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Objective: Joan McCord was an experimental criminologist who advocated for evaluating social programs for efficacy, benefits, and potential harms to guide crime prevention policy. This paper argues that criminal justice reform should be guided by evidence for effective social programs that guard against unintended harms. Programs that focus on social control are consistent with basic facts of crime and guard against the tail risk of surges in serious crime and violence. This paper discusses the evidence from evaluations of social programs which are based on principals of social control in families, schools, neighborhoods, and the criminal justice system. Methods: This paper draws upon the evaluations of social programs that have been published based on at least one high-quality experiment or two rigorous quasi-experiments, that can be scaled to entire populations, and are sustainable over time. Results: A review of experimental and quasi-experimental evidence found that social programs focused on increasing social control (formal or informal) in families, schools, communities, and by the criminal justice system are effective at preventing serious crime. Some of the social programs with rigorous evidence of preventing crime could be scaled to entire populations for prolonged durations with adequate planning and implementation models. Conclusion: Many contemporary criminal justice reforms have little evidence of efficacy, and run the risk of generating unintended adverse outcomes related to the spread of serious crime and violence. Existing evidence suggests that social programs that focus on social control can act as buffers against the tail risk of serious crime. The social programs with evidence of preventing crime should be expanded, monitored for fidelity in implementation, and continuously evaluated to improve their efficacy and sustainability as effective safeguards against the rise in serious crime and violence. [ABSTRACT FROM AUTHOR]

Iron and steel slags have a long history of both disposal and beneficial use in the coastal zone. Despite the large volumes of slag deposited, comprehensive assessments of potential risks associated with metal(loid) leaching from iron and steel by-products are rare for coastal systems. This study provides a national-scale overview of the 14 known slag deposits in the coastal environment of Great Britain (those within 100 m of the mean high-water mark), comprising geochemical characterisation and leaching test data (using both low and high ionic strength waters) to assess potential leaching risks. The seaward facing length of slag deposits totalled at least 76 km, and are predominantly composed of blast furnace (iron-making) slags from the early to mid-20th Century. Some of these form tidal barriers and formal coastal defence structures, but larger deposits are associated with historical coastal disposal in many former areas of iron and steel production, notably the Cumbrian coast of England. Slag deposits are dominated by melilite phases (e.g. gehlenite), with evidence of secondary mineral formation (e.g. gypsum, calcite) indicative of weathering. Leaching tests typically show lower element (e.g. Ba, V, Cr, Fe) release under seawater leaching scenarios compared to deionised water, largely ascribable to the pH buffering provided by the former. Only Mn and Mo showed elevated leaching concentrations in seawater treatments, though at modest levels (<3 mg/L and 0.01 mg/L, respectively). No significant leaching of potentially ecotoxic elements such as Cr and V (mean leachate concentrations <0.006 mg/L for both) were apparent in seawater, which micro-X-Ray Absorption Near Edge Structure (μXANES) analysis show are both present in slags in low valence (and low toxicity) forms. Although there may be physical hazards posed by extensive erosion of deposits in high-energy coastlines, the data suggest seawater leaching of coastal iron and steel slags in the UK is likely to pose minimal environmental risk. [ABSTRACT FROM AUTHOR]

Background: Targeting interleukin-23 (IL-23) is an important therapeutic strategy for Crohn's disease (CD). Aims: This systematic review and meta-analysis assessed the efficacy and safety of selective IL-23p19 and IL-12/23p40 inhibitors in patients with moderate-to-severe CD. Methods: MEDLINE, Embase, and the Cochrane library (CENTRAL) were searched from inception to May 24, 2023, for randomized, placebo- or active comparator-controlled induction and/or maintenance trials of selective IL-23p19 and IL-12/23p40 inhibitors in pediatric and adult patients with CD. The primary outcome was the proportion of patients in clinical remission. Secondary outcomes were clinical response, endoscopic remission, endoscopic response, and safety. Data were pooled using a random-effects model. Risk of bias and certainty of evidence were assessed using the Cochrane risk of bias tool and the GRADE criteria, respectively. Results: Eighteen trials (n = 5561) were included. Most studies were rated as low risk of bias. Targeting IL-23 was significantly superior to placebo for inducing clinical (risk ratio [RR] = 1.87, 95% confidence interval [CI] 1.58–2.21) and endoscopic (RR = 3.20, 95%CI 2.17–4.70) remission and maintaining clinical remission (RR = 1.39, 95%CI 1.10–1.77) (GRADE high certainty evidence for all outcomes). Subgroup analysis showed that targeting IL-23 was superior to placebo for inducing clinical remission in biologic-naïve (RR = 2.20, 95%CI 1.46–3.32, I2 = 0%, p = 0.39) and biologic-experienced patients (RR = 1.82, 95%CI 1.27–2.60, I2 = 56.5%, p = 0.01). Targeting IL-23 was associated with a decreased risk of serious adverse events in induction (RR = 0.55, 95%CI 0.44–0.73) and maintenance (RR = 0.72, 95%CI 0.53–0.98) trials compared to placebo (high certainty evidence). Conclusion: Targeting IL-23 is effective and safe for inducing and maintaining clinical and endoscopic remission in patients with moderate-to-severe CD. [ABSTRACT FROM AUTHOR]

Objectives: Outfitting police officers with body-worn cameras (BWCs) has been suggested to improve police-community relations. This study evaluates whether the deployment of BWCs on NYPD officers impacted resident perceptions of the police. Methods: A cluster randomized controlled trial design was used to test the influence of BWCs on resident perceptions of the NYPD in treatment precincts relative to control precincts. Dual-frame randomly selected telephone surveys were used to collect pre-intervention and post-intervention resident perception data. Results: We find no statistically significant differences between BWC treatment and control precincts in general perceptions of the NYPD or the average assessment of police officer behavior among those who have had recent encounters with the NYPD. Conclusion: Strong community support for BWC adoption and citizen expectations for videos of controversial policing events suggests the continued use of this technology. However, BWCs should be implemented with other evidence-based programs to enhance police-community relations. [ABSTRACT FROM AUTHOR]

