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Iron and Manganese pollution were widespread in the water of northern Chinese mines, exacerbating regional water scarcity and potential ecological issues. This study aimed to remove dissolved iron and manganese from acid mine water using serpentine-loaded manganese oxide (Serp-MO) prepared by a simple coprecipitation-loaded metal method. Serp-MO was microscopically characterized, and the adsorption performance and adsorption mechanism of the Serp-MO composite adsorbent for Fe2+ and Mn2+ were analyzed. After loading, the specific surface area and pore volume of the particles significantly increased, and the surface pore structure improved, which was conducive to the simultaneous adsorption and removal of iron and manganese. The optimal reaction conditions for Serp-MO treatment of composite water samples with Fe2+ and Mn2+ mass concentrations of 20 mg/L and 5 mg/L respectively, were as follows: dosage of Serp-MO 550 mg/L, temperature 35 ℃, oscillation rate 180 r/min, and reaction time 140 min. Under these conditions, the removal rates of Fe2+ and Mn2+ were 99.8% and 99.6%, respectively. The presence of coexistence cations Zn2+ and Cu2+ can inhibit the removal of Fe2+ and Mn2+ by Serp-MO, while SO42- can promote the removal. The pseudo-second-order kinetic model and Langmuir isothermal adsorption model well described the adsorption process of Fe2+ and Mn2+ by the Serp-MO. The maximum adsorption capacities of Serp-MO for Fe2+ and Mn2+ were 14.31 mg/g and 24.04 mg/g, representing improvements of 470.12% and 626.28%, respectively, compared to Serp-MO. The adsorption thermodynamics showed that ΔG was <0 and ΔH and ΔS were greater than 0 at all test temperatures, which was an entropy-increasing reaction, and that increasing the temperature was favorable for the removal of Fe2+ and Mn2+. Based on the analysis of adsorption products, Serp-MO primarily facilitates the precipitation of iron in water, while the removal of manganese was mainly by adsorption. A regeneration study over five cycles indicated that Serp-MO possessed promising reusability potential. Furthermore, the safety leaching test indicated that the material caused minimal secondary pollution. [ABSTRACT FROM AUTHOR]

In recent years, the use of "near-net forming" to manufacture key components of aeroengines has become a mainstream development direction. In this paper, "near-net forming" of rotating parts such as disks and shafts is realized by using axial closed die rolling (ACDR) deformation technology. Numerical simulation and experimentation research were utilized to compare the plastic deformation characteristics and microstructure evolution of TC11 disc component forming by upsetting and ACDR forming, including strain distribution, temperature distribution, and microstructure evolution mechanisms. The FEM results revealed that during the ACDR process, the equivalent strain exhibits a radial distribution pattern with the center of contact area between the billet and upper die. The top surface of the billet was located in the severe plastic deformation zone and had better microstructure uniformity as a whole. In addition, ACDR forming enables continuous "near-net forming" at relatively low loads. The experimental results illustrated that ACDR formation is characterized by three types of deformation: radial tension, circumferential torsion, and axial compression, and at the same time, the overall strain is higher. As a result, the initial α size in the core was finer and exhibited an equiaxial shape, and the remaining areas of the grain were relatively fine and more uniformly distributed. The ACDR forming process can obtain a uniform and refined TC11 microstructure more efficiently. The TEM morphology observation of the ACDR specimens revealed that the lamella α-phase was bent, twisted, and fractured under the combined action of axial and shear stresses. The spheroidization models are primarily the globularization model of shearing lamellar structure the grain boundary splitting model, the termination migration globularization model, and the globularization model of Rayleigh instability. [ABSTRACT FROM AUTHOR]

Coastal communities face substantial risks from long-term sea level rise and decadal sea level variations, with the North Atlantic and U.S. East Coast being particularly vulnerable under changing climates. Employing a self-organizing map-based framework, we assess the North Atlantic sea level variability and predictability using 5000-year sea level anomalies (SLA) from two preindustrial control model simulations. Preferred transitions among patterns of variability are identified, revealing long-term predictability on decadal timescales related to shifts in Atlantic meridional overturning circulation phases. Combining this framework with model-analog techniques, we demonstrate prediction skill of large-scale SLA patterns and low-frequency coastal SLA variations comparable to that from initialized hindcasts. Moreover, additional short-term predictability is identified after the exclusion of low-frequency signals, which arises from slow gyre circulation adjustment triggered by the North Atlantic Oscillation-like stochastic variability. This study highlights the potential of machine learning to assess sources of predictability and to enable long-term climate prediction. [ABSTRACT FROM AUTHOR]

This study investigates global extreme precipitation events (EPEs) during warm seasons, with a particular focus on EPEs preceded by extreme heat stress (EPE-Hs) and a comparative analysis with those not (EPE-NHs). Using reanalysis product and Earth System Model data, the spatiotemporal characteristics and temperature sensitivities of EPEs are analyzed. Results show that EPE-Hs, while less frequent, have longer duration and greater magnitude compared to EPE-NHs, particularly in high latitude regions. In the future, a significant increase is projected in the characteristics of EPE-Hs, in contrast to the stable duration and magnitude of EPE-NHs. EPE-Hs demonstrate substantially higher temperature sensitivity than EPE-NHs, especially in low latitudes. The precipitation-temperature scaling relationships diverge markedly between EPE-Hs and EPE-NHs, with notable regional variations. These insights are pivotal for crafting region-specific early warning and adaptation strategies to mitigate the risks associated with extreme precipitation under the backdrop of global warming. [ABSTRACT FROM AUTHOR]

The stability of a slope at a hydropower station is closely related to variations in water storage levels. At China's Yellow River Laxiwa Hydropower Station, although operations have been at normal water level since 2015, slope deformation intensified and local instability occurred during the impoundment process. Therefore, it is important to research the mechanism of landslides, predict possible landslide phenomena and introduce treatment measures. The Guobu slope, situated on the right bank of the Laxiwa Hydropower Station, was chosen as the research object in this paper. The three-dimensional distinct element method (DEM) was used to investigate and calculate the slope deformation and stability under different water levels. The numerical results accurately simulate the in-situ toppling deformation of the Guobu slope instability and demonstrate that impoundment and geological structures are the dominant factors contributing to the slope's significant deformation. Based on slope stability analysis, slope-cutting measures were proposed, and the modified strength reduction method was applied to the factor of safety (FOS) calculation. We use 3DEC to analyze the control factors of deformation and failure of Guobu slope instability accurately. Our findings contribute significantly to the understanding of toppling mechanisms in steep slopes, revealing how complex geological structure and reservoir level fluctuation interact to trigger instability. [ABSTRACT FROM AUTHOR]

Sodium glucose cotransporter 2 inhibitors (SGLT2i) constitute the only medication class that consistently prevents or attenuates human heart failure (HF) independent of ejection fraction. We have suggested earlier that the protective mechanisms of the SGLT2i Empagliflozin (EMPA) are mediated through reductions in the sodium hydrogen exchanger 1 (NHE1)-nitric oxide (NO) pathway, independent of SGLT2. Here, we examined the role of SGLT2, NHE1 and NO in a murine TAC/DOCA model of HF. SGLT2 knockout mice only showed attenuated systolic dysfunction without having an effect on other signs of HF. EMPA protected against systolic and diastolic dysfunction, hypertrophy, fibrosis, increased Nppa/Nppb mRNA expression and lung/liver edema. In addition, EMPA prevented increases in oxidative stress, sodium calcium exchanger expression and calcium/calmodulin-dependent protein kinase II activation to an equal degree in WT and SGLT2 KO animals. In particular, while NHE1 activity was increased in isolated cardiomyocytes from untreated HF, EMPA treatment prevented this. Since SGLT2 is not required for the protective effects of EMPA, the pathway between NHE1 and NO was further explored in SGLT2 KO animals. In vivo treatment with the specific NHE1-inhibitor Cariporide mimicked the protection by EMPA, without additional protection by EMPA. On the other hand, in vivo inhibition of NOS with L-NAME deteriorated HF and prevented protection by EMPA. In conclusion, the data support that the beneficial effects of EMPA are mediated through the NHE1-NO pathway in TAC/DOCA-induced heart failure and not through SGLT2 inhibition. [ABSTRACT FROM AUTHOR]

