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Abstract During the 2020 US presidential election, conspiracy theories about large-scale voter fraud were widely circulated on social media platforms. Given their scale, persistence, and impact, it is critically important to understand the mechanisms that caused these theories to spread. The aim of this preregistered study was to investigate whether retweet frequencies among proponents of voter fraud conspiracy theories on Twitter during the 2020 US election are consistent with frequency bias and/or content bias. To do this, we conducted generative inference using an agent-based model of cultural transmission on Twitter and the VoterFraud2020 dataset. The results show that the observed retweet distribution is consistent with a strong content bias causing users to preferentially retweet tweets with negative emotional valence. Frequency information appears to be largely irrelevant to future retweet count. Follower count strongly predicts retweet count in a simpler linear model but does not appear to drive the overall retweet distribution after temporal dynamics are accounted for. Future studies could apply our methodology in a comparative framework to assess whether content bias for emotional valence in conspiracy theory messages differs from other forms of information on social media.

Abstract Increasing levels of far-right extremist violence have generated public concern about the spread of radicalization in the United States. Previous research suggests that radicalized individuals are destabilized by various environmental (or endemic) factors, exposed to extremist ideology, and subsequently reinforced by members of their community. As such, the spread of radicalization may proceed through a social contagion process, in which extremist ideologies behave like complex contagions that require multiple exposures for adoption. In this study, I applied an epidemiological method called two-component spatio-temporal intensity modeling to data from 416 far-right extremists exposed in the United States between 2005 and 2017. The results indicate that patterns of far-right radicalization in the United States are consistent with a complex contagion process, in which reinforcement is required for transmission. Both social media usage and group membership enhance the spread of extremist ideology, suggesting that online and physical organizing remain primary recruitment tools of the far-right movement. In addition, I identified several endemic factors, such as poverty, that increase the probability of radicalization in particular regions. Future research should investigate how specific interventions, such as online counter-narratives to battle propaganda, may be effectively implemented to mitigate the spread of far-right extremism in the United States.

Many decision-making problems feature multiple objectives where it is not always possible to know the preferences of a human or agent decision-maker for different objectives. However, demonstrated behaviors from the decision-maker are often available. This research proposes a dynamic weight-based preference inference (DWPI) algorithm that can infer the preferences of agents acting in multi-objective decision-making problems from demonstrations. The proposed algorithm is evaluated on three multi-objective Markov decision processes: Deep Sea Treasure, Traffic, and Item Gathering, and is compared to two existing preference inference algorithms. Empirical results demonstrate significant improvements compared to the baseline algorithms, in terms of both time efficiency and inference accuracy. The DWPI algorithm maintains its performance when inferring preferences for sub-optimal demonstrations. Moreover, the DWPI algorithm does not necessitate any interactions with the user during inference—only demonstrations are required. We provide a correctness proof and complexity analysis of the algorithm and statistically evaluate the performance under different representation of demonstrations. [ABSTRACT FROM AUTHOR]

All large-scale telescope facilities are constructed within a geographical, social, historical, and political context that includes nested layers at the global, national, and local levels. However, discussions about the geographic siting of astronomy facilities, for example, the communities in which they are embedded or the interactions between the facility and its locale, are uncommon in social science studies of astronomy, and no extant review focused on this gap in the literature. In this literature review and discourse analysis, we explore the ways in which research about astronomy facilities and their local communities has emerged, and the extent to which it focuses on the Global South. We find that literature addressing the social and policy aspects of astronomy facilities has an emphasis on the Global North. However, literature addressing host communities has an emphasis on the Global South. Broadly, the discourses related to host communities in the Global South have emerged from reflections on the controversies related to large-scale telescopes in Hawai'i, Chile, and South Africa. One common theme linking these discourses is that a focus on benefits at the national and international levels obscures a range of problematic power dynamics and outcomes at the local level. The notion of the Global South as an 'empty space' in which astronomical observation does not constitute impactful action amongst local communities, is challenged by discourses that centre local contexts, and challenged by discourses that employ conceptual frameworks with a focus on revealing power dynamics. [ABSTRACT FROM AUTHOR]

Building Cultures of Care in schools has profound potential to support students' mental health and academic success. This is critical as students' mental and behavioral challenges are rising, and teachers report stress and burn out. To inform work in other communities, we examine the Culture of Care initiative in a tri-county region of one US state. We take a Developmental Evaluation approach, documenting the journey, including successes, challenges, adaptations, and initial outcomes over 3 years encompassing the covid-19 pandemic. In Year 1, 12 school district administrators and partners responsible for initiative launch reflected on keys to success, early outcomes, and challenges through interviews. In Year 3, 62 educators, local administrators, and community partners who implemented the initiative participated in open-ended surveys and focus groups. Results from content analysis revealed evidence of a systems approach to integrating multiple components of trauma-informed and restorative school practices into a unified initiative to create educational cultures of care. Strengths stemmed from a regional, relationship-based approach uniting educational leaders and a team of coaches across multiple districts, coupled with tailored strategies for individual schools, and adaptability to emergent needs. Challenges included escalating student needs, difficulty learning new practices, staff turnover, stress and fatigue, variability in buy-in across schools, and challenges to community and family partnerships. Yet, participants consistently pointed to indicators of success, including transformation in staff perspectives and practices, and more positive learning environments. Further research is needed to capture students' and families' perspectives and to examine equitable educational and mental health outcomes for students. [ABSTRACT FROM AUTHOR]

