1. Comparison of key interhemispheric connections and the posterior commissure in normal and hydrocephalic rat fetuses
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Carys M. Bannister, Sajida Rasul, Andrew J. Shepherd, Sarah Cains, and Swapna Vaddi
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congenital, hereditary, and neonatal diseases and abnormalities ,Third ventricle ,business.industry ,Anterior commissure ,Anatomy ,Commissure ,Corpus callosum ,medicine.disease ,lcsh:RC346-429 ,nervous system diseases ,Hydrocephalus ,Midbrain ,Cellular and Molecular Neuroscience ,medicine.anatomical_structure ,Posterior commissure ,nervous system ,Developmental Neuroscience ,Neurology ,Cerebral hemisphere ,medicine ,business ,lcsh:Neurology. Diseases of the nervous system - Abstract
Background There are a surprising number of interconnecting fibre tracts linking the two cerebral hemispheres, the largest of these being the corpus callosum, but the hippocampal and anterior commissures are also sizable structures. The posterior commissure bridges the upper part of the midbrain and lies adjacent to the posterior end of the third ventricle. Hydrocephalus is known to cause thinning of the corpus callosum but its effect on the other interconnections has not been extensively investigated. On day E18 at the onset of hydrocephalus in the HTx rat development of the corpus callosum is incomplete. The observed thinning of the corpus callosum in fetal onset hydrocephalus is likely to deprive the hemispheres of interconnections. This study was carried out to investigate the effect of hydrocephalus on the other interconnecting fibre tracts and in particular whether adaptive changes occur in any of them.
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