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As photovoltaic (PV) panels are installed outdoors, they are exposed to harsh environments that can degrade their performance. PV cells can be coated with a protective material to protect them from the environment. However, the coated area has relatively small temperature differences, obtaining a sufficient database for training is difficult, and detection in low-resolution thermal images is complicated. This paper proposes a method for detecting the relative temperature difference on PV panels and a method for accumulating detection results within consecutive thermal images. To verify the performance of the proposed method, we installed PV panels coated with three different materials. Subsequently, 60 infrared (IR) thermal and visible images were acquired using an IR thermal imaging camera mounted on the drone. When more than 16 out of 60 results were accumulated, the highest performance was achieved with an F1 score of 0.7178. This case study demonstrated that even low-resolution thermal images can be acquired continuously to detect areas with small temperature differences without applying machine learning, which requires a large database. [ABSTRACT FROM AUTHOR]

Indoor pollution and deposition dust (DD), in particular, are acquiring concern, due to long exposure time and importance of intake by humans through contact and ingestion. Hospitals look a special category of sites, owing to peculiar contaminants affecting them and to presence of people prone to adverse effects induced by toxicants. Four in-field campaigns aimed at understanding the chemical composition of DD were performed in five Italian hospitals. Measurements were performed before (autumn 2019), during (spring 2021), and after (winter 2022) the peak of SARS-CoV2 and when restrictions caused by pandemic were revoked (winter 2023). Parallel measurements were made outdoors (2022), as well as in a university and a dwelling. Targeted contaminants were n-alkanes and polycyclic aromatic hydrocarbons (PAHs), while iso- and anteiso-alkanes were analyzed to assess the impact of tobacco smoking. Total n-alkanes ranged from 3.9 ± 2.3 to 20.5 ± 4.2 mg/g, with higher percentages of short chain homologs in 2019. PAHs ranged from 0.24 ± 0.22 to 0.83 ± 0.50 mg/g, with light congeners (≤ 228 a.m.u.) always exceeding the heavy ones (≥ 252 a.m.u.). According to carbon preference indexes, alkanes originated overall from anthropogenic sources. Microorganisms resulted to affect a hospital, and tobacco smoke accounted for ~ 4–20‰ of DD mass. As for PAH sources, the diagnostic concentration ratios suggested the concourse of biological matter burning and vehicle emission. Benzo[a]pyrene equivalent carcinogenic and mutagenic potencies of depositions at hospitals ranged ~ 9–39 μg/g and ~ 15–76 μg/g, respectively, which seems of concern for health. DD composition in hospitals was different from that outside the premises, as well as that found at university and at dwelling. [ABSTRACT FROM AUTHOR]

Introduction: The three-dimensional (3D) microstructure of the cortical and trabecular bone of the proximal ulna has not yet been described by means of high-resolution 3D imaging. An improved characterization can provide a better understanding of their relative contribution to resist impact load. The aim of this study is to describe the proximal ulna bone microstructure using micro-computed tomography (micro-CT) and relate it to gross morphology and function. Materials and methods: Five dry cadaveric human ulnae were scanned by micro-CT (17 μm/voxel, isotropic). Both qualitative and quantitative assessments were performed on sagittal image stacks. The cortical thickness of the trochlear notch and the trabecular bone microstructure were measured in the olecranon, bare area and coronoid. Results: Groups of trabecular struts starting in the bare area, spanning towards the anterior and posterior side of the proximal ulna, were observed; within the coronoid, the trabeculae were orthogonal to the joint surface. Consistently among the ulnae, the coronoid showed the highest cortical thickness (1.66 ± 0.59 mm, p = 0.04) and the olecranon the lowest (0.33 ± 0.06 mm, p = 0.04). The bare area exhibited the highest bone volume fraction (BV/TV = 43.7 ± 22.4%), trabecular thickness (Tb.Th = 0.40 ± 0.09 mm) and lowest structure model index (SMI = – 0.28 ± 2.20, indicating plate-like structure), compared to the other regions (p = 0.04). Conclusions: Our microstructural results suggest that the bare area is the region where most of the loading of the proximal ulna is concentrated, whereas the coronoid, together with its anteromedial facet, is the most important bony stabilizer of the elbow joint. Studying the proximal ulna bone microstructure helps understanding its possible everyday mechanical loading conditions and potential fractures. Level of evidence: N.A. [ABSTRACT FROM AUTHOR]

Based on remote sensing, geographical information system, multi-criteria decision making and field survey, the map of groundwater potential index (GwPI) in the Centre region of Cameroon, characterised by a crystalline basement, covered by saprolite and pedolith units has been elaborated by overlapping groundwater availability, exploitability and accessibility indicator maps, using eight parameters as slopes, drainage density, lineament density, hydraulic conductivity, static levels, pumping flow rate, drilling depth and altitude, respectively. The achieved data highlight that 68% of the study area of Lekié Division (Centre Region, Cameroon) is characterized by zone with moderate/good GwPI. In these zones, the surface water infiltration and aquifers recharge are promoted by weak slope and fine lineaments density. The borehole depth ranges from 20 to 40 m and the static level is shallow (< 6 m). Consequently, for the 68% of the study area, the rate to drill positive boreholes is high, the groundwater exploitation is favourable, and the lens-shaped aquifer are bounded by gently morphological paleo-depressions of the crystalline basement, playing the role of aquiclude. In the 23.73% of the total area, characterized by poor/fair GwPI, the steepness of the slope favours runoff while the density of coarse lineaments reduces infiltration and aquifer recharge. The boreholes and the static level are deeper than 40–60 m and 10–15 m respectively, while the pumping rate is low. Consequently, the rate of positive drilling in these areas is low and groundwater exploitation is unfavourable. It cannot be excluded that for the 23.73% of the total area, groundwater is stored in scattered deep morphotectonic depressions, probably corresponding to paleo-shear zones of the crystalline basement, acting as aquifers. In summary, by saving time and costs, all the thematic maps developed allow the identification of areas where drilling and groundwater exploitation are favourable, and areas where hydrogeological and resistivity studies are mandatory before drilling. These maps can therefore be powerful tools for local authorities to optimise human and financial resources in aquifer and groundwater exploitation. [ABSTRACT FROM AUTHOR]

Chemical signature of airborne particulates and deposition dusts is subject of study since decades. Usually, three complementary composition markers are investigated, namely, (i) specific organic compounds; (ii) concentration ratios between congeners, and (iii) percent distributions of homologs. Due to its intrinsic limits (e.g., variability depending on decomposition and gas/particle equilibrium), the identification of pollution sources based on molecular signatures results overall restricted to qualitative purposes. Nevertheless, chemical fingerprints allow drawing preliminary information, suitable for successfully approaching multivariate analysis and valuing the relative importance of sources. Here, the state-of-the-art is presented about the molecular fingerprints of non-polar aliphatic, polyaromatic (PAHs, nitro-PAHs), and polar (fatty acids, organic halides, polysaccharides) compounds in emissions. Special concern was addressed to alkenes and alkanes with carbon numbers ranging from 12 to 23 and ≥ 24, which displayed distinct relative abundances in petrol-derived spills and exhausts, emissions from microorganisms, high vegetation, and sediments. Long-chain alkanes associated with tobacco smoke were characterized by a peculiar iso/anteiso/normal homolog fingerprint and by n-hentriacontane percentages higher than elsewhere. Several concentration ratios of PAHs were identified as diagnostic of the type of emission, and the sources of uncertainty were elucidated. Despite extensive investigations conducted so far, the origin of uncommon molecular fingerprints, e.g., alkane/alkene relationships in deposition dusts and airborne particles, remains quite unclear. Polar organics resulted scarcely investigated for pollution apportioning purposes, though they looked as indicative of the nature of sources. Finally, the role of humans and living organisms as actual emitters of chemicals seems to need concern in the future. [ABSTRACT FROM AUTHOR]

