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Background: Ondansetron is a selective 5-hydroxytryptamine type 3 serotonin-receptor antagonist with antiemetic properties used inadvertently in the emergency department for controlling nausea. However, ondansetron is linked with a number of adverse effects, including prolongation of the QT interval. Therefore, the purpose of this meta-analysis was to assess the occurrence of QT prolongation in pediatric, adult, and elderly patients receiving oral or intravenously administered ondansetron. Methods: A thorough electronic search was conducted on PubMed (Medline) and Cochrane Library from the databases' inception to August 10, 2022. Only those studies were considered in which ondansetron was administered orally or intravenously to participants for the treatment of nausea and vomiting. The prevalence of QT prolongation in multiple predefined age groups was the outcome variable. Analyses were conducted using Review manager 5.4 (Cochrane collaboration, 2020). Results: A total of 10 studies involving 687 ondansetron group participants were statistically analyzed. The administration of ondansetron was associated with a statistically significant prevalence of QT prolongation in all age groups. An age-wise subgroup analysis was conducted which revealed that the prevalence of QT prolongation among participants younger than 18 years was not statistically significant, whereas it was statistically significant among participants aged 18–50 years and among patients older than 50 years. Conclusions: The present meta-analysis provides further evidence that oral or intravenous administration of Ondansetron may lead to QT prolongation, particularly among patients older than 18 years of age. [ABSTRACT FROM AUTHOR]

Purpose: To analyze the effect of implant position measured in terms of offset on patient reported outcomes (PRO) following hip arthroplasty (THA).Methods: A total of 243 patients of the total hip replacement who had a one year follow-up were included in the study. Standard both hips radiograph was used to asses post-surgery implant position in terms of horizontal offset and vertical offset, and correlated with functional outcome which was evaluated as change in PRO. i.e., Harris hip score (HHS) post-op. With center of hip rotation as reference, horizontal offset was calculated as sum of distance, of centre, from proximal femoral shaft axis and a vertical line through ipsilateral teardrop, and vertical offset as limb length discrepancy. Post-op patients were classified into three groups depending on the measurement of horizontal offset of the operated hip. The patients having operated hip horizontal offset within 5 mm of the normal hip were grouped as restored offset (RO); those having shorter or higher offset by more than 5 mm compared to normal hip were labeled as decreased (DO) or increased offset (IO) group respectively. The groups were further subdivided into suboptimal and optimal function groups based on HHS, and among these groups, limb length discrepancy was evaluated.Results: Post follow-up mean HHS (78.23 ± 9.96) improved significantly in all three groups (p < 0.0001). The difference in post-operative HHS among DO, RO, and IO groups was significant, with their averages being 72.5 ± 4.7, 82.1 ± 6.5, and 75.2 ± 4.8 respectively (p = .01). Limb length discrepancy was significantly more common in patients with suboptimal functional scores in all three groups.Conclusion: This study concluded that both horizontal offset and vertical offset should be reconstructed in patients operated with unilateral THR due to hip pathology, since both factor demonstrated a comparable additive effect on clinical outcome. [ABSTRACT FROM AUTHOR]

Due to environmental issue and stringent rules over defilement and contamination of the environment, the demand for renewable and biodegradable cutting fluids is increasing. In this study, an eco-friendly minimum quantity lubrication (MQL) technique using vegetable oil–based cutting fluid (rapeseed oil) by varying MQL flow rate and MQL pressure was investigated in the grinding of AISI 202 stainless steel. In addition to explore the cooling capabilities of rapeseed oil, nano-MoS2 was added to the rapeseed oil to prepare different concentrations (0.5 wt% and 1.0 wt%) of nanofluids. The main objective of this experiment is to examine the performance of different grinding environments (dry, flood, pure MQL, and nanofluid MQL) with respect to grinding characteristics, namely, grinding forces, surface morphology, surface roughness, and temperature. Experimental results revealed that NFMQL grinding with vegetable oil was performed much superior as compared with the dry, wet, and pure MQL machining. The lowest specific normal force and tangential force are observed to be 9.2 N/mm and 0.76 N/mm respectively under 1.0 wt% concentration of MoS2 nanoparticles at oil flow rate of 120 ml/h and air pressure 90 psi under MQL grinding condition, which decreased by 43% and 33%, respectively, as compared with dry conditions. Furthermore, the application of nanofluid also leads to the reduction of surface roughness and surface temperature. MQL application with MoS2 nanofluid helps in effective flushing of chip material from the grinding zone, thereby improving the lubrication and cooling capabilities during the grinding of the AISI 202 stainless steel. In summary, appropriately chosen minimum quantity lubrication parameters can enhance the lubrication and cooling properties of the oil film and improve the grinding characteristics. [ABSTRACT FROM AUTHOR]