115 results on '"Martinez, Martin"'
Search Results
2. No evidence for an association of voxel-based morphometry with short-term non-motor outcomes in deep brain stimulation for Parkinson's disease.
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Loehrer, Philipp Alexander, Schumacher, Wibke, Jost, Stefanie T., Silverdale, Monty, Petry-Schmelzer, Jan Niklas, Sauerbier, Anna, Gronostay, Alexandra, Visser-Vandewalle, Veerle, Fink, Gereon R., Evans, Julian, Krause, Max, Rizos, Alexandra, Antonini, Angelo, Ashkan, Keyoumars, Martinez-Martin, Pablo, Gaser, Christian, Ray Chaudhuri, K., Timmermann, Lars, Baldermann, Juan Carlos, and Dafsari, Haidar S.
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- 2024
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3. Rationales and Approaches to Protecting Brain Data: a Scoping Review.
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Jwa, Anita S. and Martinez-Martin, Nicole
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Advances in neurotechnologies, artificial intelligence (AI) and Big Data analytics are allowing interpretation of patterns from brain data to identify and even predict and manipulate mental states. Furthermore, there are avenues through which brain data can move into the consumer sphere, be reidentified and brokered. In response to these developments, there have been a number of approaches proposed to strengthen protections of brain data. To better understand the landscape of brain data protection discussions, we conducted a scoping review to identify the rationales for establishing brain data protections and the proposals for protecting brain data offered in the ethics and neuroscience literature. To draw comparisons, we also surveyed the rationales given in the literature for the protection of sensitive behavioral inferences drawn from other types of personal data and associated approaches to achieving protection. This systematic examination of the rationale behind heightened protection for brain data should be useful to clarify the functional and conceptual bases given for brain data protection and to provide a better grounding for evaluating how the different approaches to brain data protection address these concerns. [ABSTRACT FROM AUTHOR]
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- 2024
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4. Economic Burden of Parkinson's Disease: A Multinational, Real-World, Cost-of-Illness Study.
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Chaudhuri, K. Ray, Azulay, Jean-Philippe, Odin, Per, Lindvall, Susanna, Domingos, Josefa, Alobaidi, Ali, Kandukuri, Prasanna L., Chaudhari, Vivek S., Parra, Juan Carlos, Yamazaki, Toru, Oddsdottir, Julia, Wright, Jack, and Martinez-Martin, Pablo
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PARKINSON'S disease ,DEEP brain stimulation ,BURDEN of care ,CLINICAL deterioration ,SYMPTOMS ,NEURODEGENERATION - Abstract
Background: Parkinson's disease is now one of the fastest-growing neurodegenerative disorders in the developed world, with an increasing prevalence and associated socioeconomic costs. Progression of the disease leads to a gradual deterioration in patients' quality of life, despite optimal treatment, and both medical and societal needs increase, often with the assistance of paid and/or unpaid caregivers. Objective: We aimed to quantify the incremental economic burden of Parkinson's disease by disease severity in a real-world setting across differing geographic regions. Methods: Demographics, clinical characteristics, health status, patient quality of life, caregiver burden, and healthcare resource utilization data were drawn from the Adelphi Parkinson's Disease Specific Program™, conducted in the USA, five European countries, and Japan. Results: A total of 563 neurologists provided data for 5299 individuals with Parkinson's disease; 61% were male, with a mean age of 64 years. Approximately 15% of individuals were deemed to have advanced disease, with significantly more comorbidities, and a poorer quality of life, than those with non-advanced disease. Overall, the mean annual healthcare resource utilization increased significantly with advancing disease, and resulted in a three-fold difference in the USA and Europe. The main drivers behind the high economic burden included hospitalizations, prescription medications, and indirect costs. Conclusions: People with Parkinson's disease, and their caregivers, incur a higher economic burden as their disease progresses. Future interventions that can control symptoms or slow disease progression could reduce the burden on people with Parkinson's disease and their caregivers, whilst also substantially impacting societal costs. [ABSTRACT FROM AUTHOR]
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- 2024
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5. A low-cost AR application to control arm prosthesis.
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Sanchez-Rocamora, Alvaro, Martinez-Martin, Ester, and Costa, Angelo
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This paper presents an augmented reality application to assist with myoelectric prostheses control for people with limb amputations. For that, we use the low-cost Myo armband coupled with low-level signal processing methods specifically built to control filters' levels and processing chain. In particular, we use deep learning techniques to process the signals and to accurately identify seven different hand gestures. From that, we have built an augmented reality projection of a hand based on AprilTag markers that displays the gesture identified by the deep learning techniques. With the aim to properly train the gesture recognition system, we have built our own dataset with nine subjects. This dataset was combined with one publicly available to work with the data of 24 subjects in total. Finally, three different deep learning architectures have been comparatively studied, achieving high accuracy values (being 95.56% the best one). This validates our hypothesis that it is possible to have an adaptive platform able to fast learn personalized hand/arm gestures while projecting a virtual hand in real-time. This can reduce the adaptation time to myoelectric prostheses and improve the acceptance levels. [ABSTRACT FROM AUTHOR]
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- 2023
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6. Impact of advanced Parkinson's disease on caregivers: an international real-world study.
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Martinez-Martin, Pablo, Skorvanek, Matej, Henriksen, Tove, Lindvall, Susanna, Domingos, Josefa, Alobaidi, Ali, Kandukuri, Prasanna L., Chaudhari, Vivek S., Patel, Apeksha B., Parra, Juan Carlos, Pike, James, and Antonini, Angelo
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PARKINSON'S disease , *SERVICES for caregivers , *BURDEN of care , *CAREGIVERS , *PATIENT satisfaction , *WELL-being - Abstract
Background: Caring for a partner or family member with Parkinson's disease (PD) negatively affects the caregiver's own physical and emotional well-being, especially those caring for people with advanced PD (APD). This study was designed to examine the impact of APD on caregiver perceived burden, quality of life (QoL), and health status. Methods: Dyads of people with PD and their primary caregivers were identified from the Adelphi Parkinson's Disease Specific Program (DSP™) using real-world data from the United States, Japan and five European countries. Questionnaires were used to capture measures of clinical burden (people with PD) and caregiver burden (caregivers). Results: Data from 721 patient-caregiver dyads in seven countries were captured. Caregivers had a mean age 62.6 years, 71.6% were female, and 70.4% were a spouse. Caregivers for people with APD had a greater perceived burden, were more likely to take medication and had lower caregiver treatment satisfaction than those caring for people with early or intermediate PD; similar findings were observed for caregivers of people with intermediate versus early PD. Caregivers for people with intermediate PD were also less likely to be employed than those with early PD (25.3% vs 42.4%) and spent more time caring (6.6 vs 3.2 h/day). Conclusions: This real-world study demonstrates that caregivers of people with APD experience a greater burden than those caring for people with early PD. This highlights the importance of including caregiver-centric measures in future studies, and emphasizes the need for implementing treatments that reduce caregiver burden in APD. Trial registration: N/A. [ABSTRACT FROM AUTHOR]
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- 2023
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7. Incidence of hypertension in young transgender people after a 5-year follow-up: association with gender-affirming hormonal therapy.
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Martinez-Martin, Francisco Javier, Kuzior, Agnieszka, Hernandez-Lazaro, Alba, de Leon-Durango, Ricardo Jose, Rios-Gomez, Carlos, Santana-Ojeda, Borja, Perez-Rivero, Jennifer Maria, Fernandez-Trujillo-Comenge, Paula Maria, Gonzalez-Diaz, Paula, Arnas-Leon, Claudia, Acosta-Calero, Carmen, Perdomo-Herrera, Esperanza, Tocino-Hernandez, Alba Lucia, del Sol Sanchez-Bacaicoa, Maria, and del Pino Perez-Garcia, Maria
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- 2023
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8. High risk of developing dementia in Parkinson's disease: a Swedish registry-based study.