Tobacco smoke (TS) is the source of a number of toxicants affecting the atmosphere and poses a threat to smokers and the whole community. Chemical, physical, and toxicological features of smoking products (vapors as well as mainstream, side stream, and third-hand smoke) have been investigated extensively. Special attention is paid to organic compounds (individually or in combination giving rise to peculiar molecular fingerprints), potentially able to act as "chemical signature" of TS. In this regard, the percent distribution of long-chainnormal, iso, and anteiso alkanes was ascertained as typical of TS. Nevertheless, until now no indexes have been identified as suitable for assessing the global TS contribution to environmental pollution, e.g., the TS percentage in carbonaceous aerosol and in deposited dusts, the only exception consisting in the use of nicotelline as tracer. This paper describes the results of an extensive study aimed at chemically characterizing the nonpolar lipid fraction associated to suspended particulates (PMs) and deposition dusts (DDs) collected at indoor and outdoor locations. Based on the iso, anteiso, and normal C29–C34 alkane profile in the samples as well in tobacco smoke- and no-TS-related emissions (literature data), various parameters describing the distribution of compounds were investigated. Finally, a cumulative variable was identified as the tobacco smoke impact index (TS%) suitable for estimating the TS percentage occurring in the particulate matter. The TS% rates were plotted vs. the exceedance of normal C31 alkane with respect to the average of C29 and C33 homologs, which results higher in TS than in most other emissions, revealing a link in the case of suspended particulates but not of deposited dusts. According to back analysis carried out on all particulate matter sets, it was found that traces of TS affect even remote areas, while inside the smokers' homes the contributions of TS to PM could account for up to ~61% and ~10%, respectively, in PM and DD. This confirms the need of valuing the health risk posed by TS to humans, by means of tools easy to apply in extensive investigations. [ABSTRACT FROM AUTHOR]

Introduction: A characterization of the internal bone microstructure of the radial head could provide a better understanding of commonly occurring fracture patterns frequently involving the (antero)lateral quadrant, for which a clear explanation is still lacking. The aim of this study is to describe the radial head bone microstructure using micro-computed tomography (micro-CT) and to relate it to gross morphology, function and possible fracture patterns. Materials and methods: Dry cadaveric human radii were scanned by micro-CT (17 μm/pixel, isotropic). The trabecular bone microstructure was quantified on axial image stacks in four quadrants: the anterolateral (AL), posterolateral (PL), posteromedial (PM) and anteromedial (AM) quadrant. Results: The AL and PL quadrants displayed the significantly lowest bone volume fraction and trabecular number (BV/TV range 12.3–25.1%, Tb.N range 0.73–1.16 mm−1) and highest trabecular separation (Tb.Sp range 0.59–0.82 mm), compared to the PM and AM quadrants (BV/TV range 19.9–36.9%, Tb.N range 0.96–1.61 mm−1, Tb.Sp range 0.45–0.74 mm) (p = 0.03). Conclusions: Our microstructural results suggest that the lateral side is the "weaker side", exhibiting lower bone volume faction, less trabeculae and higher trabecular separation, compared to the medial side. As the forearm is pronated during most falls, the underlying bone microstructure could explain commonly observed fracture patterns of the radial head, particularly more often involving the AL quadrant. If screw fixation in radial head fractures is considered, surgeons should take advantage of the "stronger" bone microstructure of the medial side of the radial head, should the fracture line allow this. [ABSTRACT FROM AUTHOR]

The water ingress phenomenon in sandwich-structured composites used in the aerospace/aeronautical sector is a current issue. This type of defect can cause in the course of time several other defects at the boundary, such as corrosions, deformations, detachments. In fact, water may change its state of physical matter going towards the freeze–thaw cycle caused by the atmosphere re-entry of, e.g. space probes. In this work, the alveoli of a composite laminate have been filled with water, which was initially transformed into ice. By taking into account, the known quantity of water, the freeze–thaw cycle was simulated by Comsol Multiphysics® software, reproducing exactly the shape of the sandwich as well as the real conditions in which it was subsequently subjected in a climatic chamber. The experimental part consisted of monitoring the front side of the specimen by means of a thermal camera operating into the long-wave infrared spectrum, and by setting both the temperature and the relative humidity of the test chamber according to the values imposed during the numerical simulation step. It was found that the numerical and experimental temperature trends are in good agreement with each other since the model was built by following a physico-chemical point-of-view. It was also seen that the application of the independent component thermography (ICT) technique was able both to retrieve the positions of the defects (i.e. the water inclusions) and to characterize the defects in which a detachment (fabricated between the fibres and the resin) is present; the latter was realized above an inclusion caused by the water ingress. To the best of our knowledge, this is the first time that ICT is applied to satisfy this purpose. [ABSTRACT FROM AUTHOR]

We hypothesize that variations of body anthropometry, conjointly with the bone strength, determine the risk of hip fracture. To test the hypothesis, we compared, in a simulated sideways fall, the hip impact energy to the energy needed to fracture the femur. Ten femurs from elderly donors were tested using a novel drop-tower protocol for replicating the hip fracture dynamics during a fall on the side. The impact energy was varied for each femur according to the donor's body weight, height and soft-tissue thickness, by adjusting the drop height and mass. The fracture pattern, force, energy, strain in the superior femoral neck, bone morphology and microarchitecture were evaluated. Fracture patterns were consistent with clinically relevant hip fractures, and the superior neck strains and timings were comparable with the literature. The hip impact energy (11 – 95 J) and the fracture energy (11 – 39 J) ranges overlapped and showed comparable variance (CV = 69 and 61%, respectively). The aBMD-based definition of osteoporosis correctly classified 7 (70%) fracture/non-fracture cases. The incorrectly classified cases presented large impact energy variations, morphology variations and large subcortical voids as seen in microcomputed tomography. In conclusion, the risk of osteoporotic hip fracture in a sideways fall depends on both body anthropometry and bone strength. [ABSTRACT FROM AUTHOR]

