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Start Over Author "Florine Cavelier" Publisher springer netherlands
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1. Original and General Strategy of Dimerization of Bioactive Molecules

Author

Matthieu Giraud, Jean Martinez, Nicole Bernad, and Florine Cavelier

Subjects
chemistry.chemical_compound, chemistry, Stereochemistry, Active compound, Bioactive molecules, Pharmacophore, Bifunctional, Combinatorial chemistry, Linker, Bivalent (genetics)
Abstract

Dimerization of an active compound often results in enhanced binding and improved pharmacological properties. This potency is attributed to a higher concentration of pharmacophores in the proximity of recognition sites. This bivalent ligand approach is generally presumed to use a symmetrical bifunctional linker X to anchor two substrates P, giving rise to the general structure P-X-P [1].

Published
2001
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