Although studies have confirmed that future self-continuity impacts the presence of meaning, evidence of cross-cultural consistency remains scarce, and the underlying mechanisms between the two are unclear. To fill this research gap, we conducted two studies using a sample of Chinese college students (N = 631). Study 1 verified the positive predictive effect of future self-continuity on the presence of meaning in the context of Eastern culture through two sub-experiments (n = 325), thereby confirming its cross-cultural consistency. Study 2, a three-wave longitudinal study, revealed the mediating mechanisms through which future self-continuity affects the presence of meaning (n = 306). The results suggest that future self-continuity at Time 1 can directly predict the presence of meaning at Time 3 and indirectly predict the presence of meaning at Time 3 through self-concept clarity at Time 2. Thus, self-concept clarity partially mediates the relationship between future self-continuity and the presence of meaning. These findings enrich cross-cultural research on the presence of meaning and provide new ideas and methods for enhancing the presence of meaning in individual lives. [ABSTRACT FROM AUTHOR]

A novel Ti/PANI/PbO2-Ce electrode was fabricated using the electrodeposition method for the degradation of 2,3-dimethylphenol, a typical phenolic pollutant in coking wastewater. Scanning electron microscopy (SEM), x-ray photoelectron spectroscopy (XPS), and x-ray diffraction (XRD) analyses confirmed the successful incorporation of Ce into the PbO2 matrix. The polyaniline (PANI) interlayer significantly enhanced the electrode's stability and service lifetime. The addition of the rare earth element Ce resulted in the formation of a three-dimensional spherical PbO2 structure, increasing the electrode's surface area and reducing the PbO2 grain size. Compared to the conventional Ti/PbO2 electrode, the Ti/PANI/PbO2-Ce electrode exhibited a higher oxygen evolution potential (OEP, 1.91 V), larger specific surface area, lower charge transfer resistance, and superior hydroxyl radical (•OH) generation capacity. The degradation conditions for 2,3-dimethylphenol were optimized through single-factor experiments, achieving a degradation efficiency of 99.86% at a voltage of 14 V, plate spacing of 1.5 cm, Na2SO4 electrolyte concentration of 0.25 mol/L, pH of 10, and reaction time of 120 min. The calculated activation energy (Ea) and thermodynamic parameters indicate that the electrocatalytic process is an endothermic process. The efficient anodic oxidation of 2,3-dimethylphenol was primarily driven by indirect •OH oxidation. Potential degradation pathways of 2,3-dimethylphenol were elucidated through UV–visible spectrophotometry and gas chromatography-mass spectrometry (GC–MS) analysis of the degradation intermediates. [ABSTRACT FROM AUTHOR]

Humid heat extreme (HHE) is a type of compound extreme weather event that poses severe risks to human health. Skillful forecasts of HHE months in advance are crucial for developing strategies to enhance community resilience to extreme events1,2. This study demonstrates that the frequency of summertime HHE in the southeastern United States (SEUS) can be skillfully predicted 0–1 months in advance using the SPEAR (Seamless system for Prediction and EArth system Research) seasonal forecast system. Sea surface temperatures (SSTs) in the tropical North Atlantic (TNA) basin are identified as the primary driver of this prediction skill. The responses of large-scale atmospheric circulation and winds to anomalous warm SSTs in the TNA favor the transport of heat and moisture from the Gulf of Mexico to the SEUS. This research underscores the role of slowly varying sea surface conditions in modifying large-scale environments, thereby contributing to the skillful prediction of HHE in the SEUS. The results of this study have potential applications in the development of early warning systems for HHE. [ABSTRACT FROM AUTHOR]

Heavy metal accumulation in agricultural products has become a major concern. Previous studies have focused on the transport of heavy metals from the soil and their accumulation in crops. However, recent studies revealed that wheat leaves, ears, and awns can also transport and accumulate heavy metals. Wheat grains can be influenced by two sources of heavy metals: soil contamination and atmospheric deposition. To comprehend the transport characteristics of heavy metals in soil, atmospheric deposition, and wheat, 37 samples each for wheat rhizosphere soil, wheat roots, stems, leaves, and grains were collected. Fifteen samples of atmospheric dry deposition and atmospheric wet deposition were collected from Linshu County (northern area), China. Based on the test data, the characteristics of heavy metals and their distribution in the study area were analyzed. Migration patterns of heavy metals in crops from different sources were investigated using Pearson correlation and redundancy analysis. Finally, a predictive model for heavy metals in wheat grains was developed using multiple linear regression analysis. Significant disparities in the distribution of heavy metals existed among wheat roots, stems, leaves, and grains. The coefficient of variation of heavy metals in atmospheric deposition was relatively high, indicating discernible spatial patterns influenced by human activities. Notably, a positive correlation was observed between the concentration of heavy metals in wheat grains and atmospheric deposition of Hg, Cd, and Pb. Conversely, Zn and Ni levels in wheat grains were significantly negatively associated with soil Zn, Ni, pH, and OM content. The contribution of heavy metal elements from different sources varied in their impact on the grain's heavy metal content. Specifically, atmospheric deposition was the primary source of Hg and Pb in wheat grains, while Cd, Ni, Cu, and Zn were predominantly derived from soil. Using a multiple linear regression model, we could accurately predict Hg, Pb, Cd, Ni, Zn, and As concentrations in crop grains. This model can facilitate quantitative evaluation of ecological risk of heavy metals accumulation in crops in the study area. [ABSTRACT FROM AUTHOR]

Milvexian, an oral activated Factor XI (FXIa) inhibitor, is in clinical studies where it may be combined with antiplatelet agents, including aspirin and/or clopidogrel, to prevent thromboembolic diseases. This phase I trial assessed safety, pharmacokinetics, and pharmacodynamics of milvexian coadministration with aspirin and/or clopidogrel in healthy participants through 3 drug-drug interaction studies using a 3-period, 3-treatment, crossover design. A total of 113 participants were randomized to receive milvexian (200 mg; twice daily for 5 days) or matched placebo coadministered with once-daily aspirin (325 mg for 5 days) and/or clopidogrel (Day 1: 300 mg; Days 2–5: 75 mg). Milvexian was safe and well tolerated, with and without aspirin and/or clopidogrel. Eight mild bleeding adverse events (AEs) were reported in 5 of 113 participants across various treatment arms. Peak and total exposures of milvexian were similar with or without clopidogrel and/or aspirin. Exposure-dependent prolongation of activated partial thromboplastin time and reduction of FXI clotting activity by milvexian were similar with coadministration of aspirin and/or clopidogrel. Milvexian, with or without coadministration of aspirin and/or clopidogrel, did not affect bleeding time or platelet aggregation. Administration of milvexian alone or with aspirin and/or clopidogrel was safe and well tolerated without increased incidence of AEs, including bleeding. Pharmacokinetic and pharmacodynamic effects of milvexian, including bleeding time, were similar with or without aspirin and/or clopidogrel. ClinicalTrials.gov Identifier: NCT03698513. [ABSTRACT FROM AUTHOR]

Hydrogenated amorphous silicon (a-Si:H) has a long history in the development of photovoltaics, especially in the research field of a-Si:H thin-film solar cells and crystalline/amorphous silicon heterojunction solar cells. More than 40 years ago, Staebler and Wronski reported conductance decrease of a-Si:H induced by light soaking. This phenomenon has been widely investigated for electronic applications. In contrast to that, we found light soaking can also improve dark conductance of a-Si:H when boron or phosphorus atoms are doped into the amorphous network. Here we survey these two photoelectronic effects, and discuss their implementations to silicon solar cells. [ABSTRACT FROM AUTHOR]