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Åström, Daniel Oudin, Simonsen, Jacob, Raket, Lars Lau, Sgarbi, Simona, Hellsten, Johan, Hagell, Peter, Norlin, Jenny M., Kellerborg, Klas, Martinez-Martin, Pablo, and Odin, Per
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PARKINSON'S disease ,DISEASE risk factors ,PROPORTIONAL hazards models - Abstract
Dementia have substantial negative impact on the affected individual, their care partners and society. Persons living with Parkinson's disease (PwP) are also to a large extent living with dementia. The aim of this study is to estimate time to dementia in PD using data from a large quality register with access to baseline clinical and patient reported data merged with Swedish national health registries. Persons with Parkinson's disease in the Swedish Neuro Registries/Parkinson's Disease Swedish PD Registry (PARKreg) in Sweden were included and linked to national health registries and matched by sex and age to controls without PD. Time to dementia was analysed with Cox regression models assuming proportional hazards, with time since diagnosis as the underlying time variable. In this large prospective cohort study, PwP had approximately four times higher risk of developing dementia as compared to age and sex-matched controls, a finding which remained after adjusting for potential confounders. The present results underline the high risk of dementia in PD and further emphasize the importance of developing symptomatic and ultimately disease modifying strategies to counteract this part of the non-motor symptomatology in PD. [ABSTRACT FROM AUTHOR]
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- 2022
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9. Cell-based receptor discovery identifies host factors specifically targeted by the SARS CoV-2 spike.
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Husain, Bushra, Yuen, Kobe, Sun, Dawei, Cao, Shengya, Payandeh, Jian, and Martinez-Martin, Nadia
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SARS-CoV-2 ,PROTEIN microarrays ,COVID-19 ,VIRUS diseases ,CELL membranes ,PLASMA interactions ,LIGAND binding (Biochemistry) ,OLFACTORY receptors - Abstract
Receptor-ligand interactions on the plasma membrane regulate cellular communication and play a key role in viral infection. Despite representing main targets for drug development, the characterization of these interactions remains challenging in part due to the dearth of optimal technologies. Here, we build a comprehensive library of human proteins engineered for controlled cell surface expression. Coupled to tetramer-based screening for increased binding avidity, we develop a high throughput cell-based platform that enables systematic interrogation of receptor-ligand interactomes. Using this technology, we characterize the cell surface proteins targeted by the receptor binding domain (RBD) of the SARS-CoV spike protein. Host factors that specifically bind to SARS CoV-2 but not SARS CoV RBD are identified, including proteins that are expressed in the nervous system or olfactory epithelium. Remarkably, our results show that Contactin-1, a previously unknown SARS CoV-2 spike-specific receptor that is upregulated in COVID-19 patients, significantly enhances ACE2-dependent pseudotyped virus infection. Starting from a versatile platform to characterize cell surface interactomes, this study uncovers host factors specifically targeted by SARS CoV-2, information that may help design improved therapeutic strategies against COVID-19. A high-throughput cell-based platform is developed for systematic investigation of receptor-ligand interactions and applied to identify cell-surface proteins that bind to SARS CoV-2. [ABSTRACT FROM AUTHOR]
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- 2022
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10. EVA: EVAluating at-home rehabilitation exercises using augmented reality and low-cost sensors
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Ester Martinez-Martin, Francisco Gomez-Donoso, Miguel Cazorla, Felix Escalona, Edmanuel Cruz, Universidad de Alicante. Departamento de Ciencia de la Computación e Inteligencia Artificial, Universidad de Alicante. Instituto Universitario de Investigación Informática, and Robótica y Visión Tridimensional (RoViT)
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Computer science ,medicine.medical_treatment ,02 engineering and technology ,Augmented reality ,Virtual reality ,Home rehabilitation ,Computer graphics ,Human–computer interaction ,Social needs ,0202 electrical engineering, electronic engineering, information engineering ,medicine ,0501 psychology and cognitive sciences ,Low-cost sensors ,050107 human factors ,Rehabilitation ,business.industry ,Deep learning ,05 social sciences ,020207 software engineering ,Ciencia de la Computación e Inteligencia Artificial ,Computer Graphics and Computer-Aided Design ,Human-computer interaction ,Visualization ,Human-Computer Interaction ,3D visualization ,Rehabilitation exercises ,Artificial intelligence ,business ,Software - Abstract
Over one billion people in the world live with some form of disability. This is incessantly increasing due to aging population and chronic diseases. Among the emerging social needs, rehabilitation services are the most required. However, they are scarce and expensive what considerably limits access to them. In this paper, we propose EVA, an augmented reality platform to engage and supervise rehabilitation sessions at home using low-cost sensors. It also stores the user’s statistics and allows therapists to tailor the exercise programs according to their performance. This system has been evaluated in both qualitative and quantitative ways obtaining very promising results. This work has been supported by the Spanish Government TIN2016-76515R Grant, supported with Feder funds. Edmanuel Cruz is funded by a Panamenian grant for Ph.D. studies IFARHU and SENACYT 270-2016-207. This work has also been supported by a Spanish grant for PhD studies ACIF/2017/243 and FPU16/00887. Thanks also to Nvidia for the generous donation of a Titan Xp and a Quadro P6000.
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- 2020
11. High-resolution mass measurements of single budding yeast reveal linear growth segments.
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Cuny, Andreas P., Tanuj Sapra, K., Martinez-Martin, David, Fläschner, Gotthold, Adams, Jonathan D., Martin, Sascha, Gerber, Christoph, Rudolf, Fabian, and Müller, Daniel J.
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MASS measurement ,CELLULAR control mechanisms ,YEAST ,CELL morphology ,CELL cycle ,YEAST culture - Abstract
The regulation of cell growth has fundamental physiological, biotechnological and medical implications. However, methods that can continuously monitor individual cells at sufficient mass and time resolution hardly exist. Particularly, detecting the mass of individual microbial cells, which are much smaller than mammalian cells, remains challenging. Here, we modify a previously described cell balance ('picobalance') to monitor the proliferation of single cells of the budding yeast, Saccharomyces cerevisiae, under culture conditions in real time. Combined with optical microscopy to monitor the yeast morphology and cell cycle phase, the picobalance approaches a total mass resolution of 0.45 pg. Our results show that single budding yeast cells (S/G2/M phase) increase total mass in multiple linear segments sequentially, switching their growth rates. The growth rates weakly correlate with the cell mass of the growth segments, and the duration of each growth segment correlates negatively with cell mass. We envision that our technology will be useful for direct, accurate monitoring of the growth of single cells throughout their cycle. Measuring the mass of individual microbial cells remains challenging. Here, the authors present a cell balance to monitor the proliferation of single budding yeast cells under culture conditions in real time, showing that single cells increase total mass in multiple linear segments of constant growth rates. [ABSTRACT FROM AUTHOR]
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- 2022
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12. Gender gap in deep brain stimulation for Parkinson's disease.
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Jost, Stefanie T., Strobel, Lena, Rizos, Alexandra, Loehrer, Philipp A., Ashkan, Keyoumars, Evans, Julian, Rosenkranz, Franz, Barbe, Michael T., Fink, Gereon R., Franklin, Jeremy, Sauerbier, Anna, Nimsky, Christopher, Sattari, Afsar, Ray Chaudhuri, K., Antonini, Angelo, Timmermann, Lars, Martinez-Martin, Pablo, Silverdale, Monty, Kalbe, Elke, and Visser-Vandewalle, Veerle
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- 2022
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13. CCAAT/enhancer binding protein δ is a transcriptional repressor of α-synuclein
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Edurne Gallastegui, Josep Saura, Carla Domuro, Oriol Bachs, Mario Ezquerra, Carme Solà, María-José Martí, Leonardo Márquez-Kisinousky, Tony Valente, Guido Dentesano, Marco Straccia, Jonatan Martinez-Martin, Yaroslau Compta, Rubén Fernández-Santiago, Instituto de Salud Carlos III, European Commission, Fernández-Santiago, Rubén, and Fernández-Santiago, Rubén [0000-0002-4582-0702]
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0301 basic medicine ,CCAAT-Enhancer-Binding Protein-delta ,Male ,Repressor ,Substantia nigra ,Article ,03 medical and health sciences ,Mice ,0302 clinical medicine ,Transcription (biology) ,Enhancer binding ,Animals ,Humans ,Molecular Biology ,Transcription factor ,Cells, Cultured ,Aged ,Synucleinopathies ,Mice, Knockout ,Messenger RNA ,Ccaat-enhancer-binding proteins ,Chemistry ,Cell Biology ,Molecular biology ,Mice, Inbred C57BL ,030104 developmental biology ,030220 oncology & carcinogenesis ,alpha-Synuclein ,Female ,Neurological disorders ,Neuroscience - Abstract
α-Synuclein is the main component of Lewy bodies, the intracellular protein aggregates representing the histological hallmark of Parkinson’s disease. Elevated α-synuclein levels and mutations in SNCA gene are associated with increased risk for Parkinson’s disease. Despite this, little is known about the molecular mechanisms regulating SNCA transcription. CCAAT/enhancer binding protein (C/EBP) β and δ are b-zip transcription factors that play distinct roles in neurons and glial cells. C/EBPβ overexpression increases SNCA expression in neuroblastoma cells and putative C/EBPβ and δ binding sites are present in the SNCA genomic region suggesting that these proteins could regulate SNCA transcription. Based on these premises, the goal of this study was to determine if C/EBPβ and δ regulate the expression of SNCA. We first observed that α-synuclein CNS expression was not affected by C/EBPβ deficiency but it was markedly increased in C/EBPδ-deficient mice. This prompted us to characterize further the role of C/EBPδ in SNCA transcription. C/EBPδ absence led to the in vivo increase of α-synuclein in all brain regions analyzed, both at mRNA and protein level, and in primary neuronal cultures. In agreement with this, CEBPD overexpression in neuroblastoma cells and in primary neuronal cultures markedly reduced SNCA expression. ChIP experiments demonstrated C/EBPδ binding to the SNCA genomic region of mice and humans and luciferase experiments showed decreased expression of a reporter gene attributable to C/EBPδ binding to the SNCA promoter. Finally, decreased CEBPD expression was observed in the substantia nigra and in iPSC-derived dopaminergic neurons from Parkinson patients resulting in a significant negative correlation between SNCA and CEBPD levels. This study points to C/EBPδ as an important repressor of SNCA transcription and suggests that reduced C/EBPδ neuronal levels could be a pathogenic factor in Parkinson’s disease and other synucleinopathies and C/EBPδ activity a potential pharmacological target for these neurological disorders., This study was supported by grants PI10/378, PI12/709, and PI14/302 from the Instituto de Salud Carlos III, Spain, cofinanced with FEDER funds.
