Search

Mindfulness and acceptance-based approaches have shown promise as alternative interventions to trauma-focused therapies for PTSD. This open trial examined the potential effectiveness of an 8-session Acceptance and Commitment Therapy (ACT) group in reducing psychiatric symptoms and improving quality of life in outpatient adults (N = 86, 79% female) receiving treatment for PTSD in a health maintenance organization (HMO) psychiatry clinic. The group therapy was an adjunct to usual care and utilized the six core processes of ACT: acceptance, cognitive defusion, mindfulness, self-as-context, values, and committed action. Participants completed self-report measures of PTSD symptoms, depression, anxiety and quality of life; and self-report ACT-specific process measures of acceptance, cognitive defusion and mindfulness at pretreatment, posttreatment and 3-month follow-up. Repeated measures analyses of variance conducted with a completer sample (n = 55) demonstrated significant improvements on all variables with medium to large effect sizes at posttreatment and follow-up. The study findings support further investigation in a randomized controlled trial. [ABSTRACT FROM AUTHOR]

Purpose of Review: Despite the growing attention toward minority stress, there remains a scarcity of studies on its associations with sexual wellbeing. This scoping review aimed to examine the empirical literature from the last five years concerning how minority stress may relate to sexual wellbeing among adults. Recent Findings: Results from the 13 peer-reviewed articles were inconsistent. Internalized negativity (e.g., homophobia) showed varying associations with sexual satisfaction and function. Concealing one's sexual identity was linked to lower sexual satisfaction and sexual function. Fear of being rejected was associated with worse sexual function. Prejudice-related events were negatively associated with sexual satisfaction and function, and positively with sexual distress. Personal discomfort with one's non-monogamous engagement did not correlate with sexual satisfaction. Summary: Findings suggest that greater minority stress tends to be related to lower sexual wellbeing, albeit inconsistently. Further research is needed to better understand the mechanisms involved in these associations. [ABSTRACT FROM AUTHOR]

Purpose: Peripheral responses might be important in handcycling, given the involvement of small muscles compared to other exercise modalities. Therefore, the goal of this study was to compare changes in muscle oxygen saturation (∆SmO2) and deoxyhemoglobin level (∆[HHb]) between different efforts and muscles. Methods: Handcyclists participated in a Wingate, a maximal incremental test and a 20-min time-trial (TT). Oxygen uptake (VO2) as well as ∆SmO2, ∆[HHb], deoxygenation and reoxygenation rates in the triceps brachii (TB), biceps brachii (BB), anterior deltoid (AD) and extensor carpi radialis brevis (ER) were measured. Results: ER ∆[HHb]max was 37% greater in the incremental test than in the Wingate (ES = 0.392, P = 0.031). TT mean power (W/kg) was associated with BB ∆SmO2min measured in the incremental test (r = −0.998 [−1.190, −0.806], P = 0.002) and in the Wingate (r = −0.994 [−1.327, −0.661], P = 0.006). MAP (W/kg) was associated with Wingate BB ∆SmO2min (r = −0.983 [−0.999, −0.839], P = 0.003), and Wingate peak (r = 0.649 [0.379, 0.895], P = 0.008) and mean power (W/kg) (r = 0.925 [0.752, 0.972], P = 0.003) was associated with right handgrip force. The strongest physiological predictor for TT performance was BB ∆SmO2min in the incremental test (P = 0.002, r2 = 0.993, SEE 0.016 W/kg), Wingate BB ∆SmO2min for MAP (P = 0.003, r2 = 0.956, SEE 0.058 W/kg) and right handgrip force for Wingate peak power (P = 0.005, r2 = 0.856, SEE 0.551 W/kg). Conclusion: Peripheral aerobic responses (muscle oxygenation) were predictive of handcycling performance. [ABSTRACT FROM AUTHOR]

In this paper, we propose a new method for selecting cases for in situ, immediate interview research: detector-driven classroom interviewing (DDCI). Published work in educational data mining and learning analytics has yielded highly scalable measures that can detect key aspects of student interaction with computer-based learning in close to real-time. These measures detect a variety of constructs and make it possible to increase the precision and time-efficiency of this form of research. We review four examples that show how the method can be used to study why students become frustrated and how they respond, how anxiety influences how students respond to frustration, how metacognition interacts with affect, and how to improve the design of an adaptive learning system. Lastly, we compare DDCI to other mixed-methods approaches and outline opportunities for detector-driven classroom interviewing in research and practice, including research opportunities, design improvement opportunities, and pedagogical opportunities for teachers. [ABSTRACT FROM AUTHOR]

In Canada, the highest increases in rates of sexually transmitted infections (STIs) and substance use disorders occur among emerging adults aged 18 to 29 years old. Most research on risk-taking behaviors have focused on adolescents or males only—especially gay and bisexual men. This study aimed to assess patterns of sexual and substance use risk-taking behavior (i.e., early sexual onset, number of sexual partners, inconsistent condom use, unconventional sexual behaviors, binge-drinking, and polysubstance use); investigate whether sociodemographic and individual characteristics predict risk-taking profiles; and examine whether risk-taking profiles are associated with differential health outcomes (i.e., STI testing and diagnosis, substance use problems). Latent class analyses were conducted on a sample of 602 heterosexual French-Canadian emerging adults (84% female; M age = 22.3) who completed an online questionnaire. Four profiles were identified: inactive low-risk (13.5%), active low-risk (34.7%), mid-risk (42.3%), and high-risk (9.5%). The two higher risk-taking profiles were overrepresented by older participants, females, and impulsive sensation seekers. Participants in the mid- and high-risk profiles had higher odds of having been screened for and been diagnosed with STIs, and of reporting more substance use problems. [ABSTRACT FROM AUTHOR]

Background: Alzheimer's disease (AD) heritability is estimated to be around 70–80%. Yet, much of it remains to be explained. Studying transmission patterns may help in understanding other factors contributing to the development of AD. Objective: In this study, we aimed to search for evidence of autosomal recessive or X- and Y-linked inheritance of risk factors in a large cohort of Portuguese AD patients. Methods: We collected family history from patients with AD and cognitively healthy controls over 75 years of age. We compared the proportions of maternal and paternal history in male and female patients and controls (to search for evidence of X-linked and Y-linked inherited risk factors). We compared the risk of developing AD depending on parents' birthplace (same vs. different), as a proxy of remote consanguinity. We performed linear regressions to study the association of these variables with different endophenotypes. Results: We included 3090 participants, 2183 cognitively healthy controls and 907 patients with AD. Men whose mother had dementia have increased odds of developing AD comparing to women whose mother had dementia. In female patients with a CSF biomarker-supported diagnosis of AD, paternal history of dementia is associated with increased CSF phosphorylated Tau levels. People whose parents are from the same town have higher risk of dementia. In multivariate analysis, this proxy is associated with a lower age of onset and higher CSF phosphorylated tau. Conclusions: Our study gives evidence supporting an increased risk of developing AD associated with an X-linked inheritance pattern and remote consanguinity. [ABSTRACT FROM AUTHOR]