Introduction of exotic species is one of the major human impacts for decline in autochthonous biodiversity. In freshwater lentic environments, alien fish introduction heavily shapes macrobenthic invertebrate structure, with special regard for Chironomidae (Diptera) community. These effects could be more evident in alpine lakes whose environments are considered as remote and undisturbed, but extremely susceptible and vulnerable to both natural and anthropogenic impacts. In this context, modern and subfossil chironomid assemblages were studied in a high-altitude lake (Balma Lake, Piedmont, Italy) which was not previously investigated and subject to brook trout introduction for recreational fishing at the end of the twentieth century (after 1970). Seasonal samplings (summer, autumn) were performed in five littoral and three deep sites, while a core sample was extracted from the deepest point of the lake. The analysis highlighted significant differences in subfossil chironomid communities before and after fish introduction and between subfossil and modern communities, with notable decrease in recent diversities. Dissimilarities were mainly related to Corynocera oliveri, Zavrelimyia, Micropsectra, Metriocnemus, and Heterotrissocladius marcidus type. Therefore, this study highlights the importance and effects of anthropic environmental events, such as fish introduction, in climate reconstructions and their interpretation, especially regarding the last 100/200-year period, when human environmental issues have become more significant. [ABSTRACT FROM AUTHOR]

Alpine lakes are extreme ecosystems located in remote areas and populated by few but well-adapted species. Because of their remote location, they are often considered pristine, unpolluted ecosystems. Since the 1980s, however, they have been affected by global anthropogenic impacts. Macrobenthic invertebrates play a pivotal role in these ecosystems and can be used as bioindicators also for monitoring the accumulation of trace elements. We characterized the macrobenthic invertebrates community of Balma Lake (Cottian Alps, Northwest Italy) and Dimon Lake (Carnic Alps, Northeast Italy) in summer and autumn and measured the levels of nine trace elements (As, Cd, Cr, Cu, Fe, Ni, Pb, Se, Zn) in the most abundant taxa (Chironomidae and Oligochaeta in both lakes and Hirudinea in Dimon Lake) in both seasons. The highest levels of trace elements were recorded for Fe, Cu, and Zn according to their environmental availability and their function as essential elements. The total amount of trace elements was highest for the Chironomidae from both lakes compared to the other two taxa. As, Cd, Pb, and Zn were measured in sediment to calculate bioaccumulation factor (BAF) values. The amount of elements in sediment and macrobenthic invertebrates was higher for Dimon Lake, suggesting a greater flux via precipitation of contaminants from the lowland. The BAF values were decreased with increasing trace elements concentration in sediment, indicating mechanisms of elements excretion in biota where the environment is contaminated. This study is the first to report on the use of macrobenthic invertebrates to monitor trace elements in Alpine lakes. [ABSTRACT FROM AUTHOR]

This work explores the potentialities of combining a multi-layer eco-friendly panel with a phase change material coating. Although the work is based on a numerical approach performed by COMSOL Multiphysics® computer program, it can be considered as rigorous, robust, and optimized since the most important parameters added to the model were experimentally evaluated. The scientific soundness was guaranteed by a comparative analysis performed in two different times. The cork-coconut-cork panel was firstly investigated as it was, and secondly it was analysed with a phase change material layer applied on. In the second step, the panel undergone a mechanical process concerning the realization of a subsurface defect simulating a detachment. The aim was based on the conduction of a thermal conductivity analysis to characterize the benefits deriving from the application of the coating, as well as the negative effects introduced by the subsurface defect resembling a potential thermal bridge. The experiments were performed in Italy in a place identified into the manuscript (see "Testing procedure" section) by means of geographical coordinates. [ABSTRACT FROM AUTHOR]

Aims: Diabetic retinopathy remains asymptomatic until its late stages but remains a leading cause of vision impairment and blindness. We studied quality of life and the ability to deal with the discomfort deriving from the presence of a chronic disease in patients with type 1 diabetes and different stages of retinopathy. Methods: Multicenter collaborative observational study involving nine centers screening for retinopathy in different areas of Italy. The National Eye Institute 25-item visual functioning questionnaire and the locus of control tool were administered to 449 people with type 1 diabetes between February 2016 and March 2018. Socio-demographic and clinical data were collected. Results: On multivariable analysis, severe retinopathy is associated with worse scores for general vision, ocular pain, near vision activities, distance vision activities, driving, color vision, peripheral vision and lower values of internal control, independently of visual acuity. Women had a perception of worse general health, distance vision activities and driving, and lower internal control and trust in others. Worse scores for visual-specific social functioning, visual-specific mental health, visual-specific role difficulties, visual-specific dependency and peripheral vision were associated with higher HbA1c levels. Fatalism increased with rising HbA1c levels. Conclusions: These results confirm that a gap exists between patients' knowledge and expectations on retinopathy and providers' expertise and assumptions. To bridge this gap, patient-centered education and engaging approaches may be more effective than simple information given during consultations. [ABSTRACT FROM AUTHOR]

Synchronous posterior retroperitoneoscopic bilateral adrenalectomy (PR-BilA) is a novel technique proposed for the definitive cure of hypercortisolism when a surgical approach is indicated. The aim of the present prospective cohort study was to compare the carbon dioxide (CO2) absorption in patients undergoing PR-BilA with those undergoing single posterior retroperitoneoscopic adrenalectomy (PRA). Twenty-nine patients undergoing PR-BilA or PRA were consecutively enrolled. Anaesthesia was standardised. In both groups, CO2 elimination (VCO2), CO2 dissolved in arterial blood (PaCO2), end-tidal CO2 (EtCO2), and volume per minute (VM) were measured at the following time points: after anaesthesia induction and before CO2 insufflation (T1), 5 min after CO2 insufflation (T2), at the time of maximum VCO2 (T3), and at desufflation (T4). VCO2 was continuously measured using a metabolic monitor. ANOVA for repeated measures was used for statistical analysis. With respect to VCO2, a significant group × time interaction was found (p = 0.03). Post hoc analysis revealed that VCO2 was significantly increased at T4 compared with T1 in both groups (p = 0.02 and p = 0.0001 in the PRA and PR-BilA groups, respectively). Regarding PaCO2, ANOVA analysis showed a significant group effect (p = 0.01), with higher values in the PR-BilA group. EtCO2 and VM did not differ between the two groups. We found that the CO2 absorption was increased in both groups at the end of surgery, in the presence of a higher trend in PaCO2 values during PR-BilA. Therefore, PR-BilA may be considered a safe surgical approach with respect to CO2 absorption, when a mild degree of hypercapnia may be accepted. [ABSTRACT FROM AUTHOR]