Rapid and uncontrolled urbanisation in many parts of Africa is a significant driver of earthquake risk. New constructions are usually built with no compliance with seismic codes, which results in a critical increase in the vulnerability of the building stock. To quantitatively assess the potential consequences of unregulated urbanisation, this study investigates the effect of building code enforcement and urban expansion on the future earthquake loss in the city of Blantyre, Malawi. The analysis, performed within a probabilistic loss assessment framework, estimates the net present value of 30-year aggregated seismic loss for different urban expansion rates and code enforcement scenarios. The results show that high urbanisation rates and lack of building regulations could lead to a threefold increase in average seismic losses in the next thirty years. On the contrary, effective code enforcement could cap the seismic loss increase at 13%, highlighting the financial gain from effective disaster risk reduction programmes. [ABSTRACT FROM AUTHOR]

Objective: Place-based blight remediation programs have gained popularity in recent years as a crime reduction approach. This study estimated the impact of a citywide vacant lot greening program in Philadelphia on changes in crime over multiple years, and whether the effects were moderated by nearby land uses. Methods: The vacant lot greening program was assessed using quasi-experimental and experimental designs. Entropy distance weighting was used in the quasi-experimental analysis to match control lots to be comparable to greened lots on pre-existing crime trends. Fixed-effects difference-in-differences models were used to estimate the impact of the vacant lot greening program in quasi-experimental and experimental analyses. Results: Vacant lot greening was estimated to reduce total crime and multiple subcategories in both the quasi-experimental and experimental evaluations. Remediating vacant lots had a smaller effect on reducing crime when they were located nearby train stations and alcohol outlets. The crime reductions from vacant lot remediations were larger when they were located near areas of active businesses. There is some suggestive evidence that the effects of vacant lot greening are larger when located in neighborhoods with higher pre-intervention levels of social cohesion. Conclusions: The findings suggest that vacant lot greening provides a sustainable approach to reducing crime in disadvantaged neighborhoods, and the effects may vary by different surrounding land uses. To better understand the mechanisms through which place-based blight remediation interventions reduce crime, future research should measure human activities and neighborly socialization in and around places before and after remediation efforts are implemented. [ABSTRACT FROM AUTHOR]

Background: Patients treated with immune checkpoint inhibitors (ICIs) may develop ICI-associated enterocolitis, for which there is no approved treatment. Aims: We aimed to systematically review the efficacy and safety of medical interventions for the prevention and treatment of ICI-associated enterocolitis. Methods: MEDLINE, EMBASE, and the Cochrane Library were searched to identify randomized controlled trials (RCTs), cohort and case–control studies, and case series/reports, evaluating interventions (including corticosteroids, biologics, aminosalicylates, immunosuppressants, and fecal transplantation) for ICI-associated enterocolitis. Clinical, endoscopic, and histologic efficacy endpoints were evaluated. The Grading of Recommendations, Assessment, Development, and Evaluation criteria were used to assess overall quality of evidence. Results: A total of 160 studies (n = 1514) were included (one RCT, 3 retrospective cohort studies, 156 case reports/case series). Very low quality evidence from one RCT suggests budesonide is not effective for prevention of ICI-associated enterocolitis in ipilimumab-treated patients (relative risk 0.93 [95% confidence interval 0.56, 1.56]). Very low quality evidence suggests that corticosteroids, infliximab, and vedolizumab may be effective for treatment of ICI-associated enterocolitis by inducing clinical response and remission. No validated indices for measuring disease activity were used. Biologic treatment was used in 42% (641/1528) of patients, as reported in 97 studies. ICIs were discontinued in 65% (457/702) of patients, as reported in 63 studies. Conclusions: Current treatment recommendations for ICI-associated enterocolitis are based on very low quality evidence, primarily from case reports and case series. Large-scale prospective cohort studies and RCTs are needed to develop prophylactic and therapeutic treatments to minimize interruption or discontinuation of oncological therapies. [ABSTRACT FROM AUTHOR]

The pedestrian-induced instability of the London Millennium Bridge is a widely used example of Kuramoto synchronisation. Yet, reviewing observational, experimental, and modelling evidence, we argue that increased coherence of pedestrians' foot placement is a consequence of, not a cause of the instability. Instead, uncorrelated pedestrians produce positive feedback, through negative damping on average, that can initiate significant lateral bridge vibration over a wide range of natural frequencies. We present a simple general formula that quantifies this effect, and illustrate it through simulation of three mathematical models, including one with strong propensity for synchronisation. Despite subtle effects of gait strategies in determining precise instability thresholds, our results show that average negative damping is always the trigger. More broadly, we describe an alternative to Kuramoto theory for emergence of coherent oscillations in nature; collective contributions from incoherent agents need not cancel, but can provide positive feedback on average, leading to global limit-cycle motion. The pedestrian-induced oscillation of the London Millennium Bridge is considered as an example of emerging synchronisation. Belykh et al. provide an alternative mechanism for emergence of coherent oscillatory bridge dynamics where synchrony is a consequence, not the cause, of the instability. [ABSTRACT FROM AUTHOR]

