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The article presents the authors' comments on the study of toxicology in clinical science. According to the authors, toxicology is the study of the adverse effects of chemicals on living organisms, which requires expertise on the chemical nature of the studied compounds, and accurate knowledge of the cellular mechanisms that can be adversely affected by toxic substances. The authors say that the identification of these adverse affects can be helpful in pharmaceutical drug development.

The author reflects on the toxic effects of arsenic. The author states besides arsenic's carcinogenicity, arsenic impact some functions in the immune system, lessened glucose tolerance. The author says that some effects are oxidative mycordial, induction of changes in DNA methylation patterns, liver injury and inhibition of neurite growth.

The article presents the authors' comments on the article about the role of oxidative stress in alcohol-induced liver injury, by Arthur I. Cederbaum and others in this issue of the periodical. The authors say that the generation of oxidative stress is the most important mechanisms causing alcoholic liver disease, and it is a cutting edge topic of their journal.