1. Clinical remission of ulcerative colitis after different modes of faecal microbiota transplantation: a meta-analysis.
- Author
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Tang, Li-li, Feng, Wen-zhe, Cheng, Jia-jun, and Gong, Yan-ni
- Subjects
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FECAL microbiota transplantation , *ULCERATIVE colitis , *DISEASE remission , *GASTROINTESTINAL diseases , *GASTROINTESTINAL system , *TRANSPLANTATION of organs, tissues, etc. - Abstract
Background: Ulcerative colitis (UC) is a chronic, recurrent and destructive disease of the gastrointestinal tract. Faecal microbiota transplantation (FMT) is a therapeutic measure in which faecal microbiota from healthy people is transplanted into patients. Aim: To systematically evaluate the safety and effectiveness of treating UC with different modes of FMT. Methods: Seven databases were searched by two independent researchers and studies related to randomized controlled trials were included in the analysis. Results: Seven studies on UC involving 431 patients were included in the analysis. The results showed that FMT had better efficacy than placebo (OR = 2.29, 95% CI 1.48–3.53, P = 0.0002). Subgroup analyses of influencing factors showed that frozen faeces from multiple donors delivered via the lower gastrointestinal tract had a better curative effect than placebo (OR = 2.76, 95% CI 1.59–4.79, P = 0.0003; OR = 2.93, 95% CI 1.67–5.71, P = 0.0002; and OR = 2.70, 95% CI 1.67–4.37, P < 0.0001); the difference in efficacy between mixed faeces from a single donor transplanted through the upper gastrointestinal tract and placebo was not significant(P = 0.05, P = 0.09 and P = 0.98). The analysis of side effects showed no significant difference between FMT and placebo (P = 0.43). Conclusions: It may be safe and effective to transplant frozen faeces from multiple donors through the lower gastrointestinal tract to treat UC. [ABSTRACT FROM AUTHOR]
- Published
- 2020
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