Objectives: This study examines the impact of alcohol consumption in a Major League Baseball (MLB) stadium on area level counts of crime. The modal practice at MLB stadiums is to stop selling alcoholic beverages after the seventh inning. Baseball is not a timed game, so the duration between the last call for alcohol at the end of the seventh inning and the end of the game varies considerably, providing a unique natural experiment to estimate the relationship between alcohol consumption and crime near a stadium on game days. Methods: Crime data were obtained from Philadelphia for the period 2006–2015 and geocoded to the area around the MLB stadium as well as popular sports bars. We rely on difference-in-differences regression models to estimate the change in crime on home game days around the stadium as the game time extends into extra innings to other areas of the city and around sports bars in Philadelphia relative to days when the baseball team plays away from home. Results: When there are extra innings and more game-time after the seventh inning alcohol sales stoppage crime declines significantly around the stadium. The crime reduction benefit of the last call alcohol policy is undone when a complex of sports bars opens in the stadium parking lot in 2012. The results suggest that alcohol consumption during baseball games is a contributor to crime. Conclusions: The findings provide further support for environmental theories of crime that note the congregation of people in places with excessive alcohol consumption is a generator of violent crime in cities. The consumption of alcohol in MLB stadiums appears to increase crime. [ABSTRACT FROM AUTHOR]

Malawi is located within the southern branch of the active East African Rift System, where earthquakes of moment magnitude (Mw) 7.0 or greater can occur along major faults. The majority of dwellings in the country are non-engineered unreinforced masonry constructions, built by local artisans with little input from engineers. These constructions are highly vulnerable to seismic events due to poor-quality materials and lack of construction detailing. This study presents a new methodology to assess the seismic fragility curves of typical dwellings located in the Central and Southern Malawi. On-site inspections of buildings are carried out to assess geometrical and structural features of 646 façades, and an experimental campaign is performed to characterise the mechanical properties of local construction materials. The collected data allow the identification of different building typologies in terms of quality of materials and construction techniques. The critical failure modes for each of the inspected façade at their ultimate limit state are evaluated analytically. Damage limit states are defined and adopted to derive simplified Static Push-Over (SPO) curves, transformed into incremental dynamic analysis (IDA) curves by using SPO2IDA. The IDA curves are then used to obtain fragility curves for the specific damage limit states. The fragility curves presented herein are the first to be calculated for these building typologies, based on local data, and unfortunately, they show that buildings in Malawi are far more vulnerable to earthquakes than estimated from previously available international reference data. The fragility curves developed in this study may prove useful for assessing the seismic risk of these building typologies in Malawi and other East African countries. [ABSTRACT FROM AUTHOR]

This study presents a building classification scheme for residential houses in Malawi by focusing upon informal construction, which accounts for more than 90% of housing in the country with the highest urbanisation rate in the world. The proposed classification is compatible with the Prompt Assessment of Global Earthquakes for Response (PAGER) method and can be used for seismic vulnerability assessments of building stock in Malawi. To obtain realistic proportions of the building classes that are prevalent in Malawi, a building survey was conducted in Central and Southern Malawi between 10th and 20th July 2017. The results from the survey are used to modify the PAGER-based proportions of main housing typologies by reflecting actual housing construction in the surveyed areas. The results clearly highlight the importance of using realistic building stock data for seismic risk assessment in Malawi; relying on global building stock information can result in significant bias of earthquake impact assessment. [ABSTRACT FROM AUTHOR]

This paper presents new insights on the galloping instability phenomenon of square-section prisms. The role of the orientation of the structural axes on the galloping response is studied through wind tunnel tests and quasi-steady theory. A new series of dynamic wind tunnel tests on a square section model were conducted to evaluate non-across-wind galloping vibrations, as well as conventional across-wind galloping. The results are then compared with theoretical predictions to evaluate the reliability of quasi-steady theory in assessing the galloping phenomenon. It is found that for a given angle of attack, the structure has different aeroelastic behaviour for different orientations of the principal axis. At an angle of attack close to the critical angle of attack of square prisms, the quasi-steady theory well predicts the critical wind velocity for the onset of non-across-wind galloping but it is not successful for the case of across-wind galloping. [ABSTRACT FROM AUTHOR]

Recently, we demonstrated that triphenylacetic acid could be used to seal dye molecules within MOF-5, but guest release required the digestion of the framework by treatment with acid. We prepared the sterically bulky photocapping group [bis-(3-nitro-benzyl)-amino]-(3-nitro-phenyl)-acetic acid (PC1) that can prevent crystal violet dye diffusion from inside MOF-5 until removed by photolysis. [ABSTRACT FROM AUTHOR]

Objective: To assess the effect of civil gang injunctions on crime. Methods: We use data on the location and date of 46 gang injunctions between 1993 and 2013 and quarterly crimes reported to the Los Angeles Police Department (LAPD) from 1988 to 2014. We estimate the effect of gang injunctions on crime over the short-term (20 quarters) and long-term (108 quarters) using difference-in-differences designs that take into account spatial and temporal correlation. Three gang injunctions were paused during the study period and provide a natural experiment from which we estimate the short-term effect of these injunctions on crime. Results: Gang injunctions are estimated to reduce total crime 5% in the short-term and 18% in the long-term, most of the effect coming from reductions in assaults. Analyses of the three interrupted injunctions yielded estimates of similar magnitude, providing further support of a crime reduction effect of gang injunctions. We found no evidence that gang injunctions are associated with displacing crime to nearby areas. Conclusions: Injunctions represent a powerful place-based intervention strategy for police and prosecutors. Courts have recently subjected gang injunctions to closer scrutiny. This study indicates that gang injunctions contributed to a meaningful amount of the crime reductions in Los Angeles. Future research should examine whether gang injunctions reduce crime by specific deterrent effects on individual gang members or by the general deterrent effect of placing an area under greater police surveillance and restricting public gatherings and other actions deemed to be indicators of gang activity. [ABSTRACT FROM AUTHOR]