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- 2020
14. Impact of age at onset on symptom profiles, treatment characteristics and health-related quality of life in Parkinson's disease.
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Raket, Lars Lau, Oudin Åström, Daniel, Norlin, Jenny M., Kellerborg, Klas, Martinez-Martin, Pablo, and Odin, Per
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PARKINSON'S disease ,AGE of onset ,QUALITY of life ,DEEP brain stimulation ,PATERNAL age effect ,DISEASE progression ,SYMPTOMS - Abstract
Parkinson's disease (PD) is typically considered an age-related disease, but the age at disease onset can vary by decades between patients. Aging and aging-associated diseases can affect the movement system independently of PD, and advanced age has previously been proposed to be associated with a more severe PD phenotype with accelerated progression. In this work, we investigated how interactions between PD progression and aging affect a wide range of outcomes related to PD motor and nonmotor symptoms as well as Health Related Quality of Life (HRQoL) and treatment characteristics. This population-based cohort study is based on 1436 PD patients from southern Sweden followed longitudinally for up to approximately 7.5 years from enrollment (3470 visits covering 2285 patient years, average follow-up time 1.7 years). Higher age at onset was generally associated with faster progression of motor symptoms, with a notable exception of dyskinesia and other levodopa-associated motor fluctuations that had less severe trajectories for patients with higher age at onset. Mixed results were observed for emergence of non-motor symptoms, while higher age at onset was generally associated with worse HRQoL trajectories. Accounting for these identified age-associated differences in disease progression could positively impact patient management and drug development efforts. [ABSTRACT FROM AUTHOR]
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- 2022
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15. Identifying Parkinson's disease subtypes with motor and non-motor symptoms via model-based multi-partition clustering.
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Rodriguez-Sanchez, Fernando, Rodriguez-Blazquez, Carmen, Bielza, Concha, Larrañaga, Pedro, Weintraub, Daniel, Martinez-Martin, Pablo, Rizos, Alexandra, Schrag, Anette, and Chaudhuri, K. Ray
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PARKINSON'S disease ,SYMPTOMS ,HYPERHIDROSIS ,PERSPIRATION ,DYSAUTONOMIA ,AGE of onset ,DISEASE duration - Abstract
Identification of Parkinson's disease subtypes may help understand underlying disease mechanisms and provide personalized management. Although clustering methods have been previously used for subtyping, they have reported generic subtypes of limited relevance in real life practice because patients do not always fit into a single category. The aim of this study was to identify new subtypes assuming that patients could be grouped differently according to certain sets of related symptoms. To this purpose, a novel model-based multi-partition clustering method was applied on data from an international, multi-center, cross-sectional study of 402 Parkinson's disease patients. Both motor and non-motor symptoms were considered. As a result, eight sets of related symptoms were identified. Each of them provided a different way to group patients: impulse control issues, overall non-motor symptoms, presence of dyskinesias and pyschosis, fatigue, axial symptoms and motor fluctuations, autonomic dysfunction, depression, and excessive sweating. Each of these groups could be seen as a subtype of the disease. Significant differences between subtypes (P< 0.01) were found in sex, age, age of onset, disease duration, Hoehn & Yahr stage, and treatment. Independent confirmation of these results could have implications for the clinical management of Parkinson's disease patients. [ABSTRACT FROM AUTHOR]
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- 2021
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16. Muscle Assessment by Ultrasonography: Agreement with Dual-Energy X-Ray Absorptiometry (DXA) and Relationship with Physical Performance.
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Neira Álvarez, M., Vázquez Ronda, Miguel A., Soler Rangel, L., Thuissard-Vasallo, I. J., Andreu-Vazquez, C., Martinez Martin, P., Rábago Lorite, I., and San Martín, G. Serralta
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WALKING speed ,GRIP strength ,SKELETAL muscle ,PHOTON absorptiometry ,PREDICTIVE tests ,ANTHROPOMETRY ,GAIT in humans ,LEAN body mass ,SARCOPENIA ,FUNCTIONAL assessment ,MUSCLE strength ,BODY movement ,CALF muscles ,QUADRICEPS muscle ,DESCRIPTIVE statistics - Abstract
Background: Different methods have been proposed to study skeletal muscle mass in sarcopenia diagnosis, although all have inherent drawbacks. The aim of this study was to evaluate the utility of muscle ultrasound in muscle assessment by studying its correlation with dual-energy x-ray absorptiometry (DXA) and calf circumference (CC), cut-off values for ultrasound-based detection of low muscle mass, and the correlation with muscle performance. Methods: Fifty-seven participants older than 70 years, underwent a muscle ultrasound study, DXA, calf circumference (CC) and functional assessment. Ultrasound measurements were taken in the femoral quadriceps (transverse plane) and in the medial gastrocnemius (transverse and longitudinal planes). Muscle function was assessed by gait speed, Short Physical Performance Battery (SPPB) and grip strength. Results: Median age was 78.9 years (IQR 74.9–81.9), and 33 were women (57.9%). We found good correlation between muscle thickness of gastrocnemius muscle in transverse and longitudinal plane and appendicular lean mass measured by DXA (r=0.546 and r=0.689 respectively) and good correlations between muscle thickness of gastrocnemius in transverse and longitudinal plane with CC (r=0.651 and r=0.447 respectively). The thickness of gastrocnemius medialis optimal cut-off points for low muscle mass were 18,5mm in the transverse plane (Sensitivity: 77,8%, Specificity: 77,1%), and 17.3mm in the longitudinal plane (Sensitivity: 100%, Specificity: 68.8%). Muscle thickness was also significantly correlated with gait speed, SPPB and grip strength. Conclusions: Measures of gastrocnemius medialis thickness obtained by ultrasound are reliable and correlate well with DXA and CC values and muscle performance. [ABSTRACT FROM AUTHOR]
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- 2021
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17. Non-motor predictors of 36-month quality of life after subthalamic stimulation in Parkinson disease.
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Jost, Stefanie T., Visser-Vandewalle, Veerle, Rizos, Alexandra, Loehrer, Philipp A., Silverdale, Monty, Evans, Julian, Samuel, Michael, Petry-Schmelzer, Jan Niklas, Sauerbier, Anna, Gronostay, Alexandra, Barbe, Michael T., Fink, Gereon R., Ashkan, Keyoumars, Antonini, Angelo, Martinez-Martin, Pablo, Chaudhuri, K. Ray, Timmermann, Lars, Dafsari, Haidar S., EUROPAR and the International Parkinson and Movement Disorders Society Non-Motor Parkinson's Disease Study Group, and Bhidayasiri, Roongroj
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- 2021
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18. Rheology of rounded mammalian cells over continuous high-frequencies.
