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Objective: To assess the effect and mechanism of compound Xiansu capsule ( ), (XSC) combined with chemotherapy in treating gastric carcinoma of mid-late stage. Methods: Sixty-one patients of the test group were treated by XSC combined with chemotherapy and 30 patients of the control group treated with chemotherapy alone. The effect of treatment and cell mediated immunity of patients were observed. Results: The effective rate of the test group and the control group was 32.8% and 13.3% respectively ( P < 0.05), the toxic reaction occurrence caused by chemotherapy was less in the former than that in the latter group ( P < 0.01). The CD level of patients in the test group decreased, and CD/CD level was raised obviously, which suggested that XSC had immuno-regulating effect on T-cell. Conclusion: XSC could enhance the efficacy and reduce the toxic and side-effect of chemotherapy. To regulate the cell mediated immunity of patients is possibly its mechanism. [ABSTRACT FROM AUTHOR]

To explore the effect of immune function on lymph node micrometastasis in esophageal cancer patients by the research on the correlation between immune function and micrometastasis. Ratios of T-lymphocyte subsets CD3+, CD4+, CD8+ and CD4+/CD8+ in peripheral blood were examined by flow cytometry, but no lymph node with metastatic cancer cells was observed in middle thoracic esophageal squamous carcinoma patients by routine pathological examination. The patients were divided into 2 groups with or without micrometastasis to detect micrometastasis by immunohistochemical method, and T-lymphocyte subsets levels were compared between the 2 groups. CD3+ and CD4+ T-lymphocytes levels of the group with micrometastasis were significantly lower than those of the group without micrometastasis, while CD8+ level of the group with micrometastasis was significantly higher than that of the group without micrometastasis. T-lymphocyte subset is closely relative with micrometastasis, and prognosis of the patients with low CD3+ and CD4+ levels but high CD8+ T-lymphocytes is comparatively poor. [ABSTRACT FROM AUTHOR]

Objective: To study immune function of children viral myocarditis and to evaluate the clinical effect of Shuanghuanglian Powder (SHLP) by injection. Methods: The 62 patients of viral myocarditis were divided into two groups randomly, the SHLP group (n = 32) treated with conventional therapy plus SHLP and the conventional treatment group (n = 30) with conventional therapy alone. Their serum antibody of Coxsackie virus group B (COXB-IgM), T-lymphocyte subsets including CD , CD , CD and CD /CD were determined with ELISA and indirect immunofluorescent assay. Results: COXB-IgM was positive in 39 of the 62 patients, which was significantly different with those of normal controls (P< 0.001). Patients' serum level of CD cells and CD /CD ratio decreased while CD increased. After treatment, the recovery of symptoms, signs and immune function in patients of the SHLP group were significantly better than those in patients treated with conventional treatment alone (P<0.01). Conclusion: Immunoregulatory disturbance is involved in children with viral myocarditis and SHLP is an effective drug in the treatment of children viral myocarditis. [ABSTRACT FROM AUTHOR]