Human p97 ATPase is crucial in various cellular processes, making it a target for inhibitors to treat cancers, neurological, and infectious diseases. Triazole allosteric p97 inhibitors have been demonstrated to match the efficacy of CB-5083, an ATP-competitive inhibitor, in cellular models. However, the mechanism is not well understood. This study systematically investigates the structures of new triazole inhibitors bound to both wild-type and disease mutant forms of p97 and measures their effects on function. These inhibitors bind at the interface of the D1 and D2 domains of each p97 subunit, shifting surrounding helices and altering the loop structures near the C-terminal α2 G helix to modulate domain-domain communications. A key structural moiety of the inhibitor affects the rotameric conformations of interacting side chains, indirectly modulating the N-terminal domain conformation in p97 R155H mutant. The differential effects of inhibitor binding to wild-type and mutant p97 provide insights into drug design with enhanced specificity, particularly for oncology applications. Human p97 ATPase, a critical drug target for neurodegenerative disorders and cancers, can be allosterically inhibited by triazole-based inhibitors. In this study, the authors investigate the structure and functions of newly designed triazole inhibitors in both wild-type and disease mutant forms of p97 to elucidate the previously unexplored inhibitory mechanisms, shedding new light on the design concept for p97 allosteric inhibitors. [ABSTRACT FROM AUTHOR]

In natural science education, experiments often lead to the collection of raw data that need to be processed into results by doing calculations. Teaching students how to approach such calculations can be done using digital learning materials that provide guidance. The goal of this study was to investigate students' behaviour regarding the use of guidance while doing scientific multi-step calculations, and to relate this behaviour to learning. Sequential pattern mining was used to i) identify students' behaviour patterns while doing calculations in an online learning environment, ii) study the relation between use of guidance and success on first attempt at submitting a calculated value, iii) study the relation between students' use of guidance and learning gain, and iv) study the relation between students' use of guidance and prior knowledge. Data showed that all students frequently used the guidance provided in the learning task. Moreover, students who used the option to check their intermediate calculations and students who studied worked examples were more likely to successfully complete the calculation on their first attempt than students who did not use this guidance. Guidance in the form of hints was used frequently. However, using the hints did not result in more success at the first attempt. We did not find a relation between learning gain and use of guidance, but we did find a trend that students with a low prior knowledge used more guidance compared to students with a high prior knowledge. The results of this study imply that providing hints and intermediate calculations is of utmost importance for students to independently complete scientific multi-step calculations. [ABSTRACT FROM AUTHOR]

Background: Endurance running is a popular sport and recreational activity yet is associated with a high prevalence of injury. Running related injuries (RRIs) are a leading cause of drop-out and represent a substantial financial burden to runners and healthcare services. There is clear evidence for the use of exercise-based injury prevention programs in games-based and youth sport settings, yet the research investigating the use of exercise to reduce injury risk in endurance runners has not been adequately reviewed recently. Objectives: The aim of this review and meta-analysis was to systematically summarize the current research that has investigated the effect of exercise-based prevention programs and their state of supervision on the risk of RRIs in endurance runners. Methods: Three databases were searched for relevant studies. Selection and review were completed by two independent reviewers using the following inclusion criteria: (1) study population used endurance running training for health, occupational, or performance outcome(s); (2) participants performed running as their main form of exercise (> 50% of their total training time); (3) study was a randomized controlled trial; (4) a non-running-based exercise intervention was used; (5) a running-only or placebo exercise control group was included; (6) injury rate or incidence was reported; (7) injuries were recorded prospectively alongside the exercise training. Two meta-analyses were conducted using random-effects models, one based on log risk ratio and one based on log incidence rate ratio. The Cochrane Risk of Bias Assessment Tool 2 was used to evaluate the quality of studies and the Grading of Recommendations Assessment, Development and Evaluations approach was employed to grade the certainty of evidence. Results: A total of nine articles containing 1904 participants were included in analysis. Overall pooled results showed no significant differences between intervention and control groups in injury risk (z = − 1.60; p = 0.110) and injury rate (z = − 0.98; p = 0.329), while a post hoc analysis evaluating supervised interventions only showed that injury risk was significantly lower in the intervention group compared to the control group (z = − 3.75, p < 0.001). Risk of bias assessment revealed that seven studies included in the analysis were of low quality. Conclusions: Exercise-based interventions do not appear to reduce the risk and rate of running-related injuries. Supervision may be essential for exercise-based intervention programs to reduce risk of RRIs, possibly due to increased compliance. Studies with more robust designs that include supervised exercise interventions should be prioritized in the future. Trial Registry: Clinical Trial Registration: PROSPERO CRD42021211274. [ABSTRACT FROM AUTHOR]

This work investigates the relationships between partial melting, melt extraction, pluton growth and silicic volcanism in garnet-bearing felsic volcanic rocks that were extruded in the Iberian Pyrite Belt, at ca. 345 Ma. The garnets are of peritectic origin, displaying textural and chemical features of disequilibrium crystallization during partial melting reactions involving biotite at high temperatures (up to 870 °C) in the middle-lower crust. Major element composition suggests compositional equilibrium with the entrained and pinitized peritectic cordierite, but reveals some subsequent homogenization by diffusion. Trace element maps and spot analyses of garnet show, nonetheless, significant trace element variations, reflecting biotite and Y-REE-P-rich accessory phase breakdown during partial melting reactions. Peritectic garnet and cordierite growth resulted in the preservation of Th- and Y-rich prograde suprasolidus monazite, which constrains the timing of partial melting of the metapelitic protolith at ca. 356.8 ± 2.4 Ma. The zircon cargo further shows that a significant amount of zircon crystals from previously crystallized felsic melts were also remobilized and erupted. These were likely stored in an upper crustal pluton that grew episodically since ca. 390 Ma during voluminous melt generation periods within the middle to lower crust, which also resulted in voluminous volcanism. The geochemical trends of the felsic volcanic rocks reflect the entrainment of xenoliths of peritectic garnet, cordierite and feldspar, and as such, the garnet-bearing felsic volcanic rocks represent an erupted mixture of a lower-temperature (ca. 770 °C) silicic melt and autocrysts, and peritectic phases and zircon crystals from previously crystallized and stored felsic melts. [ABSTRACT FROM AUTHOR]

Child maltreatment is a global concern that profoundly affects individuals throughout their lives. This study investigated the relationships between various forms of child maltreatment and behavior problems involving internalization and externalization during adolescence. Data obtained from a diverse sample of 1802 Canadians aged 14–18 years was used to examine the mediating role of alexithymia—a difficulty in recognizing and expressing emotions—in these associations. Results indicated that adolescents who experienced sexual abuse, emotional abuse, and exposure to intimate partner violence (IPV) in their childhood exhibited higher levels of alexithymia, which was correlated with elevated levels of both internalizing and externalizing problems. Physical abuse and parental neglect were only associated with externalizing problems. Gender differences also emerged, with gender-diverse adolescents reporting a higher prevalence of maltreatment, alexithymia, and behavior problems compared with their peers. However, alexithymia's mediating role was consistent across genders. Overall, this study highlights the intricate relationships between child maltreatment, alexithymia, and adolescent behavior problems. The findings of this study how different forms of child maltreatment significantly shape behavioral outcomes and indicate the importance of interventions in enhancing emotional awareness and expression in adolescents with a childhood history of maltreatment. [ABSTRACT FROM AUTHOR]