Objectives: To assess the impact of schools on crime in neighborhoods.Methods: We utilize data of charter and public schools in Philadelphia to estimate the effect of school openings on neighborhood crime patterns between 1998 and 2010. We estimate the change in crime in areas surrounding schools before and after their opening compared to areas where schools were always open with Poisson regression models. We also estimate changes in crime in census tracts as schools are added compared to census tracts that never had schools. Finally, we compare estimates from Poisson regression models to those derived from permutation tests where schools are randomly assigned different opening dates.Results: We find no evidence that school openings increase crime relative to locations where schools were always open or never had schools. The models generally produce null effects, though there is some evidence for a reduction in property crimes for public school openings and a reduction in violent crimes for charter school openings within certain distances. Estimates at the census tract level show that changes in the number of schools are not associated with any changes in crime relative to tracts with no schools.Conclusions: Contrary to a large theoretical and empirical literature, the results suggest that school locations play a minimal role in neighborhood crime production in Philadelphia. Future research should investigate specific contexts and mechanisms, such as land-use characteristics and travel patterns to schools, which may interact with specific school settings in ways that are related to crime production. [ABSTRACT FROM AUTHOR]

Objectives: To assess the impact of rail transit on crime in neighborhoods near transit stations. Methods: We use data on the location and date of all rail station openings in Los Angeles between 1990 and 2012 and crimes reported to the Los Angeles Police Department from 1988 to 2014. We estimate the effect of transit on crime using a stepped-wedge design estimated with Poisson regression with permutation tests to assess statistical significance. Two labor strikes during the study period created a natural experiment for which we assessed the short-term effect of transit on crime. Results: We find no evidence that transit station openings or disruptions in transit due to strikes result in changes in crime in surrounding neighborhoods. Conclusions: The results suggest that rail transit may produce no major consequence for overall neighborhood crime patterns. Future research should examine other cities and more fine-grained geocoded data on crime at the street segment level and by land-use characteristics that generate foot traffic, as this approach could assess under what conditions transit may generate crime increases or reductions in highly localized areas. [ABSTRACT FROM AUTHOR]

Objective: This paper addresses previous shortcomings in the literature on racial disparities in incarceration for drug offenders by taking advantage of a change in sentencing policy in California and a rich administrative dataset that is able to create a sample of comparable White and Black offenders. Method: We use a nonparametric propensity weighting approach to identify similarly situated White and Black male offenders charged with drug-related offenses. We combine this approach with a difference-in-differences model to estimate the effect that a change in California sentencing law for convicted non-violent drug offenders had on racial disparities in prison and drug treatment dispositions. Results: We find substantial reductions in the probability of a prison sentence after the policy change, but not differentially for Blacks. Blacks remain more likely to go to prison than similarly situated Whites after the policy, although the policy does lead to more referrals to treatment for Blacks. Conclusions: This paper shows that even after comparing Blacks and Whites in similarly situated contexts that racial disparities in prison commitments remain after sentencing law changes that mandate diversion to drug treatment. The results suggests that addressing racial gaps in the commitments to state prisons will likely require more than shifting the eligibility of drug convictions for prison, as accumulated criminal histories are the primary driver of prison sentences. This means that expanding diversion options from prison alone will not reduce the racial gap in commitments to prison for drug offenses more than incrementally. [ABSTRACT FROM AUTHOR]

Objectives:Persistent disease activity is associated with a poor prognosis in inflammatory bowel disease (IBD). Therefore, monitoring of patients with intent to suppress subclinical inflammation has emerged as a treatment concept. As endoscopic monitoring is invasive and resource intensive, identification of valid markers of disease activity is a priority. The objective was to evaluate the diagnostic accuracy of C-reactive protein (CRP), fecal calprotectin (FC), and stool lactoferrin (SL) for assessment of endoscopically defined disease activity in IBD.Methods:Databases were searched from inception to November 6, 2014 for relevant cohort and case-control studies that evaluated the diagnostic accuracy of CRP, FC, or SL and used endoscopy as a gold standard in patients with symptoms consistent with active IBD. Sensitivities and specificities were pooled to generate operating property estimates for each test using a bivariate diagnostic meta-analysis.Results:Nineteen studies (n=2499 patients) were eligible. The pooled sensitivity and specificity estimates for CRP, FC, and SL were 0.49 (95% confidence interval (CI) 0.34-0.64) and 0.92 (95% CI 0.72-0.96), 0.88 (95% CI 0.84-0.90) and 0.73 (95% CI 0.66-0.79), and 0.82 (95% CI 0.73-0.88) and 0.79 (95% CI 0.62-0.89), respectively. FC was more sensitive than CRP in both diseases and was more sensitive in ulcerative colitis than Crohn's disease.Conclusions:Although CRP, FC, and SL are useful biomarkers, their value in managing individual patients must be considered in specific clinical contexts. [ABSTRACT FROM AUTHOR]

Multirotor helicopters are increasingly popular platforms in the robotics community. Making them fully autonomous requires accurate state estimation. We review an improved dynamic model for multirotor helicopters and analyze the observability properties of an estimator based on this model. The model allows better use of IMU data to facilitate accurate state estimates even when updates from a sensor measuring position become less frequent and less accurate. We demonstrate that the position update rate can be cut in half versus typical approaches while maintaining the same accuracy. We also find that velocity estimates are at least twice as accurate independent of the position update rate. [ABSTRACT FROM AUTHOR]

