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Prior research has demonstrated the role of kind school climate in students' academic and social-emotional learning outcomes. However, there is sparse literature showing the link of school kindness to mental health functioning. This study examines the association of school kindness with well-being dimensions such as positive emotions and depressive symptoms among 1287 Filipino high school students. It also explored whether school kindness would have indirect effects on well-being via school belongingness. Structural equation modeling via maximum likelihood estimation approach showed that school kindness was linked to higher positive emotions and lower depressive symptoms after controlling for demographic covariates such as age and gender. Further, results of bias-corrected bootstrapping analyses demonstrated that school kindness had indirect effects on positive emotions and depressive symptoms via school belongingness. This research underscores the mental health benefits associated with fostering kindness in school contexts. [ABSTRACT FROM AUTHOR]

The Na+/Ca2+ exchanger 1 (NCX1) participates in the maintenance of neuronal Na+ and Ca2+ homeostasis, and it is highly expressed at synapse level of some brain areas involved in learning and memory processes, including the hippocampus, cortex, and amygdala. Furthermore, NCX1 increases Akt1 phosphorylation and enhances glutamate-mediated Ca2+ influx during depolarization in hippocampal and cortical neurons, two processes involved in learning and memory mechanisms. We investigated whether the modulation of NCX1 expression/activity might influence learning and memory processes. To this aim, we used a knock-in mouse overexpressing NCX1 in hippocampal, cortical, and amygdala neurons (ncx1.4over) and a newly synthesized selective NCX1 stimulating compound, named CN-PYB2. Both ncx1.4over and CN-PYB2-treated mice showed an amelioration in spatial learning performance in Barnes maze task, and in context-dependent memory consolidation after trace fear conditioning. On the other hand, these mice showed no improvement in novel object recognition task which is mainly dependent on non-spatial memory and displayed an increase in the active phosphorylated CaMKIIα levels in the hippocampus. Interestingly, both of these mice showed an increased level of context-dependent anxiety. Altogether, these results demonstrate that neuronal NCX1 participates in spatial-dependent hippocampal learning and memory processes. [ABSTRACT FROM AUTHOR]