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We investigate the development of ciliochoroidal effusion following micropulse transscleral laser therapy (MPTLT) and evaluate the relationship between the early postoperative ciliochoroidal effusion (ECE) and short-term treatment outcomes. Glaucoma patients who underwent MPTLT were assessed for ciliochoroidal effusion by anterior segment optical coherence tomography (AS-OCT) at postoperative 1, 4, 12 weeks. The subjects were classified based on AS-OCT findings at postoperative 1 week into eyes with and without ECE. The absolute intraocular pressure (IOP), IOP reduction and number of antiglaucoma medications were compared between eyes with and without ECE. A total of 50 eyes were included, of which 23 (46%) developed ciliochoroidal effusion at postoperative 1 week. Almost all effusion resolved at 4 weeks. At 12 weeks, the mean IOP (SD) significantly decreased from 28.5 (12.8) mmHg to 17.8 (10.5) mmHg (p < 0.001), and the mean number of medications (SD) decreased from 4.1 (0.9) to 3.3 (1.1) (p < 0.001). Eyes with ECE had significantly greater IOP reduction (p = 0.009) and lower absolute IOP (p = 0.008) at the 4-week visit. There was no significant difference in number of medications between the groups. In conclusion, ciliochoroidal effusion was commonly observed following MPTLT. Eyes with ECE had overall greater IOP reduction during early post-operation. [ABSTRACT FROM AUTHOR]

Purpose: To compare the patterns of retinal nerve fiber layer (RNFL) thickness loss in primary angle-closure glaucoma (PACG) and primary open-angle glaucoma (POAG) using optical coherence tomography (OCT). Methods: Forty-three participants with PACG and 60 with POAG underwent fast RNFL thickness measurement by OCT. Eyes were classified according to the visual field mean deviation (VF-MD) into mild (>−8 dB), moderate (−8 dB to >−16 dB), and advanced (≤−16 dB) glaucoma subgroups. The raw RNFL thickness data were compared with data from the Thai normative database. Results: Mean (SD) age was 67.0 (9.6) and 64.1 (11.6) years in the PACG and POAG groups, respectively ( P = 0.19). In the mild subgroups, a focal RNFL thickness loss was found in the inferior area in the POAG group, but not in the PACG group. The RNFL defect involved sectors 1, 6, and 7 in the moderately advanced disease subgroups of both PACG and POAG and extended through almost all sectors in the advanced disease subgroups. The deepest RNFL defect, −17.25 μm, was found in sector 6 of the mild POAG subgroup, compared with −8.78 μm in the PACG group ( P = 0.04). The number of affected points in each sector in the mild subgroups was greater in the POAG group than in the PACG group. Conclusion: Participants with mild POAG had deeper and more localized RNFL defects than did participants with PACG. The pattern was similar in participants with moderate or advanced disease. [ABSTRACT FROM AUTHOR]

Abstract Purpose  To investigate the distribution of retinal nerve fiber layer (RNFL) and macular retinal thickness measured by optical coherence tomography (OCT) in a Thai population. Methods  We studied one eye each of 250 healthy subjects [age ≥ 18 years; spherical refractive error within ±6 diopters (D); astigmatism ≤3 D; no ocular pathology]. A complete eye examination, standard automated perimetry, and fast RNFL and macular thickness measurement by OCT were performed, and a disc photograph was taken. The distributions of both thicknesses, including their relationship with demographic data, were analyzed. Results  The mean ± SD age of the study population was 44.7 ± 12.2 years. The mean ± SD RNFL thickness was 109.3 ± 10.5 m, which was 10% thicker than that in the OCT normative database. RNFL decreased 2.3 m per decade (P P P P Conclusions  RNFL thickness in the measured Thai population was about 10% thicker than that in the original normative database. Macular thickness and RNFL thickness in the superior and inferior quadrants decreased with advancing age. [ABSTRACT FROM AUTHOR]