Background and aims: Changes in water availability during the growing season are becoming more frequent due to climate change. Our study aimed to compare the fine-root acclimation capacity (plasticity) of six temperate tree species aged six years and exposed to high or low growing season soil water availability over five years. Methods: Root samples were collected from the five upper strata of mineral soil to a total soil depth of 30 cm in monoculture plots of Acer saccharum Marsh., Betula papyrifera Marsh., Larix laricina K. Koch, Pinus strobus L., Picea glauca (Moench) Voss and Quercus rubra L. established at the International Diversity Experiment Network with Trees (IDENT) field experiment in Sault Ste. Marie, Ontario, Canada. Four replicates of each monoculture were subjected to high or low water availability treatments. Results: Absorptive fine root density increased by 67% for Larix laricina, and 90% for Picea glauca, under the high-water availability treatment at 0–5 cm soil depth. The two late successional, slower growing tree species, Acer saccharum and Picea glauca, showed higher plasticity in absorptive fine root biomass in the upper 5 cm of soil (PIv = 0.36 & 0.54 respectively), and lower plasticity in fine root depth over the entire 30 cm soil profile compared to the early successional, faster growing tree species Betula papyrifera and Larix laricina. Conclusion: Temperate tree species show contrasting acclimation responses in absorptive fine root biomass and rooting depth to differences in water availability. Some of these responses vary with tree species successional status and seem to benefit both early and late successional tree species. [ABSTRACT FROM AUTHOR]

Background: Oral lichen planus (OLP) and oral epithelial dysplasia (OED) present diagnostic challenges due to clinical and histologic overlap. This study explores the immune microenvironment in OED, hypothesizing that immune signatures could aid in diagnostic differentiation and predict malignant transformation. Methods: Tissue samples from OED and OLP cases were analyzed using immunofluorescence/immunohistochemistry (IF/IHC) for CD4, CD8, CD163/STAT1, and PD-1/PDL-1 expression. RNA-sequencing was performed on the samples, and data was subjected to CIBERSORTx analysis for immune cell composition. Gene Ontology analysis on the immune differentially expressed genes was also conducted. Results: In OED, CD8 + T-cells infiltrated dysplastic epithelium, correlating with dysplasia severity. CD4 + lymphocytes increased in the basal layer. STAT1/CD163 + macrophages correlated with CD4 + intraepithelial distribution. PD-1/PDL-1 expression varied. IF/IHC analysis revealed differential immune cell composition between OED and OLP. RNA-sequencing identified upregulated genes associated with cytotoxic response and immunosurveillance in OED. Downregulated genes were linked to signaling, immune cell recruitment, and tumor suppression. Conclusions: The immune microenvironment distinguishes OED and OLP, suggesting diagnostic potential. Upregulated genes indicate cytotoxic immune response in OED. Downregulation of TRADD, CX3CL1, and ILI24 implies dysregulation in TNFR1 signaling, immune recruitment, and tumor suppression. This study contributes to the foundation for understanding immune interactions in OED and OLP, offering insights into future objective diagnostic avenues. [ABSTRACT FROM AUTHOR]

Through sexual exploration, adolescents learn that they are sexual beings with choices, desires, and are deserving of pleasure, which corresponds to sexual subjectivity. However, the two measures of this construct (i.e., Female Sexual Subjectivity Inventory and Male Sexual Subjectivity Inventory) have not been validated with younger adolescents and have different items for boys and girls (with no scale available for gender diverse individuals), limiting gender comparisons. This study examined (1) the factor structure of the adapted Short Sexual Subjectivity Inventory—11 items (SSSI-11) in a large sample of young cisgender, heterosexual and sexual and gender minority adolescents, (2) measurement invariance across language (English and French), gender, and sexual orientation, (3) validity with sexuality-related outcomes, and (4) one-year temporal stability. Results of a confirmatory factor analysis among 2001 adolescents (Mage = 15.5 years, SD = 0.60) revealed a multidimensional factor structure. The SSSI-11, in both English and French, showed adequate reliability and one-year temporal stability, and was invariant across genders, sexual orientations, and languages. Girls had lower scores on the entitlement to self-pleasure and self-efficacy in achieving pleasure factors, and higher scores on the entitlement to pleasure from a partner factor. No significant differences were observed on the basis of language or between heterosexual and sexual minority adolescents. The SSSI-11 correlated positively with sexuality-related variables. Findings support the strong psychometric properties of the SSSI-11, rendering it of considerable use in clinical, education, and research applications. [ABSTRACT FROM AUTHOR]

Most studies interested in understanding the role of parents in children's school adjustment have focused on mothers. Given the importance of father-child play during the preschool period, this study explores the possible links of father-child rough-and-tumble play and also father's involvement in child schooling with two dimensions of school adjustment: social adaptation and academic achievement. Observational data was collected from father-child rough-and-tumble play sessions filmed in family homes when children were average age of 4 years. Fathers completed the Family Involvement Questionnaire on parent involvement in child schooling, and teachers completed the Social Behaviour Questionnaire and the Teacher Report form to assess social adaptation, and the Teacher Rating Scale to assess academic achievement when children (40 boys; 32 girls) were average age of 8 years. Boys demonstrated more externalising behaviours at school when during rough-and-tumble play fathers let them direct the play. Boys were more prosocial at school when their fathers were more involved in school-based activities, while girls demonstrated more internalising behaviours at school when their fathers were less involved in home-based learning activities. Moreover, boys performed less well academically when fathers demonstrated more negative reactions than boys, the dyad demonstrated more upset terminations, and boys demonstrated more fear and less anger during rough-and-tumble play. Girls performed less well academically when during rough-and-tumble play fathers made more rules and fewer positive reactions towards them. Neither boys' nor girls' academic achievement was related to any type of fathers' school involvement. The study fills a gap in understanding the ways in which father involvement influences children's school adjustment according to the children's sex. [ABSTRACT FROM AUTHOR]

Average-case analysis computes the complexity of an algorithm averaged over all possible inputs. Compared to worst-case analysis, it is more representative of the typical behavior of an algorithm, but remains largely unexplored in optimization. One difficulty is that the analysis can depend on the probability distribution of the inputs to the model. However, we show that this is not the case for a class of large-scale problems trained with first-order methods including random least squares and one-hidden layer neural networks with random weights. In fact, the halting time exhibits a universality property: it is independent of the probability distribution. With this barrier for average-case analysis removed, we provide the first explicit average-case convergence rates showing a tighter complexity not captured by traditional worst-case analysis. Finally, numerical simulations suggest this universality property holds for a more general class of algorithms and problems. [ABSTRACT FROM AUTHOR]

We develop a stochastic differential equation, called homogenized SGD, for analyzing the dynamics of stochastic gradient descent (SGD) on a high-dimensional random least squares problem with ℓ2\documentclass[12pt]{minimal}\usepackage{amsmath}\usepackage{wasysym}\usepackage{amsfonts}\usepackage{amssymb}\usepackage{amsbsy}\usepackage{mathrsfs}\usepackage{upgreek}\setlength{\oddsidemargin}{-69pt}\begin{document}$$\ell ^2$$\end{document}-regularization. We show that homogenized SGD is the high-dimensional equivalence of SGD—for any quadratic statistic (e.g., population risk with quadratic loss), the statistic under the iterates of SGD converges to the statistic under homogenized SGD when the number of samples n and number of features d are polynomially related (dc≤n≤d1/c\documentclass[12pt]{minimal}\usepackage{amsmath}\usepackage{wasysym}\usepackage{amsfonts}\usepackage{amssymb}\usepackage{amsbsy}\usepackage{mathrsfs}\usepackage{upgreek}\setlength{\oddsidemargin}{-69pt}\begin{document}$$d^c \le n \le d^{1/c}$$\end{document} for some c>0\documentclass[12pt]{minimal}\usepackage{amsmath}\usepackage{wasysym}\usepackage{amsfonts}\usepackage{amssymb}\usepackage{amsbsy}\usepackage{mathrsfs}\usepackage{upgreek}\setlength{\oddsidemargin}{-69pt}\begin{document}$$c > 0$$\end{document}). By analyzing homogenized SGD, we provide exact non-asymptotic high-dimensional expressions for the generalization performance of SGD in terms of a solution of a Volterra integral equation. Further we provide the exact value of the limiting excess risk in the case of quadratic losses when trained by SGD. The analysis is formulated for data matrices and target vectors that satisfy a family of resolvent conditions, which can roughly be viewed as a weak (non-quantitative) form of delocalization of sample-side singular vectors of the data. Several motivating applications are provided including sample covariance matrices with independent samples and random features with non-generative model targets. [ABSTRACT FROM AUTHOR]

