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Keywords: Atopic dermatitis; Crisaborole; Meta-analysis; Methodology EN Atopic dermatitis Crisaborole Meta-analysis Methodology 639 642 4 04/05/21 20210401 NES 210401 This comment refers to the article available online at https://doi.org/10.1007/s13555-020-00389-5. Efficacy and safety of crisaborole ointment, a novel, nonsteroidal phosphodiesterase 4 (PDE4) inhibitor for the topical treatment of atopic dermatitis (AD) in children and adults. Effects of pimecrolimus cream 1% in the treatment of patients with atopic dermatitis who demonstrate a clinical insensitivity to topical corticosteroids: a randomized, multicentre vehicle-controlled trial. [Extracted from the article]