Purpose: Prior investigations regarding the effect of obesity on inguinal hernia repair have been mixed. The aim of our study was to retrospectively compare perioperative outcomes, recurrence rate, and quality of life between obese and non-obese patients undergoing inguinal hernia repair. Methods: Patients who underwent inguinal hernia repair by any approach at a single institution were identified from a prospectively maintained quality database. Patients with a body mass index (BMI) greater than or equal to 30 kg/m2 were considered obese. Quality of life was measured with the Surgical Outcomes Measurement System (SOMS) and Carolinas Comfort Scale (CSS) surveys. Differences between obese and non-obese patients were assessed using independent samples t-tests, Wilcoxon rank-sum, and chi-square tests. Results: Between 2010 and 2021, a total of 5575 patients underwent inguinal hernia repair. Fifteen percent of patients were identified as obese (835 patients, mean BMI 33.2 ± 3.3 kg/m2). A significantly higher percentage of obese patients were diabetic, and operative time and estimated blood loss were higher in the obese group (all p < 0.001). Rates of hernia recurrence in obese patients was significantly more likely than in non-obese patients (4.2% vs 2.0%, p < 0.001). Up to 2 years postoperatively, a greater percentage of obese patients reported worse quality of life on the SOMS and more bothersome symptoms on the CCS. Conclusions: Inguinal hernia repair in obese patients is a more technically challenging operation. Long-term follow-up revealed a greater risk of hernia recurrence and worse quality of life up to 2 years postoperatively in this patient population. [ABSTRACT FROM AUTHOR]

Hexavalent chromium [Cr(VI)] is a known lung carcinogen and a driving mechanism in human lung cells for Cr(VI)-induced lung cancer is chromosome instability, caused by prolonged Cr(VI) exposure inducing DNA double-strand breaks, while simultaneously inhibiting the repair of these breaks. In North Atlantic right whales, Cr(VI) induces breaks but does not inhibit repair. It is unclear if this repair inhibition is specific to human lung cells or occurs in other species, as it has only been considered in humans and North Atlantic right whales. We evaluated these outcomes in rodent cells, as rodents are an experimental model for metal-induced lung carcinogenesis. We used a guinea pig lung fibroblast cell line, JH4 Clone 1, and rat lung fibroblasts. Cells were exposed to two different particulate Cr(VI) compounds, ranging from 0 to 0.5 ug/cm2, for 24 or 120 h and assessed for cytotoxicity, DNA double-strand breaks, and DNA double-strand break repair. Both particulate Cr(VI) compounds induced a concentration-dependent increase in cytotoxicity and DNA double-strand breaks after acute and prolonged exposures. Notably, while the repair of Cr(VI)-induced DNA double-strand breaks increased after acute exposure, the repair of these breaks was inhibited after prolonged exposure. These results are consistent with outcomes in human lung cells indicating rodent cells respond like human cells, while whale cells have a markedly different response. [ABSTRACT FROM AUTHOR]

Urbanization has important effects on the distribution and persistence of wildlife communities. Urbanization may alter not just the distributions of individual species, but also co-occurrence patterns and thus the potential for interspecific interactions (e.g., competition, predation) that structure wildlife communities. Little is currently known about how urbanization alters species co-occurrence or how these changes shape urban species assemblages. Using tree squirrels as a model functional group, we quantified how urbanization alters species occurrence and co-occurrence patterns to shape species assemblages, and how these effects vary within and among cities. We constructed a multi-species, multi-season occupancy model to identify relationships between tree squirrel occupancy and co-occurrence and local land and tree canopy cover and examined variation in these relationships within and among nine US cities. Species' responses to canopy cover were highly variable among, but less variable within cities, suggesting that even common urban wildlife species may respond differently to urban intensity in different landscape contexts. Species co-occurrence was also highly variable among cities and weakly related to canopy cover within a city. These findings provide important evidence that both environmental attributes and species interactions shape urban wildlife communities. Important for management and conservation, they suggest that tree-canopy cover can particularly support forest species co-occurrence and that managing urban forests to provide high canopy cover could contribute to the diversity of urban wildlife communities in forested ecoregions. [ABSTRACT FROM AUTHOR]

The decline in the ovarian reserve leads to menopause and reduced serum estrogens. MicroRNAs are small non-coding RNAs, which can regulate gene expression and be secreted by cells and trafficked in serum via exosomes. Serum miRNAs regulate tissue function and disease development. Therefore, the aim of this study was to identify miRNA profiles in serum exosomes of mice induced to estropause and treated with 17β-estradiol (E2). Female mice were divided into three groups including control (CTL), injected with 4-Vinylcyclohexene diepoxide (VCD), and injected with VCD plus E2 (VCD + E2). Estropause was confirmed by acyclicity and a significant reduction in the number of ovarian follicles (p < 0.05). Body mass gain during estropause was higher in VCD and VCD + E2 compared to CTL females (p = 0.02). Sequencing of miRNAs was performed from exosomes extracted from serum, and 402 miRNAs were detected. Eight miRNAs were differentially regulated between CTL and VCD groups, seven miRNAs regulated between CTL and VCD + E2 groups, and ten miRNAs regulated between VCD and VCD + E2 groups. Only miR-200a-3p and miR-200b-3p were up-regulated in both serum exosomes and ovarian tissue in both VCD groups, suggesting that these exosomal miRNAs could be associated with ovarian activity. In the hepatic tissue, only miR-370-3p (p = 0.02) was up-regulated in the VCD + E2 group, as observed in serum. Our results suggest that VCD-induced estropause and E2 replacement have an impact on the profile of serum exosomal miRNAs. The miR-200 family was increased in serum exosomes and ovarian tissue and may be a candidate biomarker of ovarian function. [ABSTRACT FROM AUTHOR]

Tessellations (surface architectures of arrays of hard tiles) are common in natural and man-made designs. Boxfishes (Ostracioidea) are almost completely encased in a tessellated armor and have evolved a plethora of cross-sectional carapace shapes, yet whether the scutes constructing these exhibit comparable variation is unknown. Using high-resolution microCT and semi-automatic segmentation algorithms, we quantitatively examined thousands of scutes from 13 species of diverse body form. A cluster analysis revealed that certain scute types are associated with specific carapace regions independent of carapace shape. Scute types differentiate between carapace edges and flat regions, as well as between the head region with many carapace openings and the more consistently closed abdominal region, pointing at a constructional commonality or constraint shared by all boxfish species. However, the dimensions of edge scutes varied systematically with carapace shape (e.g., scute aspect ratio tended to increase with decreasing carapace height). This suggests that protection is maintained across body forms by managing scute- and carapace-level mechanisms for increasing bending resistance. Future studies on other taxa are necessary to understand whether these architectural principles are specific evolutionary solutions for building a boxfish carapace or whether they are shared by other biological systems that serve a similar protective function. Comparative architecture of the tessellated boxfish (Ostracioidea) carapace, using high-resolution microfocus computed tomography (microCT) and semi-automatic segmentation algorithms [ABSTRACT FROM AUTHOR]