Online technologies could play an important role in the sexual development of adolescents as they watch more pornography than before. Pornography may relate to adolescents' perceptions of their bodies, especially among those identifying as a sexual and/or gender minority (SGM) as they have an increased risk of body image concerns compared to their heterosexual, cisgender (HC) peers. The present study examined the cross-sectional and longitudinal associations over 3 years between adolescents' pornography use frequency and body appreciation, considering potential gender and sexual orientation-based differences. Results from linear univariate and parallel processes latent growth curve models with a multi-group approach among 2904 adolescents (MageT1 = 14.5 years, SD = 0.61; 51.4% girls, 16.3% sexual minority) demonstrated that HC and SGM girls' body appreciation slightly decreased over time. Moreover, HC boys, HC girls and SGM girls' pornography use frequency slightly increased over time. Cross-sectionally, greater pornography use frequency was associated with lower levels of body appreciation in HC girls and SGM boys, with a small effect size. However, longitudinally, pornography use frequency and body appreciation were not related to each other in either group. Our findings support that pornography use, in the short term, is negatively associated with adolescents' body appreciation, although these associations might not hold in the long term. Adolescents may be more critical of body ideals represented in pornography as they learn to think with more discernment about the pornographic depictions of bodies and sexuality. [ABSTRACT FROM AUTHOR]

We elaborate on various aspects of our top-down celestial holographic duality wherein the semiclassical bulk spacetime is a 4d asymptotically flat, self-dual Kähler geometry known as Burns space. The bulk theory includes an open string sector comprising a 4d WZW model and a closed string sector called "Mabuchi gravity" capturing fluctuations of the Kähler potential. Starting with the type I topological B-model on the twistor space of flat space, we obtain the twistor space of Burns space from the backreaction of a stack of N coincident D1 branes, while the chiral algebra is obtained from (a twist of) the brane worldvolume theory. One striking consequence of this duality is that all loop-level scattering amplitudes of the theory on Burns space can be expressed as correlation functions of an explicit 2d chiral algebra. We also present additional large-N checks, matching several 2 and 3-point amplitudes and their collinear expansions in the WZW4 sector, and the mixed WZW4-Mabuchi sector, of the bulk theory to the corresponding 2 and 3-point vacuum correlators and operator product expansions in the dual chiral algebra. Key features of the duality, along with our main results, are summarized in the introduction. [ABSTRACT FROM AUTHOR]

Purpose: A significant number of people will experience prolonged symptoms after COVID-19 infection that will greatly impact functional capacity and quality of life. The aim of this study was to identify trajectories of health-related quality of life (HRQOL) and their predictors among adults diagnosed with COVID-19. Methods: This is a retrospective analysis of an ongoing prospective cohort study (BQC-19) including adults (≥18y) recruited from April 2020 to March 2022. Our primary outcome is HRQOL using the EQ-5D-5L scale. Sociodemographic, acute disease severity, vaccination status, fatigue, and functional status at onset of the disease were considered as potential predictors. The latent class mixed model was used to identify the trajectories over an 18-month period in the cohort as a whole, as well as in the inpatient and outpatient subgroups. Multivariable and univariable regressions models were undertaken to detect predictors of decline. Results: 2163 participants were included. Thirteen percent of the outpatient subgroup (2 classes) and 28% in the inpatient subgroup (3 classes) experienced a more significant decline in HRQOL over time than the rest of the participants. Among all patients, age, sex, disease severity and fatigue, measured on the first assessment visit or on the first day after hospital admission (multivariable models), were identified as the most important predictors of HRQOL decline. Each unit increase in the SARC-F and CFS scores increase the likelihood of belonging to the declining trajectory (univariable models). Conclusion: Although to different degrees, similar factors explain the decline in HRQOL over time among the overall population, people who have been hospitalized or not. Clinical functional capacity scales could help to determine the risk of HRQOL decline. [ABSTRACT FROM AUTHOR]

We initiate the study of how the insertion of magnetically charged states in 4d self-dual gauge theories impacts the 2d chiral algebras supported on the celestial sphere at asymptotic null infinity, from the point of view of the 4d/2d twistorial correspondence introduced by Costello and the second author. By reducing the 6d twistorial theory to a 3d holomorphic-topological theory with suitable boundary conditions, we can motivate certain non-perturbative enhancements of the celestial chiral algebra corresponding to extensions by modules arising from 3d boundary monopole operators. We also identify the insertion of 4d (non-abelian) monopoles with families of spectral flow automorphisms of the celestial chiral algebra. [ABSTRACT FROM AUTHOR]

The feelings of difficulty and familiarity (FOD and FOF) are two types of metacognitive experiences. Both may influence student engagement and the application of metacognitive strategies, but these relationships are not well understood, in part because many studies have relied on self-report measures of behaviors that may not accurately reflect students' actual behaviors. In this study, FOD and FOF were related to objective measures of off-task behaviors and metacognitive strategies. These measures were extracted from 88 sixth graders' action logs within a computer-based learning environment known as Betty's Brain. Pre- and post-tests were administered to assess learning. Results reveal that high-FOD students showed more off-task behaviors and fewer strategic behaviors than low-FOD students, particularly when this difference was measured in terms of the frequency (as opposed to proportion) of strategic behaviors. FOF was not associated with off-task behaviors and metacognitive strategies but emerged as a moderator in the relationship between FOD and learning gains. Low-FOD students learned more than high-FOD students in the low-FOF group, but such a difference was not found in the high-FOF group. [ABSTRACT FROM AUTHOR]