The beer game has been used to emphasize, investigate, and analyze supply chain inefficiencies as well as the effect of decision makers' biases. This paper investigates the short- and long-run performance in the beer distribution game by analyzing Sterman's (Manag Sci 35(3): 321-339, ) model that simulates decision-making. In this model, the system may have chaotic behavior depending on the heuristics used by decision makers. We investigate how quickly the system reaches a steady state (if at all). It is known that ignoring supply line (outstanding orders) leads to the bullwhip effect in experimental research. Among other results, we show that the short-term performance of a supply chain is not a predictor of the long-term performance even when decision makers fully recognize outstanding orders. Results of the simulation and practical implications are discussed. [ABSTRACT FROM AUTHOR]

The intricate and complex interaction between different populations of neurons in the brain has imposed limits on our ability to gain detailed understanding of synaptic transmission and its integration when employing classical electrophysiological approaches. Indeed, electrical field stimulation delivered via traditional microelectrodes does not permit the targeted, precise and selective control of neuronal activity amongst a varied population of neurons and their inputs (eg, cholinergic, dopaminergic or glutamatergic neurons). Recently established optogenetic techniques overcome these limitations allowing precise control of the target neuron populations, which is essential for the elucidation of the neural substrates underlying complex animal behaviors. Indeed, by introducing light-activated channels (ie, microbial opsin genes) into specific neuronal populations, optogenetics enables non-invasive optical control of specific neurons with milliseconds precision. These approaches can readily be applied to freely behaving live animals. Recently there is increased interests in utilizing optogenetics tools to understand synaptic plasticity and learning/memory. Here, we summarize recent progress in applying optogenetics in in the study of synaptic plasticity. [ABSTRACT FROM AUTHOR]

Previously, we reported on the anti-tumor activities of two designed calix[4]arene-based topomimetics (PTX008 and PTX009) of the amphipathic, angiostatic peptide Anginex. Here, we chemically modified the hydrophobic and hydrophilic faces of PTX008 and PTX009, and discovered new calixarene compounds that are more potent, cytotoxic anti-tumor agents. One of them, PTX013, is particularly effective at inhibiting the growth of several human cancer cell lines, as well as drug resistant cancer cells. Mechanistically, PTX013 induces cell cycle arrest in sub-G1 and G0/G1 phases of e.g. SQ20B cells, a radio-resistant human head and neck carcinoma model. In the syngeneic B16F10 melanoma tumor mouse model, PTX013 (0.5 mg/Kg) inhibits tumor growth by about 50-fold better than parent PTX008. A preliminary pharmacodynamics study strongly suggests that PTX013 exhibits good in vivo exposure and a relatively long half-life. Overall, this research contributes to the discovery of novel therapeutics as potentially useful agents against cancer in the clinic. [ABSTRACT FROM AUTHOR]

Zircon is a key mineral in geochemical and geochronological studies in a range of geological settings as it is mechanically and chemically robust. However, distortion of its crystal lattice can facilitate enhanced diffusion of key elements such as U and Pb. Electron backscatter diffraction (EBSD) analysis of ninety-nine zircons from the Lewisian Gneiss Complex (LGC) of northwest Scotland has revealed five zircons with lattice distortion. The distortion can take the form of gradual bending of the lattice or division of the crystal into subgrains. Zircon lattices are distorted because of either post-crystallisation plastic distortion or growth defects. Three of the five distorted zircons, along with many of the undistorted zircons in the population, were analysed by ion microprobe to measure U and Pb isotopes, Ti and REEs. Comparison of Th/U ratio, Pb/Pb age, REE profile and Ti concentration between zircons with and without lattice distortion suggests that the distortion is variably affecting the concentration of these trace elements and isotopes within single crystals, within samples and between localities. REE patterns vary heterogeneously, sometimes relatively depleted in heavy REEs or lacking a Eu anomaly. Ti-in-zircon thermometry records temperatures that were either low (~700 °C) or high (>900 °C) relative to undistorted zircons. One distorted zircon records apparent Pb/Pb isotopic ages (−3.0 to +0.3 % discordance) in the range of ~2,420-2,450 Ma but this does not correlate with any previously dated tectonothermal event in the LGC. Two other distorted zircons give discordant ages of 2,331 ± 22 and 2,266 ± 40 Ma, defining a discordia lower intercept within error of a late amphibolite-facies tectonothermal event. This illustrates that Pb may be mobilised in distorted zircons at lower metamorphic grade than in undistorted zircons. These differences in trace element abundances and isotope systematics in distorted zircons relative to undistorted zircons are generally interpreted to have been facilitated by subgrain walls. Trace elements and isotopes would have moved from undistorted lattice into these subgrain walls as their chemical potential is modified due to the presence of the dislocations which make up the subgrain wall. Subgrain walls provided pathways for chemical exchange between crystal and surroundings. Only five per cent of zircons in this population have lattice distortion suggesting it will not have a major impact on zircon geochronology studies, particularly as three of the five distorted zircons are from strongly deformed rocks not normally sampled in such studies. However, this does suggest there may be a case for EBSD analysis of zircons prior to geochemical analysis when zircons from highly deformed rocks are to be investigated. [ABSTRACT FROM AUTHOR]