Drug discovery often involves targeting specific members within a family of similar proteins. For example, pyruvate dehydrogenase kinase (PDHK) exists as four isozymes, which exhibit varying expression patterns across multiple tissues. Different PDHK isozymes have been implicated in conditions such as cancer, heart failure, and diabetes, suggesting that targeting them with inhibitors may offer therapeutic benefits. However, simultaneous inhibition of all four PDHK isozymes has the potential to be counterproductive, or poorly tolerated, highlighting a need for isoform-selective PDHK inhibitors. Despite multiple prior reports of PDHK inhibitors, identifying isoform-specific inhibitors for each PDHK isozyme has proven elusive. In this work, we propose a comprehensive framework that combines a machine learning-based prediction method and biochemical testing to screen a library of novel and previously reported compounds, thereby identifying selective inhibitors for PDHK isozymes. Initially, a coupled tensor matrix completion (CTMC) approach is employed to predict compound-target interaction (CTI) and pinpoint target-specific inhibitors. Subsequently, biochemical testing is performed to validate the predicted CTIs. Utilizing this approach, we successfully identified five novel PDHK1-specific inhibitors, underscoring the reliability of this approach as a screening method in the early stages of drug discovery and hit identification. [ABSTRACT FROM AUTHOR]

Current understanding of soil carbon dynamics suggests that plant litter quality and soil mineralogy control the formation of mineral-associated soil organic carbon (SOC). Due to more efficient microbial anabolism, high-quality litter may produce more microbial residues for stabilisation on mineral surfaces. To test these fundamental concepts, we manipulate soil mineralogy using pristine minerals, characterise microbial communities and use stable isotopes to measure decomposition of low- and high-quality litter and mineral stabilisation of litter-C. We find that high-quality litter leads to less (not more) efficient formation of mineral-associated SOC due to soil microbial community shifts which lower carbon use efficiency. Low-quality litter enhances loss of pre-existing SOC resulting in no effect of litter quality on total mineral-associated SOC. However, mineral-associated SOC formation is primarily controlled by soil mineralogy. These findings refute the hypothesis that high-quality plant litters form mineral-associated SOC most efficiently and advance our understanding of how mineralogy and litter-microbial interactions regulate SOC formation. This study challenges the hypothesis that high-quality plant litters form stable, mineral-associated soil organic carbon most efficiently, providing evidence that litter-microbial interactions and soil mineralogy regulate soil organic carbon formation. [ABSTRACT FROM AUTHOR]

People are routinely forced to undertake cognitive challenges under the effect of sleep deprivation, due to professional and social obligations forcing them to ignore their circadian clock. However, low intra-individual and high inter-individual differences in behavioural outcomes are known to occur when people are sleep deprived, leading to the conclusion that trait-like differences to sleep deprivation could explain the differing levels of resilience. Within this study we consider if trait-like resilience to sleep deprivation, measured using psychomotor vigilance tests over a 40 h protocol, could be associated with graph metrics (mean node strength, clustering coefficient, characteristic path length and stability) calculated from EEG functional networks acquired when participants () are well rested (baseline). Furthermore, we investigated how stability (the consistency of a participant’s functional network over time measured using 2-D correlation) changed over the constant routine. We showed evidence of strong significant correlations between high mean node strength, low characteristic path length and high stability at baseline with a general resilience to extended sleep deprivation, although the same features lead to vulnerability during the period of natural sleep onset, highlighting non-uniform correlations over time. We also show significant differences in the levels of stability between resilient and vulnerable groups. [ABSTRACT FROM AUTHOR]

The purpose of this study was to determine the impact that meaningful watershed educational experiences (MWEE) had on the academic achievement of middle school students. A quantitative, ex post facto causal-comparative design was used. The sample population consisted of 1067 8th-grade students across four middle schools within the Pennsylvania Chesapeake Bay Watershed (CBW) region. The study utilized students' academic achievement scores on the Pennsylvania System of School Assessment (PSSA) and compared the scores of those with exposure to MWEE and those without to examine the difference in academic achievement on the English language arts (ELA), math, and science sections of the PSSA. Using a multivariate analysis of variance (MANOVA), the data was analyzed. The findings demonstrate a statistically significant difference between students' PSSA scores based on students' MWEE participation status. Implications for practice and future research are offered. [ABSTRACT FROM AUTHOR]

The environmental realm has been acknowledged as a pivotal arena for the emergence and propagation of antimicrobial resistance. To further explore insight into antimicrobial resistance dynamics beyond clinical and veterinary settings, we embarked on an environmental surveillance initiative targeting the prevalence of antibiotic-resistant bacteria within the bustling confines of an international airport in Japan. Our findings illuminate a high prevalence of methicillin-resistant staphylococci (46.3%) on frequently contacted surfaces in the public domain. Notably, Staphylococcus haemolyticus and S. epidermidis emerged as the preeminent carriers of the mecA gene. Intriguingly, we encountered a virulent strain of livestock-associated MRSA harboring a PVL-positive ST1232 clone, CC398 lineage. Further scrutiny unveiled a repertoire of resistance mechanisms, the methicillin-resistant isolates exhibited two or more resistance genes conferring resistance against different types of antibiotics, including beta-lactams, macrolides, lincosamides, aminoglycosides, chloramphenicol, and fosfomycin. Revealing multidrug-resistant CoNS and a LA-MRSA across various surfaces in urban public areas unearths a looming public health hazard. Thus, implementation of molecular surveillance is imperative, augmenting our capacity for early detection and mitigation of the insidious spread and potential transfer of antibiotic resistance genes and virulence factors amidst urban settings, notably within pivotal nodes such as airports. [ABSTRACT FROM AUTHOR]