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Fläschner, Gotthold, Roman, Cosmin I., Strohmeyer, Nico, Martinez-Martin, David, and Müller, Daniel J.
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RHEOLOGY ,OPTICAL measurements ,CELL size ,CELL morphology ,CHEMICAL kinetics - Abstract
Understanding the viscoelastic properties of living cells and their relation to cell state and morphology remains challenging. Low-frequency mechanical perturbations have contributed considerably to the understanding, yet higher frequencies promise to elucidate the link between cellular and molecular properties, such as polymer relaxation and monomer reaction kinetics. Here, we introduce an assay, that uses an actuated microcantilever to confine a single, rounded cell on a second microcantilever, which measures the cell mechanical response across a continuous frequency range ≈ 1–40 kHz. Cell mass measurements and optical microscopy are co-implemented. The fast, high-frequency measurements are applied to rheologically monitor cellular stiffening. We find that the rheology of rounded HeLa cells obeys a cytoskeleton-dependent power-law, similar to spread cells. Cell size and viscoelasticity are uncorrelated, which contrasts an assumption based on the Laplace law. Together with the presented theory of mechanical de-embedding, our assay is generally applicable to other rheological experiments. While rheology studies have contributed to the understanding of the viscoelastic properties of living cells, the use of higher frequencies promises elucidate the link between cellular and molecular properties. Here authors introduce a rheological assay that measures the cell mechanical response across a continuous frequency range ≈ 1 – 40 kHz. [ABSTRACT FROM AUTHOR]
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- 2021
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19. Control of oviductal fluid flow by the G-protein coupled receptor Adgrd1 is essential for murine embryo transit.
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Bianchi, Enrica, Sun, Yi, Almansa-Ordonez, Alexandra, Woods, Michael, Goulding, David, Martinez-Martin, Nadia, and Wright, Gavin J.
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G protein coupled receptors ,FLUID flow ,FLUID control ,FALLOPIAN tubes ,ORPHANS ,EMBRYOS ,ECTOPIC pregnancy - Abstract
Dysfunction of embryo transport causes ectopic pregnancy which affects approximately 2% of conceptions in the US and Europe, and is the most common cause of pregnancy-related death in the first trimester. Embryo transit involves a valve-like tubal-locking phenomenon that temporarily arrests oocytes at the ampullary-isthmic junction (AIJ) where fertilisation occurs, but the mechanisms involved are unknown. Here we show that female mice lacking the orphan adhesion G-protein coupled receptor Adgrd1 are sterile because they do not relieve the AIJ restraining mechanism, inappropriately retaining embryos within the oviduct. Adgrd1 is expressed on the oviductal epithelium and the post-ovulatory attenuation of tubal fluid flow is dysregulated in Adgrd1-deficient mice. Using a large-scale extracellular protein interaction screen, we identified Plxdc2 as an activating ligand for Adgrd1 displayed on cumulus cells. Our findings demonstrate that regulating oviductal fluid flow by Adgrd1 controls embryo transit and we present a model where embryo arrest at the AIJ is due to the balance of abovarial ciliary action and the force of adovarial tubal fluid flow, and in wild-type oviducts, fluid flow is gradually attenuated through Adgrd1 activation to enable embryo release. Our findings provide important insights into the molecular mechanisms involved in embryo transport in mice. Lack of correct embryo transport can cause ectopic pregnancy. Here, the authors show that female mice lacking the adhesion G-protein coupled receptor Adgrd1 are infertile, due to embryos being trapped in the ampulla as the result of dysregulated oviductal fluid flow. [ABSTRACT FROM AUTHOR]
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- 2021
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20. Research priorities for COVID-19 sensor technology.
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Tong, Allison, Sorrell, Tania C., Black, Andrew J., Caillaud, Corinne, Chrzanowski, Wojciech, Li, Eugena, Martinez-Martin, David, McEwan, Alistair, Wang, Rex, Motion, Alice, Bedoya, Alvaro Casas, Huang, Jun, Azizi, Lamiae, Eggleton, Benjamin J., The COVID-19 Sensor Research Priority-Setting Investigators, Al-Horani, Sarah, Andersen, Tomas, Aggett, Rodney, Baillie, Andrew, and Barratt, Alexandra
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- 2021
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21. Drooling in Parkinson's Disease: Prevalence and Progression from the Non-motor International Longitudinal Study.
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van Wamelen, Daniel J., Leta, Valentina, Johnson, Julia, Ocampo, Claudia Lazcano, Podlewska, Aleksandra M., Rukavina, Katarina, Rizos, Alexandra, Martinez-Martin, Pablo, and Chaudhuri, K. Ray
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Sialorrhoea in Parkinson's disease (PD) is an often neglected yet key non-motor symptom with impact on patient quality of life. However, previous studies have shown a broad range of prevalence figures. To assess prevalence of drooling in PD and its relationship to quality of life, we performed a retrospective analysis of 728 consecutive PD patients who had a baseline and follow-up assessment as part of the Non-motor International Longitudinal Study (NILS), and for whom drooling presence and severity were available, assessed through the Non-Motor Symptoms Scale (NMSS). In addition, we analysed the prevalence of associated dysphagia through self-reported outcomes. Quality of life was assessed through the PDQ-8 scale. Baseline (disease duration 5.6 years) prevalence of drooling was 37.2% (score ≥ 1 NMSS question 19), and after 3.27 ± 1.74 years follow-up, this was 40.1% (p = 0.17). The prevalence of drooling increased with age (p < 0.001). The severity of drooling, however, did not change (p = 0.12). While in 456 patients without drooling at baseline, only 16% (n = 73) had dysphagia (question 20 of the NMSS), in those with drooling this was 34.3% (p < 0.001). At follow-up, the number of patients with dysphagia had increased, 20.4% with no drooling had dysphagia, and 43.6% with drooling had dysphagia. Both at baseline and follow-up, drooling severity was significantly positively associated with quality of life (PDQ-8; r = 0.199; p < 0.001). In moderately advanced PD patients, subjective drooling occurs in over one-third of patients and was significantly associated with decreased quality of life. Dysphagia occurred significantly more often in patients with drooling. [ABSTRACT FROM AUTHOR]
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- 2020
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22. EVA: EVAluating at-home rehabilitation exercises using augmented reality and low-cost sensors.