Objectives: This study investigated the extent to which immigrant concentration is associated with reductions in neighborhood crime rates in the City of Los Angeles. Methods: A potential outcomes model using two-stage least squares regression was estimated, where immigrant concentration levels in 1990 were used as an instrumental variable to predict immigrant concentration levels in 2000. The instrumental variables design was used to reduce selection bias in estimating the effect of immigrant concentration on changes in official crime rates between 2000 and 2005 for census tracts in the City of Los Angeles, holding constant other demographic variables and area-level fixed effects. Non-parametric smoothers were also employed in a two-stage least squares regression model to control for the potential influence of heterogeneity in immigrant concentration on changes in crime rates. Results: The results indicate that greater predicted concentrations of immigrants in neighborhoods are linked to significant reductions in crime. The results are robust to a number of different model specifications. Conclusions: The findings challenge traditional ecological perspectives that link immigrant settlement to higher rates of crime. Immigration settlement patterns appear to be associated with reducing the social burden of crime. Study conclusions are limited by the potential for omitted variables that may bias the observed relationship between immigrant concentration and neighborhood crime rates, and the use of only official crime data which may under report crimes committed against immigrants. Understanding whether immigrant concentration is an important dynamic of changing neighborhood patterns of crime outside Los Angeles will require replication with data from other U.S. cities. [ABSTRACT FROM AUTHOR]

Background: The impact of the addition of gemcitabine to 5-fluorouracil (5-FU) chemoradiation (CRT) on 5-year overall survival (OS) in resected pancreatic adenocarcinoma are presented with updated results of a phase III trial. Methods: After resection of pancreatic adenocarcinoma, patients were randomized to pre- and post-CRT 5-FU versus pre- and post-CRT gemcitabine. 5-FU was provided continuously at 250 mg/m/day, and gemcitabine was provided at 1000 mg/m weekly. Both were provided over 3 weeks before and 12 weeks after CRT. CRT was provided at 50.4 Gy with continuously provided 5-FU. The primary end point was survival for all patients and for patients with tumor of the pancreatic head. Results: Four hundred fifty-one patients were eligible. Univariate analysis showed no difference in OS. Pancreatic head tumor patients ( n = 388) had a median survival and 5-year OS of 20.5 months and 22% with gemcitabine versus 17.1 months and 18% with 5-FU. On multivariate analysis, patients on the gemcitabine arm with pancreatic head tumors experienced a trend toward improved OS ( P = 0.08). First site of relapse local recurrence in 28% of patients versus distant relapse in 73%. Conclusions: The sequencing of 5-FU CRT with gemcitabine as done in this trial is not associated with a statistically significant improvement in OS. Despite local recurrence being approximately half of that reported in previous adjuvant trials, distant disease relapse still occurs in ≥70% of patients. These findings serve as the basis for the recently activated EORTC/U.S. Intergroup RTOG 0848 phase III adjuvant trial evaluating the impact of CRT after completion of a full course of gemcitabine. [ABSTRACT FROM AUTHOR]

Pituitary adenylate cyclase-activating polypeptide (PACAP) and vasoactive intestinal peptide (VIP) are two closely related peptides, which can activate protein kinase A (PKA). At least three receptors for PACAP and VIP have been identified. The PACAP-specific receptor, PAC1 receptor, exhibits a higher affinity for PACAP than VIP, whereas VIP receptors, VPAC1-R and VPAC2-R, have similar affinities for PACAP and VIP. Both PACAP/VIP and their cognate receptors are highly expressed in the brain, including the hippocampus. Recently, their roles in the regulation of synaptic transmission have begun to emerge. PACAP/VIP can signal through different pathways to regulate N-methyl- d-aspartate (NMDA) receptors in CA1 pyramidal cells. The activation of VPAC1/2-Rs increases evoked NMDA currents via the cyclic AMP/PKA pathway. However, the activation of PAC1-R stimulates a PLC/PKC/Pyk2/Src signaling pathway to enhance NMDA receptor function in hippocampal neurons. Furthermore, different concentrations of PACAP induce different effects on the both α-amino-3-hydroxy-5-isoxazole-propionic acid-evoked current and basal synaptic transmission by activating different receptors. Their roles in learning and memory are also demonstrated using transgenic mice and pharmacological methods. [ABSTRACT FROM AUTHOR]

Cardiac arrest victims may experience transient brain hypoperfusion leading to delayed death of hippocampal CA1 neurons and cognitive impairment. We prevented this in adult rats by inhibiting the expression of transient receptor potential melastatin 7 (TRPM7), a transient receptor potential channel that is essential for embryonic development, is necessary for cell survival and trace ion homeostasis in vitro, and whose global deletion in mice is lethal. TRPM7 was suppressed in CA1 neurons by intrahippocampal injections of viral vectors bearing shRNA specific for TRPM7. This had no ill effect on animal survival, neuronal and dendritic morphology, neuronal excitability, or synaptic plasticity, as exemplified by robust long-term potentiation (LTP). However, TRPM7 suppression made neurons resistant to ischemic death after brain ischemia and preserved neuronal morphology and function. Also, it prevented ischemia-induced deficits in LTP and preserved performance in fear-associated and spatial-navigational memory tasks. Thus, regional suppression of TRPM7 is feasible, well tolerated and inhibits delayed neuronal death in vivo. [ABSTRACT FROM AUTHOR]

There is widespread agreement in criminology that some crimes are more severe than others, but precise definitions of crime severity and straightforward methods for measuring it have been elusive. Public perceptions of crime severity and economic estimates of crime costs to society or willingness to pay offer a variety of metrics for the public’s perceptions of severity, but they may not accurately describe severity as reflected in offender preferences. The behavior of offenders is critical for understanding developmental progressions in criminal careers, as one may assume that typically more severe offenses are not undertaken until less severe crimes have been committed. In the present paper we propose an alternative metric of crime severity, drawing on findings from developmental criminology that indicate that more severe crimes occur after less severe crimes in the criminal life course, and a method for estimating crime severity that uses the generalized Bradley–Terry model of multiple paired comparisons. We demonstrate this approach on two samples of youthful offenders: the National Youth Survey and the RAND Adolescent Outcomes Project. The results suggest that sample-specific estimates of crime severity can be derived, that these estimates provide insight into the developmental progression of crime, and that they correspond well to crime severity rankings produced by the public. [ABSTRACT FROM AUTHOR]

