They can be produced in different formats and the most widely applied ones include the scFv and Fab fragments as well as single domain antibodies (sdAbs) obtained from heavy-chain antibodies from camelids (VHH), also known as nanobodies, or from sharks, referred to as variable new antigen receptor (VNAR) single domain antibodies [[6]]. These single-stranded DNA (ssDNA) or RNA molecules possess a well-defined 3D structure that binds with high affinity to their "complementary" species. Traditionally, biological receptors such as antibodies, enzymes, nucleic acids, or receptor proteins have been successfully applied to this aim. Peptides selected from combinatorial or phage display libraires, or designed in silico, have also been used as alternatives to natural antibodies, especially for sensor development, although to a much lower extent than rAbs, aptamers, and MIPs [[13]]. [Extracted from the article]