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A feature selection method based on three-way decision is proposed to solve the problem of target recognition under high-dimension and few-shot data. The main research results of this paper include the following aspects: (1) aiming at the uncertainty of existing algorithm caused by uncertain data in high-dimension and few-shot data, based on the traditional filtering feature selection ReliefF algorithm, the algorithm is improved, according to the three-way decision thought, the single threshold of original algorithm is extended into two thresholds, to increase the rate of fault tolerance of the original algorithm, avoid features is too much or too little to eliminate. (2) To solve the problem of "dimension disaster" of high-dimension and few-shot data, the features are divided into three domains according to two thresholds and feature weights, and then the features in the boundary domain are further selected by combining the wrapper feature selection idea to reduce the dimension and obtain the optimal feature subset. Finally, the experimental results show that the recognition accuracy and F1 have been improved. Experiment 1 proved the fault tolerance rate and stability of the proposed algorithm, and Experiment 2 verified the advantages of the proposed algorithm in small sample conditions. [ABSTRACT FROM AUTHOR]

One of the more concerning issues in the world today is that radioactive uranium contaminates the soil and threatens the organisms. The focus of contaminated soil remediation is to immobilize the uranium in the soil and reduce its leaching. Nano-hydroxyapatite (nHAP) and nano-hydroxyapatite/nano-zero-valent iron mixture (nHAP/nZVI) are used as immobilizer to remediate uranium-contaminated soil. The leaching characteristics and morphological changes of uranium before and after immobilization were studied by using Toxicity Characteristic Leaching Procedure (TCLP) and Tessier stepwise chemical extraction method. The results show that the leaching concentration of uranium in the soil was 0.005 mg/L when nHAP was added alone, and the leaching rate was 9.14%. The leaching concentration of uranium in the soil was only 0.004 mg/L when adding nHAP/nZVI, and the leaching rate was reduced to 8.57%. U (VI) not only reacts with nHAP to form a stable complex but also is reduced by nZVI to insoluble U (IV) when nHAP/nZVI is added. As a result, both nHAP/nZVI and nHAP can effectively immobilize uranium in the soil, and nHAP/nZVI can better promote the immobilization of the uranium in the soil. [ABSTRACT FROM AUTHOR]

Pseudomonas phages PaGz-1 and PaZq-1, two new phages infecting Pseudomonas aeruginosa, were isolated from fresh water in Guangdong province, China. The genomes of these two phages consist of 93,975 bp and 94,315 bp and contain 175 and 172 open reading frames (ORFs), respectively. The genome sequences of PaGz-1 and PaZq-1 share 95.8% identity with a query coverage of 94%, suggesting that these two phages belong to two different species. Based on results of nucleotide sequence alignment, gene annotation, and phylogenetic analysis, we propose PaGz-1 and PaZq-1 as representative isolates of two species in the genus Pakpunavirus within the family Myoviridae. [ABSTRACT FROM AUTHOR]

In the process of electrokinetic (EK) remediation of uranium-contaminated soil, the existence form of uranium in soil pore fluid will affect on its migration behavior. In this paper, a novel type of electrolyte (citric acid + ferric chloride, CA+ FeCl3) has been investigated for the EK remediation of uranium-contaminated red soil. The effects of different electrolyte and the concentrations of FeCl3 on migration behavior of U(VI) and environmental risks were investigated after EK remediation. The result showed that the optimum concentration was 0.1 mol/L CA mixed with 0.03 mol/L FeCl3 in this study. At this time, the removal efficiency of uranium was about 61.55 ± 0.41%, and the cumulative energy consumption was 0.2559 kWh. Compared with deionized water and single CA, combined CA with FeCl3 has the advantages of high removal efficiency, low leaching toxicity, and less damage to the soil after the electrokinetic remediation treatment. [ABSTRACT FROM AUTHOR]

Salmonella phages SenALZ1 and SenASZ3, two novel phages infecting Salmonella enterica, were isolated and analyzed. The genomes of these two phages consist of 154,811 and 157,630 base pairs (bp), with G+C contents of 44.56% and 44.74%, respectively. Fifty-nine of 199 open reading frames (ORFs) in the SenALZ1 genome, and 60 of the 204 in the SenASZ3 genome show similarity to reference sequences in the NCBI nr database that encode putative phage proteins with predicted functions. Based on the results of transmission electron microscopy (TEM) examination, complete genome sequence alignment, phylogenetic analysis, and gene annotation, we propose that these two phages are representative isolates of two new species of the genus Cba120virus, subfamily Cvivirinae, family Ackermannviridae. [ABSTRACT FROM AUTHOR]

The purpose of this study is to test the hypothesis that the mammalian target of rapamycin (mTOR) signaling pathway might mediate neuroprotection in a mouse model of septic encephalopathy and also to identify the role of autophagy. Mice were subjected to cecal ligation and puncture (CLP) or a sham operation, and all 50 mice were randomly assigned to five groups: sham, CLP+ saline, CLP+ rapamycin (1, 5, 10 mg/kg) groups. Two weeks after the operation, Morris water maze was conducted for behavioral test; Nissl staining was used for observing glia infiltration; immunohistochemical staining and biochemical measures in hippocampi were performed to detect mTOR targets and autophagy indicators. Immunochemistry revealed significant loss of neurons and increased glia infiltration in hippocampus after CLP operation. Inhibition of mTOR by rapamycin rescued cognitive deficits caused by sepsis ( p < 0.05). Rapamycin did not affect total mTOR targets, while phosphorylated mTOR targets (p-mTOR-Ser2448, p-p70S6k-Thr389, p-AKT-S473) decreased ( p < 0.05) and autophagy indicators (LC3-II, Atg5, Atg7) were increased, and P62 was decreased in rapamycin-treated CLP mice compared with the untreated ( p < 0.05) in hippocampus. Rapamycin improves learning after sepsis through enhancing autophagy and may be a potentially effective therapeutic agent for the treatment of sepsis-induced cognitive impairment. [ABSTRACT FROM AUTHOR]

P-glyprotein (multidrug resistance gene 1, MDR1) was the first isolated and most extensively investigated refractory epilepsy-related drug-resistant protein. Coriaria lactone (CL) can induce P-glyprotein expression of brain capillary and astrocytes in vivo. We established the primary rat brain microvascular endothelial cell (BMECs) models overexpressing P-glycoprotein induced by CL successfully and infected them with adenovirus vector, which carry small interfering RNA (siRNA) designed to target MDR1b. MDR1b mRNA levels and P-glyprotein expression in experimental group decreased significantly 72 h after infection, and the fluorescence intensity of rhodamine within the cells of experimental group increased significantly. So, CL can induce P-glyprotein overexpression in BMECs in vitro, and siRNA can effectively inhibit expression of P-glyprotein and decrease its “pumping out” function. This may offer a new method and rationale for studying the mechanism of refractory epilepsy and relevant gene therapy. [ABSTRACT FROM AUTHOR]