In this paper we present a platform for the direct consumption of web services by a Mobile Station. We give an architectural solution where Mobile Operators play the role of Trusted Third Parties supplying service credentials that allow a co-located 3GPP Network Application Function and Liberty-enabled Identity Provider entity to implement a controlled Shopping Mall service to Mobile Stations from multiple trust domains. We consider both the protocol and the structure and syntax of the various tokens required to minimise service latency over the bandwidth and performance constrained mobile system, whilst providing adequate security services to protect against the perceived threat model. To validate our proposal we have developed code to create a Web Service test scenario using SAML authentication tokens utilising readily available J2ME, Java Card, J2SE and J2EE platforms, Web Services tools from Apache, the KToolBar emulator from Sun, and the JCOPS suite of tools for Java Card applet development. [ABSTRACT FROM AUTHOR]

OBJECTIVES: To conduct a systematic review to determine effective treatments for patients with collagenous colitis or lymphocytic colitis, the two subtypes of microscopic colitis. METHODS: Relevant papers were identified via the MEDLINE, PUBMED, and Cochrane Collaboration databases, manual searches of the references of identified papers and review papers on microscopic colitis, as well as searches of abstracts from major gastroenterological meetings. RESULTS: All studies assessing treatment of microscopic colitis had relatively small sample sizes. A total of 10 randomized trials included patients with collagenous colitis. Budesonide was studied for induction of response in three trials and for maintenance of response in two trials. The pooled odds ratio for inducing clinical response with budesonide was 12.32 (95% confidence interval, CI 5.53-27.46), and for maintaining clinical response was 8.82 (95% CI 3.19-24.37), with a number needed to treat (NNT) of 2 patients for each outcome. Budesonide also induced and maintained histological response and was well tolerated. Bismuth subsalicylate, prednisolone, and mesalamine with or without cholestyramine may be effective, whereas Boswellia serrata extract and probiotics were ineffective for treating collagenous colitis. Three randomized trials included patients with lymphocytic colitis. Budesonide was shown in one study to be effective for inducing clinical response (OR 9.00; 95% CI 1.98-40.93), with an NNT of three patients. Budesonide also induced histological response and was well tolerated. Bismuth subsalicylate and mesalamine with or without cholestyramine may be effective for treating lymphocytic colitis. No trials assessed maintenance of response in patients with lymphocytic colitis. CONCLUSIONS: Budesonide is effective and well tolerated for inducing and maintaining clinical and histological responses in patients with collagenous colitis, and for inducing clinical and histological responses in patients with lymphocytic colitis. Determining the magnitude of benefit is limited by the small sample sizes of the studies. The evidence for other agents, including bismuth subsalicylate, prednisolone, B. serrata extract, probiotics, and mesalamine with or without cholestyramine is weaker. It is not clear that any of these agents induce or maintain actual remission of collagenous or lymphocytic colitis, as opposed to clinical or histological response. [ABSTRACT FROM AUTHOR]

Previous studies have shown that youth are two to three times more likely than adults to report gambling related problems. This paper reports on the development and pilot evaluation of a school-based problem gambling prevention curriculum. The prevention program focused on problem gambling awareness and self-monitoring skills, coping skills, and knowledge of the nature of random events. The results of a controlled experiment evaluating the students learning from the program are reported. We found significant improvement in the students' knowledge of random events, knowledge of problem gambling awareness and self-monitoring, and knowledge of coping skills. The results suggest that knowledge based material on random events, problem gambling awareness and self-monitoring skills, and coping skills can be taught. Future development of the curriculum will focus on content to expand the students' coping skill options. [ABSTRACT FROM AUTHOR]

This article discusses the use of regression models for count data. A claim is often made in criminology applications that the negative binomial distribution is the conditional distribution of choice when for a count response variable there is evidence of overdispersion. Some go on to assert that the overdispersion problem can be “solved” when the negative binomial distribution is used instead of the more conventional Poisson distribution. In this paper, we review the assumptions required for both distributions and show that only under very special circumstances are these claims true. [ABSTRACT FROM AUTHOR]

The effects of temperature on the decay phase of post-synaptic currents were examined to determine the extent of temperature compensation in the inferior oblique extraocular muscles of four Antarctic fishes ( Trematomus bernacchii, Trematomus pennellii, Trematomus hansoni, and Pagothenia borchgrevinki, Family Nototheniidae). At ambient temperatures, different fish produce miniature end plate currents (MEPCs), which vary in duration and rate of decay. Low temperatures normally prolong MEPCs, however, Antarctic fishes were found to produce MEPCs of significantly shorter duration than predicted (based on back-extrapolation of temperate fish data to sub-zero temperatures). Notothenioid decay time constants were approximately 500 μs faster than their temperate counterparts, extrapolated to −2°C, suggesting that the difference is consistent with temperature compensation in the neural-systems of Antarctic fish. Results presented here conform the hypothesis that post-synaptic MEPCs of Antarctic fish exhibit temperature compensation, an adaptive feature that has permitted the successful radiation throughout the Southern Ocean. [ABSTRACT FROM AUTHOR]

Reports on the pre-post controlled experimental evaluation of a problem gambling prevention program aimed at school age youth. The program was very positively received by the students. We found a significant, but small improvement in the students’ understanding of random chance; however, we did not find any evidence for changes in gambling behaviour, coping strategies, or attitudes towards gambling. [ABSTRACT FROM AUTHOR]