Partial-thickness rotator cuff tears are a common cause of pain and disability and are central to developing full-thickness rotator cuff tears. However, limited knowledge exists regarding the alterations to the mechanical environment due to these lesions. Computational models that study the alterations to the mechanical environment of the supraspinatus tendon can help advance clinical management to avoid tear progression and provide a basis for surgical intervention. In this study, we use three-dimensional validated finite element models from six intact specimens to study the effects of low- and high-grade tears originating on the articular and bursal surfaces of the supraspinatus tendon. Bursal-sided tears generally had a lower failure load, modulus, and strain than articular-sided tears. Thus, caution should be taken when managing bursal-sided tears as they may be more susceptible to tear progression. [ABSTRACT FROM AUTHOR]

Estimation of admixture proportions has become one of the most commonly used computational tools in population genomics. However, there is remarkably little population genetic theory on statistical properties of these variables. We develop theoretical results that can accurately predict means and variances of admixture proportions within a population using models with recombination and genetic drift. Based on established theory on measures of multilocus disequilibrium, we show that there is a set of recurrence relations that can be used to derive expectations for higher moments of the admixture proportions distribution. We obtain closed form solutions for some special cases. Using these results, we develop a method for estimating admixture parameters from estimated admixture proportions obtained from programs such as Structure or Admixture. We apply this method to HapMap 3 data and find that the population history of African Americans, as expected, is not best explained by a single admixture event between people of European and African ancestry. The model of constant gene flow starting at 8 generations and ending at 2 generations before present gives the best fit. [ABSTRACT FROM AUTHOR]

Purpose of Review: Despite ongoing research into alternative postsurgical pain treatments, opioids remain widely used analgesics regardless of associated adverse effects, including dependence and overdose, as demonstrated throughout the current opioid crisis. This is likely related to a failure in proving the efficacy of alternative analgesics in clinical trials, despite strong evidence supporting the potential for effective analgesia through in vitro studies. While NaV1.7 and NaV1.8 channels have shown to be key components of pain perception, studies regarding pharmacological agents utilizing these channels as targets have largely failed to demonstrate the efficacy of these proposed analgesics when compared to current multimodal pain treatment regimens. Recent Findings: However, the novel NaV1.8 channel inhibitor, VX-548 has surpassed previously studied NaV1.8 inhibitors in clinical trials and continues to hold promise of a novel efficacious analgesic to potentially be utilized in multimodal pain treatment on postsurgical patients. Additionally, NaV1.8 is encoded by the SCN10A, which has been shown to be minimally expressed in the brain, suggesting a lower likelihood of adverse effects in the CNS, including dependence and abuse. Summary: Novel pharmacologic analgesics that are efficacious without the significant side effects associated with opioids have lacked meaningful development. However, recent clinical trials have shown promising results in the safety and efficacy of the pharmacological agent VX-548. Still, more clinical trials directly comparing the efficacy of VX-548 to standard of care post-surgical drugs, including opioids like morphine and hydromorphone are needed to demonstrate the long-term viability of the agent replacing current opioids with an unfavorable side effect profile. [ABSTRACT FROM AUTHOR]

We can now measure the connectivity of every neuron in a neural circuit1–9, but we cannot measure other biological details, including the dynamical characteristics of each neuron. The degree to which measurements of connectivity alone can inform the understanding of neural computation is an open question10. Here we show that with experimental measurements of only the connectivity of a biological neural network, we can predict the neural activity underlying a specified neural computation. We constructed a model neural network with the experimentally determined connectivity for 64 cell types in the motion pathways of the fruit fly optic lobe1–5 but with unknown parameters for the single-neuron and single-synapse properties. We then optimized the values of these unknown parameters using techniques from deep learning11, to allow the model network to detect visual motion12. Our mechanistic model makes detailed, experimentally testable predictions for each neuron in the connectome. We found that model predictions agreed with experimental measurements of neural activity across 26 studies. Our work demonstrates a strategy for generating detailed hypotheses about the mechanisms of neural circuit function from connectivity measurements. We show that this strategy is more likely to be successful when neurons are sparsely connected—a universally observed feature of biological neural networks across species and brain regions.A study demonstrates how experimental measurements of only the connectivity of a biological neural network can be used to predict neural responses across the fly visual system at single-neuron resolution using deep learning techniques. [ABSTRACT FROM AUTHOR]

In the era of renewed space exploration, comprehending the effects of the space environment on human health, particularly for deep space missions, is crucial. While extensive research exists on the impacts of spaceflight, there is a gap regarding female reproductive risks. We hypothesize that space stressors could have enduring effects on female health, potentially increasing risks for future pregnancies upon return to Earth, particularly related to small-for-gestational-age (SGA) fetuses. To address this, we identify a shared microRNA (miRNA) signature between SGA and the space environment, conserved across humans and mice. These miRNAs target genes and pathways relevant to diseases and development. Employing a machine learning approach, we identify potential FDA-approved drugs to mitigate these risks, including estrogen and progesterone receptor antagonists, vitamin D receptor antagonists, and DNA polymerase inhibitors. This study underscores potential pregnancy-related health risks for female astronauts and proposes pharmaceutical interventions to counteract the impact of space travel on female health. A circulating miRNA signature linked to birth defect risk, (i.e. as small-for-gestational-age (SGA) fetuses), was identified for females exposed to the space environment. AI/ML tools were used to predict potential countermeasures to mitigate this risk. @AfshinBeheshti @PittTweet [ABSTRACT FROM AUTHOR]

Hate crimes and racist incidents are occurring with alarming and increasing frequency on college and university campuses. As colleges work to reduce racist incidents on campus, there is still a need to prepare students to respond to racism when it occurs. When students are prepared to respond to racist incidents, they tend to have better mental health. We draw on prior literature to examine whether learning about critical race theory (CRT) and receiving CRT-informed mentoring—as embedded in an undergraduate research experience program—related to four-year college students' self-assessed ability to respond to racism. Specifically, we propose and test a conceptual model to examine the benefits of participating in an undergraduate research experience program that required students to learn about CRT and receiving CRT-informed mentorship. Consistent with prior literature on undergraduate research experience programs, we found that the intervention positively related to students' sense of self-efficacy and science identity, but it did not have an independent, direct relationship with self-assessed ability to respond to racism. However, the intervention indirectly supports students' preparedness to respond to racism through its positive relationship with self-efficacy. As state legislatures around the country work to ban CRT, this paper offers empirical evidence that embedding CRT in university programs can support student development in multiple related ways. [ABSTRACT FROM AUTHOR]

