1. Pilot study of home-based monitoring for early prediction of acute exacerbations in patients with fibrosing interstitial lung diseases.
- Author
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Fu, Hongyan, Wang, Zhaojun, Hu, Zhengyu, Zhao, Tingting, Xin, Hongxia, Wu, Fan, Hou, Jia, Yang, Yanjuan, Zhang, Yanan, Jiang, Wangshu, Wang, Faxuan, Deng, Ning, and Chen, Juan
- Subjects
INTERSTITIAL lung diseases ,OXYGEN saturation ,OXYGEN in the blood ,DISEASE exacerbation ,MEDICAL research ,COUGH - Abstract
This study aimed to assess the potential of home monitoring using a monitoring application for the early prediction of acute exacerbations (AEs) in patients with fibrosing interstitial lung diseases (F-ILDs) by tracking symptoms, peripheral blood oxygen saturation (SpO
2 ), and heart rate (HR). Data on symptoms, SpO2 , and HR before and after a 1-min sit-to-stand test (1STST) were collected using an online home monitoring application. Symptoms were recorded at least 3 times a week, including cough intensity and frequency (Cough Assessment Test scale (COAT) score), breathlessness grade (modified Medical Research Council (mMRC) score), and SpO2 and HR before and after 1STST. Eighty-five patients with stable F-ILDs were enrolled. We observed a significant increase in COAT and mMRC scores, alongside a significant decrease in SpO2 before and after 1STST, 2 weeks before the first recorded AE. Furthermore, a combination of variables-an increase in COAT (≥ 4) and mMRC(≥ 1) scores, a decrease in SpO2 at rest (≥ 5%), and a decrease in SpO2 after 1STST (≥ 4%)- proved the most effective in predicting AE onset in patients with F-ILDs at 2 weeks before the first recorded AE. Home telemonitoring of symptoms, SpO2 holds potential value for early AE detection in patients with F-ILDs. [ABSTRACT FROM AUTHOR]- Published
- 2024
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