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The current study focuses on synthesizing and characterizing the Gd and Ni co-doped Ba1-xGdxFe12-yNiyO19 nanoparticles (NPs) via emulsion method. The as-fabricated NPs were characterized using X-ray diffraction (XRD) analysis , Fourier transform infrared (FTIR) analysis, Raman spectroscopy, Scanning electron microscopy (SEM), and vibrating sample magnetometer (VSM) analysis. The synthesis of single-phase Ba-hexaferrites with hexagonal geometry was successfully formed, with co-doping of Gd at tetrahedral and Ni at octahedral sites. SEM analysis revealed tubular particles with rounded spherical geometry, with an increased surface area increase in particle size from 25 to 35 nm upon doping. The magnetic investigation showed increased magnetization (45.7–70.2 emu/g) with co-doping. The doped materials showed excellent photocatalytic activities, degrading almost 90.2% of methyl green (MG) dye in 60 min of sunlight illumination in comparison with 32.26% of their counterpart. The reusability test showed excellent stability and recoverability, with only 1% loss in degradation activity after 5 runs. The results suggest that Gd- and Ni-doped Ba1-xGdxFe12-yNiyO19 NPs have superior photocatalytic activities, more magnetization, an exposed surface area, and excellent reusability, making them suitable for potential applications. [ABSTRACT FROM AUTHOR]

Using structure-based virtual screening approach, a coumarin derivative ( 1) was identified as β-glucuronidase inhibitor. A focused library of coumarin derivatives was synthesized by eco-benign version of chemical reaction, and all synthetic compounds were characterized by using spectroscopy. These compounds were found to be inhibitor of β-glucuronidase with IC values in a micromolar range. All synthetic compounds exhibited interesting inhibitory activity against β-glucuronidase, however, their potency varied substantially from IC = 9.9-352.6 µM. Of twenty-one compounds, four exhibited a better inhibitory profile than the initial hit 1. Interestingly, compounds 1e, 1k, 1n and 1p exhibited more potency than the standard inhibitor with IC values 34.2, 21.4, 11.7, and 9.9 µM, respectively. We further studied their dose responses and also checked our results by using detergent Triton ×-100. We found that our results are true and not affected by detergent. [ABSTRACT FROM AUTHOR]

Synthesis, crystal structures and biological activities for the new chlorobridged mixed valence Cu/Cu coordination polymer [Cucyclam][CuCl] 1 and [Hcyclam][CuCl] 2 are reported. Compound 1 crystallizes in the orthorhombic system, space group Pccn, with a = 22.677(4), b = 22.827(4), c = 12.506(2) Å, V = 6473.75(19) Å, Z = 8. Its crystal structure consists of one-dimensional polymer Cucyclam-Cl-Cu-Cl-Cucyclam. The coordination geometry of the Cu ion is an elongated octahedron while Cu ion is surrounded by three chlorine atoms in a trigonal geometry. The tetraazacyclotetradecane adopts the trans-III configuration. Compound 2 is monoclinic ( P2/ n), with a = 10.3675(5) Å, b = 11.2065(4) Å, c = 9.4701(5) Å, β = 116.93(0)°, V = 980.93(9) Å, Z = 2. The tetraprotonated cyclam Hcyclam has a (3,4,3,4)-B conformation. Copper(I) is tetrahedrally coordinated and two neighboring [CuCl] units share an edge to form isolated dimeric species [CuCl]. Compound 1 was tested to understand its influence on enzyme activity, immunomodulation as well as its toxicity and antiglycation potential. Effect of compound 1 was significant as immunomodulatory and inhibitory activity against β-glucuronidase enzyme (IC = 0.55 μM), but it did not affect significantly other biological activities tested. [ABSTRACT FROM AUTHOR]

New organotin (IV) derivatives of thiophene acetic acid have been prepared and characterized by IR, H- and C-NMR spectroscopic techniques. A single crystal of {[ n-BuSnOC-CH-CHS]O} has been synthesized and its cell parameters were measured. It crystallizes in the monoclinic system ( P2) [ a = 15.1337(7), b = 12.2587(5), c = 18.8766(9), and β = 105.811(5)°]. The compound showed selective inhibitory effect against β-glucuronidase enzyme (IC 3.1 ± 0.1 μM), which is more potent than our standard, d-saccharic acid 1,4-lactone (IC 48.4 ± 1.3 μM). Also, it exhibited immunomodulatory activity, and cytotoxicity against PC-3 cell line (IC = 16.9 ± 1.3 μM, and 1.2 ± 0.1 μM, respectively), which are close to the standards ibuprofen (IC 11.8 ± 1.8 μM), and doxorubicin (IC 0.9 ± 0.1 μM), respectively. This compound did not show any significant inhibition for other biological test such as α-chymotrypsin, urease, phosphodiesterase enzymes, and antiglycation activity. [ABSTRACT FROM AUTHOR]

Lichens are unique individuals which have been widely used in traditional medicines. This study was focused on the bioassay-guided phytochemical investigation, and bioactivity evaluation on a lichens species, Parmotrema cooperi. This first bioassay-directed chemical study on P. cooperi has led to the isolation of ethyl heamatomate ( 1), atraric acid ( 2), ethyl orsellinate ( 3), orsellinic acid ( 4), lecanoric acid ( 5), gyrophoric acid ( 6), and licanorin ( 7). The structures of 1-7 were mainly elucidated from spectroscopic methods including 1D, and 2D NMR spectroscopy, and mass spectrometry. These compounds were evaluated for their antiglycation, urease, α-chymotrypsin, and β-glucoronidase inhibitory activities. Few of the phenolic compounds showed significant, while most of them showed good inhibition of protein glycation, and urease activities. [ABSTRACT FROM AUTHOR]