The Dassa region is part of the Pan-African Trans-Saharan Belt, located between the West African craton and the Sahara metacraton. This region, with widespread granitoids and volcanites, is cut by the Kandi Shear Zone (KSZ) that could be connected to the 4°50' shear zone northwards in the Hoggar mountains and to the "Transbrasiliano lineamento" Northeast Brazil. The LA-ICP-MS U–Pb isotopes of zircon, whole-rock geochemistry and Sr–Nd isotope were analysed to constrain the emplacement ages and chronology of granitoids and volcanic rocks in the Dassa region in relation to the KSZ dynamics and the geochemical signatures and genesis of the magmas. Five intrusions (Dassa, Tré, Gobada, Tchetti and Fita) with the igneous rocks of the volcano-sedimentary basin of Idaho-Mahou have been investigated. Radiometric ages (U–Pb) obtained on zircons from the intrusions and the alkaline rhyolites from the Idaho-Mahou volcano-sedimentary basin indicate the Ediacaran timing emplacement in the Pan-African Dahomeyide orogen. The Dassa intrusion is dated at 633 ± 19 Ma while the Tchetti, Gobada and Tré intrusions yield 607 ± 11 Ma, 603 ± 10 Ma and 595 ± 12 Ma, respectively. The alkaline Fita granite and rhyolite of the Idaho-Mahou volcano-sedimentary basin provide U–Pb on zircon ages of 594 ± 32 Ma and 583 ± 9 Ma, respectively. Geochemical investigations reveal that the granitoids are ferroan and metaluminous; alkali-calcic (Dassa and Tré) and alkali-calcic to alkalic (Gobada, Tchetti and Fita). The mafic to intermediate volcanites and trachyte of Idaho-Mahou volcano-sedimentary basin are alkali-calcic whereas the rhyolite displays an alkalic signature. Sm–Nd isotopic analyses reveal that the ε Nd values at c. 600 Ma in the Fita granite and alkalic rhyolite of Idaho-Mahou basin are the highest (− 6.94 and − 6.07). In the other intrusions, the ε Nd values at c. 600 Ma are lower, ranging between − 9.66 and − 9.28 (Tchetti and Godada granites) and − 8.84 and − 8.56 (Dassa and Tré granites). The Tré monzonite shows an intermediate value around − 7.70. The calculated TDM model ages are very close and range between 1.80 and 2.05 Ga. All this suggests hybridization processes between an Archean to Paleoproterozoic continental crust source and a juvenile mantle (600 Ma) source for the parent magmas. But the significantly high ε Nd values of Fita granite and the alkaline rhyolite are in agreement with higher mantle contribution and a distinct more enriched mantle source for the parent magmas of alkaline rocks compared to the alkali-calcic felsic ones for which the mantle contribution is from the depleted mantle. According to these data, the Ediacaran magmatic events in the Dassa region can be divided into two main episodes with respect to the main transcurrent shearing event that started at about c. 610 Ma: a pre-transcurrent shear alkali-calcic plutonic magmatism c. 635–610 Ma and the transcurrent shear magmatism c. 610–580 Ma with contemporaneous alkali-calcic and alkaline plutonic and volcanic magmatism. The integration of existing U–Pb on zircon dating in the Benin basement indicates that in the Dahomeyide orogen, the reactivation of the Kandi shear zone toward the end of Ediacaran timing at around c. 550–540 Ma allowed emplacement of the third suite of magmatism as intrusions and volcanoes. [ABSTRACT FROM AUTHOR]

Purpose Common mental disorders (CMDs) are a major cause of sick leave. Return-to-work (RTW) interventions providing mechanisms that support the participation and collaboration of the different stakeholders appear promising in these circumstances. The Therapeutic Return-to-Work (TRW) Program offers such mechanisms designed to enable affected workers to fully reintegrate into their jobs on a sustainable basis. This study evaluated the feasibility of implementing this program for workers with CMDs, within a specialized mental health hospital. Methods The study was conducted using a multiple case design and three main data sources: (1) the worker's medical file, (2) the log completed by the clinicians, and (3) individual interviews with stakeholders. Data were analyzed using a qualitative approach. Results Twelve workers between 32 and 60 years old, mostly women with complex mental health profiles working in large enterprises, participated in this study. Three main observations were made regarding the TRW Program implementation: (1) eight cases were characterized by complete or virtually complete implementation; (2) no explanatory factor could be identified for the different implementation levels; (3) eight cases achieved RTW success (RTW to the original job or another job), which appears partially attributable to the high level of program implementation. Conclusions: The TRW Program seems highly promising for supporting the return to work of workers with CMDs. However, studies identifying the factors likely to influence the implementation process in different health service contexts and specifying the scope and nature of the program's actual impact on RTW outcomes should be conducted before larger-scale implementation takes place. [ABSTRACT FROM AUTHOR]

Background: Radioresistance of HNSCCs remains a major challenge for effective tumor control. Combined radiotherapy (RT) and immunotherapy (IT) treatment improved survival for a subset of patients with inflamed tumors or tumors susceptible to RT-induced inflammation. To overcome radioresistance and improve treatment outcomes, an understanding of factors that suppress anti-tumor immunity is necessary. In this regard, regulatory T cells (Tregs) are critical mediators of immune suppression in HNSCCs. In this study, we investigated how radiation modulates Treg infiltration in tumors through the chemokine CCL20. We hypothesized that radiation induces CCL20 secretion resulting in Treg infiltration and suppression of anti-tumor immunity. Methods: Human and mouse HNSCC cell lines with different immune phenotypes were irradiated at doses of 2 or 10 Gy. Conditioned media, RNA and protein were collected for assessment of CCL20. qPCR was used to determine CCL20 gene expression. In vivo, MOC2 cells were implanted into the buccal cavity of mice and the effect of neutralizing CCL20 antibody was determined alone and in combination with RT. Blood samples were collected before and after RT for analysis of CCL20. Tumor samples were analyzed by flow cytometry to determine immune infiltrates, including CD8 T cells and Tregs. Mass-spectrometry was performed to analyze proteomic changes in the tumor microenvironment after anti-CCL20 treatment. Results: Cal27 and MOC2 HNSCCs had a gene signature associated with Treg infiltration, whereas SCC9 and MOC1 tumors displayed a gene signature associated with an inflamed TME. In vitro, tumor irradiation at 10 Gy significantly induced CCL20 in Cal27 and MOC2 cells relative to control. The increase in CCL20 was associated with increased Treg migration. Neutralization of CCL20 reversed radiation-induced migration of Treg cells in vitro and decreased intratumoral Tregs in vivo. Furthermore, inhibition of CCL20 resulted in a significant decrease in tumor growth compared to control in MOC2 tumors. This effect was further enhanced after combination with RT compared to either treatment alone. Conclusion: Our results suggest that radiation promotes CCL20 secretion by tumor cells which is responsible for the attraction of Tregs. Inhibition of the CCR6-CCL20 axis prevents infiltration of Tregs in tumors and suppresses tumor growth resulting in improved response to radiation. [ABSTRACT FROM AUTHOR]

In this paper, we establish necessary and sufficient conditions for the existence of line segments (or flats) in the sphere of the nuclear norm via the notion of simultaneous polarization and a refined expression for the subdifferential of the nuclear norm. This is then leveraged to provide (point-based) necessary and sufficient conditions for uniqueness of solutions for minimizing the nuclear norm over an affine subspace. We further establish an alternative set of sufficient conditions for uniqueness, based on the interplay of the subdifferential of the nuclear norm and the range of the problem-defining linear operator. Finally, we show how to transfer the uniqueness results for the original problem to a whole class of nuclear norm-regularized minimization problems with a strictly convex fidelity term. [ABSTRACT FROM AUTHOR]

It is widely recognized that debugging is challenging for novice programmers and, as such, computing educators and researchers have called for explicit debugging instruction. Debugging requires various knowledge and skills, and different students may show different strengths and weaknesses. An understanding of such individual differences is important as it may guide personalized instruction. The current study investigated individual differences in debugging in an undergraduate introductory computer science course. We extracted variables related to debugging from students' submission traces to programming problems in the first month of the course. We applied latent profile analysis to these variables and identified three distinctive profiles. Profile A showed higher debugging accuracy and speed. Profile B showed lower debugging performance in runtime and logic errors, while profile C had lower performance in syntactic errors and tended to make large code edit every submission. Students' gender and self-rated programming ability predicted profile membership. Moreover, profile A got higher scores than the others in the first exam, and this difference persisted in the second and third exam, even controlling for background variables and score on the first exam. We investigated how students transitioned across debugging profiles over the duration of the course. From the beginning to the end of the course, a large part of students stayed in lower performance profiles. Overall, these findings support the call that debugging should be taught at an early stage and suggest that different groups may need different debugging instructions or support. [ABSTRACT FROM AUTHOR]