This paper reports on data relating to adolescent gambling, problem gambling and correlates of problem gambling. Participation was strongly tied to age, with only 39% of grade 5 students reporting gambling and over 80% of grade 11 reporting gambling. A large percentage of the gambling involvement was on noncommercial private bets such as card games, dice games, sports bets and games of skill. Interestingly most students rated gambling as less enjoyable than most other activities including reading. In general the students understood that gambling was mostly a matter of luck, however, the students had a very poor understanding of random chance. Problem gambling was negatively correlated with the effectiveness of coping skills and the student’s understanding of random chance. We also found an interaction between coping skills and knowledge, suggesting that the combination of poor coping skills and a poor understanding of random chance are particularly important in understanding adolescent problem gambling. [ABSTRACT FROM AUTHOR]

Milataxel is a novel taxane analog, with evidence of enhanced preclinical activity compared to paclitaxel and docetaxel, especially in cell lines that over express P-glycoprotein. Based on preclinical data that milataxel may be active in colorectal cancer (CRC), a phase II study was performed in patients with advanced previously treated CRC. Forty-four eligible patients were entered. Milataxel was administered intravenously every 3 weeks at the dose of 35 mg/m2. No objective responses were noted, stable disease was seen in three patients. The median time to progression was 1.4 months (95% CI of 1.2–2.4 months). Three subjects developed neutropenic sepsis and two died. The most frequent grade 3/4 adverse events were neutropenia (57%), leukopenia (27%), dehydration (14%), neuropathy (16%), diarrhea (14%) and thrombocytopenia (14%). The pharmacokinetics of milataxel was assessed in five subjects. The mean milataxel elimination half-life was 64 h and the mean area under the plasma concentration-time curve was 1,708 ng·h/ml. A syndrome of neutropenic sepsis and diarrhea can be life threatening and close surveillance is needed in patients treated with milataxel at the dose of 35 mg/m2 every 3 weeks. Clinical activity was not demonstrated in patients with advanced previously treated CRC. [ABSTRACT FROM AUTHOR]

As a part of the ICEFISH04 project on the RVIB Nathaniel B. Palmer, miniature end plate currents (MEPCs) were recorded from the extraocular muscles of Notothenia rossii captured at King Edward Point, South Georgia. A total of 1,176 MEPCs were recorded from the inferior oblique extraocular muscles of four specimens, over a temperature range of 1–12°C. The MEPCs were normal in form, with a rapid quasi-linear increase in inward current (typically <500 μs), followed by a slower exponential decay of the inward current to baseline. Exponential decay rates were calculated for individual MEPCs by linear regression of the log-transformed data, and converted to exponential time constants ( τ). Only those MEPCs that fit the exponential model well, with r 2 ≥ 0.95 (or in some cases r 2 ≥ 0.99) were used for further calculations. At temperatures between 1 and 2°C, τ ranged from about 2,000 to 4,000 μs, similar to values extrapolated for temperate teleosts at the same temperature, but significantly longer than τ from MEPCs of high-latitude Antarctic nototheniids. Between 11 and 12°C, τ values for the N. rossii MEPCS were mainly between 1,100 and 1,700 μs, giving a Q 10 of 2.05. An Arrhenius plot and linear regression were used to describe the effect of changing temperature on the decay phase of the N. rossii MEPCs: −ln τ = 27.887−6078/ K, yielding an Arrhenius temperature coefficient (μ or apparent E a) of −50.5 ± 2.9 (95% CL) kJ mol−1 deg−1. When compared with other nototheniids, these results showed that the neuromuscular junctions of N. rossii are compensated for low temperature, but not to the same degree as those of high Antarctic species. [ABSTRACT FROM AUTHOR]

Criminologists have long recognized that offending and victimization share common ground. Using Gottfredson and Hirschi’s general theory of crime, with its emphasis on self-control as a theoretical backdrop, we examine the extent to which self-control is related to both violent offending and homicide victimization. To examine this issue, we use 5-year post-parole data on violent offending and homicide victimization from a sample of parolees from the California Youth Authority. Using rare-events logistic regression models, results indicate that self-control is related to each outcome, but that other risk factors are also uniquely related to each outcome. The implications of this study for theory and future research are addressed. [ABSTRACT FROM AUTHOR]

OBJECTIVES: To conduct a systematic review to determine effective treatments for patients with clinically active collagenous colitis.METHODS: Relevant articles were identified via the MEDLINE, PUBMED, and Cochrane Collaboration databases, manual searches of the references of identified articles, and review articles on collagenous or microscopic colitis, as well as searches of abstracts from major gastroenterological meetings.RESULTS: Five randomized trials assessing treatments for collagenous colitis were identified. One trial studying bismuth subsalicylate (nine 262 mg tablets daily for 8 wk) included 9 patients. Patients who received the bismuth preparation were more likely to have clinicaland histologicalimprovement than those who received placebo. In a trial comparing prednisolone (50 mg daily for 2 wk) to a placebo in 11 patients, a trend toward clinical response in patients on prednisone was reported. The effect of prednisolone on histological improvement was not studied. A total of 94 patients were enrolled in three trials studying budesonide (9 mg daily or in a tapering schedule for 6–8 wk). The pooled odds ratio for clinical response to treatment with budesonide was 12.32 (95% CI: 5.53–27.46). The NNT (number of patients needed to treat with budesonide to achieve 1 improved patient) was 2 patients. This therapy was well tolerated. There was significant histological improvement with treatment in all three trials studying budesonide therapy.CONCLUSIONS: There is strong evidence that budesonide is effective and well tolerated for the treatment of collagenous colitis. The evidence for benefit with bismuth subsalicylate or prednisolone is weaker. It is not clear that any of these agents produce actual remission, as opposed to clinical and histological improvement of the disease.(Am J Gastroenterol 2004;99:2459–2465) [ABSTRACT FROM AUTHOR]