Twisted a pair of stacked two-dimensional materials exhibit many exotic electronic and photonic properties, leading to the emergence of flat-band superconductivity, moiré engineering and topological polaritons. These remarkable discoveries make twistronics the focus point of tremendous interest, but mostly limited to the concept of electrons, phonons or photons. Here, we present twist piezoelectricity as a fascinating paradigm to modulate polarization and electromechanical coupling by twisting precisely the stacked lithium niobate slabs due to the interlayer coupling effect. Particularly, the inversed and twisted bilayer lithium niobate is constructed to overcome the intrinsic mutual limitation of single crystals and giant effective electromechanical coupling coefficient k t 2 is unveiled at magic angle of 11 1 ∘ , reaching 85.5%. Theoretical analysis based on mutual energy integrals shows well agreements with numerical and experimental results. Our work opens new venues to flexibly control multi-physics with magic angle, stimulating progress in wideband acoustic-electric, and acoustic-optic components, which has great potential in wireless communication, timing, sensing, and hybrid integrated photonics. Authors bond two layers of LiNbO3 as an acoustic resonator. With interlayer coupling of fields and modulation by twisted angle, a magic-angle effect is reported, as one mode exhibits huge electromechanical coupling while its twin-mode disappears. [ABSTRACT FROM AUTHOR]

The rate of sea level rise (SLR) along the Southeast Coast of the U.S. increased significantly after 2010. While anthropogenic radiative forcing causes an acceleration of global mean SLR, regional changes in the rate of SLR are strongly influenced by internal variability. Here we use observations and climate models to show that the rapid increase in the rate of SLR along the U.S. Southeast Coast after 2010 is due in part to multidecadal buoyancy-driven Atlantic meridional overturning circulation (AMOC) variations, along with heat transport convergence from wind-driven ocean circulation changes. We show that an initialized decadal prediction system can provide skillful regional SLR predictions induced by AMOC variations 5 years in advance, while wind-driven sea level variations are predictable 2 years in advance. Our results suggest that the rate of coastal SLR and its associated flooding risk along the U.S. southeastern seaboard are potentially predictable on multiyear timescales. [ABSTRACT FROM AUTHOR]

A method for skyline query of multidimensional incomplete data based on a classification tree has been proposed to address the problem of a large amount of useless data in existing skyline queries with multidimensional incomplete data, which leads to low query efficiency and algorithm performance. This method consists of two main parts. The first part is the proposed incomplete data weighted classification tree algorithm. In the first part, an incomplete data weighted classification tree is proposed, and the incomplete data set is classified using this tree. The data classified in the first part serves as the basis for the second step of the query. The second part proposes a skyline query algorithm for multidimensional incomplete data. The concept of optimal virtual points has been recently introduced, effectively reducing the number of comparisons of a large amount of data, thereby improving the query efficiency for incomplete data. Theoretical research and experimental analysis have shown that the proposed method can perform skyline queries for multidimensional incomplete data well, with high query efficiency and accuracy of the algorithm. [ABSTRACT FROM AUTHOR]

A field trial was performed to carry out an enhanced phytoremediation technique for multi-metal contaminated copper tailings by Sudan grass (Sorghum Sudanese), ryegrass (Lolium perenne L.), and Bermuda grass (Cynodon dactylon), using conditioner (TH-LZ01) and straw combination into composite amendments as soil amendments, aimed to obtain the maximum of phytoremediation effect. The results showed that compared with untreated herbaceous plants, the application of conditioner and straw planted with herbaceous plants reduced the pH and conductivity and increased the organic matter and water content of the copper tailings to different degrees. With the addition of conditioner and straw, the DTPA-Cd, DTPA-Cu, DTPA-Pb, and DTPA-Zn contents in the copper tailings showed a decreasing trend compared with the untreated group. The herbaceous plants were promoted to reduce the percentage contents of acid soluble fractions Cd, Cu, Pb, and Zn and to increase the percentage contents of reducible, oxidizable, and residual fractions heavy metals (Cd, Cu, Pb, and Zn) in the copper tailings to different degrees. The contents of Cd, Cu, Pb, and Zn in the underground part of herbaceous plants were higher than those in the aboveground part, and the contents of Cd, Cu, Pb, and Zn in the aboveground part and underground part decreased after adding conditioner and straw, which indicated that the conditioner and straw inhibited the transport of heavy metals in the plant. Furthermore, the principal component analysis showed that the application of conditioner and straw with planting ryegrass had more potential for improving the physicochemical properties of copper tailings and reducing heavy metal toxicity, followed by Bermuda grass and Sudan grass. [ABSTRACT FROM AUTHOR]

Meteorological factors and air pollutants are associated with the spread of pulmonary tuberculosis (PTB), but few studies have examined the effects of their interactions on PTB. Therefore, this study investigated the impact of meteorological factors and air pollutants and their interactions on the risk of PTB in Urumqi, a city with a high prevalence of PTB and a high level of air pollution. The number of new PTB cases in eight districts of Urumqi from 2014 to 2019 was collected, along with data on meteorological factors and air pollutants for the same period. A generalized additive model was applied to explore the effects of meteorological factors and air pollutants and their interactions on the risk of PTB incidence. Segmented linear regression was used to estimate the nonlinear characteristics of the impact of meteorological factors on PTB. During 2014–2019, a total of 14,402 new cases of PTB were reported in eight districts, with March to May being the months of high PTB incidence. The exposure–response curves for temperature (Temp), relative humidity (RH), wind speed (WS), air pressure (AP), and diurnal temperature difference (DTR) were generally inverted "U" shaped, with the corresponding threshold values of − 5.411 °C, 52.118%, 3.513 m/s, 1021.625 hPa, and 8.161 °C, respectively. The effects of air pollutants on PTB were linear and lagged. All air pollutants were positively associated with PTB, except for O3, which was not associated with PTB, and the ER values for the effects on PTB were as follows: 0.931 (0.255, 1.612) for PM2.5, 1.028 (0.301, 1.760) for PM10, 5.061 (0.387, 9.952) for SO2, 2.830 (0.512, 5.200) for NO2, and 5.789 (1.508, 10.251) for CO. Meteorological factors and air pollutants have an interactive effect on PTB. The risk of PTB incidence was higher when in high Temp-high air pollutant, high RH-high air pollutant, high WS-high air pollutant, lowAP-high air pollutant, and high DTR-high air pollutant. In conclusion, both meteorological and pollutant factors had an influence on PTB, and the influence on PTB may have an interaction. [ABSTRACT FROM AUTHOR]

Heavy metal contamination is an urgent ecological governance problem in mining areas. In order to seek for a green and environmentally friendly reagent with better plant restoration effect to solve the problem of low efficiency in plant restoration in heavy metal pollution soil. In this study, we evaluated the effects of three biodegradable chelating agents, namely citric acid (CA), fulvic acid (FA) and polyaspartic acid (PASP), on the physicochemical properties of copper tailings, growth of ryegrass (Lolium perenne L.) and heavy metal accumulation therein. The results showed that the chelating agent application improved the physicochemical properties of copper tailings, increased the biomass of ryegrass and enriched more Cu and Cd in copper tailings. In the control group, the main existing forms of Cu and Cd were oxidizable state, followed by residual, weak acid soluble and reducible states. After the CA, FA or PASP application, Cu and Cd were converted from the residual and oxidizable states to the reducible and weak acid soluble states, whose bioavailability in copper tailings were thus enhanced. Besides, the chelating agent incorporation improved the Cu and Cd extraction efficiencies of ryegrass from copper tailings, as manifested by increased root and stem contents of Cu and Cd by 30.29–103.42%, 11.43–74.29%, 2.98–110.98% and 11.11–111.11%, respectively, in comparison with the control group. In the presence of multiple heavy metals, CA, FA or PASP showed selectivity regarding the ryegrass extraction of heavy metals from copper tailings. PCA analysis revealed that the CA-4 and PASP-7 treatment had great remediation potentials against Cu and Cd in copper tailings, respectively, as manifested by increases in Cu and Cd contents in ryegrass by 90.98% and 74.29% compared to the CK group. [ABSTRACT FROM AUTHOR]