A thermographic non-destructive inspection conducted during the winter season on precious walls confined to an indoor environment (Baiocco room, L'Aquila, Italy) is illustrated herein. The use of a heat conveyor ad hoc selected has produced a particular benefit in terms of defect detection after the application of advanced algorithms because the thermal stimulus coming from an air heater hit the finishing layer under a laminar flow regime. Thermocouples registered both the heat-up and cool-down phases to confirm the numerical simulations conducted via Comsol Multiphysics® software. The results obtained by applying the principal component thermography (PCT) technique to raw data registered in the time domain were a priori studied through thermographic simulations. Defects were modelled on the basis of results already shown in a previous work centred on the Baiocco room, too. A comparison between the results obtained from PCT and the innovative sparse principal component thermography (SPCT) technique was also added to the discussion. The SPCT results show their benefits above all when they are supplemented with ground-penetrating radar results. The experimental analyses were conducted on a multi-layer wall called thereafter rectangular portal, in which the instant thermal conductance was experimentally measured. Subsurface cracks were detected using a long heating-up phase. This procedure is preferred by the Monuments and Fine Arts Department with respect to the use of flash lamps. Indeed, short energy pulses should be avoided on finishing layers having low emissivity values because producing spurious reflections affecting the thermographic results. A discussion on this point is also provided. On the basis of the data analysis, it is possible to say that the thermal waves should arrive at the interface between the masonry and its top layer in order to obtain a clear thermal map of the defects present at different depths. As shown, this goal can be realized through a smart solution based on: (a) the inverse knowledge of the aedicula via thermal analyses, (b) the best mesh to be selected for the numerical model, and (c) the optimal type of thermal stress to be delivered to the object under inspection. [ABSTRACT FROM AUTHOR]

Despite the Mediterranean Sea basin is among the most sensitive areas over the world for climate change and air quality issues, it still remains less studied than the oceanic regions. The domain investigated by the research ship Minerva Uno cruise in Summer 2015 was the Tyrrhenian Sea. An overview on the marine boundary layer (MBL) concentration levels of carbonyl compounds, ozone (O3), and sulfur dioxide (SO2) is reported. The north-western Tyrrhenian Sea samples showed a statistically significant difference in acetone and SO2 concentrations when compared to the south-eastern ones. Acetone and SO2 values were higher in the southern part of the basin; presumably, a blend of natural (including volcanism) and anthropogenic (shipping) sources caused this difference. The mean acetone concentration reached 5.4 μg/m3; formaldehyde and acetaldehyde means were equal to 1.1 μg/m3 and 0.38 μg/m3, respectively. Maximums of 3.0 μg/m3 for formaldehyde and 1.0 μg/m3 for acetaldehyde were detected along the route from Civitavecchia to Fiumicino. These two compounds were also present at levels above the average in proximity of petrol-refining plants on the coast; in fact, formaldehyde reached 1.56 μg/m3 and 1.60 μg/m3, respectively, near Milazzo and Augusta harbors; meanwhile, acetaldehyde was as high as 0.75 μg/m3 at both sites. The levels of formaldehyde agreed with previously reported measurements over Mediterranean Sea and elsewhere; besides, a day/night trend was observed, confirming the importance of photochemical formation for this pollutant. According to this study, Mediterranean Sea basin, which is a closed sea, was confirmed to suffer a high anthropic pressure impacting with diffuse emissions, while natural contribution to pollution could come from volcanic activity, particularly in the south-eastern Tyrrhenian Sea region. [ABSTRACT FROM AUTHOR]

Graphene-h-BN hybrid nanostructures are grown in one step on the Pt(111) surface by ultra-high vacuum chemical vapor deposition using a single precursor, the dimethylamino borane complex. By varying the deposition conditions, different nanostructures ranging from a fully continuous hybrid monolayer to well-separated Janus nanodots can be obtained. The growth starts with heterogeneous nucleation on morphological defects such as Pt step edges and proceeds by the addition of small clusters formed by the decomposition of the dimethylamino borane complex. Scanning tunneling microscopy measurements indicate that a sharp zigzag in-plane boundary is formed when graphene grows aligned with the Pt substrate and consequently with the h-BN layer as well. When graphene is rotated by 30°, the graphene armchair edges are seamlessly connected to h-BN zigzag edges. This is confirmed by a thorough density functional theory (DFT) study. Angle resolved photoemission spectroscopy (ARPES) data suggests that both h-BN and graphene present the typical electronic structure of self-standing non-interacting materials. [ABSTRACT FROM AUTHOR]

We further extended the use of microswitch-cluster technology for promoting occupational activities and reducing hand biting of six adolescents with fragile X syndrome and severe to profound developmental disabilities. The primary rehabilitative goal was to enhance the adaptive response (i.e., inserting three different objects in the three containers within a 4 s time interval). The secondary objective was to evaluate the effects of the intervention on indices of positive participation as outcome measure of the participants 'quality of life. Finally, a social validation assessment involving sixty-six external raters was conducted. The study was carried out according to an ABB1AB1 experimental sequence for each participant. Thus, A indicated baselines, B indicated the intervention focused on promoting the adaptive response irrespective of the challenging behavior, and B1 indicated the cluster phases with the provision of positive stimulation only if the adaptive response was exhibited with the absence of the challenging behavior. A one-year follow-up was implemented. Results showed an improved performance for all the participants, which was maintained over the time. Indices of positive participation increased as well. Social raters favorably scored the use of the microswitch-cluster technology. Clinical, educational, psychological, and rehabilitative implications of the findings were critically discussed. [ABSTRACT FROM AUTHOR]

Background: Previous studies have focused on the role of deep neuromuscular blockade (NMB) in improving surgical conditions during laparoscopic bariatric surgery. However, a wide inter-individual variability has been noted. The aim of this study was to identify patient-related factors affecting surgeon satisfaction with the surgical space and surgery duration in laparoscopic bariatric surgery under deep NMB.Methods: One hundred eighty-five patients scheduled for laparoscopic gastric bypass were enrolled. Anesthesia was standardized. A deep NMB was maintained together with fixed patient positioning (30 reverse Trendelenburg) and constant pneumoperitoneum pressure (14 mmHg) during the whole surgical procedure. Immediately after surgery, the surgeon was invited to state his satisfaction with the surgical space through a verbal numeric scale (VNS) ranging from 0 (extremely poor) to 10 (optimal).Results: VNS score was negatively correlated with male gender (r = − 0.35; p = 0.0001), BMI (r = − 0.16; p = 0.03), and age (r = − 0.20; p = 0.008). Surgery duration was positively correlated with male gender (r = 0.27; p = 0.0003) and BMI (r = 0.22; p = 0.006). Multivariate linear regressions showed that lower VNS scores were predicted by male gender (p = 0.000001) and increased age (p = 0.009), and that a longer surgery duration was predicted by male gender (p = 0.0002).Conclusions: Findings showed that male gender and higher patient age were independent predictors of lower surgeon satisfaction with the workspace during laparoscopic bariatric surgery. Male gender also had a significant role in predicting longer surgery duration. The role of android obesity, which is more frequently associated with male gender, in affecting surgeon-perceived workspace conditions needs further investigation. [ABSTRACT FROM AUTHOR]

An innovative two-stage AD system to treat food waste with cow manure is presented to address the problem of ammonia inhibition and improve the stability of methanogenic reactor. The liquid digestate recirculation in the first phase was adopted to enhance the hydrolysis rate and the solubilization of organic matter. A stable long-term run (80 days) was found. The reactor configuration and the digestate post-treatment with natural zeolite led to a low ammonia concentration in reactor outlet. The biogas production in the methanogenic reactor was very stable and high: The specific biogas production in the second phase was equal to 0.68-0.92 Nm3/kgTVSadded and the average methane concentration was equal to 85%. Good performances were also found for the first-stage digestate, with 75% soluble COD removal efficiency. The high reactor performances were related to two-stage configuration, no ammonia and VFA inhibition. [ABSTRACT FROM AUTHOR]

