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Background: Lung adenocarcinoma (LUAD), a subtype of non-small cell lung cancer (NSCLC), causes high mortality around the world. Previous studies have suggested that the metabolic pattern of tumor is associated with tumor response to immunotherapy and patient's survival outcome. Yet, this relationship in LUAD is still unknown. Methods: Therefore, in this study, we identified the immune landscape in different tumor subtypes classified by metabolism-related genes expression with a large-scale dataset (tumor samples, n = 2181; normal samples, n = 419). We comprehensively correlated metabolism-related phenotypes with diverse clinicopathologic characteristics, genomic features, and immunotherapeutic efficacy in LUAD patients. Results: And we confirmed tumors with activated lipid metabolism tend to have higher immunocytes infiltration and better response to checkpoint immunotherapy. This work highlights the connection between the metabolic pattern of tumor and tumor immune infiltration in LUAD. A scoring system based on metabolism-related gene expression is not only able to predict prognosis of patient with LUAD but also applied to pan-cancer. LUAD response to checkpoint immunotherapy can also be predicted by this scoring system. Conclusions: This work revealed the significant connection between metabolic pattern of tumor and tumor immune infiltration, regulating LUAD patients' response to immunotherapy. [ABSTRACT FROM AUTHOR]

Temperature-sensitive poly(N-isopropylacrylamide)/montmorillonite (PNIPAM/MMT) composite hydrogel was prepared by frontal polymerization. The effects of the MMT content and size of the reactor on the polymerization process and the properties of the products were investigated. The results indicated that the rapid thermal front propagation effectively suppressed the phase separation and caused a uniform distribution of MMT particles inside the PNIPAM matrix. The addition of MMT increased the compressive strength of composite hydrogel by 70% when compared to the one of the homopolymer but did not affect the lower critical solution temperature ) (LCST) of the hydrogel. The product containing 5 wt% MMT presented the quickest temperature response among all tested samples. As the diameter of the reactor increased, the front velocity and the front temperature increased but the compressive strength had a tendency to decrease. During the cycle uses, the performance of the composite gel prepared by frontal polymerization was almost maintained constant in contrast to the ones of the conventionally polymerized-product. [ABSTRACT FROM AUTHOR]

In RCS estimation, usually a plane wave is assumed; while in real measurements at terahertz frequencies, generally a Gaussian beam or a similar beam source is adopted. In this paper, the RCS of a conducting sphere is discussed under the condition that the incident wave is a Gaussian beam. In the estimation, the influence of 2.52 THz collimated laser beam on RCS is discussed and the RCS changing with scattering angle and some other factors is obtained; at the same time, the comparisons between different incident beams, plane wave and Gaussian beam, are also given. The estimation results show that choosing a beam width of 40 mm is appropriate when the sphere radius is 10 mm and the distance between the sphere and the beam source is 1 m. [ABSTRACT FROM AUTHOR]