Background: Longer hospital length of stay (LOS) has been associated with worse outcomes and increased resource utilization. However, diagnostic and patient-level factors associated with LOS have not been well studied on a large scale. The goal was to identify patient, surgical and organizational factors associated with longer patient LOS for adult patients at a high-volume quaternary spinal care center. Methods: We performed a retrospective analysis of 13,493 admissions from January 2006 to December 2019. Factors analyzed included age, sex, admission status (emergent vs scheduled), ASIA grade, operative vs non-operative management, mean blood loss, operative time, and adverse events. Specific adverse events included surgical site infection (SSI), other infection (systemic or UTI), neuropathic pain, delirium, dural tear, pneumonia, and dysphagia. Diagnostic categories included trauma, oncology, deformity, degenerative, and "other". A multivariable linear regression model was fit to log-transformed LOS to determine independent factors associated with patient LOS, with effects expressed as multipliers on mean LOS. Results: Mean LOS for the population (SD) was 15.8 (34.0) days. Factors significantly (p < 0.05) associated with longer LOS were advanced patient age [multiplier on mean LOS 1.011/year (95% CI: 1.007–1.015)], emergency admission [multiplier on mean LOS 1.615 (95% CI: 1.337–1.951)], ASIA grade [multiplier on mean LOS 1.125/grade (95% CI: 1.051–1.205)], operative management [multiplier on mean LOS 1.211 (95% CI: 1.006–1.459)], and the occurrence of one or more AEs [multiplier on mean LOS 2.613 (95% CI: 2.188–3.121)]. Significant AEs included postoperative SSI [multiplier on mean LOS 1.749 (95% CI: 1.250–2.449)], other infections (systemic infections and UTI combined) [multiplier on mean LOS 1.650 (95% CI: 1.359–2.004)], delirium [multiplier on mean LOS 1.404 (95% CI: 1.103–1.787)], and pneumonia [multiplier on mean LOS 1.883 (95% CI: 1.447–2.451)]. Among the diagnostic categories explored, degenerative patients experienced significantly shorter LOS [multiplier on mean LOS 0.672 (95%CI: 0.535–0.844), p < 0.001] compared to non-degenerative categories. Conclusion: This large-scale study taking into account diagnostic categories identified several factors associated with patient LOS. Future interventions should target modifiable factors to minimize LOS and guide hospital resource allocation thereby improving patient outcomes and quality of care and decreasing healthcare-associated costs. [ABSTRACT FROM AUTHOR]

Phthalates are ubiquitous plasticizer chemicals found in consumer products. Exposure to phthalates during pregnancy has been associated with adverse pregnancy and birth outcomes and differences in placental gene expression in human studies. The objective of this research was to evaluate global changes in placental gene expression via RNA sequencing in two placental cell models following exposure to the phthalate metabolite mono(2-ethylhexyl) phthalate (MEHP). HTR-8/SVneo and primary syncytiotrophoblast cells were exposed to three concentrations (1, 90, 180 µM) of MEHP for 24 h with DMSO (0.1%) as a vehicle control. mRNA and lncRNAs were quantified using paired-end RNA sequencing, followed by identification of differentially expressed genes (DEGs), significant KEGG pathways, and enriched transcription factors (TFs). MEHP caused gene expression changes across all concentrations for HTR-8/SVneo and primary syncytiotrophoblast cells. Sex-stratified analysis of primary cells identified different patterns of sensitivity in response to MEHP dose by sex, with male placentas being more responsive to MEHP exposure. Pathway analysis identified 11 KEGG pathways significantly associated with at least one concentration in both cell types. Four ligand-inducible nuclear hormone TFs (PPARG, PPARD, ESR1, AR) were enriched in at least three treatment groups. Overall, we demonstrated that MEHP differentially affects placental gene expression based on concentration, fetal sex, and trophoblast cell type. This study confirms prior studies, as enrichment of nuclear hormone receptor TFs were concordant with previously published mechanisms of phthalate disruption, and generates new hypotheses, as we identified many pathways and genes not previously linked to phthalate exposure. [ABSTRACT FROM AUTHOR]

Adopting a family system perspective, this study sets out to explore the association between family configurations of mother-child and father-child attachment to better understand children’s externalizing and internalizing behaviors in toddlerhood. A total of 182 heterosexual biparental families and their children (90 boys) were recruited from the general population. Most of the fathers and mothers were Canadian-born and the personal income and education level of the parents were high in comparison to the population of the province of Quebec at large. Attachment was assessed by direct observation using the Strange Situation Procedure (SSP) in infants aged 12–18 months. Children’s internalizing and externalizing behaviors were assessed in toddlers aged 24–30 months using questionnaires completed by both parents. Results showed that infants with resistant attachment to one parent and secure attachment to the other parent have more externalizing behaviors than children with a secure attachment to both parents. Moreover, children with a disorganized attachment to both parents showed more internalizing and externalizing problems than children with a disorganized attachment with one parent and secure with the other parent. These results highlight the need of adopting a systemic family perspective to better understand the link between attachment and children’s behavior problems. [ABSTRACT FROM AUTHOR]

Throughout Mary Shelley's early life, she was exposed to numerous well-known and influential people regarding cultural, political, and socio-economic matters. As she began writing, these influences undoubtedly played a role in her narrative. Her novel, Frankenstein, written during the time of the first Industrial Revolution in Britain, was one such novel that exhibited her political and economic influences through science fiction. This article addresses many of those influences, including the introduction of the machine into manufacturing. It further addresses how Frankenstein's Monster may have been one of the first created forms of artificial intelligence (AI). We further expound upon many economic concepts that have persisted through time and are relevant today given the faciliatory aspects, as well as the uncertainty, of AI. We relate these through the literary piece Frankenstein to explore how a two-century-year-old tale provides a blueprint for understanding the conflict among humans and machines and provides a roadmap for harmonization in the past, present, and future. [ABSTRACT FROM AUTHOR]

Background: Early ileostomy closure (EIC), ≤ 2 weeks from creation, is a relatively new practice. Multiple studies have demonstrated that this approach is safe, feasible, and cost-effective. Despite the demonstrated benefits, this is neither routine practice, nor has it been studied, in North America. This study aimed to assess patient and surgeon perspectives about EIC. Methods: A mixed-methods, cross-sectional study of patients and surgeons was performed. Rectal cancer survivors from a single institution who underwent restorative proctectomy with diverting loop ileostomy and subsequent closure within the last 5 years were contacted. North American surgeons with high rectal cancer volumes (> 20 cases/year) were included. Surveys (patients) and semi-structured interviews (surgeons) were conducted. Analysis employed descriptive statistics and thematic analysis, respectively. Results: Forty-eight patients were surveyed (mean age 65.1 ± 11.8 years; 54.2% male). Stoma closure occurred after a median of 7.7 months (IQR 4.8–10.9) and 50.0% (24) found it "difficult" or "very difficult" to live with their stoma. Patients considered improvement in quality of life and quicker return to normal function the most important advantages of EIC, whereas the idea of two operations in two weeks being too taxing on the body was deemed the biggest disadvantage. Most patients (35, 72.9%) would have opted for EIC. Surgeon interviews (15) revealed 4 overarching themes: (1) there are many benefits to EIC; (2) specific patient characteristics would make EIC an appropriate option; (3) many barriers to implementing EIC exist; and (4) many logistical hurdles need to be addressed for successful implementation. Most surgeons (12, 80.0%) would "definitely want to participate" in a North American randomized-controlled trial (RCT) on EIC for rectal cancer patients. Conclusions: Implementing EIC poses many logistical challenges. Both patients and surgeons are interested in further exploring EIC and believe it warrants a North American RCT to motivate a change in practice. [ABSTRACT FROM AUTHOR]

