (P < 0.05). The amount of CD4+, CD8+ cells of the treatment group was significantly lower than that of control group (P < 0.05). The amount of CD4+/CD8+ cells of the treatment group was higher than that of control group (P < 0.05), significantly decreased after treatment (P < 0.05). Conclusion Promoting liver cell growth hormone combination from the Gongying Yinchen soup can influence expression of T lymphocytes PD-1/B7-H1 path in patients with severe hepatitis depression, enhance the body’s immune response.

Objective Discuss the effect of using Hepatocyte growth-promoting factors combined with Gongying Yinchen soup to cure depression in patients with fulminant hepatitis. Methods Choose 61 cases of fulminant hepatitis patients with depression, With reference to the American psychiatric association Mental disorders diagnostic and statistical manual (DSM-IV) Classification standard, 31 cases patients were randomly divided into treatment group, which was given Gongying Yinchen soup and intravenous drip of 10 % glucose injection 250 ml containing Hepatocyte growth-promoting factors 120 rag, once daily, 15 days for a course of treatment and 30 in the control group, application of this method at the same time added nutgrass galingale rhizome, radix curcumae, radix angelicae sinensis, radix paeoniae alba, radix aucklandiae and other drugs. After three courses of treatment, HAMD rating scale, scores of TCM symptoms. Determine the efficacy. Results Use Gongying Yinchen soup combined with promoting liver cell growth hormone treatment of severe hepatitis patients with depression after treatment, pretherapy and post-treatment in the two groups of HAMD scale total score, treatment group before treatment 45.23 ± 17.29, after the treatment 44.25 ± 18.14; the control group before treatment 43.25 ± 18.30, after the treatment 28.46 ± 14.08, the therapeutic effect of control group patients was much better than that of treatment group cases (P < 0.05); Chinese medicine symptom curative effect as a whole,Treatment group total effectiveness 80.6 %, control group 93.3 %, had significant statistical differences were compared (P < 0.05). Conclusions Promoting liver cell growth to combination the Gongying Yinchen soup curative effect in patients with severe hepatitis depression significantly.

The papers about Hepatitis in Pubmed were retrieved, and Medical Subject Headings (MeSH) in retrieved papers were analyzed (word frequency analysis, clustering analysis, co-word network graph), it suggested that the current Hepatitis receptor research focus had focus on Programmed Cell Death Receptor, Tumor Necrosis Factor Receptor, Interleukin Receptor, also the most important of which was the Programmed Cell Death Receptor, the current hypertension ligand research focus had focus on making Antiviral Agents (Interferon-alpha) by Recombinant Proteins.

Objective Discuss the effect of Hepatocyte growth-promoting factors combined with Gongying Yinchen soup on peripheral blood SIL-2R of depression in fulminant hepatitis patients. Methods Choose 88 cases of fulminant hepatitis patients with depression,With reference to the American psychiatric association Mental disorders diagnostic and statistical manual (DSM-IV) Classification standard, The treatment group 88 cases, which was given GongYing Yinchen soup and intravenous drip of 10 % glucose injection 250 ml containing Hepatocyte growth-promoting factors 120 rag, once daily, 15 days for a course of treatment, Application of above methods at the same time to add with the Gongying Yinchen soup, etc. (Dandelion, radix et rhizoma rhei, radix bupleuri, herba artemisiae capillaris, glabrous greenbrier rhizome, radix isatidis, grifola, bitter ginseng). After the treatment for three courses, Peripheral blood levels of SIL-2R in all patients with severe hepatitis depression were detected,and 30 healthy blood donors were used as controls. Methods Adopt the method of ELISA for levels of SIL-2R in all patients of two groups were detected pre and post-treatment. Results Compare the blood level of SIL-2R of Each group patients with severe hepatitis and health adults, there is significant statistical significance (P < 0.05, P < 0.05). Treatment group after treatment level of serum SIL-2R significantly decreased, There was a significant difference in comparison with the pretreatment (P < 0.01). Conclusions Hepatocyte growth-promoting factors combined with Gongying Yinchen soup can influence peripheral blood SIL-2R of depression in fulminant hepatitis patients, efficacy significantly on severe hepatitis, Can enhance the body’s immune response.

The papers about hypertension in Pubmed were retrieved, and Medical Subject Headings (MeSH) in retrieved papers were analyzed (word frequency analysis, clustering analysis, co-word network graph), it suggested that the current hypertension treatment research hotspots had focus on angiotensin, vasodilator agent, calcium channel blockers, etc., also the most importance of which was the angiotensin.

Objective to study the chronic suppurative otitis media relations with bacterial infection and drug sensitivity test of Er yannig. Methods 55 cases of different type according to the regulation method of ear cavity samples of patients with chronic suppurative otitis media, test their anaerobic bacteria, aerobic bacteria respectively, and at the same time observe ear drug sensitive test. Results 55 pathogens of chronic suppurative otitis media patients 52 strains, including aerobic bacterium infection nine strains, accounting for 36.5 %. 18 strains of anaerobic bacteria infection accounted for 34.6 %, mixed aerobic and anaerobic bacteria infection 15 strains, accounting for 28.8 %; Er yanning drug sensitive test, the bacteriostasis of aerobic bacteria rate was 67.7–94.4 %, is sensitive to all anaerobic bacteria. Conclusion chronic suppurative otitis media by anaerobic bacteria and aerobic bacteria mixed infection, Er yanning has a dual antibacterial effect.