The aim of this work is to evaluate the potentiality of a multi-technique nondestructive approach for characterizing the state of conservation of precious bookbindings. In particular, the bookbinding of an ancient book dating back nineteenth century was inspected by infrared thermography, near-infrared reflectography and transmittography, digital speckle photography, holographic interferometry, and proton magnetic resonance relaxometry. Data were processed by different and innovative methodologies, among which, a calibration procedure of the camera for correlation analyses based on specklegrams. The results were compared, showing a promising synergy for the diagnostic purposes, on the basis of the relationship between structure, properties, and uses of the analyzed materials. [ABSTRACT FROM AUTHOR]

Gradient of stressful conditions affect plant physiological and morphological traits. Previous studies have shown that plants located at higher altitudes might exhibit higher levels of both fluctuating asymmetry and leaf thickness. Although it is expected that higher fluctuating asymmetry levels should be accompanied by higher leaf consumption by herbivores, lower herbivory could be expected for elevated leaf thickness. Aiming to investigate this contradiction our objective was to determine the effects of altitude on fluctuating asymmetry and leaf thickness, and evaluate the importance of these two morphological traits on herbivory levels of Tibouchina granulosa Cogn. (Melastomatecea) in Brazilian Atlantic Forest. The study was conducted in southern Brazil, along a continuous altitudinal gradient raging from 1275 to 1950 m, where we measured fluctuating asymmetry, leaf thickness and herbivory from leaves of 29 individuals of T. granulosa. There was a positive effect of altitude on both fluctuating asymmetry and leaf thickness but only fluctuating asymmetry was related to herbivore. Our results suggest that as altitude increases plants face more stressful conditions, leading to higher fluctuating asymmetry. This may lead to a higher nutritional quality of leaves and herbivores may use leaf asymmetry as a cue for plant quality. The lack of a relationship between leaf thickness and herbivory gives us evidence that, in the studied location, leaf thickness is not primarily used as plant defense and probably has other functions related, for example, to water, solar radiation, and nutrient stresses. These results may be considered a baseline for the understanding on how altitudinal stress and potential herbivory pressure influence plant populations. [ABSTRACT FROM AUTHOR]

We further extended the use of a microswitch-based program for assessing contingency awareness and promoting locomotion fluency of five adolescents with Rett syndrome. A second goal was to evaluate the effectiveness and the suitability of the rehabilitative intervention on participants’ indices of happiness as outcome measure of their quality of life and on the reduction of their stereotypic behaviors. Finally, a social validation procedure involving 40 parents of children with severe developmental disabilities and 40 caregivers was carried out. The study was conducted according to an ABABCBCB experimental sequence for each participant, with A representing baselines, B indicating the contingent intervention closely linked to the adaptive responding, and C reporting a non-contingent control phase with positive stimulation occurring throughout the session, irrespective of the adaptive behavior. Results showed an improved performance for all the participants during contingent intervention phases. The control phases revealed that all participants acquired the contingency awareness. The indices of happiness increased as sign of an enhanced quality of life. Both groups of raters favorably scored the use of such technology. Clinical, practical, and psychological implications of the findings were discussed. [ABSTRACT FROM AUTHOR]

This study aimed at assessing the feasibility of a discrete algebraic reconstruction technique (DART) to be used in in vivo small animal bone studies. The advantage of discrete tomography is the possibility to reduce the amount of X-ray projection images, which makes scans faster and implies also a significant reduction of radiation dose, without compromising the reconstruction results. Bone studies are ideal for being performed with discrete tomography, due to the relatively small number of attenuation coefficients contained in the image [namely three: background (air), soft tissue and bone]. In this paper, a validation is made by comparing trabecular bone morphometric parameters calculated from images obtained by using DART and the commonly used standard filtered back-projection (FBP). Female rats were divided into an ovariectomized (OVX) and a sham-operated group. In vivo micro-CT scanning of the tibia was done at baseline and at 2, 4, 8 and 12 weeks after surgery. The cross-section images were reconstructed using first the full set of projection images and afterwards reducing them in number to a quarter and one-sixth (248, 62, 42 projection images, respectively). For both reconstruction methods, similar changes in morphometric parameters were observed over time: bone loss for OVX and bone growth for sham-operated rats, although for DART the actual values were systematically higher (bone volume fraction) or lower (structure model index) compared to FBP, depending on the morphometric parameter. The DART algorithm was, however, more robust when using fewer projection images, where the standard FBP reconstruction was more prone to noise, showing a significantly bigger deviation from the morphometric parameters obtained using all projection images. This study supports the use of DART as a potential alternative method to FBP in X-ray micro-CT animal studies, in particular, when the number of projections has to be drastically minimized, which directly reduces scanning time and dose. [ABSTRACT FROM AUTHOR]

Psychotropic substances (PSs) are known to affect air and waters, while scarce attention has been paid to their occurrence in settled dusts although they can reach important concentrations there; moreover, no procedures have been developed for this specific purpose. In this study, a list of PSs (i.e., nicotine, cotinine, caffeine, cocaine, cannabinol, Δ-tetrahydrocannabinol, cannabidiol, amphetamine, heroin, and methadone) were characterized in dusts from Rome and Fiumicino international airport, Italy, and from Ouargla city, Algeria. The analytical procedure, based on ultra-sonic bath extraction, silica column chromatography, and GC-MSD analysis, provided good recovery, uncertainty, sensitivity, and lack of interferences for all substances except amphetamine. In NIST SRM-2585 house dust, nicotine, cotinine, caffeine, cocaine, and cannabinol accounted for ~5.95, 0.87, 4.17, 7.0, and 2.2 μg/g, respectively; on the other hand, methadone, tetrahydrocannabinol, cannabidiol, and heroin (all <0.025 μg/g) were below the detection limit of the method. Two sites at the Fiumicino airport were affected by different loads of PSs (e.g., 0.76 and 2.80 ng/m of cocaine). In Ouargla, where dust was collected in a primary school and a dwelling, nicotine ranged from ~60 ± 50 to ~86 ± 89 ng/m, cocaine was absent, and cannabinoids (0.35 ± 0.43 ng/m as total) were found only in the home. In Rome, nicotine, caffeine, cocaine, and cannabinol reached ca. 700, 1470, 0.82, and 2.4 ng/m, respectively, in a smokers' home, but they were ca. 1300, 25,000, 670, and 1700 ng/m in a non-smoker home. In conclusion, all dusts revealed the presence of illicit PSs. Further studies are necessary to understand the links between the PS amounts in airborne particulates and in dusts, as well as the PS origin and fate in interiors. [ABSTRACT FROM AUTHOR]

The article focuses on the using the technology of microswitch-cluster for the improvement in the adaptive behavior of the children suffering from mental disability and Autism Spectrum Disorders. Particular focus is given to the promotion of occupation activities and decrease in the behavior of mouthing in the children. Effect of the technology observed by the adaptive response of the children is also discussed.