The American Society of Colon and Rectal Surgeons (ASCRS) and the Society of American Gastrointestinal and Endoscopic Surgeons (SAGES) are dedicated to ensuring high-quality innovative patient care for surgical patients by advancing the science, prevention, and management of disorders and diseases of the colon, rectum, and anus as well as minimally invasive surgery. The ASCRS and SAGES society members involved in the creation of these guidelines were chosen because they have demonstrated expertise in the specialty of colon and rectal surgery and enhanced recovery. This consensus document was created to lead international efforts in defining quality care for conditions related to the colon, rectum, and anus and develop clinical practice guidelines based on the best available evidence. While not proscriptive, these guidelines provide information on which decisions can be made and do not dictate a specific form of treatment. These guidelines are intended for the use of all practitioners, healthcare workers, and patients who desire information about the management of the conditions addressed by the topics covered in these guidelines. These guidelines should not be deemed inclusive of all proper methods of care nor exclusive of methods of care reasonably directed toward obtaining the same results. The ultimate judgment regarding the propriety of any specific procedure must be made by the physician in light of all the circumstances presented by the individual patient. This clinical practice guideline represents a collaborative effort between the American Society of Colon and Rectal Surgeons (ASCRS) and the Society of American Gastrointestinal and Endoscopic Surgeons (SAGES) and was approved by both societies. [ABSTRACT FROM AUTHOR]

Purpose This article provides a state-of-the-art review of issues and factors associated with the sustainable return to work (S-RTW) of ethnocultural minority workers experiencing disability situations attributable to one of four major causes: musculoskeletal disorders, common mental disorders, other chronic diseases or cancer. Methods Using an interpretive description method, an integrative review was conducted of the literature on ethnocultural factors influencing S-RTW issues and factors associated with these four major work-disability causes. An initial review of the 2006–2016 literature was subsequently updated for November 2016–May 2021. To explore and contextualize the results, four focus groups were held with RTW stakeholders representing workplaces, insurers, the healthcare system and workers. Qualitative thematic analysis was performed. Results A total of 56 articles were analyzed and 35 stakeholders participated in four focus groups. Two main findings emerged. First, belonging to an ethnocultural minority group appears associated with cumulative risk factors that may contribute to vulnerability situations and compound the complexity of S-RTW. Second, cultural differences with respect to the prevailing host-country culture may generate communication and trust issues, and conflicts in values and representations, in turn possibly hindering the establishment of positive relationships among all stakeholders and the ability to meet workers' needs. Being a woman in these groups and/or having a lower level of integration into the host country's culture also appear associated with greater S-RTW challenges. Conclusions Based on our findings, we recommend several possible strategies, such as the cultural humility model, for preventing differences from exacerbating the already significant vulnerability situation of some ethnocultural minority workers. [ABSTRACT FROM AUTHOR]

The Variscan basement of the Aiguilles-Rouges massif (Western Alps) exposes the Servoz syncline which consists of a metavolcano-sedimentary sequence composed of (i) a volcanic unit of unknown age and origin, (ii) Early Carboniferous sedimentary series affected by the Variscan orogeny and intruded by the Montées-Pélissier pluton, and (iii) a Late Carboniferous late-orogenic sedimentary sequence. We combined field investigations, Raman Spectroscopy on Carbonaceous Material geothermometry, and LA-ICPMS U-Th-Pb geochronology on zircon in order to reappraise the sedimentary sequence of the Servoz syncline. Our results allow us to identify three distinct sedimentary formations (F1, F2 and F3). The F1 formation is composed of metagreywackes, bimodal volcanic and magmatic rocks formed during basin opening at an early rifting stage (370–350 Ma) within a back-arc geodynamic setting. This extensional regime was responsible for a high thermal event recorded by a ca. 115 °C/km apparent geothermal gradient. Local anatexis of the basement rocks under the basin is dated at 351 ± 5 Ma. Basin inversion occurred between 350 and 330 Ma in response to oblique collision, with the development of large-scale dextral shear zones and syn-kinematic 340–330 Ma granite intrusions. Subsequent dextral transtension was responsible for the opening of a pull-apart basin between ca. 330 and 310 Ma with the deposition of the F2 phyllite formation that was later deformed by the ongoing dextral transcurrent Variscan tectonics at temperatures between 200 and 350 °C. Finally, the F3 terrigenous sedimentary rocks deposited at ca. 310–290 Ma in a late-orogenic extensional basin. The Alpine-related tectonic event overprinted all the temperatures below 350 °C. Although similar basins have been recognized in other External Crystalline Massifs of the Alps, the Servoz syncline is the first example that allows a major part of the polyphase tectonic evolution, since the early stages of the Devonian, to be recognized. Comparison with similar back-arc basins from the French Central massif, the Vosges massif and the Bohemian massif suggests that the External Crystalline Massifs initially belonged to the Moldanubian hinterlands of the Variscan belt. [ABSTRACT FROM AUTHOR]

During Earth's history, geosphere-biosphere interactions were often determined by momentary, catastrophic changes such as large explosive volcanic eruptions. The Miocene ignimbrite flare-up in the Pannonian Basin, which is located along a complex convergent plate boundary between Europe and Africa, provides a superb example of this interaction. In North Hungary, the famous Ipolytarnóc Fossil Site, often referred to as "ancient Pompeii", records a snapshot of rich Early Miocene life buried under thick ignimbrite cover. Here, we use a multi-technique approach to constrain the successive phases of a catastrophic silicic eruption (VEI ≥ 7) dated at 17.2 Ma. An event-scale reconstruction shows that the initial PDC phase was phreatomagmatic, affecting ≥ 1500 km2 and causing the destruction of an interfingering terrestrial–intertidal environment at Ipolytarnóc. This was followed by pumice fall, and finally the emplacement of up to 40 m-thick ignimbrite that completely buried the site. However, unlike the seemingly similar AD 79 Vesuvius eruption that buried Pompeii by hot pyroclastic density currents, the presence of fallen but uncharred tree trunks, branches, and intact leaves in the basal pyroclastic deposits at Ipolytarnóc as well as rock paleomagnetic properties indicate a low-temperature pyroclastic event, that superbly preserved the coastal habitat, including unique fossil tracks. [ABSTRACT FROM AUTHOR]

We propose a new program for computing a certain integrand of scattering amplitudes of four-dimensional gauge theories which we call the form factor integrand, starting from 6d holomorphic theories on twistor space. We show that the form factor integrands can be expressed as sums of products of 1.) correlators of a 2d chiral algebra, related to the algebra of asymptotic symmetries uncovered recently in the celestial holography program, and 2.) OPE coefficients of a 4d non-unitary CFT. We prove that conformal blocks of the chiral algebras are in one-to-one correspondence with local operators in 4d. We use this bijection to recover the Parke-Taylor formula, the CSW formula, and certain one-loop scattering amplitudes. Along the way, we explain and derive various aspects of celestial holography, incorporating techniques from the twisted holography program such as Koszul duality. This perspective allows us to easily and efficiently recover the infinite-dimensional chiral algebras of asymptotic symmetries recently extracted from scattering amplitudes of massless gluons and gravitons in the celestial basis. We also compute some simple one-loop corrections to the chiral algebras and derive the three-dimensional bulk theories for which these 2d algebras furnish an algebra of boundary local operators. [ABSTRACT FROM AUTHOR]

