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Summary ¶An Objective 500-hPa cyclone detection and analysis is performed during the warm-dry period (16 April to 15 October) of the year for the Central and Eastern Mediterranean Region (30°?N?50°?N, 5°?E?35°?E). The 40-year NCEP/NCAR reanalyzes gridded data of geopotential height and temperature employed in the study, enable a climatic approach with a spatial (2.5°Ö2.5°) and a 6-hour temporal (00, 06, 12, 18 UTC) resolution. The occurrence frequency for the entire region shows a high interannual variability without significant trends. The frequency maximization over land in the middle of the warm period indicates a possible relationship with land-air temperature difference. Three primary activity centers (Turkey, Black Sea and Genoa) are objectively determined in the frequency domain as local maxima and their intensity is assessed in terms of average geopotential height and temperature values. The Turkey center, though the most frequent, consists of shallow lows in contrast to the Black Sea center, which is second in frequency, but on average, contains the deepest lows amongst the three. The Genoa center, which comes third in frequency, shows the highest variability in the intensity of the lows. Frequency distributions in the area, during the three sub periods (Early, Middle and Late Warm Period) and during the four synoptic hours, provide insight in to the origins of these systems at the three locations and reveal secondary centers, such as the centers in the Adriatic (at 18 UTC), Northern Greece (during Middle Warm Period) and the South Aegean Sea (during Late Warm Period). [ABSTRACT FROM AUTHOR]