The present study is based on the non-destructive inspection of two marquetries representing arms' coats, which were produced by the Technical University in Zvolen (Slovakia) and tested under laboratory conditions. The aforesaid samples were made of traditional European and exotic wood species, while the veneers of the decorative layers were prepared through the technology cutting technique, emphasizing in such a manner the wooden texture. One sample was a defect-free panel, while the second one consisted of three sub-superficial flaws and one superficial putty insert, added during the manufacturing stage. The samples were inspected by different non-destructive techniques, such as visible imaging, ultraviolet testing, near-infrared reflectography and transmittography, infrared thermography, holographic interferometry, digital image correlation, laser speckle contrast imaging and ultrasonic testing. Sometimes a comparison was not performed, by avoiding unnecessary data processing. Numerical simulations focusing on the optimization of the provided thermal flux anticipated the experimental results. The latter analysis proved the necessity for the integration of experimental and numerical testing in similar case studies. A peculiarity of this work is the additional creation of an ad hoc Matlab $$^\circledR $$ code, written under the LSCI conditions, which identifies the wooden texture. The interactive methodology applied in the present study verified the synergy of the selected inspection methods enabling the production of a complete view for the preservation state of the inspected marquetry samples, through the comparison and/or the correlation of the individual informative content produced by each inspection procedure. [ABSTRACT FROM AUTHOR]

Objective: To investigate the effect of caffeic acid phenethyl ester (CAPE) on local and systemic inflammation and bone loss in collagen antibody-induced arthritis (CAIA) mice. Methods: Four groups of mice ( n = 8 per group) were allocated; control, CAPE (1 mg/kg), CAIA and CAIA + CAPE (1 mg/kg). Local inflammation and bone loss were evaluated using clinical paw scores, in vivo micro-computed tomography (micro-CT), histological assessment and tartrate-resistant acid phosphatase (TRAP) staining. Serum levels of C-reactive protein (CRP) and C-terminal telopeptide (CTX-1) were measured by ELISA. Jejunum and colon sections were evaluated histopathologically for damage and toxicity. Results: Greater paw scores and percentage change in paw volume were observed in CAIA + CAPE compared to the control groups ( p < 0.05). Bone volume over time remained unchanged ( p = 0.94) and the number of multinucleated TRAP-positive cells was greatest in CAIA + CAPE mice ( p < 0.05). CRP and CTX-1 levels did not differ between groups. CAIA + CAPE mice exhibited lower colon toxicity scores and a reduced percentage of cavitated goblet cells in the colon crypts compared with CAIA mice ( p = 0.026 and p = 0.003, respectively). Histopathology in the jejunum was not altered. Conclusion: CAPE did not reduce paw inflammation or bone loss in CAIA mice. CAPE reduced histopathological changes in the colon of CAIA mice. [ABSTRACT FROM AUTHOR]

The air quality of three different microenvironments (school, dwelling, and coffee bar) located in the city of Rome, Italy, was assessed. Indoor and outdoor concentrations of polycyclic aromatic hydrocarbons (PAHs) associated with PM particles were determined during an intensive 3-week sampling campaign conducted in March 2013. In interiors, total particulate PAHs ranged from 1.53 to 4.96 ng/m while outdoor air contained from 2.75 to 3.48 ng/m. In addition, gaseous toxicants, i.e., NO, NO, SO, O, and BTEX (benzene, toluene, ethyl-benzene, and xylene isomers), were determined both in internal and external air. To solve the origin of indoor and outdoor PAHs, several source apportionment methods were applied. Multivariate analysis revealed that emissions from motor vehicles, biomass burning for heating purposes, and soil resuspension were the major sources of PAHs in the city. No linear correlation was established between indoor and outdoor values for PM and BTEX; the respective indoor/outdoor concentration ratios exceed unity except for PM in the no smoking home and benzene in all school floors. This suggests that important internal sources such as tobacco smoking, cleaning products, and resuspension dust contributed to indoor pollution. Using the monitoring stations of ARPA Lazio regional network as reference, the percentage within PAH group of benzo[a]pyrene, which is the WHO marker for the carcinogenic risk estimates, was ca. 50 % higher in all locations investigated. [ABSTRACT FROM AUTHOR]

The article focuses on a study regarding checking the effective use of Speech Generating Device (SGD) in children with multiple disabilities. such as blindness or minimal residual vision. It mentions the possible effectiveness of SGD technology in children with multiple disabilities. It also mentions that SGD technology have impact and usability.

The feasibility of square-pulsed thermography nondestructive testing for the detection of defects in one ceramic material sample has been carried out by finite element (FE) analysis. In particular, a ceramic plate containing defects of different diameters, depths, locations, nature, and shapes has been numerically investigated by means of Comsol Multiphysics computer program, taking into account the results coming from both a MATLAB™ script and the infrared thermography (IRT) technique. Indeed, the FE method simulates through a 3D model the heat transfer process induced into the ceramic material by two halogen lamps that have been applied in order to provoke an optimum thermal stress. Moreover, further defects like cracks arose beneath the surface of the plate due to the shrinkage process, have been discovered, and contrasted using a non-usual segmentation algorithm that when correlated in the time to IRT data simulates the thermo-elastic effect. Following the non-direct procedure proposed, both the depth of each defect and its main dimensions have been retrieved into a satisfactory accuracy. [ABSTRACT FROM AUTHOR]

Three-dimensional (3D) characterization of cortical porosity, most of which is under 100 µm in diameter, is usually confined to measurements made in 3-4 mm diameter cylinders of bone. We used micro-computed tomography (micro-CT) scanning of entire transaxial cross sections of human proximal femoral shafts (30-35 mm diameter) to quantify regional variation in porosity within the same scan. Complete, up to 10-mm-thick, transaxial slices of femoral upper shafts from 8 female cadavers were studied ( n = 3 aged 29-37 years, n = 5 aged 72-90 years). Scanning was performed using high-resolution micro-CT (8.65 µm/voxel). Micro-CT volumes (10 × 10 × 5 mm) were selected via software in the anterior, medial and lateral regions. Images were segmented with voids appearing as 3D-interconnected canals. The percent void-to-tissue volume (Vo.V/TV) and the corresponding void surface area/TV were 86-309 % higher in older than younger subjects in anterior ( p = 0.034), medial ( p = 0.077), and lateral aspects ( p = 0.034). Although not significant, void separation was reciprocally lower by 19-39 %, and void diameter was 65 % larger in older than younger subjects; void number tended to be 24-25 % higher medially and laterally but not anteriorly. For all specimens combined, medially there was higher Vo.V/TV and void surface area/TV than anteriorly (+48 %, p = 0.018; +33 %, p = 0.018) and laterally (+56 %, p = 0.062; +36 %, p = 0.043). There is regional heterogeneity in the 3D microarchitecture of the intracortical canals of the femoral shaft. The higher void volume in advanced age appears to be due to larger, rather than more, pores. However, creation of new canals from existing canals may contribute, depending on the location. High-resolution micro-computed tomography scanning of entire bone segments enables quantification of the 3D microanatomy of the intracortical void network at multiple locations. [ABSTRACT FROM AUTHOR]

