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5 results on '"Wyss, Patrik O."'

1. Metabolic profile of complete spinal cord injury in pons and cerebellum: A 3T 1H MRS study.

Author

Richter, Johannes K., Vallesi, Vanessa, Zölch, Niklaus, Chan, Kimberly L., Hunkeler, Nadine, Abramovic, Mihael, Hashagen, Claus, Christiaanse, Ernst, Shetty, Ganesh, Verma, Rajeev K., Berger, Markus F., Frotzler, Angela, Eisenlohr, Heidrun, Eriks Hoogland, Inge, Scheel-Sailer, Anke, and Wyss, Patrik O.

Subjects
SPINAL cord injuries, NUCLEAR magnetic resonance spectroscopy, CEREBELLUM, CEREBELLAR cortex, METHYL aspartate receptors
Abstract

The aim of this exploratory study was the assessment of the metabolic profiles of persons with complete spinal cord injury (SCI) in three region-of-interests (pons, cerebellar vermis, and cerebellar hemisphere), with magnetic resonance spectroscopy, and their correlations to clinical scores. Group differences and association between metabolic and clinical scores were examined. Fifteen people with chronic SCI (cSCI), five people with subacute SCI (sSCI) and fourteen healthy controls were included. Group comparison between cSCI and HC showed lower total N-acetyl-aspartate (tNAA) in the pons (p = 0.04) and higher glutathione (GSH) in the cerebellar vermis (p = 0.02). Choline levels in the cerebellar hemisphere were different between cSCI and HC (p = 0.02) and sSCI and HC (p = 0.02). A correlation was reported for choline containing compounds (tCho) to clinical scores in the pons (rho = − 0.55, p = 0.01). tNAA to total creatine (tNAA/tCr ratio) correlated to clinical scores in the cerebellar vermis (rho = 0.61, p = 0.004) and GSH correlated to the independence score in the cerebellar hemisphere (rho = 0.56, p = 0.01). The correlation of tNAA, tCr, tCho and GSH to clinical scores might be indicators on how well the CNS copes with the post-traumatic remodeling and might be further examined as outcome markers. [ABSTRACT FROM AUTHOR]

Published
2023
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2. Functional connectivity and amplitude of low-frequency fluctuations changes in people with complete subacute and chronic spinal cord injury.

Author

Vallesi, Vanessa, Richter, Johannes K., Hunkeler, Nadine, Abramovic, Mihael, Hashagen, Claus, Christiaanse, Ernst, Shetty, Ganesh, Verma, Rajeev K., Berger, Markus, Frotzler, Angela, Eisenlohr, Heidrun, Eriks-Hoogland, Inge, Scheel-Sailer, Anke, Michels, Lars, and Wyss, Patrik O.

Subjects
FUNCTIONAL connectivity, SPINAL cord injuries, FUNCTIONAL magnetic resonance imaging, PREFRONTAL cortex, SENSORIMOTOR cortex, EXECUTIVE function
Abstract

After spinal cord injury (SCI), reorganization processes and changes in brain connectivity occur. Besides the sensorimotor cortex, the subcortical areas are strongly involved in motion and executive control. This exploratory study focusses on the cerebellum and vermis. Resting-state functional magnetic resonance imaging (fMRI) was performed. Between-group differences were computed using analysis of covariance and post-hoc tests for the seed-based connectivity measure with vermis and cerebellum as regions of interest. Twenty participants with complete SCI (five subacute SCI, 15 with chronic SCI) and 14 healthy controls (HC) were included. Functional connectivity (FC) was lower in all subjects with SCI compared with HC in vermis IX, right superior frontal gyrus (pFDR = 0.008) and right lateral occipital cortex (pFDR = 0.036). In addition, functional connectivity was lower in participants with chronic SCI compared with subacute SCI in bilateral cerebellar crus I, left precentral- and middle frontal gyrus (pFDR = 0.001). Furthermore, higher amplitude of low-frequency fluctuations (ALFF) was found in the left thalamus in individuals with subacute SCI (pFDR = 0.002). Reduced FC in SCI indicates adaptation with associated deficit in sensory and motor function. The increased ALFF in subacute SCI might reflect reorganization processes in the subacute phase. [ABSTRACT FROM AUTHOR]

Published
2022
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3. Generic acquisition protocol for quantitative MRI of the spinal cord

