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Metal nanoparticles (MNPs) have gained considerable attention for their diverse applications across various fields, including medicine, electronics, and environmental remediation, agriculture and manufacturing. The relationship between metal nanoparticles and the microorganisms, highlighting the diverse mechanisms through which nanotoxicity manifests and influences microbial communities. Metal nanoparticles, owing to their unique physicochemical properties, can interact with the microbiome directly or indirectly, disrupting microbial homeostasis and functionality. The interactions are complex, involving mechanisms such as membrane disorganization, reactive oxygen species (ROS) generation, and oxidative Deoxyribonucleic acid (DNA) damage. Comprehending the different types of metal nanoparticles, their antimicrobial properties, and the mechanisms that underlie their nanotoxicity towards microorganisms is imperative for the secure advancement and implementation of nanotechnology, paving the way for innovative strategies to mitigate adverse effects and promote sustainable nanomaterial applications. Nanotechnology has witnessed remarkable advancements in various fields, yet concerns regarding its potential adverse effects on biological systems, particularly the microbiome, have emerged as a significant area of investigation. This abstract highlight the importance of interdisciplinary approaches encompassing nanoscience, microbiology, and toxicology to unravel the intricate dynamics of metal nanoparticle-microbes' interactions and facilitate the design of safer nanoproducts for diverse applications. Overall, this study emphasizes the need for more investigation to clarify the complex dynamics of metal nanoparticles in microbial environments and their long-term effects on sustainability and environmental health. [ABSTRACT FROM AUTHOR]

Part 2 of the review discusses modern processes for biotechnological conversion of lignocellulosic biomass into the valuable chemicals. It also recognizes the new approaches toward the development of more efficient enzymes for the depolymerization of biomass and the properties of the microorganisms employed in the fermentation of the biomass-derived sugars. Various biotechnological approaches to the fermentation of the depolymerized biomass products are described, including SHF, SSF, NSSF, SSFF, SSCF, and CBP. It is demonstrated that that the main tendencies for development of the new technologies for biotechnological biomass processing are the application of genetic engineering, synthetic biology and reduction of the number of processing steps. Application of one-pot processing of lignocellulosic biomass is promising for development of the new and efficient manufacturing technologies for production of valuable chemicals. [ABSTRACT FROM AUTHOR]

Part 3 of the review discusses the modern aspects in the biotechnological synthesis of the valuable chemicals derived from the lignocellulosic biomass, including ethanol, n-butanol, isobutanol, 2,3-butanediol, and lactic and succinic acids. A comparative characteristic of different approaches (including SHF, SSF, SSCF and CBP) toward biosynthesis of valuable products is given. It is shown that the consolidated processing of lignocellulose into the valuable chemicals is a promising approach toward their direct synthesis by fermentation, but remains less efficient than other processing methods. Development of genetic engineering tools and the application of synthetic biology will allow to develop more efficient strains and advanced biotechnological processes for lignocellulose processing. [ABSTRACT FROM AUTHOR]

Volatiles produced by the leaves of medicinal plants are increasingly used as a new plant disease management strategy due to their induction of diverse antimicrobial activities, it is highly essential for the development of a new phyto-fumigant product to sustain crop production. The present study attempted to find the active role of Mentha spicata-associated volatile formulation in the suppression of the growth of Pythium aphanidematum under pot culture and field conditions. Damping off disease-causing P. aphanidermatum is a devastating disease that infects the tomato crop from seed sprouting to the seedling stage. To mitigate the damping off incidence, the nature of volatile molecules produced by M. spicata was completely suppressed during di-trophic interaction with P. aphanidermatum. Molecular docking of volatile compound reported carvone as a ligand recorded with the highest binding energy of − 8.5 kcal/mol against the target protein structure of P. aphanidermatum. Application of M. spicata immobilized vermiculite ball in tomato revealed that pathogenesis-related protein (SlPR1) (2.69 folds) and jasmonic acid signaling (SlLOX) (2.65 folds) genes were highly expressed after 48 HPT on tri-trophic interaction of pathogen inoculated tomato plants while the gene SlWRKY and SlTLP exhibited a lower level of gene expression. A significant reduction in the severity of damping off incidence was observed due to the exposure of volatiles of M. spicata in the tomato plant’s raised beds with relatively abundant control of P. aphanidematum. This is the first study that attempted to develop the volatile-based formulation and its role in antifungal activities during di-trophic interaction with P. aphanidematum in tomato crops. The present study concludes that the volatiles produced from M. spicata leaves immobilized vermiculite ball could be explored for the management of soil-borne pathogens infecting vegetable crops. [ABSTRACT FROM AUTHOR]