Purpose: In the literature, inter-vertebral MRI signal intensity changes (Modic changes) were associated with corresponding histological observations on endplate biopsies. However, tissue-level studies were limited. No quantitative histomorphometric study on bone biopsies has yet been conducted for Modic changes. The aim of this study was to characterise the bone micro-architectural parameters and bone remodelling indices associated with Modic changes. Methods: Forty patients suffering from disabling low back pain, undergoing elective spinal surgery, and exhibiting Modic changes on MRI (Modic 1, n = 9; Modic 2, n = 25; Modic 3, n = 6), had a transpedicular vertebral body biopsy taken of subchondral bone. Biopsies were first examined by micro-CT, for 3D morphometric analysis of bone volume fraction (BV/TV), trabecular thickness (Tb.Th), trabecular separation, trabecular number, and structure model index. Then, samples underwent histological analysis, for determination of bone remodelling indices: osteoid surface to bone surface ratio (OS/BS), eroded surface to bone surface (ES/BS) and osteoid surface to eroded surface ratio (OS/ES). Results: Micro-CT analysis revealed significantly higher BV/TV (up to 70 % increase, p < 0.01) and Tb.Th (up to +57 %, p < 0.01) in Modic 3 biopsies, compared to Modic 1 and 2. Histological analysis showed significantly lower OS/BS in Modic 2 biopsies (more than 28 % decrease, p < 0.05) compared to 1 and 3. ES/BS progressively decreased from Modic 1 to 2 to 3, whereas OS/ES progressively increased with significantly higher values in Modic 3 (up to 159 % increase, p < 0.05) than in Modic 1 and 2. Conclusions: Significant differences were found in bone micro-architectural parameters and remodelling indices among Modic types. Modic 1 biopsies had evidence of highest bone turnover, possibly due to an inflammatory process; Modic 2 biopsies were consistent with a reduced bone formation/remodelling stage; Modic 3 biopsies suggested a more stable sclerotic phase, with significantly increased BV/TV and Tb.Th compared to Modic 1 and 2, linked to increased bone formation and reduced resorption. [ABSTRACT FROM AUTHOR]

Particle-induced bone loss by osteoclasts is a common cause of aseptic loosening around implants. This study investigates whether caffeic acid phenethyl ester (CAPE), a potent and specific inhibitor of nuclear factor of activated T cells, cytoplasmic, calcineurin-dependent 1 and nuclear factor kappa B, at a low dose reduces bone resorption in a murine calvarial model of polyethylene (PE) particle-induced osteolysis. The effects of particles and CAPE treatment on gastrointestinal tract (GIT) histopathology were also evaluated. Mice were scanned using in vivo animal micro-computed tomography (μCT) as a baseline measurement. PE particles (2.82 × 10 particles/mL) were implanted over the calvariae on day 0. CAPE was administered subcutaneously (1 mg/kg/day) at days 0, 4, 7 and 10. Mice were killed at day 14 and serum was analysed for Type-1 carboxyterminal collagen crosslinks (CTX)-1 and osteoclast-associated receptor (OSCAR) levels. Ex vivo μCT scans were conducted to assess bone volume (BV) change and percentage area of calvarial surface resorbed. Calvarial and GIT tissue was processed for histopathology. By day 14, PE particles significantly induced calvarial bone loss compared with control animals as evidenced by resorption areas adjacent to the implanted PE in three-dimensional μCT images, an increase in percentage of resorbed area ( p = 0.0022), reduction in BV ( p = 0.0012) and increased Tartrate-resistant acid phosphatase positive cells. Serum CTX-1 ( p = 0.0495) and OSCAR levels ( p = 0.0006) significantly increased in the PE implant group. CAPE significantly inhibited PE particle-induced calvarial osteolysis, as evidenced by a significant reduction in surface bone resorption ( p = 0.0012) and volumetric change ( p = 0.0154) compared with PE only, but had no effect on systemic CTX-1. Neither particles nor CAPE had an effect on GIT histopathology. [ABSTRACT FROM AUTHOR]

This study proposed the use of assistive technology (AT) to promote communication and leisure opportunities by three children with traumatic brain injury (TBI). Furthermore, it assessed the effects of such technology on the indices of positive participation and provided a social validation procedure. Three children emerged from a minimal conscious state and presenting extensive motor disabilities were involved. The intervention program allowed the participants to request and to choice preferred items independently and to perform literacy through a keyboard emulator. A multiple probe design across behaviors with post-intervention check was employed. Outcome measures were correct requests, understandable words, intervals with positive participation, and scores of social validation assessment. Request and choice behaviors and literacy improved significantly during intervention phases. During post-intervention check, all participants consolidated their performance. Moreover, indices of positive participation increased during intervention phases. Scores of social validation assessment showed that the combination of both behaviors was preferable to the same considered separately. AT program showed to be suitable for promoting constructive engagement and literacy behaviors by children with TBI. Future research is needed to generalize this data to a larger sample and to develop new technology for people with different levels of disabilities due to TBI. [ABSTRACT FROM AUTHOR]

This study assessed whether a computer-aided program presenting static pictorial instructions or video prompts according to prearranged time intervals would be suitable for teaching six persons with multiple (i.e., intellectual, sensory, and social) disabilities to perform simple daily activities. The program was applied with each participant according to a multiple probe across activities design. The results showed that all participants (i.e., the five using pictorial instructions and the one using video prompts) had a fairly rapid performance improvement with the introduction of the program. A post-intervention probe carried out to verify whether the participants had eventually become capable of performing the activities independent of the instructions showed clear declines in performance. Such declines underlined the enduring relevance of the instructions. These results (a) extend previous evidence on the use of visual instructions and computer-aided programs for supporting their presentation and (b) have clear practical implications for daily contexts. [ABSTRACT FROM AUTHOR]

Measurement of areal bone mineral density (aBMD) in intravertebral subregions may increase the diagnostic sensitivity of dual-energy X-ray absorptiometry (DXA)-derived parameters for vertebral fragility. This study investigated whether DXA-derived bone parameters in vertebral subregions were better predictors of vertebral bone strength in specimens with low aBMD, compared to those with higher aBMD. Twenty-five lumbar vertebrae (15 embalmed and 10 fresh-frozen) were scanned with posteroanterior- (PA) and lateral-projection DXA, and then mechanically tested in compression to ultimate failure. Whole-vertebral aBMD and bone mineral content (BMC) were measured from the PA- and lateral-projection scans and within 6 intravertebral subregions. Multivariate regression was used to predict ultimate failure load by BMC, adjusted for vertebral size and specimen fixation status across the whole specimen set, and when subgrouped into specimens with low aBMD and high aBMD. Adjusted BMC explained a substantial proportion of variance in ultimate vertebral load, when measured over the whole vertebral area in lateral projection (adjusted R 0.84) and across the six subregions (ROIs 2-7) (adjusted R range 0.58-0.78). The association between adjusted BMC, either measured subregionally or across the whole vertebral area, and vertebral failure load, was increased for the subgroup of specimens with identified 'low aBMD', compared to those with 'high aBMD', particularly in the anterior subregion where the adjusted R differed by 0.44. The relative contribution of BMC measured in vertebral subregions to ultimate failure load is greater among specimens with lower aBMD, compared to those with higher aBMD, particularly in the anterior subregion of the vertebral body. [ABSTRACT FROM AUTHOR]