Introduction: Azithromycin is an effective treatment for various respiratory conditions but its effect on cough is poorly understood. We synthesised data from randomised controlled trials (RCTs) and noncomparative studies (NCT) examining its effect on objective and subjective cough. Methods: After prospective registration on PROSPERO, we searched MEDLINE, EMBASE, and CENTRAL for both RCTs and NCT trials examining the effect azithromycin on cough in respiratory disease. Results: We identified 1240 studies of which 6 (4 RCTs and 2 NCT studies) were included in the meta-analysis, with a total of 275 patients. Azithromycin was associated with significant improvement in Leicester Cough Questionnaire scores at follow-up when compared to baseline scores (SMD = 0.62 [95% CI 0.12 to 1.12], p = 0.01). However, when only RCTs were synthesised, no significant effect was observed (SMD = 0.12 [95% CI − 0.36 to 0.60], p = 0.62). There was no significant reduction in cough severity VAS score (SMD = − 0.39 [95% CI − 0.92 to 0.14], p = 0.15). There was no significant reduction in objective cough count (SMD = − 0.41 [95% CI − 1.04 to 0.32], p = 0.09). Conclusion: Azithromycin therapy improves cough-related quality of life in various chronic respiratory diseases; however, there was no significant effect on cough outcomes when only data from RCTs were synthesised. We believe that to accurately identify which patients whose cough would benefit from azithromycin a large-scale clinical trial of patients with a broad spectrum of respiratory diseases, with sufficiently severe cough, should be undertaken with subgroup analysis of individual disease areas. [ABSTRACT FROM AUTHOR]

This study has investigated the effect of NaCl and different gaseous environments on the stress corrosion cracking susceptibility of CMSX-4 at 550 °C. The presence of SOx leads to the rapid dissociation of NaCl into Na2SO4 and the release Cl2 and HCl, which then trigger an active oxidation mechanism and stress corrosion cracking. The incubation time for crack initiation at 690 MPa and in the presence of a sulphur containing environment is 10 min. A working hypothesis is that stress corrosion cracking occurs due to the hydrogen released at the oxide/alloy interface when metal chlorides are formed; however, this hypothesis needs to be further explored. [ABSTRACT FROM AUTHOR]

The Kampmann–Wagner Numerical (KWN) model of precipitation is a powerful tool to simulate the precipitation of the second phase considering the nucleation, growth, and coarsening. Some quantities such as interfacial energy and nucleation site number density are required to accomplish the simulation. Practically, those quantities are hard to measure in the experiment directly, and the derivation of those quantities through modeling can also be costly. In this work, we hereby adopt the minimization algorithm implemented in the open-source Scipy Python package to derive that important information in terms of very limited experimental data. The convergence and robustness of different algorithms are discussed. Among those algorithms, the Nelder–Mead and Powell algorithms are successfully applied to optimize multiple parameters during KWN modeling. This work will shed light on the design of experiments/processes and facilitate integrated computational materials engineering (ICME). [ABSTRACT FROM AUTHOR]

Background: Despite excellent surgical outcomes, a minority of qualified patients undergo weight loss surgery. Endoscopic Sleeve Gastroplasty (ESG), an incisionless procedure, has proven to be effective in achieving weight loss and comorbidity improvement. We aim to compare outcomes of ESG to those of Laparoscopic Sleeve Gastrectomy (LSG). Method: A retrospective review of a prospective database of patients who underwent ESG and LSG at NorthShore University HealthSystem from 2016 to 2023 was completed. Demographic and outcome data were analyzed. Pre- and post-surgical data were compared using chi-square and two-sample t tests. Improvement or resolution of obesity-related comorbidities were also assessed. Results: A total of 212 LSG and 68 ESG patients were reviewed. ESG patients were older (47 ± 10 vs. 43 ± 12, p = 0.006) and less obese (BMI 37.0 ± 5.5 vs. 45.8 ± 0.4, p < 0.001) than LSG patients. Median length of stay after ESG was 0 days and after LSG 1 day (p < 0.001). Severe adverse events were seen less frequent after ESG (1.47%, vs 3.77%). LSG achieved more significant %TBWL at 6 months (25.2 ± 8.9 vs 14.9 ± 7.4), 1 year (27.5 ± 10.8 vs 14.1 ± 9.8), and 2 years (25.7 ± 10.8 vs 10.5 ± 8.8, all p < 0.001) after surgery when compared to ESG. LSG achieved significantly greater %EWL compared to ESG at 6 months (57.0 ± 20.7 vs 50.4 ± 29.2, p = 0.137), 1 year (61.4 ± 24.6 vs 46.5 ± 34.0, p = 0.026), and 2 years postoperatively (59.7 ± 25.5 vs 32.6 ± 28.2, p = 0.001). There were no statistically significant differences in rates of improvement or resolution of diabetes, obstructive sleep apnea, hyperlipidemia, or hypertension. Conclusion: ESG is an effective procedure for weight loss and comorbidity resolution. Obesity-related comorbidities are comparably improved and resolved following ESG vs LSG. Although the weight loss in LSG is significantly higher, patients can expect a shorter hospital length of stay and a lower rate of complications after ESG. ESG continues to show promise for long-term weight loss and improvement in health. [ABSTRACT FROM AUTHOR]

