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Ca2+ influx evoked across the plasma membrane upon internal store depletion is essential for a myriad of cellular functions including gene expression, cell proliferation, differentiation and even apoptosis. Darier’s disease (DD), an autosomal dominant inherited disorder of the skin, arising due to mutations in the isoform 2 of the sarco (endo) plasmic reticulum Ca2+ ATPase (SERCA2), exemplifies an anomaly of Ca2+ signaling disturbances. Owing to loss of function mutations in SERCA2, keratinocytes in DD patients have a reduced pool of endoplasmic reticulum (ER) Ca2+. Importantly, the status of ER Ca2+ is critical for the activation of a class of plasma membrane Ca2+ channels referred to as store operated Ca2+ channels (SOCs). The widely expressed transient receptor potential (TRP) family of channels is proposed to be SOCs. In this review we discuss DD from the viewpoint of Ca2+ signaling and present a potential role for TRPC1 in the disease pathogenesis. [ABSTRACT FROM AUTHOR]

Laser light sheet visualisation, coupled with image processing, was utilised to understand the effect of exit geometry on the integral properties of jets in cross flow. The study involved jets emanating from circular and rectangular nozzles of different aspect ratios deflected by a uniform free-stream. The investigation considers incompressible momentum jets with exit Reynolds number in the range of 4400–9200, the velocity ratios being 3.9, 5.9 and 7.8. In contrast to a deflected circular jet, those jets emanating from blunt configurations tend to have higher growth rates initially and are devoid of the horse-shoe or the bound vortex system in their cross section. [ABSTRACT FROM AUTHOR]

Daunomycin and adriamycin, are more mutagenic and antibacterial for a strain of Salmonella typhimurium defective for the uvrB gene than for its uvr counterpart. Other intercalating agents, as some acridine dyes, affect equally the two bacterial strains. [ABSTRACT FROM AUTHOR]