The intensive campaign conducted in March 2013 in Rome, Italy, at one coffee bar, one primary school and two homes revealed that in indoor environments, drugs can reach concentration levels exceeding orders of magnitude those recorded outdoors, even when the same substances are not consumed there. At homes, the gross average of cocaine reached 0.13 ng/m indoors and 0.09 ng/m outdoors (ratio ~ 1.6); Δ-tetrahydrocannabinol was 6.6 ng/m indoors and 1.1 ng/m outdoors (ratio ~ 7); cannabidiol reached 0.30 and 0.07 ng/m, respectively (ratio ~ 6); and cannabinol 2.3 ng/m indoors and 0.7 ng/m outdoors (ratio ~ 3). At the coffee bar, the average drug burdens were even higher, namely 0.33, 4.7, 14.3 and 2.5 ng/m, respectively, for cocaine, cannabidiol, tetrahydrocannabinol and cannabinol. The school presented a special behaviour: the indoor/outdoor concentration ratios of cocaine, cannabidiol, tetrahydrocannabinol and cannabinol accounting for ~1.5, ~0, ~4 and ~0.5, in the order. Cocaine was more abundant on weekdays at all sites except one home indoors, whilst total cannabinoids prevailed on weekends at the other home and the school. Using the regional network stations as reference, all indoor locations except one were more contaminated by cocaine by a factor ≥1.5, whilst cannabinoids were, aside from the school, up to 100 times higher. [ABSTRACT FROM AUTHOR]

In women of fertile age, iron loss consequent to excessive menstrual discharge is by far the most frequent cause of iron-deficient anemia. However, the relationship between menstrual discharge and iron loss is poorly understood. In this prospective study, total menstrual and iron losses were assayed in a large cohort of non-anemic women and women with excessive menstrual blood losses (menorrhagia) in order to provide data useful for intervention. One hundred and five Caucasian women aged 20-45 years were recruited. Blood cell count and serum ferritin (SF) levels were determined in each case before menses. Menstrual fluid losses (MFL) were determined using a standardized pads' weight method. Hematin concentration was assayed by a variant of the Alkaline Hematin Method from which iron concentration was calculated. Mean SF levels were 36.2 (range 8.6-100) ng/ml in healthy women and 6.4 (range 5-14) ng/ml in patients with menorrhagia. Median values of iron lost/cycle were 0.87 mg in healthy women and 5.2 mg in patients with menorrhagia (ranges 0.102-2.569 and 1.634-8.665 mg, respectively, p < 0.001). In women with menorrhagia, iron lost/cycle strongly correlated (0.789, p < 0.001) with MFL. In conclusion, healthy women with normal menses lose, on average, 1 mg iron/cycle. Average iron losses in patients with menorrhagia are, at least in our cohort, on average, five-to-six times higher than normal. Most women with menorrhagia had totally depleted iron stores. Indirect, quantitative evaluation of iron lost with menses may be useful to assess the risk of developing iron-deficient anemia in individual patients. [ABSTRACT FROM AUTHOR]

Olfactory receptor (OR) expression is also present in the sperm cells and could mediate sperm chemotaxis. OR1D2 was the first OR expressed in the testis demonstrated to be involved in chemotaxis and to be expressed also in the nose with a similar behavior. Bourgeonal is the OR1D2 most potent known agonist. Infertility affects ~15 % of couples in western countries and sometimes it is unexplained. This pilot study compared the bourgeonal olfactory thresholds, the ability of sperm to sense the bourgeonal and the frequency of 13 single nucleotide polymorphisms (SNPs) of OR1D2 gene in nine males suffering of unexplained infertility with a control group of 15 healthy males. The mean olfactory threshold for bourgeonal was statistically different between the study group (10.5 ± 3.7; median 12.3) and the control group (14.0 ± 2.8; median 15.5) ( p = 0.006). Statistical analysis showed a significantly higher percentage of spermatozoa that migrated toward the capillaries filled with bourgeonal in the control group compared to the study group ( p < 0.0001). Sperm migration was equally inhibited in both groups of subjects when, together with bourgeonal, capillaries were filled with undecanal, a strong bourgeonal inhibitor ( p = 0.42). The 13 SNPs of OR1D2 revealed a statistically significant difference for allele and genotype frequency of rs769423 in study group versus control group ( p = 0.02). The present preliminary study seems to confirm the important role of OR1D2 both in nose and spermatozoa and may explain the idiopathic infertility of the study group. Further studies on larger series are mandatory to confirm our preliminary evidence. [ABSTRACT FROM AUTHOR]

This study extended the comparison of active (self-regulated) music stimulation versus passive (outer-regulated) music stimulation with seven new patients in the severe or low moderate stage of Alzheimer's disease. In the active condition, the patients used a simple hand response and a microswitch to self-regulate music stimulation inputs. In the passive condition, music stimulation was automatically presented to them. Data showed an increase in the patients' indices of positive participation (e.g., singing or music-related movements, and smiles) during both music conditions. The increase in the active condition was greater than that in the passive condition for five of the seven patients. The other two patients showed comparable data across conditions and a smaller increase in the active condition, respectively. The implications of the findings are analyzed in relation to recent data in the area concerning both patients' indices of positive participation and social raters' perception of the two stimulation conditions. [ABSTRACT FROM AUTHOR]

Background: The effectiveness of restrictive procedures has been inferior to that of malabsorbitive ones. Recent variants of restrictive procedures, i.e., gastric banding and sleeve gastrectomy, confirm the strive for more efficacious solutions with less complications. We investigated the balance between effectiveness and complications for a new restrictive procedure, a Transoral Endoscopic Vertical Gastroplasty (TOGa®) Methods: Seventy-nine morbidly obese patients were submitted to one out of three surgical procedures: TOGa® (29 patients), laparoscopic gastric bypass (LRYGBP; 20 patients), and biliopancreatic diversion (BPD; 30 patients). Mean BMI were 41.7 (35.4-46.6), 44.8 (36.4-54), and 47.5 (41-60.3), respectively. All the patients reached a 2-year follow-up. Results: In TOGa® group BMI, respectively at 12 and 24 months, was 34.5 and 35.5, with 44 and 48.3 % of patients with BMI lower than 35. In LRYGBP group, BMI was 30.7 and 29.2 kg/m, with 80 and 85 % of patients with BMI < 35. In BPD group, BMI was 30 and 29.6 kg/m, with 100 and 93.3 % of patients with BMI < 35. In TOGa® group, 59 % of patients with an initial BMI < 45 reached a BMI < 35, in comparison to 48 % recorded in the whole group and to 14.3 % in patients with initial BMI ≥ 45. Conclusions: In selected patients, TOGa®, was associated with good results after two years in terms of weight loss, even in comparison with LRYGBP and BPD. Minimal trauma, absence of complications, and short hospital stay justify this procedure for patients with low BMI. [ABSTRACT FROM AUTHOR]