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Escalona, Felix, Martinez-Martin, Ester, Cruz, Edmanuel, Cazorla, Miguel, and Gomez-Donoso, Francisco
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EXERCISE ,HOME rehabilitation ,AUGMENTED reality ,DETECTORS ,POPULATION aging ,CHRONIC diseases - Abstract
Over one billion people in the world live with some form of disability. This is incessantly increasing due to aging population and chronic diseases. Among the emerging social needs, rehabilitation services are the most required. However, they are scarce and expensive what considerably limits access to them. In this paper, we propose EVA, an augmented reality platform to engage and supervise rehabilitation sessions at home using low-cost sensors. It also stores the user's statistics and allows therapists to tailor the exercise programs according to their performance. This system has been evaluated in both qualitative and quantitative ways obtaining very promising results. [ABSTRACT FROM AUTHOR]
- Published
- 2020
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23. Imaging modes of atomic force microscopy for application in molecular and cell biology
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Andreas Engel, Daniel J. Müller, Christoph Gerber, David Martinez-Martin, David Alsteens, Yves F. Dufrêne, Toshio Ando, Ricardo Garcia, National Fund for Scientific Research (Belgium), European Research Council, Belgian Science Policy Office, Swiss National Science Foundation, University of Basel, Université Catholique de Louvain, Walloon Excellence in Life Sciences and BIOtechnology, Communauté Française de Belgique, EMBO, Ministerio de Economía y Competitividad (España), Japan Society for the Promotion of Science, and Japan Science and Technology Agency
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0301 basic medicine ,Computer science ,Atomic force microscopy ,Cytological Techniques ,Biomedical Engineering ,Bioengineering ,Nanotechnology ,Cell Biology ,02 engineering and technology ,Microscopy, Atomic Force ,021001 nanoscience & nanotechnology ,Condensed Matter Physics ,Atomic and Molecular Physics, and Optics ,03 medical and health sciences ,030104 developmental biology ,Animals ,Humans ,General Materials Science ,Electrical and Electronic Engineering ,0210 nano-technology ,Molecular Biology - Abstract
Atomic force microscopy (AFM) is a powerful, multifunctional imaging platform that allows biological samples, from single molecules to living cells, to be visualized and manipulated. Soon after the instrument was invented, it was recognized that in order to maximize the opportunities of AFM imaging in biology, various technological developments would be required to address certain limitations of the method. This has led to the creation of a range of new imaging modes, which continue to push the capabilities of the technique today. Here, we review the basic principles, advantages and limitations of the most common AFM bioimaging modes, including the popular contact and dynamic modes, as well as recently developed modes such as multiparametric, molecular recognition, multifrequency and high-speed imaging. For each of these modes, we discuss recent experiments that highlight their unique capabilities., Y.F.D. was supported by the Université catholique de Louvain, the European Research Council (ERC) under the European Union's Horizon 2020 research and innovation programme (grant agreement no. 693630), the WELBIO (grant no. WELBIO-CR-2015A-05), the National Fund for Scientific Research (FNRS), the Federal Office for Scientific, Technical and Cultural Affairs (Interuniversity Poles of Attraction Programme) and the Research Department of the Communauté française de Belgique (Concerted Research Action). D.A. and D.M.M. were supported by the European Molecular Biology Organization (EMBO; ALTF 265-2013 and ALTF 506-2012). D.J.M. was supported by the Swiss National Science Foundation (SNF; grants 205320_160199 and 310030B_160225), the NCCR Molecular Systems Engineering and the Swiss Commission for Technology and Innovation (CTI; grant 17970.1). C.G. was supported by the Swiss Nano Institute (SNI) of the University of Basel. R.G. acknowledges financial support from the European Research Council AdG no. 340177 and the Ministerio de Economia y Competitividad MAT2016-76507-R. T.A. was supported by the Japan Society for the Promotion of Science (JSPS; grants 24227005 and 26119003) and by the Japan Science and Technology Agency (JST; CREST program on Structural Life Science and Advanced Core Technology for Innovative Life Science Research).
- Published
- 2017
24. Dry Reforming of Methane over Ni–Al2O3 and Ni–SiO2 Catalysts: Role of Preparation Methods.
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Dekkar, S., Tezkratt, S., Sellam, D., Ikkour, K., Parkhomenko, K., Martinez-Martin, A., and Roger, A. C.
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NICKEL catalysts ,MICROEMULSIONS ,SYNTHESIS gas ,CHEMICAL stability ,CATALYSTS ,BASE catalysts ,CATALYTIC activity - Abstract
The production of synthesis gas via the conversion of the two greenhouse gases CO
2 and CH4 is an efficient process due to its dual industrial and environmental interest. The catalysts based on Ni–SiO2 and Ni–Al2 O3 are typical and suitable for this reaction due to their mechanical strength, their good chemical and thermal stability in addition to their low cost and good availability. In this work, we have compared the catalytic performances of these two types of catalysts prepared by two different synthesis methods in dry reforming of methane (DRM).The results indicate that the catalytic performances are much more dependent on the support properties and that they are deeply influenced by the catalyst synthesis method. The textural properties as shown by N2 -physisorption analysis are strongly dependent on the support nature in the case of the catalysts prepared by the microemulsion (ME) method and the alumina-based Ni catalyst has a higher specific surface area and a higher pore volume compared to the SiO2 based one. The XRD, H2 -TPR and XPS results indicate that the preparation method has a significant influence on the state of NiO species. A Ni particle in the two Ni–SiO2 –ME and Ni–Al2 O3 –ME catalysts prepared by microemulsion is much smaller. The strong metal support interaction promotes the formation of NiAl2 O4 and Ni2 SiO4 species respectively during the catalyst preparation process and makes the reduction of corresponding catalysts very difficult which may lead to a decrease in the content of active Ni species and give the Ni–Al2 O3 –ME catalyst a relatively low catalytic activity in DRM, especially when it is reduced under unfavorable conditions as is the case in this work. However, the strong metal support interaction between Ni and the support is also of beneficial to the formation and stabilization of small Ni particles well dispersed on the support after reduction of the Ni–SiO2 –ME catalyst. In this system, the sintering and the carbon deposition are inhibited and the catalyst presents both better activity and stability. The Ni/Al2 O3 catalyst exhibits a synergistic effect between the various phases NiO and NiAl2 O4 formed during the synthesis process due to the different interactions strength between metal and support, which are in favor of the dispersion and stabilization of NiO species. As a result, Ni/Al2 O3 provided with both proper textural properties and this synergistic effect, exhibits superior catalytic performances in term of activity, selectivity and stability in DRM. Despite the formation of carbon over this catalyst, it maintains its stability during a long-term test of more than 66 hours. This is due to the formation of active type of carbon and the delocalization of the Ni active sites on the latter to maintain their activity. [ABSTRACT FROM AUTHOR]- Published
- 2020
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25. Tolerability of non-ergot oral and transdermal dopamine agonists in younger and older Parkinson's disease patients: an European multicentre survey.
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Rizos, A., Sauerbier, A., Falup-Pecurariu, C., Odin, P., Antonini, A., Martinez-Martin, P., Kessel, B., Henriksen, T., Silverdale, M., Durner, G., and Ray Chaudhuri, K.
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PARKINSON'S disease ,DOPAMINE agonists ,OLDER patients ,DISEASE duration - Abstract
In older patients with Parkinson's disease (PD), the use of dopamine agonists (DA) has been limited due to uncertainties related to their tolerability in spite of potential gains with the advent of longer acting or transdermal therapies. Comparative real-life data addressing the tolerability of DA therapy across age ranges are currently sparse. This study addressed the tolerability (Shulman criteria, continued intake of DA therapy for at least 6 months) in PD patients across several European centres treated with long-acting and transdermal DA (Rotigotine skin patch, Ropinirole extended release, or Pramipexole prolonged release) as part of routine clinical care in younger and older PD patients. A medical record-based retrospective data capture and clinical interview-based follow-up survey of patients initiating or initiated on DA treatment (short and long acting) in a real-life setting. 425 cases were included [mean age 68.3 years (range 37–90), mean duration of disease 7.5 years (range 0–37), 31.5% older age (≥ 75 years of age)]. Tolerability was above 90% irrespective of age, with no significant differences between younger and older patients. Based on our findings, we suggest that long-acting/transdermal DA are tolerated in non-demented older patients, as well as in younger patients, however, with lower daily dose in older patients. [ABSTRACT FROM AUTHOR]
- Published
- 2020
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26. Beneficial effect of 24-month bilateral subthalamic stimulation on quality of sleep in Parkinson's disease.
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Dafsari, Haidar S., Ray-Chaudhuri, K., Ashkan, Keyoumars, Sachse, Lena, Mahlstedt, Picabo, Silverdale, Monty, Rizos, Alexandra, Strack, Marian, Jost, Stefanie T., Reker, Paul, Samuel, Michael, Visser-Vandewalle, Veerle, Evans, Julian, Antonini, Angelo, Martinez-Martin, Pablo, Timmermann, Lars, EUROPAR, the IPMDS Non Motor P.D. Study Group, Ray-Chaudhuri, Kallol, Schrag, Anette, and Weintraub, Daniel
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SUBTHALAMIC nucleus ,PARKINSON'S disease ,DEEP brain stimulation ,SLEEP ,BRAIN stimulation - Abstract
Background: Subthalamic nucleus (STN) deep brain stimulation (DBS) improves quality of life (QoL), motor, and sleep symptoms in Parkinson's disease (PD). However, the long-term effects of STN-DBS on sleep and its relationship with QoL outcome are unclear. Methods: In this prospective, observational, multicenter study including 73 PD patients undergoing bilateral STN-DBS, we examined PDSleep Scale (PDSS), PDQuestionnaire-8 (PDQ-8), Scales for Outcomes in PD-motor examination, -activities of daily living, and -complications (SCOPA-A, -B, -C), and levodopa-equivalent daily dose (LEDD) preoperatively, at 5 and 24 months follow-up. Longitudinal changes were analyzed with Friedman-tests or repeated-measures ANOVA, when parametric tests were applicable, and Bonferroni-correction for multiple comparisons. Post-hoc, visits were compared with Wilcoxon signed-rank/t-tests. The magnitude of clinical responses was investigated using effect size. Results: Significant beneficial effects of STN-DBS were observed for PDSS, PDQ-8, SCOPA-A, -B, and -C. All outcomes improved significantly at 5 months with subsequent decrements in gains at 24 months follow-up which were significant for PDSS, PDQ-8, and SCOPA-B. Comparing baseline and 24 months follow-up, we observed significant improvements of PDSS (small effect), SCOPA-A (moderate effect), -C, and LEDD (large effects). PDSS and PDQ-8 improvements correlated significantly at 5 and 24 months follow-up. Conclusions: In this multicenter study with a 24 months follow-up, we report significant sustained improvements after bilateral STN-DBS using a PD-specific sleep scale and a significant relationship between sleep and QoL improvements. This highlights the importance of sleep in holistic assessments of DBS outcomes. [ABSTRACT FROM AUTHOR]
- Published
- 2020
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27. Dementia in long-term Parkinson's disease patients: a multicentre retrospective study.
