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The effects of changing soil moisture conditions and oxidation–reduction (redox) processes on dissolved fractions of arsenic (As), cadmium (Cd), copper (Cu), iron (Fe), manganese (Mn), lead (Pb) and zinc (Zn) were studied in floodplain soils in the Lower Lahn Valley (Germany). Multiple weirs and locks affect the groundwater levels in the adjacent river banks by modifying the river’s discharge rate. Redox conditions act as a key factor for sorption and desorption processes and are strongly regulated by groundwater levels. Hence, floodplain soils situated up- and downstream of impounded river segments were characterized by various contents of their mobile heavy metal fraction. To quantify the variations of the dissolved heavy metal concentrations during seasonal and periodic fluctuations of the groundwater levels, a 2-year field study was conducted. The results indicated that higher seasonal changes of river discharge downstream of a weir caused higher amplitudes of groundwater levels, redox changes and variations in dissolved As, Fe and Mn in soil depths (50–60 cm) with a strong groundwater influence. Upstream of a weir, higher dissolved concentrations and more smooth variations of As, Fe and Mn dominated within the same depths. A high rise of capillary waters within the same study site caused significant enrichments of dissolved Cd and Zn in the middle (25–35 cm) of the soil profile. The comparison of floodplain soils along the Lahn River showed how the stream regulations influence heavy metal concentrations of soil pore waters, which may in turn influence the quality of the river water. [ABSTRACT FROM AUTHOR]

An amendment to this paper has been published and can be accessed via a link at the top of the paper. [ABSTRACT FROM AUTHOR]

An amendment to this paper has been published and can be accessed via a link at the top of the paper. [ABSTRACT FROM AUTHOR]

Long non-coding RNAs (lncRNAs) are important regulatory molecules that are implicated in cellular physiology and pathology. In this work, we dissect the functional role of the HOXB-AS3 lncRNA in patients with NPM1-mutated (NPM1mut) acute myeloid leukemia (AML). We show that HOXB-AS3 regulates the proliferative capacity of NPM1mut AML blasts in vitro and in vivo. HOXB-AS3 is shown to interact with the ErbB3-binding protein 1 (EBP1) and guide EBP1 to the ribosomal DNA locus. Via this mechanism, HOXB-AS3 regulates ribosomal RNA transcription and de novo protein synthesis. We propose that in the context of NPM1 mutations, HOXB-AS3 overexpression acts as a compensatory mechanism, which allows adequate protein production in leukemic blasts. LncRNAs at the HOX gene locus are increased in expression in NPM1 mutant acute myeloid leukemia. In this study, the authors show that one such lncRNA, HOX3B-AS3, has a role in regulating gene transcription and protein synthesis in leukemia cells. [ABSTRACT FROM AUTHOR]