1. Maternal outcomes and risk factors for COVID-19 severity among pregnant women
- Author
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Andrea Papadia, Marco De Santis, Brian Cleary, Feras Al-Kharouf, Irene Hoesli, Kurt Hecher, Javiera Fuenzalida, Sandrine Ackermann, Guillaume Favre, Anis Feki, Lucie Sedille, Ameth Hawkins-Villarreal, Lavinia Schuler-Faccini, Chloe Moreau, Carmen De Luca, David Baud, Eduard Gratacos Solsona, Fernanda Garanhani Surita, Andrea Bloch, Silke Johann, Begoña Martinez de Tejada, Karen Castillo, Uri Amikam, Claudia Grawe, Mariana Horn Scherer, Uma M. Reddy, Adriana Gomes Luz, Véronique Lambert, Ron Maymon, Olga Grechukhina, Betania Bohrer, Anda-Petronela Radan, Alejandra Abascal-Saiz, Karin Nielsen Saines, Marie-Claude Rossier, Najeh Hcini, Sandra A. Heldstab, Oscar Martinez-Perez, Martin Kaufmann, Renato Augusto Moreira de sa, Pedro Viana Pinto, Jorge A Carvajal, Cristina Granado, Helena Bartels, Jute Richter, Yves Ville, Inês S. Martins, Melissa Charvet, Mohamed Derouich, Sandra Andrea Heldstab, Anne-Claude Muller Brochut, Gustavo Malinger, Albert I. Ko, Karoline Aebi-Popp, Gabriel Carles, Julien Stirnemann, Carolina Borrelli, Manon Vouga, Guillaume Ducarme, Marylene Giral, Michel Boulvain, Jan Deprest, Mary Catherine Cambou, Maria Celeste Osório Wender, Mingzhu Yin, Susan Knowles, María Fernanda Escobar-Vidarte, Annina Haessig, Xiang Chen, Carolina C. Ribeiro-do-Valle, Gaston Grant, Albaro José Nieto Calvache, Maria Lúcia Rocha Oppermann, Manuel Guerra Canales, Anna Goncé, Monya Todesco Bernasconi, Brigitte Strizek, Tina Fischer, Loïc Sentilhes, Alice Panchaud, Maria Camila Lopez-Giron, Gaetan Plantefeve, Cécile Monod, Laura Forcen Acebal, Marina Moucho, Juan Manuel Burgos-Luna, Brigitte Weber, Charles Garabedian, Amanda Dantas-Silva, Thibaud Quibel, Camila Giugliani, Fergal D. Malone, Patrick Rozenberg, Eran Hadar, Diogo Ayres de Campos, Paul Böckenhoff, Mary Higgins, Rita Figueiredo, Karina Krajden Haratz, Olivia Hernandez, Lennart Van der Veeken, Luigi Raio, N. Kölble, Christian R Kahlert, Arnaud Toussaint, Maria Rosa Vila Hernandez, Luciana Friedrich, Dirk Bassler, Damien Subtil, Béatrice Eggel-Hort, Eric Giannoni, Ann-Christin Tallarek, Joanna Sichitiu, Nicolas Mottet, Panagiotis Kanellos, Bénédicte Breton, Leonhard Schäffer, Léo Pomar, Maria Teresa Vieira Sanseverino, Niamh Keating, Daniel Surbek, Romina Capoccia Brugger, Laurent Salomon, Michael Geary, Christophe Poncelet, Doris Mueller, Helene Pelerin, Yariv Yogev, and Lucas Trigo
- Subjects
Adult ,Reproductive signs and symptoms ,medicine.medical_specialty ,Neonatal intensive care unit ,Science ,medicine.medical_treatment ,610 Medicine & health ,Disease ,macromolecular substances ,01 natural sciences ,Article ,03 medical and health sciences ,0302 clinical medicine ,Pregnancy ,360 Social problems & social services ,Respiratory signs and symptoms ,Diabetes mellitus ,Humans ,Medicine ,Caesarean section ,030212 general & internal medicine ,Pregnancy Complications, Infectious ,0101 mathematics ,Clinical microbiology ,Multidisciplinary ,SARS-CoV-2 ,business.industry ,Obstetrics ,010102 general mathematics ,Pregnancy Outcome ,Case-control study ,COVID-19 ,medicine.disease ,Risk factors ,Viral infection ,Premature birth ,Case-Control Studies ,Cohort ,Premature Birth ,Female ,Pregnant Women ,Infection ,business - Abstract
Pregnant women may be at higher risk of severe complications associated with the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), which may lead to obstetrical complications. We performed a case control study comparing pregnant women with severe coronavirus disease 19 (cases) to pregnant women with a milder form (controls) enrolled in the COVI-Preg international registry cohort between March 24 and July 26, 2020. Risk factors for severity, obstetrical and immediate neonatal outcomes were assessed. A total of 926 pregnant women with a positive test for SARS-CoV-2 were included, among which 92 (9.9%) presented with severe COVID-19 disease. Risk factors for severe maternal outcomes were pulmonary comorbidities [aOR 4.3, 95% CI 1.9-9.5], hypertensive disorders [aOR 2.7, 95% CI 1.0-7.0] and diabetes [aOR2.2, 95% CI 1.1-4.5]. Pregnant women with severe maternal outcomes were at higher risk of caesarean section [70.7% (n = 53/75)], preterm delivery [62.7% (n = 32/51)] and newborns requiring admission to the neonatal intensive care unit [41.3% (n = 31/75)]. In this study, several risk factors for developing severe complications of SARS-CoV-2 infection among pregnant women were identified including pulmonary comorbidities, hypertensive disorders and diabetes. Obstetrical and neonatal outcomes appear to be influenced by the severity of maternal disease. ispartof: SCIENTIFIC REPORTS vol:11 issue:1 ispartof: location:England status: published
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- 2021