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Szeto, Jennifer Y. Y., Walton, Courtney C., Rizos, Alexandra, Martinez-Martin, Pablo, Halliday, Glenda M., Naismith, Sharon L., Chaudhuri, K. Ray, and Lewis, Simon J. G.
- Published
- 2020
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28. Discussing sexuality with Parkinson's disease patients: a multinational survey among neurologists.
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de Rooy, F. B. B., Buhmann, C., Schönwald, B., Martinez-Martin, P., Rodriguez-Blazquez, C., Putter, H., Elzevier, H. W., and van der Plas, A. A.
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PARKINSON'S disease ,NEUROLOGISTS ,PATIENT surveys ,SEXUAL dysfunction ,CROSS-cultural differences - Abstract
Sexual dysfunction is a major non-motor feature of Parkinson's disease (PD) that may affect the quality of life of many patients. In a Dutch survey, we demonstrated that neurologists often fail to discuss sexuality with their patients. Our objective was to determine to which extent neurologists in Spain and Germany address sexuality with their patients and whether cross-cultural differences exist. A 30-item questionnaire was sent out to 1650 German and 460 Spanish neurologists. The questionnaire addressed attitudes, knowledge, barriers, and feelings of responsibility regarding sexuality in PD. 160 German and 32 Spanish respondents completed and returned the questionnaire. The majority of German and Spanish participants discuss sexual dysfunction 'regularly' with male patients (61.7% and 78.9%, respectively), but 'seldom' with female patients (68.8% and 78.1%, respectively). Important barriers for German and Spanish respondents to discuss sexual dysfunction were patients not expressing sexual complaints spontaneously (52.9% and 75.0%, respectively) and insufficient consultation time (32.2% and 71.9%, respectively). Sexual dysfunction in PD was considered important by 68.3% of German and 96.9% of Spanish participants. German and Spanish neurologists do not routinely discuss sexual dysfunction with their patients, although many of them consider it important to address this topic. It is unclear why this lack of discussing sexual dysfunction is especially found for female patients and whether cultural aspects are involved. We recommend a self-assessment tool for patients to track their symptoms prior to consultation visits and advocate local guidelines that formulate who is responsible for discussing sexual dysfunction. [ABSTRACT FROM AUTHOR]
- Published
- 2019
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29. Exploring hyperhidrosis and related thermoregulatory symptoms as a possible clinical identifier for the dysautonomic subtype of Parkinson's disease.
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van Wamelen, Daniel J., Leta, Valentina, Podlewska, Aleksandra M., Wan, Yi-Min, Krbot, Katarina, Jaakkola, Elina, Martinez-Martin, Pablo, Rizos, Alexandra, Parry, Miriam, Metta, Vinod, and Ray Chaudhuri, Kallol
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HYPERHIDROSIS ,PARKINSON'S disease ,RESTLESS legs syndrome ,SLEEP disorders - Abstract
Objective: To identify associated (non-)motor profiles of Parkinson's disease (PD) patients with hyperhidrosis as a dominant problem. Methods: This is a cross-sectional, exploratory, analysis of participants enrolled in the Non-motor Longitudinal International Study (NILS; UKCRN No: 10084) at the Parkinson's Centre at King's College Hospital (London, UK). Hyperhidrosis scores (yes/no) on question 28 of the Non-Motor Symptom Questionnaire were used to classify patients with normal sweat function (n = 172) and excessive sweating (n = 56) (Analysis 1; n = 228). NMS scale (NMSS) question 30 scores were used to stratify participants based on hyperhidrosis severity (Analysis 2; n = 352) using an arbitrary severity grading: absent score 0 (n = 267), mild 1–4 (n = 49), moderate 5–8 (n = 17), and severe 9–12 (n = 19). NMS burden, as well as PD sleep scale (PDSS) scores were then analysed along with other correlates. Results: No differences were observed in baseline demographics between groups in either analysis. Patients with hyperhidrosis exhibited significantly higher total NMSS burden compared to those without (p < 0.001). Secondary analyses revealed higher dyskinesia scores, worse quality of life and PDSS scores, and higher anxiety and depression levels in hyperhidrosis patients (p < 0.001). Tertiary analyses revealed higher NMSS item scores for fatigue, sleep initiation, restless legs, urinary urgency, and unexplained pain (p < 0.001). Conclusions: Chronic hyperhidrosis appears to be associated with a dysautonomia dominant subtype in PD patients, which is also associated with sleep disorders and a higher rate of dyskinesia (fluctuation-related hyperhidrosis). These data should prompt the concept of hyperhidrosis being used as a simple clinical screening tool to identify PD patients with autonomic symptoms. [ABSTRACT FROM AUTHOR]
- Published
- 2019
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30. Psychometric properties of the Berg balance scale in idiopathic Parkinson' disease in the drug off-phase.
- Author
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Taghizadeh, Ghorban, Martinez-Martin, Pablo, Fereshtehnejad, Seyed-Mohammad, Habibi, Seyed Amirhasan, Nikbakht, Negar, Alizadeh, Naeeme Haji, Salehi, Sheyda, and Mehdizadeh, Maryam
- Subjects
- *
PARKINSON'S disease , *ACCIDENTAL falls , *FUNCTIONAL assessment , *TEST validity , *TEST reliability , *COMMUNICATION , *POSTURAL balance , *PSYCHOMETRICS , *QUESTIONNAIRES , *SOCIAL skills , *ACTIVITIES of daily living , *SENSORY disorders , *SEVERITY of illness index , *DISEASE complications , *PSYCHOLOGY ,RESEARCH evaluation - Abstract
Background: Having an appropriate tool for assessment of the balance status during the drug off-phase in idiopathic Parkinson's disease (PD) is relevant for clinical and research settings. Our objective was to assess the clinimetric properties of the Berg balance scale (BBS) during drug off-phase in PD.Method: Balance of 98 PD patients (mean age ± SD, 59.19 ± 10.88 years) was evaluated with the BBS. Other assessments in the study included the Fall Efficacy Scale-International (FES-I), Functional Reach Test (FRT), Section II of the Unified Parkinson's Disease Rating Scale-3.0, Parkinson's Disease Questionnaire-39 (PDQ-39), and Schwab and England Activities of Daily Living Scale. All evaluations took place during the drug off-phase. Internal consistency and inter- and intra-rater reliability were evaluated by Cronbach's alpha coefficient and intraclass correlation coefficient, respectively. Dimensionality was explored by factor analysis. Discriminative validity was tested by comparing BBS score between PD patients with and without a history of falling.Results: Internal consistency was high (α = 0.98), as were intra- and inter-rater reliability (ICC = 0.98 and 0.95, respectively). Factor analysis identified only one dimension for the BBS, whose convergent validity with FES-I, FRT, and domain mobility of the PDQ-39 were moderate or high (rS = |0.60-0.74|). Correlation of BBS with functional scales and PDQ-39 Summary Index was moderate (rS = |0.45-0.62|). Finally, the BBS showed a moderate strength to discriminate between PD patients with and without a history of falling.Conclusion: Our study suggests that BBS has satisfactory internal consistency, reliability, and construct validity for measuring functional balance in people with PD during the drug off-phase. [ABSTRACT FROM AUTHOR]- Published
- 2018
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31. Improvement of impulse control disorders associated with levodopa-carbidopa intestinal gel treatment in advanced Parkinson’s disease.
