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The all-order structure of scattering amplitudes is greatly simplified by the use of Wilson line operators, describing eikonal emissions from straight lines extending to infinity. A generalization at subleading powers in the eikonal expansion, known as Generalized Wilson Line (GWL), has been proposed some time ago, and has been applied both in QCD phenomenology and in the high energy limits of gravitational amplitudes. In this paper we revisit the construction of the scalar gravitational GWL starting from first principles in the worldline formalism. We identify the correct Hamiltonian that leads to a simple correspondence between the soft expansion and the weak field expansion. This allows us to isolate the terms in the GWL that are relevant in the classical limit. In doing so we devote special care to the regularization of UV divergences that were not discussed in an earlier derivation. We also clarify the relation with a parallel body of work that recently investigated the classical limit of scattering amplitudes in gravity in the worldline formalism. [ABSTRACT FROM AUTHOR]

Among recipients of intra-abdominal solid-organ transplants, bloodstream infections (BSIs) are a major cause of mortality. We undertook a retrospective cohort study of recipients of kidney, pancreas, and/or liver transplants with BSIs at a single center over an 11-year period. Multivariate analysis using logistic regression was used to determine independent predictors of 15-day mortality and clinical cure, with a focus on the use of statins. Three hundred and eleven recipients of solid-organ transplants had 604 episodes of BSI. Forty-four (14%) died within 15 days of BSI. Sixteen percent did not achieve clinical cure. In the multivariate model, each one point increase in the APACHE score was associated with a 1.09-fold increased risk of death (95% confidence interval [CI] 1.00–1.18, P = 0.03). The lack of appropriate antibiotic therapy was associated with a four-fold higher risk of death within 15 days (odds ratio [OR] 4.65, 95% CI 1.46–14.78, P = 0.009). Statin use was protective (OR 0.18, 95% CI 0.04–0.78). Patients with high APACHE scores, nosocomial rather than community source of BSI, lack of appropriate antibiotic therapy, and mental status changes were less likely to achieve clinical cure of their BSIs. In conclusion, appropriate antibiotic therapy and statin use are associated with lower risk of mortality from BSIs in this patient population. [ABSTRACT FROM AUTHOR]

Post-transplant hypertension remains a significant risk factor for graft loss, but whether or not specific blood pressure (BP) medications affect graft outcome is still unknown. We assessed the interaction between BP control and antihypertensive drugs on graft outcome. We retrospectively examined clinic BP data for 1662 renal transplant (RTx) patients, transplanted between 1994 and 2000 at our centre. The analysis examined all patients who received centrala-agonists and peripherala-antagonists, beta-blockers, calcium channel blockers (CCBs), angiotensin-converting enzyme (ACE) inhibition (ACEI), angiotensin receptor blockers (ARBs). BP recordings during treatment were categorized for each agent. Thus, a particular BP could be categorized for multiple medications. A total of 1462 patients (pts) (88%) were Caucasian and 800 pts (46%) received cadaveric RTx. There were 10.6±6.8 BP measurements for each patient post-RTx. CCBs, alone among the classes of antihypertensive drugs evaluated, reduced the risk for graft loss (RR: 0.736; P=0.035) in the overall analysis. Interestingly, stratifying levels of BP control unmasked a beneficial effect on graft survival of ACEI/ARB therapy in individuals with higher levels of systolic (>152?mmHg) and diastolic blood pressure (>98?mmHg) treated with ACEI/ARBs compared to individuals treated with CCBs (P<0.01 for each). Thus, stabilizing BP is important post-RTx. CCBs are associated with improved rates of graft survival. Their role in a compromised RTx, however, deserves further study. ACEI/ARBs have clear benefits, improving graft survival in individuals with elevated systolic blood pressure and proteinuria. CCBs are not as efficacious in this setting.Journal of Human Hypertension (2004) 18, 871-877. doi:10.1038/sj.jhh.1001767 Published online 19 August 2004 [ABSTRACT FROM AUTHOR]

Transplantation is an extremely successful form of therapy for many end-stage organ diseases. Medical problems and complications are frequent because of immunosuppressive therapy and the underlying diseases that afflict the patient prior to transplantation. For the most part, management of chronic disease is easier after transplantation because of improvement in the patient's clinical status. Although medical complications are frequent, they are usually easily managed. Appreciation of organ-specific complications in relationship to potential drug interactions with immunosuppressive medications is important for the treatment of these patients. [ABSTRACT FROM AUTHOR]

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Copyright of Monatshefte Für Chemie Und Verwandte Teile Anderer Wissenschaften is the property of Springer Nature and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)

Copyright of Monatshefte Für Chemie Und Verwandte Teile Anderer Wissenschaften is the property of Springer Nature and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)

Copyright of Monatshefte Für Chemie Und Verwandte Teile Anderer Wissenschaften is the property of Springer Nature and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)

Copyright of Monatshefte Für Chemie Und Verwandte Teile Anderer Wissenschaften is the property of Springer Nature and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)

α-Dicyclopentadien wie Dihydro-α-dicyclopentadien werden mit Peressigsäure in Eisessig ausschließlich in die entsprechenden Oxidoverbindungen übergeführt, es unterbleibt also auffallenderweise die Acetolyse als Folgereaktion. Darstellung von Tetrahydro-α-dicylopentadien-on-(3) durch Isomerisierung von Dihydro-α-dicyclopentadienoxyd mittels Magnesiumbromid in absolut ätherischer Lösung. [ABSTRACT FROM AUTHOR]

Copyright of Microchimica Acta is the property of Springer Nature and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)