Our objective was to determine whether Child Opportunity Index (COI), a measure of neighborhood socioeconomic and built environment specific to children, mediated the relationship of census tract Black or Hispanic predominance with increased rates of census tract violence-related mortality. The hypothesis was that COI would partially mediate the relationship. This cross-sectional study combined data from the American Community Survey 5-year estimates, the COI 2.0, and the Illinois Violent Death Reporting System 2015–2019 for the City of Chicago. Individuals ages 0–19 years were included. The primary exposure was census tract Black, Hispanic, White, and other race predominance (> 50% of population). The primary outcome was census tract violence-related mortality. A mediation analysis was performed to evaluate the role of COI as a potential mediator. Multivariable logistic regression modeling census tract violence-related mortality demonstrated a direct effect of census tract Black predominance (adjusted odds ratio [aOR] 2.59, 95% confidence interval [CI] 1.30–5.14) on violence-related mortality compared to White predominance. There was no association of census tract Hispanic predominance with violence-related mortality compared to White predominance (aOR 1.57, 95% CI 0.88–2.84). Approximately 64.9% (95% CI 60.2–80.0%) of the effect of census tract Black predominance and 67.9% (95% CI 61.2–200%) of the effect of census tract Hispanic predominance on violence-related mortality was indirect via COI. COI partially mediated the effect of census tract Black and Hispanic predominance on census tract violence-related mortality. Interventions that target neighborhood social and economic factors should be considered to reduce violence-related mortality among children and adolescents. [ABSTRACT FROM AUTHOR]

Australian wild limes occur in highly diverse range of environments and are a unique genetic resource within the genus Citrus. Here we compare the haplotype-resolved genome assemblies of six Australian native limes, including four new assemblies generated using PacBio HiFi and Hi-C sequencing data. The size of the genomes was between 315 and 391 Mb with contig N50s from 29.5 to 35 Mb. Gene completeness of the assemblies was estimated to be from 98.4 to 99.3% and the annotations from 97.7 to 98.9% based upon BUSCO, confirming the high contiguity and completeness of the assembled genomes. High collinearity was observed among the genomes and the two haplotype assemblies for each species. Gene duplication and evolutionary analysis demonstrated that the Australian citrus have undergone only one ancient whole-genome triplication event during evolution. The highest number of species-specific and expanded gene families were found in C. glauca and they were primarily enriched in purine, thiamine metabolism, amino acids and aromatic amino acids metabolism which might help C. glauca to mitigate drought, salinity, and pathogen attacks in the drier environments in which this species is found. Unique genes related to terpene biosynthesis, glutathione metabolism, and toll-like receptors in C. australasica, and starch and sucrose metabolism genes in both C. australis and C. australasica might be important candidate genes for HLB tolerance in these species. Expanded gene families were not lineage specific, however, a greater number of genes related to plant-pathogen interactions, predominantly disease resistant protein, was found in C. australasica and C. australis.Key message: The haplotype-resolved genomes for six Australian native taxa have enabled the identification of their novel gene repertoire and characterization of genes related to plant pathogens and abiotic stress responses. [ABSTRACT FROM AUTHOR]

This article examines Higher Education students' experiences of academic reading as a grudging act: something that is performed reluctantly or half-heartedly, because it has to be done. Drawing on group interviews with 30 social science undergraduates, registered at a research-intensive UK university, we offer a reflexive thematic analysis of academic reading, experienced as 'a struggle', as 'a chore' and as 'pointless'. Our analysis centres the experiential dimensions of reading, revealing how student orientations towards reading—and the teaching that surrounds it—can influence their practices. The article makes two original contributions to the developing literature about student reading experiences in Higher Education. First, by examining student accounts of reading through Bottero's (2022) sociology of 'grudging acts', we extend what is known about the intersection between reading experiences and practices, raising important questions for educators in the social sciences and beyond. Second, by examining what educators can do in response to these challenges, we collate and extend existing guidance for educators that seek to support student engagement with academic reading in Higher Education. [ABSTRACT FROM AUTHOR]

Distributed denial of service (DDoS) attacks pose a significant threat to Software Defined Networking (SDN) and are frequently employed by malicious actors. SDN has emerged as a prominent networking paradigm, providing users with a decoupled control and data plane, which grants greater control and programmability over the network. In comparison to traditional networks, SDN offers dynamic, agile, cost-effective, and manageable solutions. However, a notable drawback of SDN is that the central controller becomes a vulnerable attack surface, rendering it susceptible to complete network takeover through DDoS attacks. The novelty of this paper is to gather resources that will be used to mitigate DDoS attacks in SDN environments. This paper focuses on the exploration of open datasets featuring DDoS attacks, as well as examining attack detection and mitigation techniques and frameworks. By analyzing various detection and mitigation strategies, network administrators and security professionals can make informed decisions to enhance the robustness and resilience of SDN environments in the face of evolving DDoS threats. [ABSTRACT FROM AUTHOR]

We introduce the concept of LabLinking: a technology-based interconnection of experimental laboratories across institutions, disciplines, cultures, languages, and time zones - in other words human studies and experiments without borders. In particular, we introduce a theoretical framework of LabLinking, describing multiple dimensions of conceptual, organizational, and technical aspects. The framework defines LabLinking levels (LLL), which describe the degree of tightness of empirical interconnection between labs. In several examples, we describe the technological infrastructure in terms of hard- and software required for the respective LLLs and share insights about the challenges and benefits. This comprises the connection of multiple labs in a collection of multiple synchronized biosignals (including an MRI scanner) for a decision making study, a human-robot interaction study to investigate attention-adaptive communication behavior, as well as an experiment for LabLinking through Virtual Reality in a virtual commerce setting, for an increased feeling of immersion. In sum, we argue that LabLinking provides a unique platform for a continuous exchange between scientists and experimenters, thereby enabling a time synchronous execution of experiments performed with and by decentralized users and researchers, allowing to establish novel experimental designs that would not be feasible without LabLinking, such as the investigation of high-resolution neural signals in everyday activity situations, which was realized by interconnecting a control participant in an fMRI with an execution participant in a kitchen environment.Article Highlights: Provides a theoretical understanding, a structured framework, and practical solutions for the novel concept LabLinking. Describes the technical, organizational, and conceptual dimensions of the framework along with LabLinking-Levels that define the tightness of integration. Discusses real-world instantiations of LabLinking with concrete implementations and pointers to our open source tools. Combines conceptual and practical perspectives which will enable readers to design and implement their own distributed LabLinking studies. [ABSTRACT FROM AUTHOR]