- Author
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Catalan, Maria Jose, Molina-Arjona, Jose Antonio, Mir, Pablo, Cubo, Esther, Arbelo, Jose Matias, Martinez-Martin, Pablo, and On behalf of the EDIS Study Group
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PARKINSON'S disease treatment ,PARKINSON'S disease patients ,DOPA ,CARBIDOPA ,NEUROBEHAVIORAL disorders ,OBSESSIVE-compulsive disorder ,GASTROSTOMY ,THERAPEUTICS - Abstract
Impulse control behaviors are a frequent comorbidity for patients with Parkinson’s disease (PD). The objective of the present study was to evaluate the effectiveness levodopa-carbidopa intestinal gel (LCIG) therapy on impulse control disorders (ICDs) in patients with advanced PD. We conducted a multicenter, observational, and prospective (6 months follow-up) study that included consecutive PD patients assigned to LCIG through routine medical practice. Patients completed visits at baseline, 1, 3, and 6 months after percutaneous endoscopic gastrostomy procedure. The following outcomes were evaluated: presence and severity of ICDs and other neuropsychiatric disorders, sleep disturbances, patients’ quality of life, and caregivers’ burden. Sixty-two patients were included at baseline: mean age 72.2 years (SD ± 7.0), 42% women. Median duration of PD symptoms was 13.5 years (IQR 5.5-21.5) and median time with motor fluctuations was 5.0 years (IQR 1.0-9.0). Treatment with LCIG infusion was associated with progressive and significant improvements in ICDs symptoms over the study period (64.4% reduction in the Questionnaire for Impulsive-Compulsive Disorders in Parkinson’s disease—Rating Scale score). Psychotic and other neuropsychiatric symptoms were also significantly reduced, and patients’ sleep quality and psychosocial function improved. Caregivers’ burden remained unchanged. There was a significant improvement in the daily “Off” time [7.4 h (SD ± 4.0) vs 1.5 h (SD ± 1.8); p < 0.0001] at the end of follow-up, whereas duration of dyskinesias was not affected. ICDs significantly improved after 6-month LCIG treatment in a group of PD patients with mild-to-moderate neuropsychiatric disturbances. [ABSTRACT FROM AUTHOR]
- Published
- 2018
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32. Virus stamping for targeted single-cell infection in vitro and in vivo.
- Author
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Schubert, Rajib, Trenholm, Stuart, Balint, Kamill, Kosche, Georg, Cowan, Cameron S, Mohr, Manuel A, Munz, Martin, Martinez-Martin, David, Fläschner, Gotthold, Newton, Richard, Krol, Jacek, Scherf, Brigitte Gross, Yonehara, Keisuke, Wertz, Adrian, Ponti, Aaron, Ghanem, Alexander, Hillier, Daniel, Conzelmann, Karl-Klaus, Müller, Daniel J, and Roska, Botond
- Abstract
Genetic engineering by viral infection of single cells is useful to study complex systems such as the brain. However, available methods for infecting single cells have drawbacks that limit their applications. Here we describe 'virus stamping', in which viruses are reversibly bound to a delivery vehicle-a functionalized glass pipette tip or magnetic nanoparticles in a pipette-that is brought into physical contact with the target cell on a surface or in tissue, using mechanical or magnetic forces. Different single cells in the same tissue can be infected with different viruses and an individual cell can be simultaneously infected with different viruses. We use rabies, lenti, herpes simplex, and adeno-associated viruses to drive expression of fluorescent markers or a calcium indicator in target cells in cell culture, mouse retina, human brain organoid, and the brains of live mice. Virus stamping provides a versatile solution for targeted single-cell infection of diverse cell types, both in vitro and in vivo. [ABSTRACT FROM AUTHOR]
- Published
- 2018
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33. Advanced Parkinson's or 'complex phase' Parkinson's disease? Re-evaluation is needed.
- Author
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Titova, Nataliya, Martinez-Martin, Pablo, Katunina, Elena, and Chaudhuri, K.
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- *
PARKINSON'S disease treatment , *INDIVIDUALIZED medicine , *DISEASE progression , *PALLIATIVE treatment , *HISTORY of medicine , *STEREOTACTIC radiosurgery - Abstract
Holistic management of Parkinson's disease, now recognised as a combined motor and nonmotor disorder, remains a key unmet need. Such management needs relatively accurate definition of the various stages of Parkinson's from early untreated to late palliative as each stage calls for personalised therapies. Management also needs to have a robust knowledge of the progression pattern and clinical heterogeneity of the presentation of Parkinson's which may manifest in a motor dominant or nonmotor dominant manner. The 'advanced' stages of Parkinson's disease qualify for advanced treatments such as with continuous infusion or stereotactic surgery yet the concept of 'advanced Parkinson's disease' (APD) remains controversial in spite of growing knowledge of the natural history of the motor syndrome of PD. Advanced PD is currently largely defined on the basis of consensus opinion and thus with several caveats. Nonmotor aspects of PD may also reflect advancing course of the disorder, so far not reflected in usual scale based assessments which are largely focussed on motor symptoms. In this paper, we discuss the problems with current definitions of 'advanced' PD and also propose the term 'complex phase' Parkinson's disease as an alternative which takes into account a multimodal symptoms and biomarker based approach in addition to patient preference. [ABSTRACT FROM AUTHOR]
- Published
- 2017
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34. The Analysis of Cell Cycle, Proliferation, and Asymmetric Cell Division by Imaging Flow Cytometry.
- Author
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Filby, Andrew, Day, William, Purewal, Sukhveer, and Martinez-Martin, Nuria
- Published
- 2016
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35. Leisure Activities and Quality of Life Among Older Adults in Spain.
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Lardies-Bosque, Raul, Fernandez-Mayoralas, Gloria, Rojo-Perez, Fermina, Forjaz, Maria João, Martinez-Martin, Pablo, and Rojo-Abuin, José-Manuel
- Published
- 2015
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36. Quantitative assessment of non-motor fluctuations in Parkinson's disease using the Non-Motor Symptoms Scale (NMSS).
- Author
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Storch, Alexander, Schneider, Christine, Klingelhöfer, Lisa, Odin, Per, Fuchs, Gerd, Jost, Wolfgang, Martinez-Martin, Pablo, Koch, Rainer, Reichmann, Heinz, Chaudhuri, K., and Ebersbach, Georg
- Subjects
PARKINSON'S disease ,BRAIN diseases ,EXTRAPYRAMIDAL disorders ,PARKINSONIAN disorders ,SHOCK (Pathology) - Abstract
Data on frequency, severity and correlations of NMS with motor complications are only available for a limited number of NMS. The NMS Scale (NMSS) is a validated tool to assess a broad range of NMS, which has not been used in NMS fluctuations. We assessed fluctuations of a broad range of non-motor symptom (NMS) for a 1-month time period in fluctuating Parkinson's disease (PD) in a multicenter cross-sectional study using the NMSS assessing NMS in motor On (NMSS) and Off state (NMSS) combined with clinical NMS and motor function scoring in 100 fluctuating PD patients. ΔNMSS was defined as the differences of NMSS scores between On and Off. Complete NMSS datasets were available from 73 patients (53 % men; age: 68.2 ± 9.7 years) with mean total NMSS score in On state of 41.5 ± 37.6 and in Off state of 75.6 ± 42.3 ( P < 0.001). Scores were higher in Off compared to On state for all domains except for domain 'perceptual problems/hallucinations' ( P = 0.608). Clinimetric properties of the NMSS were similar to those reported previously for NMS assessments independent of motor oscillations. NMSS, NMSS and ΔNMSS showed weak to moderate correlations with demographics, indicators of motor symptom severity as well as with other measures of NMS, depression and quality of life. Correlations of NMSS items/domains with independent measures of related constructs were weak to moderate. In conclusion, when assessed with the NMSS, a broad range of NMS fluctuate with motor oscillations, but these fluctuations do neither correlate with motor function nor with measures of disease progression. [ABSTRACT FROM AUTHOR]
- Published
- 2015
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37. Quality of Life Scales.
- Author
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Martinez-Martin, Pablo, Rodriguez-Blazquez, Carmen, Forjaz, Maria João, and Chaudhuri, Kallol Ray
- Published
- 2014
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38. Global Severity Assessments.
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Martinez-Martin, Pablo, Rodriguez-Blazquez, Carmen, Forjaz, Maria João, and Chaudhuri, Kallol Ray
- Published
- 2014
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39. Cognition and Neuropsychiatric Symptoms.
