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Mutations in the EIF2AK3 gene underlie susceptibility to the Wolcott-Rallison syndrome, which is a monogenic disease associated with insulin-deficient neonatal diabetes. Furthermore, suggestive evidence of linkage between type 1 diabetes (T1DM) and the EIF2KA3 chromosomal region has been reported in Scandinavian families. We have investigated the hypothesis that polymorphic variants in and around the EIF2AK3 gene might partially account for susceptibility to T1DM in South Indian subjects. Excess transmission of the common alleles of two polymorphic markers (D2S1786 and 15INDEL, located within the gene) downstream of EIF2AK3, either singly (D2S1786, P=0.01) and 15INDEL (P=0.02) or as a combination (P<0.001), were found in 234 families with a T1DM proband. There was also a clear paternal effect for the 15INDEL marker (P=0.005) on disease susceptibility. The presence of the common allele of both markers was found in decreased frequency in the subjects with normal glucose tolerance compared to probands with T1DM (both P?0.0001). Major common mutations of the EIF2AK3 gene in T1DM were excluded. In conclusion, this pilot study demonstrates an association between the region around the EIF2AK3 locus and T1DM susceptibility.Genes and Immunity (2004) 5, 648-652. doi:10.1038/sj.gene.6364139 Published online 14 October 2004 [ABSTRACT FROM AUTHOR]

The results are given of 21 experiments on the incubation period of the eggs of the mite Halotydeus destructor Tucker at 13 different, constant temperatures in the range 7. 8 to 27. 5° C. A total of 10,100 eggs were used, and about 90 p.c. of the eggs hatched in each experiment, except at 27.5° C, when only 51 p.c. hatched. The data have been fitted to a temperature-velocity curve and a temperature-time curve. A temperature-velocity curve having the formula: 100/y = 44.95/1 + e3.193706 - .16389x faithfully represents the trend in the speed of development of the eggs up to 22° C. (peak temperature). The greatest deviation of any of the ten observed points, within this range, from the calculated value, is .971 at 20° C. The root-mean square deviation between the observed and calculated points for the ten given temperatures is .4468 which is 1.9 p.c. of the calculated value at 20° C. [ABSTRACT FROM AUTHOR]