The supraspinatus tendon plays a crucial role in shoulder abduction, making it one of the common structures affected by injury. Clinically, crescent-shaped tears are the most commonly seen tear shape. By developing six specimen-specific, three-dimensional, supraspinatus-infraspinatus finite element model with heterogeneous material properties, this study aimed to examine the changes in tissue deformation (maximum principal strain) of the supraspinatus tendon due to specimen-specific material properties and rotator cuff tear size. FE models with small- and medium-sized full-thickness crescent-shaped tears were subjected to loads seen during activities of daily living and physiotherapy. Six fresh-frozen cadaveric shoulders were dissected to mechanically test the supraspinatus tendon and develop and validate FE models that can be used to assess changes in strain due to small (< 1 cm, equivalent to 20-30% of the tendon width) and medium-sized (1–3 cm, equivalent to 40–50% of the tendon width) tears that are located in the middle and posterior regions of the supraspinatus tendon. FE predictions of maximum principal strain at the tear tips were examined to determine whether failure strain was reached during activities of daily living (drinking and brushing teeth) and physiotherapy exercises (prone abduction and external rotation at 90° abduction). No significant differences were observed between the middle and posterior tear failure loads for small- and medium-sized tears. For prone abduction, there was a potential risk for tear progression (exceeded failure strain) for medium-sized tears in the supraspinatus tendon's middle and posterior regions. For external rotation at 90° abduction, one model with a middle tear and two with posterior tears experienced failure. For all daily activity loads, the strain never exceeded the failure strain. Our three-dimensional supraspinatus-infraspinatus FE model shows that small tears appear unlikely to progress based on the regional strain response; however, medium-sized tears are at higher risk during more strenuous physiotherapy exercises. Furthermore, differences in patient-specific tendon material properties are important in determining whether the tear will progress. Therefore, patient-specific management plans based on tear size may be beneficial to improve clinical outcomes. [ABSTRACT FROM AUTHOR]

Article #1 discusses a clinical trial that examined the effects of delaying intubation in comatose patients with acute poisoning. The study found that delaying intubation was safe and resulted in lower rates of ICU admission and complications. However, the lack of deaths suggests that more research is needed, particularly involving confirmed overdoses. Article #2 explores lead exposure in veterinary workers who handle lead shielding during radiography. The study found that the use of lead shielding is associated with lead exposure, but wearing disposable gloves can significantly reduce this exposure. However, the study had limitations, such as potential bias from the questionnaire and the lack of evaluation of hand washing. Article #3 focuses on the use of angiotensin II (AT2) for treating refractory shock. While AT2 has shown improvement in blood pressures, its impact on mortality is still unclear. The study aims to determine if adding AT2 improves 30-day mortality in patients with severe, refractory shock. However, the study is retrospective and underpowered, so further research is needed to establish its effectiveness. The study found that there was no significant difference in mortality between the AT2 group and the control group, and baseline characteristics differed between the two groups. Overall, the study concluded that AT2 was not associated with improved mortality or organ dysfunction in patients with severe shock. [Extracted from the article]

A study was conducted to investigate the temperature dependence of thermomechanical coupling in Inconel 718 (IN718). IN718 was selected as a model material due to deformation being predominantly accommodated by planar slip. Split-Hopkinson (or Kolsky) tension bar experiments were conducted at a nominal strain rate of 750 s - 1 at room temperature and 450 ∘ C, representing homologous temperatures ( T H = T / T melt ) of T H = 0.2 and T H = 0.5 , respectively. During deformation, specimen gauge sections were imaged with a high-speed infrared camera. Using one-dimensional wave analysis, the transient heat conduction equation, and temperature-dependent specific heat capacity values, the temperature rise as a function of plastic strain was used to calculate plastic work, thermal work, and the plastic work to heat conversion efficiency, commonly known as the Taylor–Quinney coefficient (TQC). As expected, a significant reduction in plastic work was observed during testing at elevated temperatures. The temperature rise due to plastic deformation was observed to be lower at room temperature compared to elevated temperature experiments. It is reported here for the first time that the TQC is a temperature-sensitive quantity. At T H = 0.5 , a nearly complete conversion of plastic work to heat was observed (TQC ≈ 1.0 ). Under ambient conditions of T H = 0.2 , a much lower efficiency TQC ≈ 0.4 was observed. [ABSTRACT FROM AUTHOR]

Introduction: Numerous studies comment on quality of life outcomes comparing complete and partial fundoplication with or without a bougie. Society guidelines are moving toward recommending partial fundoplication over complete fundoplication due to improved side effect profile with similar outcomes. Retrospective studies and randomized trials have elucidated that use of a bougie during Nissen fundoplication does impact long-term dysphagia. To date there are no retrospective or prospective data that guide practice for partial fundoplications. Objective: The purpose of this project is to investigate the clinical implications of using a bougie for Toupet fundoplication with regard to short-term and long-term dysphagia and need for further therapeutic interventions. Methods: A retrospective review of a prospectively maintained gastroesophageal database was performed. Demographic, pre-operative quality of life outcomes data, perioperative, and post-operative quality of life outcomes data of 373 patients from 2011 to 2022 undergoing Toupet fundoplication without bougie or with a traditional Savary 56Fr or 58Fr bougie were reviewed. The two groups were compared using student's t-test to identify statically significant differences between the groups. Results: Between 2011 and 2022, 373 patients underwent Toupet fundoplication (276 with traditional bougie, 97 without). Median follow-up in the bougie group was 19 months, versus 9 months in the non bougie group. There was no difference between early (3 weeks) and late dysphagia scores (6 months). In the bougie group there were two mucosal perforations due to the bougie. There were no statistically significant differences in GERD-HRQL, gas bloat, and dysphagia scores between groups at one year. Conclusion: There is no difference observed in early or late dysphagia scores, GERD-HRQL, gas bloat or need for dilation in patients undergoing Toupet fundoplication with or without a traditional bougie. It is reasonable to discontinue the use of a traditional bougie during Toupet fundoplication, especially due to risk of esophageal perforation. [ABSTRACT FROM AUTHOR]