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Martinez-Martin, Pablo, Rodriguez-Blazquez, Carmen, Forjaz, Maria João, and Chaudhuri, Kallol Ray
- Published
- 2014
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40. Comprehensive Non-motor Symptoms Assessments.
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Martinez-Martin, Pablo, Rodriguez-Blazquez, Carmen, Forjaz, Maria João, and Chaudhuri, Kallol Ray
- Published
- 2014
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41. Scales that Evaluate Specific Non-motor Disorders.
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Martinez-Martin, Pablo, Rodriguez-Blazquez, Carmen, Forjaz, Maria João, and Chaudhuri, Kallol Ray
- Published
- 2014
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42. Multi-domain Scales.
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Martinez-Martin, Pablo, Rodriguez-Blazquez, Carmen, Forjaz, Maria João, and Chaudhuri, Kallol Ray
- Published
- 2014
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43. FrontMatter.
- Author
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Martinez-Martin, Pablo, Rodriguez-Blazquez, Carmen, Forjaz, Maria João, and Chaudhuri, Kallol Ray
- Published
- 2014
44. Motor Impairment and Disability Scales.
- Author
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Martinez-Martin, Pablo, Rodriguez-Blazquez, Carmen, Forjaz, Maria João, and Chaudhuri, Kallol Ray
- Published
- 2014
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45. Introduction.
- Author
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Martinez-Martin, Pablo, Rodriguez-Blazquez, Carmen, Forjaz, Maria João, and Chaudhuri, Kallol Ray
- Published
- 2014
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46. Animal Social Behaviour: A Visual Analysis.
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Martinez-Martin, Ester and del Pobil, Angel P.
- Published
- 2014
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47. Scales for Measuring Parkinsonism in Demented Patients.
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Rodriguez-Blazquez, Carmen, Sauerbier, Anna, Chaudhuri, K. Ray, and Martinez-Martin, Pablo
- Abstract
The term ˵parkinsonism″ refers to a syndrome combining motor symptoms such as bradykinesia, rigidity, tremor, and other clinical signs characteristic of Parkinson's disease. A large range of these disorders can simultaneously express parkinsonism and dementia, although with variable occurrence particularly related to the onset of disease and expression of clinical symptoms. Therefore, motor and cognitive assessment in these conditions are relevant, for both clinical research and practice. Most of the rating scales applied in this situation are measures coming from the realm of the movement disorders, used for evaluation of Parkinson's disease, multiple system atrophy, progressive supranuclear palsy, etc. Also, there are generic scales designed for assessment of motor state that may be useful in the appropriate context. Some of the most frequently used scales are reviewed in this chapter, with particular attention to their description and basic clinimetric properties. [ABSTRACT FROM AUTHOR]
- Published
- 2014
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48. Impact of Pharmacotherapy on Quality of Life in Patients with Parkinson's Disease.
- Author
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Martinez-Martin, Pablo, Rodriguez-Blazquez, Carmen, Forjaz, Maria Joao, Kurtis, Monica M, and Forjaz, Maria João
- Abstract
Quality of life (QoL) is a patient-reported outcome frequently included in Parkinson's disease (PD) clinical trials as a secondary or tertiary endpoint. However, QoL is an important variable that reflects the impact of disease and treatment from the patients' perspective. In a chronic, neurodegenerative disease such as PD, with a wide range of complex symptoms, QoL provides valuable and comprehensive information on the patients' health status. This narrative review aims to evaluate the effect of specific PD treatments currently in use on patients' QoL measured with the Parkinson's Disease Questionnaire, 39-item (PDQ-39) or 8-item (PDQ-8) version. A quantification of this effect is provided by calculation of the relative change and effect size. These two parameters allow an intuitive standardized approach to the importance of change based on its magnitude. Some high-quality studies (Level I) were found for levodopa (immediate- or extended-release formulations), levodopa with added-on catechol-O-methyltransferase (COMT) inhibitors, levodopa/carbidopa gel for intestinal infusion, some dopamine agonists (ropinirole, cabergoline, pergolide), and the monoamine oxidase B (MAO-B) inhibitor safinamide. As a whole, these studies found a beneficial effect of variable magnitude, weak to moderate, on patients' QoL. Studies with a lower level of evidence or not providing enough data to estimate relative change and effect size, including those for the apomorphine subcutaneous pump, also reported improvement of QoL, but the evidence was insufficient to confirm the effect. More high-quality studies focused on QoL are needed to determine the real impact of PD drug treatments for this important outcome. [ABSTRACT FROM AUTHOR]
- Published
- 2015
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49. Impact of Pharmacotherapy on Quality of Life in Patients with Parkinson 's Disease.
- Author
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Martinez-Martin, Pablo, Rodriguez-Blazquez, Carmen, Forjaz, Maria, and Kurtis, Monica
- Subjects
PARKINSON'S disease treatment ,PARKINSON'S disease patients ,NEURODEGENERATION ,CLINICAL trials ,QUALITY of life ,HEALTH outcome assessment - Abstract
Quality of life (QoL) is a patient-reported outcome frequently included in Parkinson's disease (PD) clinical trials as a secondary or tertiary endpoint. However, QoL is an important variable that reflects the impact of disease and treatment from the patients' perspective. In a chronic, neurodegenerative disease such as PD, with a wide range of complex symptoms, QoL provides valuable and comprehensive information on the patients' health status. This narrative review aims to evaluate the effect of specific PD treatments currently in use on patients' QoL measured with the Parkinson's Disease Questionnaire, 39-item (PDQ-39) or 8-item (PDQ-8) version. A quantification of this effect is provided by calculation of the relative change and effect size. These two parameters allow an intuitive standardized approach to the importance of change based on its magnitude. Some high-quality studies (Level I) were found for levodopa (immediate- or extended-release formulations), levodopa with added-on catechol- O-methyltransferase (COMT) inhibitors, levodopa/carbidopa gel for intestinal infusion, some dopamine agonists (ropinirole, cabergoline, pergolide), and the monoamine oxidase B (MAO-B) inhibitor safinamide. As a whole, these studies found a beneficial effect of variable magnitude, weak to moderate, on patients' QoL. Studies with a lower level of evidence or not providing enough data to estimate relative change and effect size, including those for the apomorphine subcutaneous pump, also reported improvement of QoL, but the evidence was insufficient to confirm the effect. More high-quality studies focused on QoL are needed to determine the real impact of PD drug treatments for this important outcome. [ABSTRACT FROM AUTHOR]
- Published
- 2015
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- View/download PDF
50. Change and predictors of quality of life in institutionalized older adults with dementia.
- Author
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Castro-Monteiro, Emilia, Forjaz, Maria, Ayala, Alba, Rodriguez-Blazquez, Carmen, Fernandez-Mayoralas, Gloria, Diaz-Redondo, Alicia, and Martinez-Martin, Pablo
- Subjects
DEMENTIA ,QUALITY of life ,INSTITUTIONALIZED persons ,DISEASES in older people ,REGRESSION analysis ,FOLLOW-up studies (Medicine) ,HEALTH - Abstract
Purpose: This study aims to assess the change in and predictive factors of the quality of life (QoL) of institutionalized older adults with dementia over a 20-month period. Methods: Information was used from a follow-up study conducted over an average period of 19.61 ± 1.93 months on a sample of 274 institutionalized older adults aged 60 or over, diagnosed with dementia. Two linear regression models were built to predict change in the EQ-5D index and the quality of life in Alzheimer's disease (QOL-AD) scale, taking as independent variables: sociodemographic characteristics and measures of functional ability (Barthel Index), depression in dementia (Cornell Scale), number of chronic health problems, cognitive level (MEC, the Spanish Mini-Mental State Examination) and severity of dementia (Clinical Dementia Rating) at baseline. Results: The majority of the participants were women (81.75 %) with an average age of 84.70 ± 6.51 years, single (78.15 %), with severe dementia and moderate functional dependence. There was a significant decrease on the EQ-5D, EQ-VAS and QOL-AD between baseline and follow-up scores. The main predictors of QoL of the institutionalized older adults with dementia were the number of chronic problems and baseline scores of the QoL measures. Conclusions: A significant decrease in the QoL of institutionalized older adults was observed over a 20-month period. Results suggest that interventions aimed at reducing the number of chronic medical conditions may have a beneficial effect on older adults' QoL. [ABSTRACT FROM AUTHOR]
- Published
- 2014
- Full Text
- View/download PDF
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