Author

Cohen-Adad, Julien, Alonso Ortiz, Eva, Abramovic, Mihael, Arneitz, Carina, Atcheson, Nicole, Barlow, Laura, Barry, Robert L., Barth, Markus, Battiston, Marco, Büchel, Christian, Budde, Matthew, Callot, Virginie, Combes, Anna J. E., De Leener, Benjamin, Descoteaux, Maxime, de Sousa, Paulo Loureiro, Dostál, Marek, Doyon, Julien, Dvorak, Adam, Eippert, Falk, Epperson, Karla R., Epperson, Kevin S., Freund, Patrick, Finsterbusch, Jürgen, Foias, Alexandru, Fratini, Michela, Fukunaga, Issei, Wheeler-Kingshott, Claudia Angela M. Gandini, Germani, Giancarlo, Gilbert, Guillaume, Giove, Federico, Gros, Charley, Grussu, Francesco, Hagiwara, Akifumi, Henry, Pierre-Gilles, Horák, Tomáš, Hori, Masaaki, Joers, James, Kamiya, Kouhei, Karbasforoushan, Haleh, Keřkovský, Miloš, Khatibi, Ali, Kim, Joo-Won, Kinany, Nawal, Kitzler, Hagen, Kolind, Shannon, Kong, Yazhuo, Kudlička, Petr, Kuntke, Paul, Kurniawan, Nyoman D., Kusmia, Slawomir, Labounek, René, Laganà, Maria Marcella, Laule, Cornelia, Law, Christine S., Lenglet, Christophe, Leutritz, Tobias, Liu, Yaou, Llufriu, Sara, Mackey, Sean, Martinez-Heras, Eloy, Mattera, Loan, Nestrasil, Igor, O'Grady, Kristin P., Papinutto, Nico, Papp, Daniel, Pareto, Deborah, Parrish, Todd B., Pichiecchio, Anna, Prados, Ferran, Rovira, Àlex, Ruitenberg, Marc J., Samson, Rebecca S., Savini, Giovanni, Seif, Maryam, Seifert, Alan C., Smith, Alex K., Smith, Seth A., Smith, Zachary A., Solana, Elisabeth, Suzuki, Yuichi, Tackley, George, Tinnermann, Alexandra, Valošek, Jan, Van De Ville, Dimitri, Yiannakas, Marios C., Weber, Kenneth A., Weiskopf, Nikolaus, Wise, Richard G., Wyss, Patrik O., Xu, Junqian, Cohen-Adad, Julien, Alonso Ortiz, Eva, Abramovic, Mihael, Arneitz, Carina, Atcheson, Nicole, Barlow, Laura, Barry, Robert L., Barth, Markus, Battiston, Marco, Büchel, Christian, Budde, Matthew, Callot, Virginie, Combes, Anna J. E., De Leener, Benjamin, Descoteaux, Maxime, de Sousa, Paulo Loureiro, Dostál, Marek, Doyon, Julien, Dvorak, Adam, Eippert, Falk, Epperson, Karla R., Epperson, Kevin S., Freund, Patrick, Finsterbusch, Jürgen, Foias, Alexandru, Fratini, Michela, Fukunaga, Issei, Wheeler-Kingshott, Claudia Angela M. Gandini, Germani, Giancarlo, Gilbert, Guillaume, Giove, Federico, Gros, Charley, Grussu, Francesco, Hagiwara, Akifumi, Henry, Pierre-Gilles, Horák, Tomáš, Hori, Masaaki, Joers, James, Kamiya, Kouhei, Karbasforoushan, Haleh, Keřkovský, Miloš, Khatibi, Ali, Kim, Joo-Won, Kinany, Nawal, Kitzler, Hagen, Kolind, Shannon, Kong, Yazhuo, Kudlička, Petr, Kuntke, Paul, Kurniawan, Nyoman D., Kusmia, Slawomir, Labounek, René, Laganà, Maria Marcella, Laule, Cornelia, Law, Christine S., Lenglet, Christophe, Leutritz, Tobias, Liu, Yaou, Llufriu, Sara, Mackey, Sean, Martinez-Heras, Eloy, Mattera, Loan, Nestrasil, Igor, O'Grady, Kristin P., Papinutto, Nico, Papp, Daniel, Pareto, Deborah, Parrish, Todd B., Pichiecchio, Anna, Prados, Ferran, Rovira, Àlex, Ruitenberg, Marc J., Samson, Rebecca S., Savini, Giovanni, Seif, Maryam, Seifert, Alan C., Smith, Alex K., Smith, Seth A., Smith, Zachary A., Solana, Elisabeth, Suzuki, Yuichi, Tackley, George, Tinnermann, Alexandra, Valošek, Jan, Van De Ville, Dimitri, Yiannakas, Marios C., Weber, Kenneth A., Weiskopf, Nikolaus, Wise, Richard G., Wyss, Patrik O., and Xu, Junqian

