1. Cardiogoniometric parameters for detection of coronary artery disease at rest as a function of stenosis localization and distribution.
- Author
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Huebner T, Michael Schuepbach WM, Seeck A, Sanz E, Meier B, Voss A, Pilgram R, Huebner, Thomas, Schuepbach, W M Michael, Seeck, Andrea, Sanz, Ernst, Meier, Bernhard, Voss, Andreas, and Pilgram, Roland
- Abstract
Cardiogoniometry (CGM), a spatiotemporal electrocardiologic 5-lead method with automated analysis, may be useful in primary healthcare for detecting coronary artery disease (CAD) at rest. Our aim was to systematically develop a stenosis-specific parameter set for global CAD detection. In 793 consecutively admitted patients with presumed non-acute CAD, CGM data were collected prior to elective coronary angiography and analyzed retrospectively. 658 patients fulfilled the inclusion criteria, 405 had CAD verified by coronary angiography; the 253 patients with normal coronary angiograms served as the non-CAD controls. Study patients--matched for age, BMI, and gender--were angiographically assigned to 8 stenosis-specific CAD categories or to the controls. One CGM parameter possessing significance (P < .05) and the best diagnostic accuracy was matched to one CAD category. The area under the ROC curve was .80 (global CAD versus controls). A set containing 8 stenosis-specific CGM parameters described variability of R vectors and R-T angles, spatial position and potential distribution of R/T vectors, and ST/T segment alterations. Our parameter set systematically combines CAD categories into an algorithm that detects CAD globally. Prospective validation in clinical studies is ongoing. [ABSTRACT FROM AUTHOR]
- Published
- 2010
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