1. Antibiotic susceptibility of Haemophilus influenzae strains isolated from various clinical sources in Hokkaido Prefecture, Japan.
- Author
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Shin-ichi Yokota, Kiyoshi Sato, Tasuku Hayashi, Keiko Matsuda, Osamu Kuwahara, Hirotsugu Akizawa, and Nobuhiro Fujii
- Subjects
ANTIBACTERIAL agents ,ANTIBIOTICS ,HAEMOPHILUS influenzae ,CHLORAMPHENICOL ,GENETIC polymorphisms ,GENETIC research - Abstract
Abstract Any increase in β-lactam-resistant Haemophilus influenzae is a serious problem in respiratory and otolaryngology medicine. In this study, we examined the antibiotic susceptibility and genotype of 457 clinical Haemophilus influenzae strains isolated in Hokkaido Prefecture, Japan. Strains with β-lactam-resistant mutations in gene encoding penicillin-binding protein 3 were more frequently found in lower respiratory tract specimens (sputa) than in upper respiratory tract specimens, such as rhinorrhea. The existence of the TEM-1 β-lactamase gene occurred more frequently in adult patients than in pediatric patients. The results suggest that β-lactam-resistant or nonsusceptible strains are more prevalent in adult patients with respiratory diseases. We observed only a very few strains which were nonsuscpetible to third-generation cephalosporins (CEPs) and carbapenems. However, 12%–13% of the strains were shown to be resistant to penicillins and second-generation CEPs, and approximately 4% of the strains were shown to be nonsusceptible to fourth-generation CEPs. In addition, we identified tetracycline-resistant (2.8%), chloramphenicol-resistant (0.6%), clarithromycin-resistant (2.6%), and fluoroquinolone-nonsusceptible (approximately 2%) H. influenzae strains. [ABSTRACT FROM AUTHOR]
- Published
- 2008