Increasingly sophisticated molecular techniques and research tools have greatly advanced the understanding of species diversity and phylogenetic relationships in freshwater mussels. However, malacologists have been puzzled by the taxonomic position and species validity of certain species, particularly those described solely based on conchological characteristics. The genus Lepidodesma is one such group. Here, we integrate shell morphology, soft-body anatomy, and molecular phylogeny to delimit the species validity of Lepidodesma aligera (Heude in Conchyliologie Fluviatile de la Provoince de Nanking 3:17–24, 1877) and Lepidodesma languilati (Heude in Journal De Conchyliologie 22:112–118, 1874). Comparative morphology reveals that L. aligera can be distinguished from L. languilati by its higher post-dorsal wing covered with scattered nodules, as well as differences in the incurrent aperture, excurrent aperture, and gill. Additionally, the average genetic distance based on DNA barcodes (COI) between both species is 4.0%. Integrative taxonomy supports the distinct species of L. aligera, rather than synonymy for L. languilati. Mitochondrial phylogenomic analyses confirm four monophyletic groups (Ambleminae + (Gonideinae + (Unioninae + Parreysiinae))) within the family Unionidae. L. aligera and L. languilati have a well-supported sister-group relationship and form a basal clade splitting from the rest of Unioninae. Therefore, the genus Lepidodesma should be classified as Lepidodesmini in Unioninae. The molecular clock with fossil calibration indicates that Lepidodesma originated in the Early Cretaceous (~121.30 Mya, 95% HPD = 90.37–156.54 Mya) and diverged in the Middle Neogene (~12.94 Mya, 95% HPD = 6.72–22.13 Mya). This study firstly provides anatomical features and molecular data for L. aligera and demonstrates the species validity and the systematic position of Lepidodesma taxa, which enrich our understanding of this rare group and facilitate its management and conservation. [ABSTRACT FROM AUTHOR]

Soil heavy metal pollution, especially compound pollution, has been widely concerned and studied at home and abroad. However, the analysis of heavy metal accumulation levels and their health risks in soils that have not yet reached the polluted level is relatively lacking. Nearly 20 years ago, an incident of human lead poisoning caused by heavy metals occurred in Hui County, Gansu Province, China. However, the degree of heavy metal accumulation and health risks in farmland soil in the area are still unclear. Thus, 361 surface soil samples and 86 crop samples of arable land were comprehensively and systematically collected from Hui County. The accumulation degree of heavy metals in arable land and crops was characterized by the geoaccumulation index and bioconcentration factor, respectively. The carcinogenicity and non-carcinogenicity risk were analyzed with the human health risk model put forward by the US EPA. The influencing factors of heavy metal accumulation were analyzed by the geographic detectors. The results showed that the geoaccumulation index of heavy metals in the soil of the study area was in the order of Hg>Cd>Pb>As>Cr, among which As and Cr did not accumulate, and one-third of the sampling sites had a moderate accumulation of Hg and Cd; Meanwhile, Cd and Hg were highly enriched in crops. Local residents do not have a non-carcinogenic risk when consuming a single heavy metal element through crops, but there is a non-carcinogenic risk when consuming multiple heavy metal elements. At the same time, the intake of Cd, Cr, and As had significant carcinogenic risks, as order of Cd>Cr>As, and higher in children than in adults. The spatial differentiation of heavy metal accumulation in the study area was significantly affected by factors such as DEM, average temperature and average precipitation during the sampling season, and distance from the railway. Furthermore, the interaction of topography, climate, and anthropogenic factors had a more significant effect on the spatial differentiation of heavy metal accumulation in the study area. This research could provide a scientific basis for precise prevention and control of soil heavy metal pollution and human health protection in the study area and the same situation. [ABSTRACT FROM AUTHOR]

Compound extremes of lethal heat stress-heavy precipitation events (CHPEs) seriously threaten social and ecological sustainability, while their evolution and effects at the global scale under climate warming remain unclear. Here we develop the global picture of projected changes in CHPEs under various scenarios and investigate their socioeconomic and ecosystem risks combining hazard, exposure, and vulnerability through the composite indicator approach. We find a high percentage of heat stress is followed by heavy precipitation, probably driven by atmospheric conditions. Global average frequency and intensity of CHPEs are projected to increase in the future under high-emission scenarios. Joint return periods of CHPEs are projected to decrease globally, predominantly driven by changes in heat stress extremes. In the long-term future, over half of the population, gross domestic product, and gross primary productivity may face high risk in most regions, with developed regions facing the highest risks under SSP5-8.5 and developing regions facing the highest risks under SSP3-7.0. [ABSTRACT FROM AUTHOR]

To explore the influence of meteorological factors on the incidence of tuberculosis (TB) in Yingjisha County, Kashgar Region, Xinjiang, and to provide a scientific basis for the prevention and control of TB. The Spearman correlation analysis and distribution lag nonlinear model analysis were conducted on the number of daily reported cases of TB from 2016 to 2023 to study the association effect of various meteorological factors and the daily incidence number of TB in Yingjisha County. A total of 13,288 TB cases were reported from January 2016 to June 2023, and June to October is the peak period of annual TB incidence. Spearman correlation analysis revealed that average daily temperature (AT) and average daily wind speed (WS) were positively correlated with TB incidence (rAT = 0.110, rWS = 0.090); and average daily relative humidity (RH) and TB incidence was negatively correlated (rRH = − 0.093). When AT was − 15 °C, the RR reached a maximum of 2.20 (95% CI: 0.77–6.29) at a lag of 21 days. When RH was 92%, the RR reached a maximum of 1.05 (95% CI: 0.92–1.19) at a lag of 6 days. When WS was 5.2 m/s, the RR reached a maximum of 1.30 (95% CI: 0.78–2.16) at a lag of 16 days. There is a non-linearity and a certain lag between meteorological factors and the occurrence and prevalence of TB in the population, which is mainly manifested in the fact that the risk of incidence of TB decreases with the increase of the daily AT, has a hazardous effect within a certain range of humidity as the average daily RH rises, and gradually increases with the increase of the average daily WS. Local residents are advised to pay attention to climate change so as to take appropriate preventive measures, especially women and middle and old age group should pay close attention to climate change and add more clothes in time, minimise travelling in hazy weather and windy and sandy weather, maintain good nutrition, adequate sleep and moderate exercise in daily life to enhance their immunity, wash hands frequently and ventilate the air, and try to avoid staying in humid and confined spaces in order to reduce the risk of latent TB patients developing the disease. [ABSTRACT FROM AUTHOR]

Local climate zones (LCZs) are an effective nexus linking internal urban structures to the local climate and have been widely used to study urban thermal environment. However, few studies considered how much the temperature changed due to LCZs transformation and their synergy. This paper quantified the change of urban land surface temperature (LST) in LCZs transformation process by combining the land use transfer matrix with zonal statistics method during 2000–2019 in the Xi'an metropolitan. The results show that, firstly, both LCZs and LST had significant spatiotemporal variations and synchrony. The period when the most LCZs were converted was also the LST rose the fastest, and the spatial growth of the LST coincided with the spatial expansion of the built type LCZs. Secondly, the LST difference between land cover type LCZs and built type LCZs gradually widened. And LST rose more in both built type LCZs transferred in and out. Finally, the Xi'an-Xianyang profile showed that the maximum temperature difference between the peaks and valleys of the LST increased by 4.39°C, indicating that localized high temperature phenomena and fluctuations in the urban thermal environment became more pronounced from 2000 to 2019. [ABSTRACT FROM AUTHOR]