Abstract

Quantitative spinal cord (SC) magnetic resonance imaging (MRI) presents many challenges, including a lack of standardized imaging protocols. Here we present a prospectively harmonized quantitative MRI protocol, which we refer to as the spine generic protocol, for users of 3T MRI systems from the three main manufacturers: GE, Philips and Siemens. The protocol provides guidance for assessing SC macrostructural and microstructural integrity: T1-weighted and T2-weighted imaging for SC cross-sectional area computation, multi-echo gradient echo for gray matter cross-sectional area, and magnetization transfer and diffusion weighted imaging for assessing white matter microstructure. In a companion paper from the same authors, the spine generic protocol was used to acquire data across 42 centers in 260 healthy subjects. The key details of the spine generic protocol are also available in an open-access document that can be found at https://github.com/spine-generic/protocols. The protocol will serve as a starting point for researchers and clinicians implementing new SC imaging initiatives so that, in the future, inclusion of the SC in neuroimaging protocols will be more common. The protocol could be implemented by any trained MR technician or by a researcher/clinician familiar with MRI acquisition.

Published
2021

4. Open-access quantitative MRI data of the spinal cord and reproducibility across participants, sites and manufacturers

Author

Cohen-Adad, Julien, Alonso Ortiz, Eva, Abramovic, Mihael, Arneitz, Carina, Atcheson, Nicole, Barlow, Laura, Barry, Robert L., Barth, Markus, Battiston, Marco, Büchel, Christian, Budde, Matthew, Callot, Virginie, Combes, Anna J. E., De Leener, Benjamin, Descoteaux, Maxime, de Sousa, Paulo Loureiro, Dostál, Marek, Doyon, Julien, Dvorak, Adam, Eippert, Falk, Epperson, Karla R., Epperson, Kevin S., Freund, Patrick, Finsterbusch, Jürgen, Foias, Alexandru, Fratini, Michela, Fukunaga, Issei, Wheeler-Kingshott, Claudia Angela M. Gandini, Germani, Giancarlo, Gilbert, Guillaume, Giove, Federico, Gros, Charley, Grussu, Francesco, Hagiwara, Akifumi, Henry, Pierre-Gilles, Horák, Tomáš, Hori, Masaaki, Joers, James, Kamiya, Kouhei, Karbasforoushan, Haleh, Keřkovský, Miloš, Khatibi, Ali, Kim, Joo-Won, Kinany, Nawal, Kitzler, Hagen H., Kolind, Shannon, Kong, Yazhuo, Kudlička, Petr, Kuntke, Paul, Kurniawan, Nyoman D., Kusmia, Slawomir, Labounek, René, Laganà, Maria Marcella, Laule, Cornelia, Law, Christine S., Lenglet, Christophe, Leutritz, Tobias, Liu, Yaou, Llufriu, Sara, Mackey, Sean, Martinez-Heras, Eloy, Mattera, Loan, Nestrasil, Igor, O’Grady, Kristin P., Papinutto, Nico, Papp, Daniel, Pareto, Deborah, Parrish, Todd B., Pichiecchio, Anna, Prados, Ferran, Rovira, Àlex, Ruitenberg, Marc J., Samson, Rebecca S., Savini, Giovanni, Seif, Maryam, Seifert, Alan C., Smith, Alex K., Smith, Seth A., Smith, Zachary A., Solana, Elisabeth, Suzuki, Y., Tackley, George, Tinnermann, Alexandra, Valošek, Jan, Van De Ville, Dimitri, Yiannakas, Marios C., Weber II, Kenneth A., Weiskopf, Nikolaus, Wise, Richard G., Wyss, Patrik O., Xu, Junqian, Cohen-Adad, Julien, Alonso Ortiz, Eva, Abramovic, Mihael, Arneitz, Carina, Atcheson, Nicole, Barlow, Laura, Barry, Robert L., Barth, Markus, Battiston, Marco, Büchel, Christian, Budde, Matthew, Callot, Virginie, Combes, Anna J. E., De Leener, Benjamin, Descoteaux, Maxime, de Sousa, Paulo Loureiro, Dostál, Marek, Doyon, Julien, Dvorak, Adam, Eippert, Falk, Epperson, Karla R., Epperson, Kevin S., Freund, Patrick, Finsterbusch, Jürgen, Foias, Alexandru, Fratini, Michela, Fukunaga, Issei, Wheeler-Kingshott, Claudia Angela M. Gandini, Germani, Giancarlo, Gilbert, Guillaume, Giove, Federico, Gros, Charley, Grussu, Francesco, Hagiwara, Akifumi, Henry, Pierre-Gilles, Horák, Tomáš, Hori, Masaaki, Joers, James, Kamiya, Kouhei, Karbasforoushan, Haleh, Keřkovský, Miloš, Khatibi, Ali, Kim, Joo-Won, Kinany, Nawal, Kitzler, Hagen H., Kolind, Shannon, Kong, Yazhuo, Kudlička, Petr, Kuntke, Paul, Kurniawan, Nyoman D., Kusmia, Slawomir, Labounek, René, Laganà, Maria Marcella, Laule, Cornelia, Law, Christine S., Lenglet, Christophe, Leutritz, Tobias, Liu, Yaou, Llufriu, Sara, Mackey, Sean, Martinez-Heras, Eloy, Mattera, Loan, Nestrasil, Igor, O’Grady, Kristin P., Papinutto, Nico, Papp, Daniel, Pareto, Deborah, Parrish, Todd B., Pichiecchio, Anna, Prados, Ferran, Rovira, Àlex, Ruitenberg, Marc J., Samson, Rebecca S., Savini, Giovanni, Seif, Maryam, Seifert, Alan C., Smith, Alex K., Smith, Seth A., Smith, Zachary A., Solana, Elisabeth, Suzuki, Y., Tackley, George, Tinnermann, Alexandra, Valošek, Jan, Van De Ville, Dimitri, Yiannakas, Marios C., Weber II, Kenneth A., Weiskopf, Nikolaus, Wise, Richard G., Wyss, Patrik O., and Xu, Junqian