We discuss a set of heterotic and type II string theory compactifications to 1 + 1 dimensions that are characterized by factorized internal worldsheet CFTs of the form V 1 ⊗ V ¯ 2 , where V 1 , V 2 are self-dual (super) vertex operator algebras. In the cases with spacetime supersymmetry, we show that the BPS states form a module for a Borcherds–Kac–Moody (BKM) (super)algebra, and we prove that for each model the BKM (super)algebra is a symmetry of genus zero BPS string amplitudes. We compute the supersymmetric indices of these models using both Hamiltonian and path integral formalisms. The path integrals are manifestly automorphic forms closely related to the Borcherds–Weyl–Kac denominator. Along the way, we comment on various subtleties inherent to these low-dimensional string compactifications. [ABSTRACT FROM AUTHOR]

In this contribution, we investigate the spatial and temporal evolution of mid-crustal flow in the Agly Massif (North Pyrenean Zone) that represents the southern foreland of the Variscan orogenic plateau. In the Agly Massif, the middle crust is represented by an Ediacarian–Devonian series of metasedimentary rocks that recorded high-grade metamorphism synchronously with crustal thinning (D2) and dextral wrenching (D3) during Carboniferous. D2 crustal thinning formed a penetrative S2 flat-lying foliation and localized C2 extensional shear zones with a top-to-the-North kinematics. D2 planar fabrics are deformed by a D3 dextral transpression localized into a two-kilometer wide high-strain zone. We performed LA-ICPMS U–Th–Pb dating on zircon and monazite from small magmatic bodies and from metamorphic rocks showing strain features relative to D2 and/or D3. Our results, compiled with published data, argue that the middle crust of the Agly Massif reached high-temperature and suprasolidus conditions at ca. 325–320 Ma and was partially molten until ca. 300 Ma. They also indicate that the D2 thinning and top-to-the north shearing was active from ca. 325–290 Ma. D2 extension and D3 transpression were synchronous from ca. 308–290 Ma. Making a comparison with the Pyrenean Axial Zone, the Montagne Noire and the French Central Massif, we propose a two-step tectonic model for the mid-crustal flow with a horizontal flow towards South in both the orogenic plateau and the southern forelands between ca. 325 and 310 Ma and locally reoriented into an E–W longitudinal flow between 310 and 300 Ma in high-strain dextral strike-slip shearing domains. [ABSTRACT FROM AUTHOR]

Purpose: Work disability stakeholders may not share the same understanding and solutions among themselves or with researchers, causing misunderstandings and hindering collaboration regarding solutions for preventing work disability. To reduce such differences, this study sought to build a common vocabulary among stakeholders and researchers, using a transdisciplinary research framework. Methods: A consensus method based on a constructivist approach was used. A theoretical sampling method was applied to identify researchers or stakeholders representing one of the four systems in the work disability paradigm. A preliminary set of definitions for key terms was assessed using a Web-based questionnaire. It documented participants' level of agreement with each term's inclusion and relevance in the field, and the clarity of the definition, while soliciting suggestions for other terms or clearer definitions. Disagreements were discussed at group meetings, yielding consensus on the final terms and definitions. Results: Eleven stakeholders representing patients, employers, unions, healthcare professionals, and legislative and insurance systems, along with 10 multidisciplinary researchers, participated. The questionnaire yielded initial consensus on the inclusion and definitions of 49 terms, and 109 suggestions mostly for modified definitions (average = 6 suggestions/term). Two preliminary terms were excluded and three terms were added. Ultimately, 80 terms and their definitions yielded consensus. Conclusions: The process we used to build a common vocabulary was carried out within a transdisciplinary framework. It required a constructivist approach, promoting idea exchanges among participants and co-construction of generally agreed results. The results were rooted in local contexts, thus ensuring the same reference points, regardless of participants' different understandings. [ABSTRACT FROM AUTHOR]

Background: As one of the 12 clinical pathways of the Society of American Gastrointestinal and Endoscopic Surgeons (SAGES) Masters Program, the Colorectal Pathway intends to deliver didactic content organized along 3 levels of performance (competency, proficiency and mastery) each represented by an anchoring procedure (laparoscopic right colectomy, laparoscopic left/sigmoid colectomy, and intracorporeal anastomosis during minimally invasive (MIS) ileocecal or right colon resection). In this article, the SAGES Colorectal Task Force presents focused summaries of the top 10 seminal articles selected for laparoscopic right colectomy which surgeons should be familiar with. Methods: Using a systematic literature search of Web of Science, the most cited articles on laparoscopic right colectomy were identified, reviewed, and ranked by the SAGES Colorectal Task Force and invited subject experts. Additional articles not identified in the literature search were included if deemed impactful by expert consensus. The top 10 ranked articles were then summarized, with emphasis on relevance and impact in the field, findings, strengths and limitations, and conclusions. Results: The top 10 seminal articles selected for the laparoscopic right colectomy anchoring procedure include articles on surgical techniques for benign and malignant disease, with anatomical and video illustrations, comparative outcomes of laparoscopic vs open colectomy, variations in technique with impact on clinical outcomes, and assessment of the learning curve. Conclusions: The top 10 seminal articles selected for laparoscopic right colectomy illustrate the diversity both in content and format of the educational curriculum of the SAGES Masters Program to support practicing surgeon progression to mastery within the Colorectal Pathway. [ABSTRACT FROM AUTHOR]

Introduction: Ovarian cancer (OC) is the most lethal gynecological cancer. Cytoreductive surgery (CRS) combined with hyperthermic intraperitoneal chemotherapy appears to increase survival, and normothermic intraperitoneal chemotherapy (IPC) could improve overall survival (OS). Furthermore, intraperitoneal epinephrine could decrease the toxicity of chemotherapy by decreasing the systemic absorption of chemotherapy. The goal of this study was to assess the effects of CRS and IPC with intraperitoneal epinephrine, as first-line therapy, on the survival of patients with serous epithelial OC (EOC) with peritoneal metastases. Methods: A prospective monocentric database was retrospectively searched for all patients with advanced serous EOC treated by interval or consolidative CRS plus IPC with intraperitoneal epinephrine after neoadjuvant chemotherapy. OS and disease-free survival (DFS), postoperative complications, and prognostic factors were analyzed. Results: From January 2003 to December 2017, 124 patients with serous EOC were treated with interval (n = 58) or consolidative (n = 66) complete CRS plus IPC with intraperitoneal epinephrine. The median follow-up was 77.8 months, the median OS was 60.8 months, and the median DFS was 21.2 months. In our multivariate analysis, a higher Peritoneal Cancer Index (PCI) and positive lymph node status resulted in worse OS, while higher World Health Organization score, higher PCI score, and positive lymph node status were risk factors for worse DFS. Grade 3 or higher surgical morbidity occurred in 27.42% of cases; only 3.2% had grade 3 renal toxicity and mortality was 0.8%. Conclusion: CRS and IPC with intraperitoneal epinephrine in stage III EOC offer good OS and DFS with acceptable morbidity and mortality rates. [ABSTRACT FROM AUTHOR]