An efficient prediction of the extreme value of traffic loads is crucial for the structural design, reliability evaluation, maintenance planning, and further life-cycle cost analysis of bridges. In this work, a novel method is proposed for predicting the appropriate extreme traffic load distribution. Specifically, the average conditional exceedance rate (ACER) statistical model is estimated from the historical traffic loads which was collected through a weigh-in-motion system installed in toll stations. The basic idea of the ACER approach lies in the introduction of a cascade of conditioning approximations and the average exceedance rate to capture the dependence effects and obtain the data tail, the trend features of which are fitted with a similar Gumbel distribution function and extrapolated to the concerned level. An illustration case dealing with traffic loads using the ACER strategy is presented, the extreme value and confidence interval (CI) in any return period can be predicted by application of this approach. Furthermore, the peaks-over-threshold (POT) method based on the asymptotic extreme theory is also applied to illustrate the advantages of the ACER method. The ACER method has advantages in analyzing extreme traffic loads, with good robustness and the ability to handle extreme value prediction for different sampling strategies, it also can produce more accurate confidence intervals and predicts consistent extreme values. The study results are expected to help accurately determine traffic loads and ensure safety in bridge engineering. [ABSTRACT FROM AUTHOR]

A series of mesoporous silica-alumina composites (Si-Al-X) were successfully synthesized from coal fly ash (CFA) and used for cadmium Cd(II) adsorption. The structure was characterized and analyzed by XRD, SEM, BET, and TEM. The effects of silica-alumina composites prepared with different amounts of hydrochloric acid on the adsorption of Cd(II) under different pH environments, different adsorbent amounts, and adsorption times were investigated. The results showed that Si-Al-10 has excellent adsorption efficiency and reached adsorption equilibrium after 30 min. When the initial concentration of Cd(II) was 20 mg/L, the pH value was 5.5 ± 0.1, and the amount of adsorbent was 2 g/L, the removal rate of Cd was 97.54%, and the adsorption capacity of Cd(II) was 19.51 mg/g. The Si-Al-10 had well Cd(II) removal rate in a wide pH range of 3–7, the Cd(II) solution of concentration reduced from 5 mg/L to 5 μg/L. [ABSTRACT FROM AUTHOR]

To review and summarize the clinical features, treatment strategies, and prognosis of subcutaneous panniculitis-like T-cell lymphoma complicated with hemophagocytic lymphohistiocytosis (SPTCL–HLH). We searched the Web of Science, Embase, Cochrane Library, and PubMed databases. The keywords were subcutaneous panniculitis-like T-cell lymphoma and hemophagocytic lymphohistiocytosis or hemophagocytic syndrome. The patients were divided into a mutated group and a wild-type group based on the existence of HAVCR2 gene mutation. A total of 45 reports, including 63 patients with SPTCL–HLH, were included in the systematic review. Twelve patients detected gene mutations, including 11 with the HAVCR2 gene mutation and 1 with the STXBP2 gene mutation. Thirty-one patients were tested for autoantibodies. Compared with the wild-type group, patients in the mutated group were younger (p = 0.017), and the autoantibody-positive rate was higher (p = 0.006). The main treatment target of 17 patients was to control HLH, yielding an ORR of 88.2%. Two cases relapsed, and both were treated with corticosteroid monotherapy. The corticosteroid monotherapy experienced a higher recurrence rate than the corticosteroids plus other immunoregulatory agents therapy (66.7 vs. 0.0%, p = 0.029). Eighteen patients received initial anthracycline-based chemotherapy, and 50.0% reached remission. The ORR of initial chemotherapy aiming at controlling HLH was higher than those of anthracycline-based chemotherapy (p = 0.015). The ORR was higher in patients initially controlled for HLH versus chemotherapy without HLH control first (90.5 vs. 61.5%, p = 0.024). Interestingly, one patient with juvenile idiopathic arthritis developed SPTCL–HLH during tocilizumab therapy, discontinuing tocilizumab led to a remission of the disease spontaneously. Sixteen patients received stem cell transplantation (SCT). Fifteen patients, including 5 with relapsed/refractory SPTCL–HLH, responded well and survived after receiving SCT. One case who received a sibling-identical SCT relapsed. Further analysis revealed a homozygous HAVCR2 mutation with the donor. The 2-year overall survival (OS) was 91.0% ± 4.4%. There was a significant difference in the OS among patients of different age groups, and patients aged 40–60 had the lowest 2-year OS (66.7% ± 19.2%). Patients with HAVCR2 gene mutations are younger and more likely to be misdiagnosed with autoimmune diseases. Initial treatment of corticosteroids plus immunoregulatory agents attaches great significance to avoiding too aggressive therapies. Intensive anthracycline-based chemotherapy such as CHOP or CHOP-like regimens can also induce long-term remission for aggressive disease. SCT is still a reliable strategy currently. In addition, a watch and wait approach is recommended in patients with mild SPTCL–HLH caused by drugs. The occurrence of HLH does not necessarily mean a more rapidly progressive disease and worse prognosis in patients with SPTCL, but older patients with SPTCL–HLH may be associated with a lower survival rate. [ABSTRACT FROM AUTHOR]

Feed intolerance (FI) is significantly associated with poor prognosis in critically ill patients. This study aimed to understand the characteristics of children with FI and identify the factors predicting FI in critically ill children. This retrospective cohort study was conducted between January 2017 and June 2022 in the Pediatric Intensive Care Unit of a specialized children's hospital. Eighteen factors, including age, body mass index for age z-score (BAZ) < -2, paediatric index of mortality (PIM)3 score, Glasgow coma scale score, mechanical ventilation (MV), enteral nutrition delay, vasoactive drugs, sedatives, sepsis, heart disease, neurological disease, hypokalemia, arterial PH < 7.35, arterial partial pressure of oxygen (PaO2), blood glucose, hemoglobin, total protein, and albumin, were retrieved to predict FI. The outcome was FI during PICU stay. During the study period, a total of 854 children were included, of which 215 children developed FI. Six predictors of FI were selected: PIM3 score, MV, sepsis, hypokalemia, albumin, and PaO2. Multivariate logistic regression analysis showed that higher PIM3 score, MV, sepsis, hypokalemia, and lower PaO2 were independent risk factors for FI, whereas higher albumin was an independent protective factor for FI. The C-index of the predictive nomogram of 0.943 was confirmed at internal validation to be 0.940, indicating a good predictive value of the model. Decision curve analysis shows good clinical applicability of the nomogram in predicting FI. Conclusion: The nomogram was verified to have a good prediction performance based on discrimination, calibration, and clinical decision analysis. What is Known: • Research has demonstrated that gastrointestinal (GI) dysfunction is not only a fundamental element of Multiple Organ Dysfunction Syndrome (MODS), but also the initiator of MODS. • Previous study has demonstrated a significant association between FI and poor prognosis in critically ill patients. What is New: • We excluded patients with primary gastrointestinal tract disease from our study, and we observed an incidence of FI of 25.2% in the Pediatric Intensive Care Unit (PICU). • Our study revealed that PIM3 score, MV, sepsis, hypokalemia, albumin, and PaO2 are significant predictors of FI. [ABSTRACT FROM AUTHOR]