Abstract

In a companion paper by Cohen-Adad et al. we introduce the spine generic quantitative MRI protocol that provides valuable metrics for assessing spinal cord macrostructural and microstructural integrity. This protocol was used to acquire a single subject dataset across 19 centers and a multi-subject dataset across 42 centers (for a total of 260 participants), spanning the three main MRI manufacturers: GE, Philips and Siemens. Both datasets are publicly available via git-annex. Data were analysed using the Spinal Cord Toolbox to produce normative values as well as inter/intra-site and inter/intra-manufacturer statistics. Reproducibility for the spine generic protocol was high across sites and manufacturers, with an average inter-site coefficient of variation of less than 5% for all the metrics. Full documentation and results can be found at https://spine-generic.rtfd.io/. The datasets and analysis pipeline will help pave the way towards accessible and reproducible quantitative MRI in the spinal cord.

Published
2021

5. Acute effects of ketamine on the pregenual anterior cingulate: linking spontaneous activation, functional connectivity, and glutamate metabolism.

Author

Gärtner, Matti, Weigand, Anne, Scheidegger, Milan, Lehmann, Mick, Wyss, Patrik O., Wunder, Andreas, Henning, Anke, and Grimm, Simone

Subjects
CINGULATE cortex, FUNCTIONAL connectivity, KETAMINE, NUCLEAR magnetic resonance spectroscopy, GLUTAMATE receptors, METHYL aspartate receptors, GLUTAMIC acid
Abstract

Ketamine exerts its rapid antidepressant effects via modulation of the glutamatergic system. While numerous imaging studies have investigated the effects of ketamine on a functional macroscopic brain level, it remains unclear how altered glutamate metabolism and changes in brain function are linked. To shed light on this topic we here conducted a multimodal imaging study in healthy volunteers (N = 23) using resting state fMRI and proton (1H) magnetic resonance spectroscopy (MRS) to investigate linkage between metabolic and functional brain changes induced by ketamine. Subjects were investigated before and during an intravenous ketamine infusion. The MRS voxel was placed in the pregenual anterior cingulate cortex (pgACC), as this region has been repeatedly shown to be involved in ketamine's effects. Our results showed functional connectivity changes from the pgACC to the right frontal pole and anterior mid cingulate cortex (aMCC). Absolute glutamate and glutamine concentrations in the pgACC did not differ significantly from baseline. However, we found that stronger pgACC activation during ketamine was linked to lower glutamine concentration in this region. Furthermore, reduced functional connectivity between pgACC and aMCC was related to increased pgACC activation and reduced glutamine. Our results thereby demonstrate how multimodal investigations in a single brain region could help to advance our understanding of the association between metabolic and functional changes. [ABSTRACT FROM AUTHOR]

Published
2022
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