The present study examines how supportive touch impacts evaluations of esteem support content containing high emotion-focused (HEF) or high problem-focused (HPF) messages during observed esteem support interactions. A 2 (verbal content; i.e., HEF or HPF) by 2 (nonverbal content; i.e., presence or absence of supportive tactile communication) experiment was conducted to test for main and interactional effects. Results revealed that HEF conditions were perceived to be more effective by observers at enhancing the recipient's state self-esteem, state self-efficacy, and alleviating distress compared to HPF conditions. The supportive tactile communication conditions were perceived as better at enhancing state self-esteem and alleviating distress compared to the no supportive tactile communication conditions by observers. However, these main effects were qualified by significant two-way interactions between message content and nonverbal behavior on ratings of state self-esteem and distress alleviation, such that the addition of supportive tactile communication enhanced the effectiveness of HPF message content but not HEF content. [ABSTRACT FROM AUTHOR]

Purpose of Review: The present investigation evaluated integration of novel medication technology to enhance treatment options, while improving patient outcomes in acute pain management. In this regard, we focused on determining the role of development and utilization of cutting-edge pharmaceutical advancements, such as targeted drug delivery systems, as well as non-pharmacologic interventions in addressing acute pain states. Further research in this area is warranted related to the need for increased patient comfort and reduced adverse effects. Recent Findings: Recent innovations and techniques are discussed including pharmacologic drugs targeting sodium and calcium channels, peptide-based pharmacologic drugs, and non-medicinal methods of alleviating pain such as soothing music or virtual reality. Summary: The present investigation included review of current literature on the application of these innovative technologies, analyzing mechanisms of action, pharmacokinetics, and clinical effectiveness. Our study also investigated the potential benefits in terms of pain relief, reduced side effects, and improved patient adherence. The research critically examines the challenges and considerations associated with implementing these technologies in acute pain management, considering factors like cost, accessibility, and regulatory aspects. Additionally, case studies and clinical trials are highlighted which demonstrate practical implications of these novel medication technologies in real-world scenarios. The findings aim to provide healthcare professionals with a comprehensive understanding of the evolving landscape in acute pain management while guiding future research and clinical practices toward optimizing their use in enhancing patient care. [ABSTRACT FROM AUTHOR]

Coastal marsh ecosystems are changing and being lost at a rapid rate around the world. One of the fastest rates of land loss, specifically coastal marsh habitat, occurs in Louisiana on the Northern Gulf Coast of the USA. To address this issue, state and federal agencies have undertaken massive wetland restoration efforts to preserve and restore coastal marsh habitats in Louisiana. For these efforts to be successful in the long-term, it is critical to understand what methodologies and techniques result in resilient restoration projects. However, traditional methods to monitor restoration success rely on labor intensive field measurements that are often limited in scope, difficult to maintain, and underfunded. Recent technological developments with uncrewed aircraft systems (UASs) and image processing have substantially improved the ability of restoration practitioners to use off-the-shelf UASs and cameras to map projects. We present a streamlined method using a commercially available drone with a high-resolution red, green, blue (RGB) camera to assess the effects of wetland restoration and integrate more modern tools into evaluation approaches. We conducted drone flights at restored brackish marshes of various ages using a space for time substitution with the goal of understanding the long-term success of marsh restoration. We observed that created marshes had higher land to water ratios than natural marshes. This finding suggests that these restored areas were gaining and maintaining elevation after approximately 10 years. Our method shows that drone surveys offer low-cost, minimally invasive methods for evaluating restored wetlands and ultimately tell us more about ecosystem function through realistic site-level habitat configurations. [ABSTRACT FROM AUTHOR]

Optoacoustic imaging (OAI) is an emerging field with increasing applications in patients and exploratory clinical trials for breast cancer. Optoacoustic imaging (or photoacoustic imaging) employs non-ionizing, laser light to create thermoelastic expansion in tissues and detect the resulting ultrasonic emission. By combining high optical contrast capabilities with the high spatial resolution and anatomic detail of grayscale ultrasound, OAI offers unique opportunities for visualizing biological function of tissues in vivo. Over the past decade, human breast applications of OAI, including benign/malignant mass differentiation, distinguishing cancer molecular subtype, and predicting metastatic potential, have significantly increased. We discuss the current state of optoacoustic breast imaging, as well as future opportunities and clinical application trends. Clinical relevance statement: Optoacoustic imaging is a novel breast imaging technique that enables the assessment of breast cancer lesions and tumor biology without the risk of ionizing radiation exposure, intravenous contrast, or radionuclide injection. Key Points: • Optoacoustic imaging (OAI) is a safe, non-invasive imaging technique with thriving research and high potential clinical impact. • OAI has been considered a complementary tool to current standard breast imaging techniques. • OAI combines parametric maps of molecules that absorb light and scatter acoustic waves (like hemoglobin, melanin, lipids, and water) with anatomical images, facilitating scalable and real-time molecular evaluation of tissues. [ABSTRACT FROM AUTHOR]

People are manifestly polarized. On many topics, extreme perspectives are much easier to find than ‘reasonable’, ‘moderate’ perspectives. A natural reaction to this situation is that something epistemically irrational is afoot. Here, I question this natural reaction. I argue that often polarization is epistemically innocuous. In particular, I argue that certain mechanisms that underlie polarization are rational, and polarized beliefs are often fully justified. Additionally, even reflective subjects, who recognize themselves as in a polarized or polarizing situation shouldn’t necessarily reduce confidence in the relevant beliefs. Finally, I draw attention to some often overlooked epistemic benefits associated with polarization. A fuller understanding of the epistemology of polarization requires incorporating both the potential costs and the potential benefits, and being more precise about exactly what is—and is not—epistemically objectionable in these situations. [ABSTRACT FROM AUTHOR]