Key Message: QMS-5B, a major QTL for photo-thermo-sensitive genic male sterility in wheat, was fine mapped in a 2.15 Mb region harboring a serine/threonine protein kinase gene TraesCS5B03G0887500, which was the most likely candidate gene. Genic male sterility is an essential trait in the utilization of heterosis and hybrid seed production for wheat. Currently, genic male sterile genes have been reported in wheat mutants, but the sterile genes controlling photo-thermo-sensitive genic male sterility in wheat have not been studied systematically. Here, 235 doubled haploid lines derived from a cross between photo-thermo-sensitive genic male sterile line BS462 and its restorer line CP279 were used to map male sterile gene by GenoBaits® Wheat 100 K Panel, bulked segregant exome sequencing (BSE-Seq) and wheat 660 K array. As a result, the major stable QTL on chromosome 5B, QMS-5B, was identified in all four environments, accounting for 7.3–36.4% of the phenotypic variances. Ulteriorly, QMS-5B was delimited to an approximate 2.15 Mb physical interval between KASP-5B5 and KASP-5B6 using kompetitive allele-specific PCR (KASP) markers. Within the interval, twenty-nine high-confidence genes were predicted according to Chinese Spring RefSeq v2.1. TraesCS5B03G0887500, encoding a serine/threonine protein kinase, was identified as the most likely candidate gene for QMS-5B based on weighted gene co-expression network analysis. Expression analysis confirmed that TraesCS5B03G0887500 was significantly differentially expressed in anthers of BS462 and CP279 at different stages under fertile and sterile environments. In addition, flanking KASP marker KASP-5B6 can effectively genotype male sterile lines and restorer lines, and can be used for molecular marker-assisted selection. This study provides insights into for exploring the mechanism of photo-thermo-sensitive genic male sterility in wheat. [ABSTRACT FROM AUTHOR]

Introduction: The benefits of adjuvant chemoradiation therapy (CRT) for heterogeneous pathological N2 (pN2) diseases remain unclear in non-small cell lung cancer (NSCLC). This study aimed to investigate suitable pN2 patients for adjuvant CRT. Material and methods: This study retrospectively reviewed the data of patients with pN2 NSCLC in Shanghai Pulmonary Hospital from January 2012 to December 2016. Included cases were subdivided as highest mediastinal lymph node (HM) (n = 732) metastasis and non-HM metastasis (n = 677) groups according to the International Association for the Study of Lung Cancer (IASLC). Furthermore, the Kaplan–Meier and Cox models were used to evaluate the prognostic benefits of adjuvant CRT in heterogeneous pN2 subgroups. Results: A total of 1409 patients were enrolled in this study, with a median follow-up time of 63.8 months. Patients with HM involvement had worse prognoses (p < 0.001 for recurrence-free survival (RFS) and overall survival (OS)). Furthermore, the survival improvement of adjuvant CRT was significant for these patients (p < 0.001 for RFS and p = 0.032 for OS), regardless of whether it was single (p < 0.001 for RFS and p = 0.029 for OS) or multiple pN2 (p < 0.001 for RFS and p = 0.026 for OS) diseases. According to multivariable cox analysis, the long-term RFS and OS in the cancerous HM group were independently predicted by pathological N stage (p = 0.002 for RFS and p < 0.001 for OS) and adjuvant CRT (p < 0.001 for RFS and p = 0.011 for OS). Conclusion: Metastatic HM was associated with a worse prognosis in pN2 disease. Our analysis supported that adjuvant CRT significantly improved both RFS and OS for these patients. [ABSTRACT FROM AUTHOR]

This paper focuses on the solvability of multistage pseudomonotone stochastic variational inequalities (SVIs). On the one hand, some known solvability results of pseudomonotone deterministic variational inequalities cannot be directly extended to multistage pseudomonotone SVIs, so we construct the isomorphism between both and then establish theoretical results on the existence, convexity, boundedness and compactness of the solution set for multistage pseudomonotone SVIs via such an isomorphism. On the other hand, there does not exist a special algorithm for solving the multistage pseudomonotone SVIs so far, so we propose some sufficient conditions on the elicitability of multistage pseudomonotone SVIs, which opens the door for applying Rockafellar's elicited progressive hedging algorithm to solve such SVIs. Numerical results on solving a two-stage stochastic market optimization problem and randomly generated two-stage pseudomonotone linear complementarity problems are presented. [ABSTRACT FROM AUTHOR]

Microorganisms are fundamental for the functioning of marine ecosystems and are involved in the decomposition of organic matter, transformation of nutrients and circulation of biologically-important chemicals. Based on the complexity of the natural geographic characteristics of the Changjiang River Estuary, the geographic distribution of sedimentary microorganisms and the causes of this distribution are largely unexplored. In this work, the surface sediment samples from the adjacent sea area of the Changjiang River Estuary were collected. Their prokaryotic diversity was examined by high-throughput sequencing technology, and the environmental factors of the bacterial community were investigated. The results indicated that the distribution of prokaryotic communities in the sediments of the study areas showed obvious spatial heterogeneity. The sampling sequences divided the sample regions into three distinct clusters. Each geographic region had a unique community structure, although Proteobacteria, Bacteroidota, Desulfobacterota, Acidobacteriota, and Actinobacteriota all existed in these three branches. Canonical correspondence analysis demonstrated that prokaryotic diversity and community distribution were significantly correlated with the geographic location of sediment, seawater depth, and in particular, nutrient content (e.g., total phosphorus, total organic carbon and dissolved oxygen). Moreover, it was found for the first time that the metal ions obviously affected the composition and distribution of the prokaryotic community in this area. In general, this work provides new insights into the structural characteristics and driving factors of prokaryotic communities under the background of the ever-changing Changjiang River Estuary. [ABSTRACT FROM AUTHOR]

Sesquiterpenes are the major pharmacodynamic components of agarwood, a precious traditional Chinese medicine obtained from the resinous portions of Aquilaria sinensis trees that form in response to environmental stressors. To characterize the sesquiterpene synthases responsible for sesquiterpene production in A. sinensis, a bioinformatics analysis of the genome of A. sinensis identified six new terpene synthase genes, and 16 sesquiterpene synthase genes were identified as type TPS-a in a phylogenetic analysis. The expression patterns for eight of the sesquiterpene synthase genes after treatment with various hormones or hydrogen peroxide were analyzed by real-time quantitative PCR. The results suggest that 100 μM methyl jasmonate, ethephon, (±)-abscisic acid or hydrogen peroxide could be effective short-term effectors to increase the expression of sesquiterpene synthase genes, while 1 mM methyl salicylate may have long-term effects on increasing the expression of specific sesquiterpene synthase genes (e.g., As-SesTPS, AsVS, AsTPS12 and AsTPS29). The expression changes in these genes under various conditions reflected their specific roles during abiotic or biotic stresses. Heterologous expression of a novel A. sinensis sesquiterpene synthase gene, AsTPS2, in Escherichia coli produced a major humulene product, so AsTPS2 is renamed AsHS1. AsHS1 is different from ASS1, AsSesTPS, and AsVS, for mainly producing α-humulene. Based on the predicted space conformation of the AsHS1 model, the small ligand molecule may bind to the free amino acid by hydrogen bonding for the catalytic function of the enzyme, while the substrate farnesyl diphosphate (FPP) probably binds to the free amino acid on one side of the RxR motif. Arg450, Asp453, Asp454, Thr457, and Glu461 from the NSE/DTE motif and D307 and D311 from the DDxxD motif were found to form a polar interaction with two Mg2+ clusters by docking. The Mg2+-bound DDxxD and NSE/DTE motifs and the free RXR motif are jointly directed into the catalytic pocket of AsHS1. Comparison of the tertiary structural models of AsHS1 with ASS1 showed that they differed in structures in several positions, such as surrounding the secondary catalytic pocket, which may lead to differences in catalytic products. Based on the results, biosynthetic pathways for specific sesquiterpenes such as α-humulene in A. sinensis are proposed. This study provides novel insights into the functions of the sesquiterpene synthases of A. sinensis and enriches knowledge on agarwood formation. [ABSTRACT FROM AUTHOR]

