Search

Your search keyword '"Hagiwara Y."' showing total 48 results
Start Over Author "Hagiwara Y." Publisher springer netherlands
48 results on '"Hagiwara Y."'

47. Minimal important differences of EORTC QLQ-C30 for metastatic breast cancer patients: Results from a randomized clinical trial.

Author

Kawahara T, Taira N, Shiroiwa T, Hagiwara Y, Fukuda T, Uemura Y, and Mukai H

Subjects
Female, Humans, Research Design, Surveys and Questionnaires, Breast Neoplasms, Quality of Life psychology
Abstract

Purpose: To establish minimal important differences (MIDs) for the European Organisation for Research and Treatment for Cancer Quality of life Questionnaire core 30 (EORTC QLQ-C30) in patients with metastatic breast cancer., Methods: The dataset was obtained from the SELECT BC-CONFIRM randomized clinical trial. Anchors obtained from patients (transition items) and clinicians (performance status) were used for anchor-based methods. Anchors obtained through 6 months after starting treatment were used for this analysis. Correlation coefficients of anchor and change in QLQ-C30 and effect size were used to qualify for estimating MIDs. Mean change method and generalized estimating equation were applied to estimate MIDs. Distribution-based methods were used for comparison., Results: We analyzed a dataset of 154 metastatic breast cancer patients. MIDs were estimated in 8 of 15 scales of QLQ-C30. Estimated MIDs for within-group improvement varied from 7 to 15 and those for deterioration varied from - 7 to - 17. Estimated MIDs for between-group improvement varied from 5 to 11 and those for deterioration varied from - 5 to - 8 across QLQ-C30 scales. Patient-reported anchors were more susceptible to early changes in health status than clinician-reported anchors., Conclusion: We provided the MIDs of the QLQ-C30 using both patient- and clinicians-reported anchors measured in a randomized trial of Japanese patients with metastatic breast cancer. We recommend patient-reported anchors for anchor-based estimation of MID. Our results can aid patients and clinicians, as well as researchers, in the interpretation of QLQ-C30., (© 2022. The Author(s).)

Published
2022
Full Text
View/download PDF

48. Long-term health status as measured by EQ-5D among patients with metastatic breast cancer: comparison of first-line oral S-1 and taxane therapies in the randomized phase III SELECT BC trial.

Author

Shiroiwa T, Fukuda T, Shimozuma K, Mouri M, Hagiwara Y, Doihara H, Akabane H, Kashiwaba M, Watanabe T, Ohashi Y, and Mukai H

Subjects
Adult, Aged, Breast Neoplasms drug therapy, Drug Combinations, Female, Humans, Middle Aged, Quality of Life, Surveys and Questionnaires, Breast Neoplasms psychology, Health Status, Oxonic Acid therapeutic use, Quality-Adjusted Life Years, Taxoids therapeutic use, Tegafur therapeutic use
Abstract

Purpose: The goal of chemotherapy for metastatic breast cancer (MBC) is to prolong survival and maintain health-related quality of life. This study aimed to evaluate long-term health status of patients with MBC who participated in the phase III randomized SELECT BC trial., Methods: In the SELECT BC trial, patients were randomly allocated to the S-1 or taxane (paclitaxel or docetaxel) arm. Health status was assessed by EQ-5D at pre-treatment, 3 and 6 months after randomization, and every 6 months thereafter to the extent possible. Least square mean scores were assessed to compare EQ-5D index values between groups. Time to deterioration analysis was also performed by defining the minimally important difference of EQ-5D as 0.05 or 0.1., Results: The number of patients for EQ-5D analysis was 175 and 208 in the taxane and S-1 arms, respectively. Least square mean EQ-5D index values up to 60 months were 0.741 (95 % CI [0.713-0.769]) in the taxane arm and 0.748 [0.722-0.775] in the S-1 arm. The EQ-5D index value during PFS up to 12 months in the S-1 was superior to the corresponding index value in the taxane (0.812 [0.789-0.834] vs. 0.772 [0.751-0.792], P = 0.009). Time to deterioration analysis also revealed that S-1 significantly delayed the deterioration of EQ-5D index value during the period before progression (P = 0.002 and 0.003)., Conclusions: Our findings suggest that the EQ-5D index value was higher in patients treated with S-1 during first-line chemotherapy. Considering non-inferiority of S-1 in terms of OS, obtained quality-adjusted life years may be greater in the S-1 arm., Competing Interests: M. Mouri has received honoraria from Asahi Kasei Pharma. Y. Ohashi has received honoraria from Statcom, Sanofi-Aventis, and Eisai; a grant from Chugai, Taiho, Shionogi, Kowa, and Eisai. H. Mukai has received honoraria from Chugai, AstraZeneca, Eisai, Novartis, Daiichi Sankyo, Taiho, Boehringer Ingelheim, and Ono; grant from Chugai, Daiichi Sankyo, Eisai, Nippon Kayaku, Novartis, Pfizer, and Sanofi-Aventis. All remaining authors have declared no conflict of interest. Ethical approval All procedures performed in studies involving human participants were in accordance with Ethical Guidelines for Clinical Research of the Japanese Ministry of Health, Labour and Welfare and with the 1964 Helsinki Declaration and its later amendments. Informed consent Informed consent was obtained from all individual participants included in the study.

Published
2017
Full Text
View/download PDF

Catalog

Books, media, physical & digital resources
See catalog results