1. Hexamethylenetetramine grafted layered double hydroxides as a novel and green heterogeneous ionic liquid catalyst for the synthesis of pyrido[2,3-d]pyrimidine derivatives.
- Abstract
Abstract: In this research layered double hydroxides functionalized with (3r,5r,7r)-1-(3-(triethoxysilyl)propyl)-1,3,5,7-tetraazaadamantan-1-ium chloride (LDHs-TPTAACl) as a novel, green, efficient and recyclable heterogeneous ionic liquid were synthesized and characterized by various methods, such as FT-IR, TGA, SEM, EDX, TEM and XRD. The mentioned catalyst was applied as a new ionic liquid catalyst for the one-pot three-component synthesis of a new class of pyrido[2,3-d]pyrimidine derivatives through combination of aromatic aldehydes, 2,4-thiazolidinedione and N,N-dimethyl-6-amino uracil using water as solvent in high to excellent yield and short reaction times. The LDHs-TPTAACl catalyst could be simply recycled and reused up to five continuous runs with no substantial structural change and loss of activity.Graphical Abstract:
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