Adenosine-to-inosine tRNA-editing enzyme has been identified for more than two decades, but the study on its DNA editing activity is rather scarce. We show that amphioxus (Branchiostoma japonicum) ADAT2 (BjADAT2) contains the active site 'HxE-PCxxC' and the key residues for target-base-binding, and amphioxus ADAT3 (BjADAT3) harbors both the N-terminal positively charged region and the C-terminal pseudo-catalytic domain important for recognition of substrates. The sequencing of BjADAT2-transformed Escherichia coli genome suggests that BjADAT2 has the potential to target E. coli DNA and can deaminate at TCG and GAA sites in the E. coli genome. Biochemical analyses further demonstrate that BjADAT2, in complex with BjADAT3, can perform A-to-I editing of tRNA and convert C-to-U and A-to-I deamination of DNA. We also show that BjADAT2 preferentially deaminates adenosines and cytidines in the loop of DNA hairpin structures of substrates, and BjADAT3 also affects the type of DNA substrate targeted by BjADAT2. Finally, we find that C89, N113, C148 and Y156 play critical roles in the DNA editing activity of BjADAT2. Collectively, our study indicates that BjADAT2/3 is the sole naturally occurring deaminase with both tRNA and DNA editing capacity identified so far in Metazoa. An adenosine-to-inosine tRNA-editing deaminase ADAT2 from amphioxus (Branchiostoma japonicum) in complex with ADAT3 can perform A-to-I editing of tRNA and convert C-to-U and A-to-I deamination of DNA. [ABSTRACT FROM AUTHOR]

Purpose: Tumor spread through air space (STAS) is a novel pattern of invasion related to poor prognosis in non-small cell cancer (NSCLC). Nevertheless, little is known about the role of STAS in small cell lung cancer (SCLC). We sought to determine whether STAS has a significant effect on recurrence among SCLC patients. Methods: We collected clinical and follow-up information from 181 resected stage I–III SCLC patients and compared overall survival (OS) and disease-free survival (DFS) between the patients with or without STAS using the Kaplan‒Meier method. To explore the effect of STAS on recurrence, a competing-risk analysis was conducted. Results: Among 181 SCLC patients, STAS was observed in 56 (30.94%) patients, and 125 (69.06%) patients did not have STAS. Furthermore, 33 (18.23%) patients had recurrence, including 12 patients with brain metastases. Patients with STAS had worse DFS. The cumulative incidence of any recurrence was higher in patients with STAS than in those without STAS. Univariate and multivariate competing-risk regression analyses revealed that sublobar resection and STAS were independent risk factors for SCLC recurrence (p = 0.009 and p = 0.029 for multivariate analysis, respectively). Conclusion: SCLC patients with STAS have worse DFS than SCLC patients without STAS. STAS is an independent prognostic factor in SCLC patients. [ABSTRACT FROM AUTHOR]

In the present study, the effects of SiC whiskers on the microstructure of the SAC0307-xSiC (x = 0 wt.%, 0.02 wt.%, 0.04 wt.%, 0.06 wt.%, 0.08 wt.% and 0.10 wt.%) composite solders and their related properties have been investigated. The results showed that the appropriate addition of SiC whiskers (< 0.10 wt.%) significantly refined the precipitated phases (Ag3Sn and Cu6Sn5), enhanced the wettability and hardly affected the melting point of the composite solders. Additionally, the admixture of SiC whiskers inhibited the growth of the interfacial intermetallic compound (IMC) layer between the composite solder and Cu substrate during reflow soldering. The thickness of IMCs was reduced from 2.52 μm for the plain SAC0307/Cu to 1.93 μm with 0.10 wt.% SiC whisker addition. Moreover, when the amount of SiC whisker addition reached 0.06 wt.%, the shear strength of solder joints reached a maximum 28.0 MPa, 55.6% higher than that of the pristine counterpart, and then decreased because of the agglomeration of SiC whiskers with the increase of SiC whisker content. [ABSTRACT FROM AUTHOR]

Adaptation to selective pressures is crucial for clinically important pathogens to establish epidemics, but the underlying evolutionary drivers remain poorly understood. The current epidemic of carbapenem-resistant Klebsiella pneumoniae (CRKP) poses a significant threat to public health. In this study we analyzed the genome sequences of 794 CRKP bloodstream isolates collected in 40 hospitals in China between 2014 and 2019. We uncovered a subclonal replacement in the predominant clone ST11, where the previously prevalent subclone OL101:KL47 was replaced by O2v1:KL64 over time in a stepwise manner. O2v1:KL64 carried a higher load of mobile genetic elements, and a point mutation exclusively detected in the recC of O2v1:KL64 significantly promotes recombination proficiency. The epidemic success of O2v1:KL64 was further associated with a hypervirulent sublineage with enhanced resistance to phagocytosis, sulfamethoxazole-trimethoprim, and tetracycline. The phenotypic alterations were linked to the overrepresentation of hypervirulence determinants and antibiotic genes conferred by the acquisition of an rmpA-positive pLVPK-like virulence plasmid and an IncFII-type multidrug-resistant plasmid, respectively. The dissemination of the sublineage was further promoted by more frequent inter-hospital transmission. The results collectively demonstrate that the expansion of O2v1:KL64 is correlated to a repertoire of genomic alterations convergent in a subpopulation with evolutionary advantages. Authors carry out a genomic analysis of carbapenem-resistant Klebsiella pneumoniae bloodstream isolates, noting subclonal expansion, associated with the emergence of a hypervirulent subpopulation. [ABSTRACT FROM AUTHOR]

The assembly of small batch electrical and mechanical products still relies on manual operation, with the problems of high rechecking time and low assembly efficiency and quality. The augmented reality technology can be used to assist assembly to improve efficiency. In view of the high professionalism, labor, and time cost for the traditional posture detection method, a posture detection method is proposed to match the assembly posture by pre-calibrating the assembly posture template. The YOLO-6D model is brought in to increase the robustness of tracking registration. And the detection from both translation and rotation perspectives is designed to enhance the adaptability to different assembly tasks. For the generation of training datasets, a weighted sampling method based on part features is proposed to optimize the accuracy of position estimation with the limited training samples. Taking the assembly process of a typical electronic product as an example, the developed augmented reality aided assembly system is used to boost the assembly efficiency of the assembly operator effectively as compared to the traditional posture detection method. [ABSTRACT FROM AUTHOR]

The iodine status of children has improved and stabilized since China implemented salt iodization measures 25 years ago, but routine monitoring of iodine cannot reflect regional factors that influence the iodine level in children. Therefore, we conducted a regional spatial–temporal analysis of children's median urinary iodine concentration (MUIC) and searched for possible factors that might affect children's iodine levels by mining monitoring data. We analyzed data from Xinjiang collected as part of the "Iodine Deficiency Disease National Monitoring Program" from 2017 to 2020. The study population consisted of 76,268 children who participated in the study. We used global autocorrelation analysis to determine whether the MUIC of children was spatially clustered, local autocorrelation analysis to identify specific clustering areas, local cold and hot spot analysis to verify the reliability of the local autocorrelation results, and a spatial lag model to identify factors affecting the children's MUIC. The MUIC values were 217.70, 227.00, 230.67, and 230.67 µg/L in 2017, 2018, 2019, and 2020, respectively. Global autocorrelation analysis showed that the MUIC of all children in the study was significantly related to region (Z scores all > 1.96, P values all < 0.05) from 2017 to 2020. Partial auto-correlation analysis showed that counties with clusters of high values were mostly concentrated in the southwestern region of Xinjiang, whereas counties with clusters of low values were located in the northern part of Xinjiang. Partial cold spot and hot spot analysis showed the same trend, and there are more overlapping districts and counties in 4 years. Three-dimensional trend analysis indicated that children from the western part of Xinjiang had high levels of urinary iodine. According to spatial lag model, urine iodine concentration level is positively correlated with thyroid volume, average salary, and urbanization rate classification. The MUIC of 8–10-year-old children in Xinjiang was spatially clustered and related to geographic region. Our results show that spatial analysis of survey data combined with geographic technology and public health data can accurately identify areas with abnormal iodine concentrations in children. Additionally, understanding the factors that influence iodine levels in the human population is conducive to improving monitoring methods. [ABSTRACT FROM AUTHOR]

This study aimed to compare the serum levels of 34 cytokines of children with hemophagocytic lymphohistiocytosis (HLH) and explored the specific cytokine pattern of HLH subtypes and the relationship between cytokine levels and prognosis. This retrospective study assessed the clinical data and cytokine levels of newly diagnosed children with HLH in Beijing Children's Hospital, Capital Medical University, from January 2017 to December 2021. A total of 101 children were enrolled in the study. The levels of IFN-γ and IL-18 increased in more than 90% of patients, and MIP-1α, SDF-1α, IP-10, IL-6, IL-8, IL-10, IL-1 RA, and TNF-α increased at different levels in more than 50% of patients. The levels of IL-10 in EBV-HLH increased significantly, followed by IFN-γ and IL-18, while IL-10 and IFN-γ in CAEBV-HLH had a slight increase. Except for IL-10, the levels of IL-6, Eotaxin, IL-13, IL-18, IFN-γ, and MIP-1β in Rh-HLH increased significantly. F-HLH had significantly high IL-10 levels and a slight increase in IL-13. We showed that various cytokines could assist in differentiating HLH subtypes with ROC curve analysis. When IL-10/IL-6 was 1.37, the sensitivity and specificity of diagnosing EBV-HLH were higher than 80% (AUC = 0.837, p < 0.001). The effect of cytokine ratio on classifying HLH subtypes (17/22, 77.3%) was more significant than the single cytokine (5/22, 22.7%). The 3-year overall survival (OS) rate of children with F-HLH was the lowest during the follow-up. The 3-year OS of patients with EBV-HLH and CAEBV-HLH was significantly higher than that with F-HLH (88.1% ± 5.0% vs. 94.1% ± 5.7% vs. 57.1% ± 14.6%, p = 0.017). Cox proportional hazards model revealed that elevated GM-CSF and MCP-1, as well as CNS involvement, were independent risk factors for poor outcomes for patients with HLH. Various cytokines play important roles in HLH. Different subtypes of HLH have their specific cytokines pattern, and the ratio of cytokines may be more significant in differentiating HLH subtypes than the single one. Elevated GM-CSF and MCP-1 could be useful biomarkers for a poor prognosis for patients with HLH. [ABSTRACT FROM AUTHOR]

We evaluated differences in the pathology and humoral immune status in one- and two-month-old weaned pigs infected with virulent Chinese genotype GIIa and GIIb strains of porcine epidemic diarrhea virus (PEDV). All pigs infected with the GIIa strain developed severe diarrhea (100%), while the morbidity of the GIIb strain in one- and two-month-old weaned pigs was 80% (4/5) and 40% (2/5), respectively. There was no significant difference in IgA, IgG, or virus-neutralizing (VN) antibody levels associated with GIIa and GIIb in one-month-old weaned pigs (P > 0.05), but in two-month-old weaned pigs, the IgA, IgG, and VN antibody levels associated with GIIa were significantly higher than those associated with GIIb (P < 0.05). [ABSTRACT FROM AUTHOR]

The tensor complementarity problem is a special instance in the class of nonlinear complementarity problems, which has many applications in multi-person noncooperative games, hypergraph clustering problems and traffic equilibrium problems. Two most important research issues are how to identify the solvability and how to solve such a problem via analyzing the structure of the involved tensor. In this paper, based on the concept of monotone mappings, we introduce a new class of structured tensors and the corresponding monotone tensor complementarity problem. We show that the solution set of the monotone tensor complementarity problem is nonempty and compact under the feasibility assumption. Moreover, a necessary and sufficient condition for ensuring the feasibility is given via analyzing the structure of the involved tensor. Based on the Huber function, we propose a regularized smoothing Newton method to solve the monotone tensor complementarity problem and establish its global convergence. Under some mild assumptions, we show that the proposed algorithm is superlinearly convergent. Preliminary numerical results indicate that the proposed algorithm is very promising. [ABSTRACT FROM AUTHOR]

Although previous RNA sequencing methods have been widely used in orthopedic research and have provided ideas for therapeutic strategies, the specific mechanisms of some orthopedic disorders, including osteoarthritis, lumbar disc herniation, rheumatoid arthritis, fractures, tendon injuries, spinal cord injury, heterotopic ossification, and osteosarcoma, require further elucidation. The emergence of the single-cell RNA sequencing (scRNA-seq) technique has introduced a new era of research on these topics, as this method provides information regarding cellular heterogeneity, new cell subtypes, functions of novel subclusters, potential molecular mechanisms, cell-fate transitions, and cell‒cell interactions that are involved in the development of orthopedic diseases. Here, we summarize the cell subpopulations, genes, and underlying mechanisms involved in the development of orthopedic diseases identified by scRNA-seq, improving our understanding of the pathology of these diseases and providing new insights into therapeutic approaches. [ABSTRACT FROM AUTHOR]

The gray model is very useful for small sample prediction. Compared with the homogeneous gray model, the nonhomogeneous gray model (NGM) improves the prediction differential equation; thus, the NGM is able to effectively predict a nonhomogeneous exponential sequence. However, the NGM cannot be applied to nonlinear samples because of the linear whitening equation. Inspired by multikernel learning, the central alignment multikernel learning method is integrated into the NGM, and a centered alignment multikernel NGM (CAMKNGM) is presented in this paper. In our model, the kernel trick and kernel function are used to overcome the difficulties in solving the nonlinear mapping problems of the NGM. Additionally, more than one kernel function is utilized to generate responding kernel matrices by mapping the nonlinear features to different kernel spaces. Centered alignment multikernel learning optimization can be carried out according to the obtained kernel matrices to form a more sufficient feature space so that the combined kernel matrix can be used to greatly capture the nonlinear factors of the time series. Through multikernel learning optimization, the proposed model with unknown nonlinear transformation can be solved easily. In the experiment, we assess the performance of our model on three samples and compare the CAMKNGM with the single-kernel NGM (KRNGM) and other state-of-the-art models. The results show that the CAMKNGM model is obviously better than the support vector regression, NGM, optimized NGM and KRNGM. [ABSTRACT FROM AUTHOR]

Slow–fast dynamics such as bursting behaviors are common in many physical and engineering systems. In the previous study, some focused on the bursting behavior caused by the codimension-1 bifurcations, and others focus on the bursting behavior due to the particular structures. However, systems under critical conditions may exhibit many complicated dynamics due to the high co-dimensional bifurcations. Our research aims to investigate the bursting oscillations near a triple zero eigenvalues singularity. A perturbation model of the double pendulum system with external excitation is taken as an example and investigated the dynamical mechanism of bursting behaviors. Because of the order gap between the exciting frequency and natural frequency, the perturbation model with the external excitation can be regarded as a generalized autonomous system. By overlapping the transformed phase portrait and the equilibrium branch, four types of bursting oscillations are determined: fold/fold type, zero-Hopf/zero-Hopf type, symmetrical zero-Hopf/sup-Hopf/fold-cycle type, and symmetrical zero-Hopf/sup-Hopf/fold-cycle/sub-Hopf type. Primarily, we find that due to the singularity of compound fold conditions, many bifurcations of the limit cycle occur, which cause many complex dynamics such as 2-D tori bursting, breaking of symmetric structure, and chaotic bursting. These results play an essential role in understanding the stability of a system with high co-dimensional bifurcation conditions. They can be expected to provide a theoretical basis for formulating a control strategy. [ABSTRACT FROM AUTHOR]

We propose a new kind of stochastic absolute value equations involving absolute values of variables. By utilizing an equivalence relation to stochastic bilinear program, we investigate the expected value formulation for the proposed stochastic absolute value equations. We also consider the expected residual minimization formulation for the proposed stochastic absolute value equations. Under mild assumptions, we give the existence conditions for the solution of the stochastic absolute value equations. The solution of the stochastic absolute value equations can be gotten by solving the discrete minimization problem. And we also propose a smoothing gradient method to solve the discrete minimization problem. Finally, the numerical results and some discussions are given. [ABSTRACT FROM AUTHOR]